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2015
MSc. Romeu Moreira dos Santos
2017
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INTRODUÇÃO
Bases celulares, histológicas e anatômicas do sistema imune
• As células do sistema imune (SI) inato e adaptativo estão presentes
como:
• células circulantes no sangue e na linfa;
• aglomerados anatomicamente definidos nos órgãos linfóides;
• distribuídos praticamente em todos os tecidos.
• Organização – fundamental importância para a geração das respostas
imunológicas.
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Origem
Bases celulares, histológicas e anatômicas do sistema imune
Todos os elementos
celulares do sangue,
incluindo as células do
sistema imune, derivam das
células tronco
hematopoiéticas
pluripotentes da medula
óssea.
Os linfócitos diferemdos outros leucócitos
por apresentaremreceptores antigênicos
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Células do sistema imune
Bases celulares, histológicas e anatômicas do sistema imune
• Granulócitos
• Eosinófilo
• Basófilo
• Mastócito
• Fagócitos
• Monócito/ macrófago
• Célula dendrítica
• Neutrófilo
• Linfócitos
• Linfócitos B
• Linfócitos T
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Células do sistema imune
Bases celulares, histológicas e anatômicas do sistema imune
- Grânulos com citocinase histamina;
- Expressam receptoresde membrana para afração Fc de IgE eIgG (revestidos);
- Liberam o conteúdodos grânulos após aligação do Ag aos Acsna membrana;
- Importantes narespostas contra
helmintos e doençasalérgicas.
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Fagócitos
Bases celulares, histológicas e anatômicas do sistema imune
Células cuja função primária é identificar, ingerir e destruir patógenos.
Respostas funcionais dos fagócitos:
-
-
-
-
-
Recrutamento das células para os sítios de infecção;
Reconhecimento e ativação dos fagócitos pelos microrganismos;
Ingestão pelo processo de fagocitose;
Destruição dos patógenos;
comunicação com outras células por contato direto e secreção de
proteínas, promovendo ou regulando as respostas imunes.
Fagócitos: macrófagos, células dendríticas e neutrófilos
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Fagócitos - macrófagos
Bases celulares, histológicas e anatômicas do sistema imune
Monócitos sangue periféricoMacrófagos tecidos linfóides ou periféricos
Funções: ingestão e morte de patógenos; ingestão de células mortas dohospedeiro; secreção de citocinas ativadoras e atuam na apresentação deantígenos para os linfócitos T.
Sistema Fagocítico MononuclearNomes especiais: micróglia (SNC), cels. Kupffer (fígado), macrófagos alveolares(vias aéreas), osteoblastos (tecido ósseo)
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Fagócitos – células dendriticas (CD)
Bases celulares, histológicas e anatômicas do sistema imune
São as APCs mais importantes na apresentação de Ags e na ativação de célulasT naive e desempenham grande papel na resposta imune inata contra asinfecções e na ligação entre imunidade inata e adquirida;
Em resposta a ativação por patógenos tornam-se móveis, migram para os gânglios linfáticos e apresentam os antígenos aos linfócitos T.
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LOGOCélulas Apresentadoras de Ags (APCs) -Resumo
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Fagócitos – Neutrófilos
Bases celulares, histológicas e anatômicas do sistema imune
População de fagócitos mais abundante circulantes
Medeiam as fases iniciais das reações inflamatórias;
Citoplasma com grânulos contendo enzimas (lisozima, colagenase ), lisossomos esubstâncias microbicidas.
Após a entrada nos tecidos, os neutrófilos atuam por algumas horas e em seguida morrem.
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Linfócitos
Bases celulares, histológicas e anatômicas do sistema imune
• Principais células da imunidade adquirida;
• Únicas células que expressam receptores de antígenos(BCR ou TCR) cada qual com uma especificidade distintapara diferentes determinantes antigênicos;
Subtipos
- Consistem em subtipos que diferem nas suas funções, seus produtos proteicos(citocinas) e seus receptores;---
Morfologicamente similaresLinfócitos B produção de anticorposLinfócitos T mediadores da imunidade celular (TCD4+ auxiliar e TCD8+citotóxico)
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Classe de linfócitos
Bases celulares, histológicas e anatômicas do sistema imune
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Classe de linfócitos
Bases celulares, histológicas e anatômicas do sistema imune
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Linfócitos – Células NK
Bases celulares, histológicas e anatômicas do sistema imune
• Natural killer
• Tipo de linfócito;
• Função efetora semelhante a TCD8+;
• Célula timo-independente;
• Diferente dos linfócitos T e B os seusreceptores não são recombinadossomaticamente;
• Importante na imunidade inata.
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Células NK - funções
Bases celulares, histológicas e anatômicas do sistema imune
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Bases celulares, histológicas e anatômicas do sistema imune
Maturação e destino dos linfócitos T e B
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Desenvolvimento dos Linf. T
Bases celulares, histológicas e anatômicas do sistema imune
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LOGOSeleção negativa
Bases celulares, histológicas e anatômicas do sistema imune
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Bases celulares, histológicas e anatômicas do sistema imune
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Marcadores linf. T
Bases celulares, histológicas e anatômicas do sistema imune
Principais marcadores e Receptores na Superfície dos Linfócitos T
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Desenvolvimento dos Linf. B
Bases celulares, histológicas e anatômicas do sistema imune
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Bases celulares, histológicas e anatômicas do sistema imune
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Principais marcadores e Receptores na Superfície dos Linfócitos B
Bases celulares, histológicas e anatômicas do sistema imune
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Tecidos e órgãos do sistema imune
Bases celulares, histológicas e anatômicas do sistema imune
As células dos sistema imune se originam na medulaóssea, onde muitas também amadurecem. A partirda medula, elas migram patrulhando os tecidos ecirculando no sangue em um sistema especializadode vasos, chamado SISTEMA LINFÁTICO.
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Órgãos linfóides
Bases celulares, histológicas e anatômicas do sistema imune
• Primários- Medula Óssea- Timo
• Secundários-----
BaçoLinfonodosPlacas de PeyerTonsilasAdenoides
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Órgãos linfoides Primários
Bases celulares, histológicas e anatômicas do sistema imune
Medula óssea
Importantes na produção e maturação das células
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Órgãos linfoides Primários
Bases celulares, histológicas e anatômicas do sistema imune
TimoDesenvolvimento e maturação dos linfócitos T
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Órgãos linfoides secundários
Bases celulares, histológicas e anatômicas do sistema imune
Linfonodos
Importantes na captura do antígeno e inicio da resposta imune adaptativa
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Órgãos linfoides secundários
Bases celulares, histológicas e anatômicas do sistema imune
Baço
Coleta de antígenos da circulação sanguínea e hemácias senescentes – hemocaterese
O antígeno do linfonodo chega através da linfa e no baço chega do sangue
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LOGOÓrgãos linfoides secundários
Baço – Características Histológicas
Bases celulares, histológicas e anatômicas do sistema imune
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Órgãos linfoides secundários
Bases celulares, histológicas e anatômicas do sistema imune
O SISTEMA IMUNE ASSOCIADO ÀS MUCOSAS - MALT
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Órgãos linfoides secundários
Bases celulares, histológicas e anatômicas do sistema imune
TonsilaContém numerosos nódulos linfáticos
Invaginações epiteliais formando criptas
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Órgãos linfoides secundários
Bases celulares, histológicas e anatômicas do sistema imune
Placas de PeyerNódulos linfáticos – mucosa íleo
Mucosa – Celulas M
Centros germinativos - Ricos em linfócitos B
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Órgãos linfoides primário (Aves)
Bases celulares, histológicas e anatômicas do sistema imune
Bursa de fabricius
Órgão primário (timo)
Tonsila cloacal
Específico de aves
Grandes quantidades de linfócitos B
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Obrigado!
REGULAÇÃO DA RESPOSTA IMUNE