![Page 1: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/1.jpg)
Marguerite Mueller, MD
Associate Medical Director
Bluegrass Care Navigators
Clinical Assistant Professor
University of Kentucky
![Page 2: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/2.jpg)
COPD
Asthma
Lung Cancer
Pneumonia
ARDS
Influenza
Cystic Fibrosis
![Page 3: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/3.jpg)
Pulmonary Fibrosis
Effects of Chemotherapy
Effects of Sickle Cell Disease
Restrictive Disease due to Skeletal Abnormalities
Restrictive Disease due to Neurological Disease or Injury
Restrictive Disease due to Muscular disease
![Page 4: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/4.jpg)
Is the disease static or progressive?
Is the disease chronic or acute?
What are the patient’s other comorbid conditions?
How compliant has the patient been historically?
Would this patient best be served in the palliative or hospice arena?
Would this patient best be served in an outpatient clinic, acute care hospital, other healthcare facility or at home?
![Page 5: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/5.jpg)
Medical care focused on the relief of symptoms in patients with a life limiting condition
Ideally provides multidisciplinary team support
Team members may include nursing, respiratory therapy, physician, social worker, chaplain depending on the location of services
Usually provided on a consultative basis in acute care
Does not necessarily mean end of life care
![Page 6: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/6.jpg)
End of life care by definition with anticipation of patient demise within 6 months if the disease follows it’s expected trajectory – can be very difficult to predict for pulmonary/respiratory patients, with the greatest accuracy as the patient gets closer to death
Services again multidisciplinary and can be provided at home or in many healthcare facilities
Patient is no longer seeking curative type treatment but instead seeking comfort
![Page 7: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/7.jpg)
Static diseases are few but examples include scarring from a prior injury, stable neurological injury
Most entities are progressive
![Page 8: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/8.jpg)
Or is it both?
COPD
Recurrent Pneumonia
Pulmonary Fibrosis
Cystic Fibrosis
Influenza
![Page 9: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/9.jpg)
Heart disease
Cancer
Diabetes
CVA
Renal Disease
Dementia
Osteoporosis
Spinal Cord Injury
Peripheral Vascular Disease
Drug Addiction
![Page 10: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/10.jpg)
Why is this question important?
What treatments can we realistically offer?
What barriers are preventing patient compliance?
![Page 11: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/11.jpg)
Prognosis
Location
Curative vs. comfort only approach
![Page 12: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/12.jpg)
“End of Life”
“Terminally Ill”
“Actively Dying”
“Terminal Care”
“Transition of Care”
Journal of Pain and Symptom Mgmt 2013 Hui Concepts and Definitions: A Systemic Review
![Page 13: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/13.jpg)
Everyone will die < 10% suddenly
> 90% prolonged illness
Last opportunity for life closure
Little experience with death exaggerated sense of dying process
![Page 14: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/14.jpg)
Time course is unpredictable
Any setting that permits privacy, intimacy
Anticipate need for medications, equipment, supplies
Regularly review the plan of care
![Page 15: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/15.jpg)
Death in Institutions 1949 : 50% of patients
1958 : 61%
1980 : 74%
2001 : 77% 53% in acute care hospitals
24% in nursing homes
(23% home) 1) Teno et al, Brown Site of Death Atlas of the U.S:
www.chcr.brown.edu/dying/usa_statistics.htm and
2) National Mortality Follow-Back Survey
![Page 16: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/16.jpg)
Bronchospasm
Secretions
Dyspnea
Tachypnea
Stridor
Hemoptysis
Cough
![Page 17: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/17.jpg)
70%: Anorexia
61%: Dys81%: Fatigue
pnea
58%: Xerostomia
52%: Cough
49%: Pain
37%: Confusion
35%: Constipation
30%: Nausea
23%: Insomnia
22%: Vomiting
Ng, von Gunten, J P Symptom Management 1998;16:307-316. Fainsinger R, Miller MJ, et.al. J Palliat Med 1991; 7: 5-11.
![Page 18: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/18.jpg)
Treatment influenced by goals of care of patient and family
Treatment influenced at times by prognosis
![Page 19: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/19.jpg)
Decision maker
Chances of recovery
Prognosis
Most troubling symptoms
What setting is the patient in
What type of respiratory support is the patient requiring
How does the patient and or family define comfort
![Page 20: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/20.jpg)
Patient
Guardian
Healthcare Surrogate
Spouse
Majority of Adult children
Parents
Majority of second degree relatives
![Page 21: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/21.jpg)
Patients can have focus on comfort and hospice care but it is a step wise process and each step must be petitioned for independently
![Page 22: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/22.jpg)
Will other underlying conditions lead to the patient’s death making recovery from another process a moot point
Will recovery be too long and laborious for the patient to survive to full recovery or is the patient predisposed to not want to pursue full recovery due to the amount of work involved
![Page 23: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/23.jpg)
It is what the patient says it is
![Page 24: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/24.jpg)
All three are interlinked
Palliative extubation or removal of BiPAP may occur at home or in the hospital or inpatient hospice unit
![Page 25: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/25.jpg)
History and Physical
Examination of the sputum Presence of food particles
Hematemesis
T/E fistula
Purulent sputum Infection
Laboratory and X-ray studies Chest x-ray
CT with contrast
![Page 26: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/26.jpg)
History and Physical
Examination of the sputum Presence of food particles
Hematemesis
T/E fistula
Purulent sputum Infection
Laboratory and X-ray studies Chest x-ray
CT with contrast
![Page 27: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/27.jpg)
Does not equal withdrawal of care.
Does require investment of time, energy and knowledge to perform successfully.
![Page 28: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/28.jpg)
Most recent published article from 2013 in Journal of Palliative Medicine
Limited number of article compared to many other topics
2 new articles in 2015
5 additional articles last year
![Page 29: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/29.jpg)
Two out of 10
![Page 30: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/30.jpg)
Average time to death 8.9 hours
56% dead at 24 hours
25% discharge alive
![Page 31: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/31.jpg)
Awake, decisional patients have the ultimate choice regarding level of life support and focus of care
Those patients who are not decisional may still wish participation in discussions with providers and loved ones if able with healthcare surrogate or healthcare POA ultimately providing decisions
![Page 32: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/32.jpg)
Awake – high risk for distress
Cognitively impaired – able to experience distress
Unconscious – may or may not be able to experience distress
Brain dead – unable to experience distress
![Page 33: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/33.jpg)
Discussion of daily changes
Education regarding medication choices and route of administration
Discussion of information needed from staff to best help patient and family
Utilize all available appropriate staff
Do not forget to include respiratory
![Page 34: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/34.jpg)
Study by Kirchoff and Kowalkowski, AJCC, 2010 – only 29% were confidant in their ability to care for patients during withdrawal
![Page 35: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/35.jpg)
Antibiotics
Lipid lowering agents
Appropriate routes
Alzheimer’s medications
Seizure medications
Nebulizers
![Page 36: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/36.jpg)
Pain
Anxiety
Agitation
Nausea/vomiting
Secretions
![Page 37: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/37.jpg)
![Page 38: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/38.jpg)
● Pathophysiology not well understood as it
may be due to multiple etiologies (lesions,
pleural effusion, bronchospasm, etc.).
● Afferent signals from chemoreceptors and
mechanoreceptors in the airway, lungs, and
chest wall are sent to respiratory center in
the brainstem, which then transmits
information to the cerebral cortex.
![Page 39: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/39.jpg)
● Subjective sensation that includes air
hunger, work/effort, and chest tightness.
● Influenced by physical, psychological,
social, and spiritual factors.
● 21-78% of cancer population, but is just
as prevalent in non-cancer population
(56% in COPD patients, 68% terminal
HIV/AIDS, 61% CHF patients).
![Page 40: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/40.jpg)
● Five etiologic categories
– Cardiac
– Pulmonary
– Neuromuscular
– Psychiatric/Social/Spiritual
– Any combination of the above
![Page 41: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/41.jpg)
Reaction Level Scale – Starmark, et al., 1988 – If able to withdraw to pain or more – likely to experience distress
Respiratory Distress Observational Scale
Utilize BORG scale as outpatient
![Page 42: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/42.jpg)
Heart rate, restlessness, accessory muscle use, paradoxical respirations, grunting at end expiration or guttural sound, nasal flaring, look of fear – all rated on a 0-2 scale.
Distress Intensity cut-point is 3 – thus use of <4 as goal
Campbell et al., Pall Med, 2015
![Page 43: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/43.jpg)
Sum boluses given as pre-medication and to treat distress
Begin infusion rate at 50% of summed boluses
Titrate to RDOS <4
![Page 44: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/44.jpg)
Midazolam
Lorazepam
Phenobarbital
![Page 45: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/45.jpg)
Glycopyrrolate
Hyoscyamine
Scopolamine
Atropine
![Page 46: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/46.jpg)
Cuff leak
Steroids
Cool air
Nebulized racemic epinephrine
![Page 47: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/47.jpg)
Acute infections (PNA, Bronchitis)
Chronic infections (Chronic bronchitis, Bronchiectasis)
Airway disease (COPD, Asthma)
Cardiac (LV failure, pulmonary edema)
Irritant (GERD, Foreign body)
Pleural disease (Pneumothorax, pleural effusion)
![Page 48: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/48.jpg)
Infection- Epiglottitis, diphtheria
Tumor
Aspirated objects Thick sputum
Blood clots
Foreign objects
Crohn’s Disease- rare
Achalasia- Mega esophagus compression of trachea
Myasthenia gravis
![Page 49: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/49.jpg)
Postural manipulation
Heimlich maneuver- for acute onset
Physiotherapy
Bronchoscopy or laryngoscopy
Tracheostomy
Stents
Medications Decadron high dose
Oxygen/Helium 4:1 mixture
Infliximab- for Crohn’s Disease
![Page 50: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/50.jpg)
Cardiac function
Renal function
Hepatic function
Gastric/intestinal function
![Page 51: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/51.jpg)
Protussive Improve cough effectiveness and secretion clearance.
Adequate hydration
Physiotherapy (only in select pts with COPD or bronchiectasis)
Pharyngeal suctioning
Meds
![Page 52: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/52.jpg)
![Page 53: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/53.jpg)
Majority of cases are mild to moderate
<20% are massive (>500cc per day)
Most common causes Infection ~80%
TB
Abscesses
Bronchiectasis
Malignancy ~20%
![Page 54: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/54.jpg)
Anticipation Education of patient, family, and caregivers
Goals of Care
Dark colored towels
Morphine
Anxiolytics
![Page 55: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/55.jpg)
Antitussive treatments Measures to prevent or eliminate cough (used primarily
for dry, non-productive cough. Opioids
Oral local anesthetics
Nebulized anesthetics
Other antitussive agents
![Page 56: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/56.jpg)
Once decision made – prepare family and patient, if appropriate, what to expect
Select a time if at all possible that will allow greatest ease of managing symptoms while in hospital
![Page 57: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/57.jpg)
When do you stop different medications
The art of medicine may supersede the science of medicine when reviewing the different techniques utilized by different providers
What can staff do to ease the process for family?
![Page 58: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/58.jpg)
Diurese
Restrict Fluids
Begin Dexamethasone (4mg IV Q6 Hr) to reduce risk of post-extubation stridor
Consider cuff leak test
![Page 59: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/59.jpg)
FiO2
PEEP
Rate
Length of tubing
Cuff Leak
![Page 60: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/60.jpg)
Now supported by study published 2016 by Campbell, et al., J Pall Med
Much greater measure of respiratory comfort noted with weaning process versus one step
More studies still needed regarding palliative and end of life care in the ICU setting
![Page 61: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/61.jpg)
Each parameter should be adjusted individually
Should be adjusted in 10-20% increments
After patient has had a chance to equilibrate on the new settings then need for medications should be assessed
After determined to have remained comfortable then may adjust settings further. It may be possible to make adjustments every 10 minutes or it may take longer depending on the patient’s individual needs
![Page 62: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/62.jpg)
After final adjustments and patient remains comfortable the patient may be extubated with evaluation for oxygen need based on the RDOS
At times oxygen placed in hospital initially for the benefit of staff and families and may be weaned as well with patient comfort the determiner
Again remember up to 25% of patients palliativelyextubated will leave the hospital alive
![Page 63: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/63.jpg)
Sat <85% and RDOS≥3 – consider low flow oxygen
Sat <85% and RDOS<3 – oxygen not needed
Sat >85% and RDOS≥3 – treat with opiate
![Page 64: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/64.jpg)
As a noninvasive form of respiratory support many of the parameters will require weaning just as with a traditional ventilator
Do not simply remove without appropriate patient assessment
![Page 65: Marguerite Mueller, MD Associate Medical Director](https://reader031.vdocument.in/reader031/viewer/2022012517/6191bfd4760a0d60c2232ee9/html5/thumbnails/65.jpg)
Dignity
Dignity
Dignity