Lymphocyte development
Wilaiwan Petsophonsakul
Contents
• Overview of lymphocyte development
• Stage of B cell maturation
• Selection of the mature B cell repertoire in bone marrow
• Stage of T cell maturation
• Role of the thymus in T cell maturation
• Section processes in the maturation of MHC-restricted ab T cells
• Antigen receptor gene rearrangement and expression
• Commitment to the B and T Cell Lineages
Development of B and T cells
Pluripotent stem cells give rise to distinct B and T lineages
FO B = Follicular B-2 B cell
MZ B = marginal B-2 B cell
B-1B = B-1 cell
ab T = ab T cell gd T = gd T cell ILC = innate lymphoid cell
Lymphocyte maturation
Diversity in Ig and TCR genes
B cell maturation
B cell subsets
Stage of B cell maturation
T cell maturation
T cell development
T cell maturation
Thymic selection
Self MHC restriction
Self tolerance
The function of AIRE in deletion of T cells in thymus
Stage of T cell maturation
Checkpoints in lymphocyte maturation
