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MARK BARTLETT, PHD
Vice President, Global Research and DevelopmentPharmanex
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DIE YOUNG
..as late in life as possible
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Our product development efforts and investment enable us to CONTINUALLY REFRESH the vibrancy of the business
opportunity through PRODUCT INNOVATION
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• Science in product development– Discovery process– Development process
• Scientific assets– Multiple unique tools to discover and
develop anti-aging products with meaningful benefits
Our anti-aging product strategyis to leverage LEADING EDGE SCIENCE to further understand the aging process.
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FIGURE DESCRIPTION: This heatmap illustrates gene expression of three groups from a pre-clinical test with one of the ageLOC Vitality ingredients: young (column 1), old (column 2), and old with ageLOC science (column 3). Each row represents one of 52 genes comprising the mitochondrial Youth Gene Cluster (mtYGC). Columns 1 and 2 show that each of the 52 genes became more or less active during the aging process. In column 3, the YGC activity pattern of the old with ageLOC science group has been reset to a gene expression pattern similar to the young group in column 1.1
1 Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, August 22-27, 2010. Les Diablerets Conference Center, Les Diablerets, Switzerland.
GENE EXPRESSION IN YOUNG TISSUE
GENE EXPRESSION IN OLD TISSUE
OLD GENE EXPRESSION
AFTER AGELOC
Low Expression
HighExpression
Gene Expression Scale
AGELOC GENE TECHNOLOGY
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• Our Science, Your guarantee– Quality– Innovation– Safety– Substantiated claims
6S Quality ProcessSelection; Sourcing; Standardization;Safety; Structure; Substantiation
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TOOLKIT
ageLOC science 6S process
ANTI-AGING PRODUCT DEVELOPMENT PROCESS
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R&D ENGINE - PROVO INNOVATION CENTER
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R&D ENGINE CHINA INNOVATION PARK
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NEW ANTI-AGING AGELOC TOOLS
LifeGen • Patented technologies to
study anti-aging interventions through gene expression science
• Acquired November 2011
NOX Technologies • Patented anti-aging
technology• Incorporated in ageLOC
Transformation and Galvanic Gels
• Acquired November 2012
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Nutrition Science
Antioxidant Science
Healthy Aging
GeneScience
???
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AGELOC GAMMA: WEIGHT MANAGEMENT SYSTEM
• AN ADVANCED WEIGHT MANAGEMENT SYSTEM that incorporates gene expression science
• ageLOC Gamma helps you look slimmer and healthier in 90 days when used in conjunction with a healthy diet and exercise
Simple Eating & Lifestyle Plan
Advanced ageLOC Products
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AGELOC GAMMA: INFLUENCING WEIGHT
• Key Tissues – There are key tissues that address critical areas of weight
loss through gene expression. ageLOC Gamma will focus on these key tissues
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AGELOC GAMMA
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AGELOC GAMMA: STUDIES• LifeGen (gene expression science)
– Gene array analysis to elucidate YGCs• Clinical Studies
– Open label study (ongoing)– Larger trial (starting in 2013)
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GAMMA SYSTEM
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Incorporating ageLOC science and clinically demonstrated ingredients
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AGELOC GAMMA REPRESENTS A MAJOR INNOVATION WITH GENE
EXPRESSION SCIENCE
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S3: SCANNER UPGRADECOMING SUMMER 2013
• 25% smaller• Wireless• Battery operated
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FUTURE PIPELINE
INNOVATIVE ageLOC SKIN CARE and NUTRITION
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AGELOC INNOVATION PATTERN
2010 20202013
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