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MEMBRANE RECEPTOR FOR ANTIGEN
Kelompok : 4
Ninda Sahriyani (105090100111010)
Ganys Tri S. (115090107111020)
Agatha Mia(115090101111010)
Vita Agustina(115090100111011)
Jurusan Biologi
Fakultas Matematika dan Ilmu pengetahuan Alam
Universitas Brawijaya
2013
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THREE LIMBS OF IMMUNE RESPONE
Fig 1. Three Limbs Immune Respone
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• Group of genes that code for proteins that found on the surfaces of cells that help the immune system recognize foreign substances
• Also known as HLA (Human Leukocyte Antigen)
Two types:Class I• Found in every
nucleated cell• Bound to cytotoxic T
cell (CD8)
Class II• Found in special cell
such as macrophage, dendritic cell, B cell, and thymus
• Bound to Helper T cell
Major Histocompatability Complex (MHC)
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1.Determinate between the self and nonself antigens
2.Presenting antigen to T cells
3.Determinate interaction between B cells, T cells and other cells.
Function of MHC
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There are 3 ways of processing and presentation antigens :
1. Protein from extracellular pathogen broken down and processed by exogen pathway
2. Protein from self-protein and virus protein processed by endogen pathway
3. Lipid and derivate processed like extracelular protein and endosom, with CD1, that similiar to MHC and presented to CD8 T cell.
Function of MHC
Degradation Process (Processing and Presentation) Antigen
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Fig 2. MHC Structures
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TABLE 1. DIFFERENCES BETWEEN CLASS I AND CLASS II MHC
Variable Class I MHC Class II MHC
Bound to CD8 T cell CD4 T cell
Enzyme to form peptide
Cytosolic protease Endosome and lysosom protease
Peptide binding site in cell
Reticulum endoplasmic Vesicle specialized compartment
Peptide size 8-9 amino acid 13-17 amino acid
Expression and Presentation
• Expressed to hematopoietic cells• Presented by all nucleated cells.
• Expressed to hematopoietic cell and stromal cell at thymus• Presented by macrophage, dendritic cell, B cell
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SIMILARITIES OF ANTIGEN PRESENTING BY MHC MOLECULES
• Presented to T cell on the surface of APC (Antigen Presenting Cell)
• Every MHC can only bind to single antigen fragment at one time, at the peptide binding cleft
• The presented antigen fragment is only amino acid chain
• The binding is done intracellular
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Fig 2. Class I MHC Antigen Presenting Pathway
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Fig 3. Class II MHC Antigen Presenting Pathway
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T
• Mature T cell have thousands identical receptor on the cell surface
• 2 kinds of receptor:–Alpha/beta (αβ) chain T cell (95%)–Gamma/delta (γδ) chain T cell (5%)
• Co-receptor : CD4 and CD8
T Cell Receptor (TCR)
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Fig 5. TCR-CD3 • TCR binding to MHC-antigen• The long cytoplasmic tail of the CD3 functions in signal transduction.
T Cell Receptor Complex: TCR-CD3
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Fig. 6 Role of co- receptor CD 4 and CD8 : they may act as adhesion molecule helping the T cell bind to the APC during antigen presentation for duration that is sufficient for antigen recognition or act as signal transducers.
Role of co-receptors in TCR binding affinity
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THANK YOU FOR YOUR ATTENTION…
ANY QUESTION???
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VIDEO
Link : T Cell Dependent Antigenshttp://highered.mcgraw-hill.com/olc/dl/120110/micro33.swf
Cytotoxic T Cellhttp://highered.mcgraw-hill.com/olc/dl/
120110/micro34.swf