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Miro1 Regulates Activity Driven Positioning
Mitochondria within Astrocytic Processes Appose
Synapses to Regulate Intracellular Calcium Signaling
Terri-Leigh Stephen et al.
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Interaction between Presynaptic neuron and Ast
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Role of Miro1 in mitochondria mobilty
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Hypothesis
•
Miro1 regulates trafficking and retention of mitochondria inprocesses of astrocytes and synapse.
• This Miro1 regulated mitochondrial trafficking play a key rolintracellular calcium signaling.
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Results
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Fig 1: Basal
mitochondrial
traffickingdynamics
differ inAstrocytic
and Neuronal
processes
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Fig 2: Enhancingneuronal activity
alters mitochondrialtrafficking dynamics
and morphology inastrocyte processes.
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Fig 3: Neuronal activity induces astrocyte mitochondrial posnear synapses.
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Fig 4: Glutamatedecreases thefusion rate of
mitochondria inastrocytic processes
in situ.
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Fig 5: The Calcium
sensing EF hands
of Miro1 areessential for
regulatingmitochondrial
trafficking and
morphology inastrocytes in
primary cultures
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Fig 6: Mutant Miro1 expression in situ dirups the abilitmitochondria to response to neuronal activity and alte
trafficking
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Fig 7: Mutant Miro1 expression in slices disrupts
intracellularastrocytes Calcium signalling
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Pros
• The experiments are well organized and ordered.
•Establishes their hypothesis very well.
• Give rise to some important questions that can lead to potefuture researches.
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Cons
• The mechanism by which Calcium get entry into astrocyte is not they block NMDAR mitochondrial mobility get normal, it indicateget entry through NMDA channel is responsible, but astrocytes centry involve other Glutamate dependent channels and ion exchwhy blocking them wont affect mobility.
• They provide little emphasizes on mitochondrial fission and fusiospecially fission. It may be the proper way to answer why the
mitochondrial length decreased.• The authors just give a reference of Miro1 dependent Mitochond
trafficking in Neurons, but they don’t light up the mechanisms obe they can compare Neuronal and astrocytes Miro1 dependentMitochondrial trafficking in the discussion to clarify.