Download - Kilo lab-vacuum dryers and centrifuges
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HEINKEL Filtering Systems
Centrifuge and Vacuum Drying Technology – Kilo-lab/Pilot Plant
Presented to:
Date:
Presented by: Tom Patnaik
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The Inverting Filter Centrifuge
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Pharmaceutical - Fine Chemical Process Equipment
Kilo Lab Dryer Portable Unit R&D Peeler Pilot Dryer
cGMP Peeler Pilot Vertical Inverting Filter cGMP Vertical
Chemical Basket Production Peeler Dryer Production Vertical
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Pilot Plant Centrifuge Applications Different types of centrifuges with variable basket diameters offer the
Operator a wide variety solutions for Pilot applications
Heinkel Pilot Plant centrifuges are designed to be flexible according to production and installation requirements in Pilot Plant Labs
Centrifuges with small basket diameters are mainly used in Kilo Labs and small production facilities
HEINKEL fulfils the strict requirements regarding equipment quality, acceptance tests and documentation for Pilot Plant machines
HEINKEL Pilot Plant centrifuge technology is ideal for Product Transfer through out the development phase
Excellent Data Logging Capabilities and Features
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Basics of Cake Filtration
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Intrinsic Moisturecannot be removed
mechanically
Pendular Moisturecan be removed under
high G-Forces
CapillaryMoisture
Bowl Wall
Surface-moisture
Drying:Surface < 36°CCapillary 100°CInherent > 150°C
Filter Cloth
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Selecting the Proper Centrifuge for Multi-Product Environments
cGMP ProcessVertical
Basket Top Unloading
Vertical Basket
Bottom Discharge
Horizontal Peeler
Inverting Filter / PAC
•Easy-to-filter materials• Low containment
• Low risk of exposure• Manual operation
•Easy-to-filter materials• Automatic discharge
• Low Risk of Exposure• Higher Throughput
• Medium to Slightly Difficult Filtering
• Residual Heel Issues!• Higher Containment• Improved Washing
Efficiency
• Most Versitale Centrifuge•Difficult to Easy Filtering
• No Residual Heel• High containment
• Ideal for Multiple Products• Best Wash Efficiency
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Vertical Centrifuge Interchangable Bowls
Technical Data V 200 V 300 V 400
Basket diameter [mm] 200 300 400
Basket height [mm] 100 150 250
Filter area [m²] 0.062 0.14 0.31
Nominal volume [l] 1.5 4.9 16
Max. load [kg] 2.0 8.0 20.0
Max. speed [rpm] 4,200 3,000 2,000
Max. g-force [-] 1,960 2,055 900
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Multi-Purpose Application Automatic recognition of the basket size Jacketed housing for cooling or heating
Basket diameter 200mmBasket diameter 300mmBasket diameter 400mm
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Filtering Basket / Removable Lip
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Portable Vertical Basket• Mobile
Plug-In Power
The vertical machines can be Table Top or Cart Mounted design
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Technical Details / Connections
Filtrate discharge
Feed pipe
Wash pipe
CIP N2 – purge out
N2 – purge in
Control air
Electrical connection
Light glass
Sight glass
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Over-Flow Solid-BowlApplication:
• Clarifying of liquids if solids fraction tends to settle quickly
Process requirement:• The s.g. of the solids must be higher than the s.g. of the liquid
Steps:• Slurry is fed into the bowl
• The products slowly flows down inside feed cone & migrates across bottom of basket and up the sides
• Solids can be removed manually – or - back flushed
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Sedimentation Basket
•Application: Clarifying of liquids• Processes that require longer spinning
times compared to Overflow Basket are required or if solids concentration in the feed is high.
• Process Requirement and Functionality are similar to Overflow Basket
•Intended for longer spin-times
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Skimming Tube Solid-Bowl
Application:• Separation of two liquids with different s.g. in a continuous process
Steps:• Feed enters bowl via ditribution cone.
• The liquid with the higher s.g. is skimmed with the upper skimming pipe.
• The liquid with the lower s.g. is skimmed with the lower skimming pipe.
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Selecting the Proper Centrifuge for Multi-Product Environments
cGMP ProcessVertical
Basket Top Unloading
Vertical Basket
Bottom Discharge
Horizontal Peeler
Inverting Filter / PAC
•Easy-to-filter materials• Low containment
• Low risk of exposure• Manual operation
•Easy-to-filter materials• Automatic discharge
• Low Risk of Exposure• Higher Throughput
• Medium to Slightly Difficult Filtering
• Non Compressing Heel • Higher Containment• Improved Washing
Efficiiency
• Most Versitale Centrifuge•Difficult to Easy Filtering
• No Residual Heel• High containment
• Ideal for Multiple Products
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New TechnologyHeinkel Kilo Lab Peeler Centrifuge
250mm - 320mm Bowl
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New TechnologyHeinkel Kilo Lab Peeler Centrifuge
250mm - 320mm Bowl
Technical Data
H 250 H 320
Basket Diameter 250 mm 320 mm
Basket Depth 120 mm 65 mm
Filter Area 0.098 m² 0.065 m²
Nominal Volume 2.5 L 3.38 L
Max. Load 3.1 kg 5.0 kg
Max. Basket Speed
3,800 RPM 3,350 RPM
Max. G-force 2,020 2,000
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cGMP Horizontal Peeler Centrifuge
H 500 – H 630Technical
DataH 500 H 630
Basket Diameter
500 mm 630 mm
Basket Depth 250 mm 315 mm
Filter Area 0.39 m²0.62 m²
Nominal Volume
20 l 42 l
Max. Load 25 kg 53 kg
Max. Basket Speed
2.670 RPM
2.400 RPM
Max. G-force 2.000 1900
H 500 – Roche, Basel Switzerland
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Selecting the Proper Centrifuge for Multi-Product Environments
cGMP ProcessVertical
Basket Top Unloading
Vertical Basket
Bottom Discharge
Horizontal Peeler
Inverting Filter / PAC
•Easy-to-filter materials• Low containment
• Low risk of exposure• Manual operation
•Easy-to-filter materials• Automatic discharge
• Low Risk of Exposure• Higher Throughput
• Medium to Slightly Difficult Filtering
• Non Compressing Heel • Higher Containment• Improved Washing
Efficiiency
• Most Versitale Centrifuge•Difficult to Easy Filtering
• No Residual Heel• High containment
• Ideal for Multiple Products
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What is PAC?PAC stands for Pressure Added Centrifugation. This system allows the Heinkel Inverting Filter
Centrifuge to further dewater and even dry products in the bowl of the centrifuge by introducing pressure up to <6-bar before the solids are discharged - while still under rotation.
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Pressure Added Centrifugation = PAC®
FC
FS
FC
FS
FC
FS
pCapillary Forces
Centrifugal Forces
p p
seal betweenfeed pipe androtating bowl
Nitrogen withup to 6 bar
rotational speedcan be reducedduring pressurestep!
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PAC® also Improves Cake Consistency
Before PAC – Paste Like After Pac – Solid Product
► Difficult-to-filter products can be dewatered►Products will not stick to the Solids Housing► No cannon-balling in dryers
6 bar
PAC can also improve the cakeconsistency, e.g. thyrotrophiccakes, which may stick onthe Solids Housing.
Pressure-Added-Centrifugation(PAC) to pre-dry the filter cake. Will avoid problems coming From discharging a “wet” cake.
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.Test with standard centrifugation (no PAC !!) LOD > 55 % LOD
Wet and Sticky Products = Product Loss
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Test with Pressure Added Centrifugation: LOD = 20%
Surface Moisture Removed = Higher Throughput and Profitability (minimal product loss)
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Filling
Suspension
`
toFiltrate-receiver
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Washing
Wash liquid
toFiltratereceiver
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Spinning – Cake dewatering
ToFiltrate-receiver
Filling Washing Spinning Discharging
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HypercentrifugationPressure Added Centrifugation PAC®
≤ 6 bar
To Filtrate
Receiver
Vent of BowlNitrogen
Real Pressure Added Centrifugationis only possible with theHEINKEL Inverting Basket!
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Discharging of Filter CakeFilling Washing Spinning Discharging
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Inverting Filter Discharge
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Pressure Added CentrifugationPAC® — Examples
Product nameResidual moisture
centrifugationResidual moisture with PACHYPERCENTRIFUGATION®
Antiallergical Substance
Alkaloid
Food Additive
Metal Powder
Silicon Carbide
Vitamin
30 %
45 %
22 %
26 %
19 %
39 %
11 %
32 %
5 %
12 %
6 %
24 %
► PAC reduces significantly the residual moisture! ► Inverting Filter Centrifuges is the only type which
can operate with pressure centrifugation!
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The PAC Difference
API after Discharge without PAC
API after Discharge with 20 minutes of PAC at 100 deg. C
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Compact F-Series Inverting Filter Centrifuge
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Heinkel F-Series Inverting Filter Centrifuge
Ideal for Existing Plant Equipment Upgrades
• Small Foot Print• Fewer Parts• Faster Rotation Speeds• Functional Clean Room Design
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References
CustomerYear of
CostructionType MOC Basket Area
Alessa Chemie
Frankfurt, D2006
HEINKEL GFTV 400-O
316 SS Vertical Explosion-proof
Sanofi-Aventis
Neuville, F2007
HEINKEL GFTH 250
316 SS Horizontal Explosion-proof
PDC VerfahrenstechnikGrambach, A
2007HEINKEL GFT
V 300-O316 SS Vertical Explosion-proof
TEVA
Valby, DK2007
HEINKEL GFTV 300-O
316 SS Vertical Explosion-proof
Roche AG
Penzberg, D 2007
HEINKEL GFTV 400-O
316 SS VerticalExplosion-proof
Roche AG
Basel, CH2006
HEINKEL GFT
V 200-OHC 22 Vertical
Non explosion-proof
Roche AG
Basel, CH1998
HEINKEL GFT
H 500HC-22 Horizontal
Explosion Proof
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New TechnologyBolz MiniDry
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New Concept of a Kilo Lab Mixer - Dryer
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Vessel and Cover welded or made by milling
Orbit arm welded or made by milling
Mixing screw welded or made by milling
Challenge
Milling from one piece
welded
Milling from one piece
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Hybrid Agitator
Interchangeable Mixing Tools
- Orbiting Arm Mixing Screw
- Central Shaft - Helical
Low Investment Cost
Evaluation / Comparison ofDifferent Mixing Devices
2 in 1
Realization of trials: Phase IIII: Testing the BS-miniDRY®
with a special Hybrid mixing tool
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Bolz MiniDry Interchangeable Mixing Devices
Central Shaft Helical Orbital Arm – Rotary Screw
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Suitable for
• Research
• Development
• Optimization
• Small Product Volume
• 150ml to 1500ml
• Data Recording
Application & Process
• Drying
• Mixing
• Moistening
• Granulating
• Homogenizing
• Product Transfer
Markets
• Pharmaceutical
• Fine Chemical
• Chemical
• Food
• Cosmetics
• Minerals
• Metals
• Others
MiniDry Applications and Markets
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Thank You For Your Attention
HEINKEL Filtering Systems520 Sharptown Rd
Swedesboro, NJ 08085856-467-3399
www.heinkelusa.com