Kitten with Pruritis

Dennis B. DeNicola, DVM, PhD, DACVPChief Veterinary Educator

IDEXX Laboratories

“Kitten” – 6 month old DSH6 months oldIntact femaleDomestic Shorthair

Presented with clinical history of pruritis

Cat was depressed upon presentation but became extremely excited during blood collection process

“Kitten” – 6 month old DSHWBC = 17.76 K/L ( 5.50 – 19.50 )LYM = 2.36 K/L ( 0.90 – 7.00 )MONO = 1.78 K/L HIGH ( 0.10 – 0.79 )NEU = 12.29 K/L ( 2.50 – 12.50 )EOS = 1.29 K/L ( 0.10 – 0.79 )BASO = 0.05 K/L ( 0.00 – 0.10 )%LYM = 13.3 %%MONO = 10.0 %%NEU = 69.2 %%EOS = 7.2 %%BASO = 0.3 %HCT = 23.9 % LOW ( 30.0 – 45.0 )RBC = 6.11 M/L ( 5.00 – 10.00 )HGB = 8.5 g/dL ( 8.0 – 15.1 )RETIC = 102.8 K/L%RETIC = 1.7 %MCV = 39.1 fL LOW ( 41.0 – 58.0 )RDW = 22.7 % HIGH ( 17.3 – 22.0 )MCHC = 35.5 g/dL ( 29.0 – 36.0 )MCH = 13.86 pg ( 12.50 – 17.60 )PLT = 905 K/L HIGH ( 175 – 600 )MPV = 16.69 fLPCT = 1.5 %PDW = 17.9 %

“Kitten” – 6 month old DSHErythronHCT = 23.9 % LOW ( 30.0 – 45.0 )RBC = 6.11 M/L ( 5.00 – 10.00 )HGB = 8.5 g/dL ( 8.0 – 15.1 )RETIC = 102.8 K/L%RETIC = 1.7 %MCV = 39.1 fL LOW ( 41.0 – 58.0 )RDW = 22.7 % HIGH ( 17.3 – 22.0 )MCHC = 35.5 g/dL ( 29.0 – 36.0 )MCH = 13.86 pg (12.50 – 17.60)

“Kitten” – 6 month old DSHErythronHCT = 23.9 % LOW ( 30.0 – 45.0 )RBC = 6.11 M/L ( 5.00 – 10.00 )HGB = 8.5 g/dL ( 8.0 – 15.1 )

“Kitten” – 6 month old DSHErythronHCT = 23.9 % LOW ( 30.0 – 45.0 )RBC = 6.11 M/L ( 5.00 – 10.00 )HGB = 8.5 g/dL ( 8.0 – 15.1 )

Anemia Mild

“Kitten” – 6 month old DSHErythronHCT = 23.9 % LOW ( 30.0 – 45.0 )RBC = 6.11 M/L ( 5.00 – 10.00 )HGB = 8.5 g/dL ( 8.0 – 15.1 )RETIC = 102.8 K/L%RETIC = 1.7 %

“Kitten” – 6 month old DSHErythronHCT = 23.9 % LOW ( 30.0 – 45.0 )RBC = 6.11 M/L ( 5.00 – 10.00 )HGB = 8.5 g/dL ( 8.0 – 15.1 )RETIC = 102.8 K/L%RETIC = 1.7 %

Anemia Mild, regenerative

“Kitten” – 6 month old DSHErythronHCT = 23.9 % LOW ( 30.0 – 45.0 )RBC = 6.11 M/L ( 5.00 – 10.00 )HGB = 8.5 g/dL ( 8.0 – 15.1 )RETIC = 102.8 K/L%RETIC = 1.7 %MCV = 39.1 fL LOW ( 41.0 – 58.0 )RDW = 22.7 % HIGH ( 17.3 – 22.0 )MCHC = 35.5 g/dL ( 29.0 – 36.0 )MCH = 13.86 pg (12.50 – 17.60)

“Kitten” – 6 month old DSHErythronHCT = 23.9 % LOW ( 30.0 – 45.0 )RBC = 6.11 M/L ( 5.00 – 10.00 )HGB = 8.5 g/dL ( 8.0 – 15.1 )RETIC = 102.8 K/L%RETIC = 1.7 %MCV = 39.1 fL LOW ( 41.0 – 58.0 )RDW = 22.7 % HIGH ( 17.3 – 22.0 )MCHC = 35.5 g/dL ( 29.0 – 36.0 )MCH = 13.86 pg (12.50 – 17.60)

Anemia Mild, regenerative, microcytic and potential mild

anisocytosis

Erythron – Data InterpretationAnemia

MildMicrocytic (decreased MCV) Regenerative (increased Reticulocyte Count)Potential mild anisocytosis (increased RDW)

Erythron – Blood Film

Erythron – Blood Film

Erythron – Blood Film

Erythron – Blood Film

Erythron – Blood Film

Erythron – Blood Film

Erythron – Blood Film InterpretationAnemia

MildRegenerative - reticulocytosis

PolychromasiaAnisocytosis

Erythron – Blood Film InterpretationAnemia

MildRegenerative - reticulocytosis

PolychromasiaAnisocytosis

Blood loss anemiaDeveloping Iron deficiency

“Kitten” – 6 month old DSHLeukonWBC = 17.76 K/L ( 5.50 – 19.50 )LYM = 2.36 K/L ( 0.90 – 7.00 )MONO = 1.78 K/L HIGH ( 0.10 – 0.79 )NEU = 12.29 K/L ( 2.50 – 12.50 )EOS = 1.29 K/L ( 0.10 – 0..79 )BASO = 0.05 K/L ( 0.00 – 0.10 )%LYM = 13.3 %%MONO = 10.0 %%NEU = 69.2 %%EOS = 7.2 %%BASO = 0.3 %

“Kitten” – 6 month old DSHLeukonWBC = 17.76 K/L ( 5.50 – 19.50 )

High normal leukocyte count

“Kitten” – 6 month old DSHLeukonWBC = 17.76 K/L ( 5.50 – 19.50 )LYM = 2.36 K/L ( 0.90 – 7.00 )MONO = 1.78 K/L HIGH ( 0.10 – 0.79 )NEU = 12.29 K/L ( 2.50 – 12.50 )EOS = 1.29 K/L ( 0.10 – 0..79 )BASO = 0.05 K/L ( 0.00 – 0.10 )%LYM = 13.3 %%MONO = 10.0 %%NEU = 69.2 %%EOS = 7.2 %%BASO = 0.3 %

“Kitten” – 6 month old DSHLeukonWBC = 17.76 K/L ( 5.50 – 19.50 )LYM = 2.36 K/L ( 0.90 – 7.00 )MONO = 1.78 K/L HIGH ( 0.10 – 0.79 )NEU = 12.29 K/L ( 2.50 – 12.50 )EOS = 1.29 K/L ( 0.10 – 0..79 )BASO = 0.05 K/L ( 0.00 – 0.10 )%LYM = 13.3 %%MONO = 10.0 %%NEU = 69.2 %%EOS = 7.2 %%BASO = 0.3 %

High normal leukocyte count Mild monocytosis

“Kitten” – 6 month old DSHLeukonWBC = 17.76 K/L ( 5.50 – 19.50 )LYM = 2.36 K/L ( 0.90 – 7.00 )MONO = 1.78 K/L HIGH ( 0.10 – 0.79 )NEU = 12.29 K/L ( 2.50 – 12.50 )EOS = 1.29 K/L ( 0.10 – 0..79 )BASO = 0.05 K/L ( 0.00 – 0.10 )%LYM = 13.3 %%MONO = 10.0 %%NEU = 69.2 %%EOS = 7.2 %%BASO = 0.3 %

High normal leukocyte count Mild monocytosis Low normal lymphocytes in

face of excitement !

“Kitten” – 6 month old DSHLeukonWBC = 17.76 K/L ( 5.50 – 19.50 )LYM = 2.36 K/L ( 0.90 – 7.00 )MONO = 1.78 K/L HIGH ( 0.10 – 0.79 )NEU = 12.29 K/L ( 2.50 – 12.50 )EOS = 1.29 K/L ( 0.10 – 0..79 )BASO = 0.05 K/L ( 0.00 – 0.10 )%LYM = 13.3 %%MONO = 10.0 %%NEU = 69.2 %%EOS = 7.2 %%BASO = 0.3 %

High normal leukocyte count Mild monocytosis Low normal lymphocytes in

face of excitement ! High normal eosinophils with

possible “stress”

Erythron – Blood Film

Erythron – Blood Film

Erythron – Blood Film

Erythron – Blood Film

Erythron – Blood Film

Erythron – Blood Film

Erythron – Blood Film

Erythron – Blood Film

Erythron – Blood Film

Leukogram InterpretationNormal leukocyte count

No lymphocytosis in face of excitementProbable underlying glucocorticoid influence (“stress”)

High normal eosinophil count in face of possible glucocorticoid influence (“stress”)

High probability of underlying eosinophilic inflammatory condition

“Kitten” – 6 month old DSHWBC = 17.76 K/L ( 5.50 – 19.50 )LYM = 2.36 K/L ( 0.90 – 7.00 )MONO = 1.78 K/L HIGH ( 0.10 – 0.79 )NEU = 12.29 K/L ( 2.50 – 12.50 )EOS = 1.29 K/L ( 0.10 – 0.79 )BASO = 0.05 K/L ( 0.00 – 0.10 )%LYM = 13.3 %%MONO = 10.0 %%NEU = 69.2 %%EOS = 7.2 %%BASO = 0.3 %HCT = 23.9 % LOW ( 30.0 – 45.0 )RBC = 6.11 M/L ( 5.00 – 10.00 )HGB = 8.5 g/dL ( 8.0 – 15.1 )RETIC = 102.8 K/L%RETIC = 1.7 %MCV = 39.1 fL LOW ( 41.0 – 58.0 )RDW = 22.7 % HIGH ( 17.3 – 22.0 )MCHC = 35.5 g/dL ( 29.0 – 36.0 )MCH = 13.86 pg ( 12.50 – 17.60 )PLT = 905 K/L HIGH ( 175 – 600 )MPV = 16.69 fLPCT = 1.5 %PDW = 17.9 %