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![Page 1: Megaloblastic Anemiahemepathreview.com/Heme-Review/Part5-5-MegaloblasticAnemia.pdfFig. 3.12 Megaloblastic anaemia: peripheral blood film in a severe case, showing oval macrocytes,](https://reader035.vdocument.in/reader035/viewer/2022063022/5fe6bdc57f61f11dcd53cef6/html5/thumbnails/1.jpg)
Megaloblastic Anemia
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Macrocytic anemia
•Megaloblastic macrocytic anemia: Vitamin B12 or folate deficiency
•Normoblastic macrocytic anemia: Alcohol, liver disease, pregnancy
(MCV not as high as the above group)
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Oval macrocyte; hypersegmented PMNs
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Erythroid hyperplasia; erythroid dysplasia;
giant bands and metamyelocytes
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Vit B12 or folate def may lead to pancytopenia
In B12 or folate def there is increase in intramedullary destruction (increased LDH 1&2); young RBCs have LDH1; therefore more increase in LDH1