Download - Neurons- The matter of the nervous system
Neurons- The matter of the nervous system
Chapter 7: Pgs 120-133
The Nervous system controls the entire body
• It is the interface between stimulus and response
• Allows animals to interact with their environment
• Brain and spinal cord: central nervous system (CNS)
• Other nerves: peripheral nervous system (PNS)
The nervous system is the interface between stimulus and response
The Neuron is the base unit of the nervous system
Neurons are large cells supported by a variety of glial cells
• Human neurons can be 1m in length
• Potentially thousands of glial cells support a single neuron
• Provide nutrition, support, insulation
• Schwann cells are an example
Schwann cells are glial cells which protect neurons with myelin
The 3 kinds of neurons work together to
interface between stimulus and response
• The reflex arc is the simplest neural circuit
• Consists of – 1 sensory neuron– 1 interneuron– 1 motor neuron
The synapse is the connection point between
neurons• Vesicles sit in
axon terminals, loaded with neurotransmitters
Some important neurotransmitters
• Acetylcholine- Neuromuscular
• Dopamine-Exitatory• Norepinephrine • GABA- Inhibitory• Serotonin-Regulatory
Many Drugs copy the action of neurotransmitters
• Methamphetamine is structurally similar to dopamine
• Dopamine involved in learning and reward systems
Dopamine
Methamphetamine
Many synapses make complex information processing possible
• Cell interactions form logic circuits
• AND, NOT, etc. gates are formable
• Human Brain: 100 billion neurons
• Up to 10,000 synaptic connections/neuron
Which one of the following statements is false?
A) Sensory neurons convey signals from the CNS to
sensory receptors. B) Motor neurons convey signals from the CNS to
effector cells. C) Interneurons integrate data and relay
appropriate signals to other interneurons or to motor neurons.
D) The PNS includes nerves and ganglia. E) The CNS consists of the brain and spinal cord.
The Nerve impulse
The nervous system runs on electricity
• Current- The movement of charge (electrons or ions)
• Voltage- potential energy stored in a charge disparity over distance
• Nervous system uses ions (Na+, K+, Cl-, Ca++) to send signals from one neuron to another
At rest, neurons must be ready to respond in milliseconds
Water behind a dam is stored potential energy
Charge and concentration gradients hold potential chemical energy
Neurons have a resting membrane potential
• Negatively charged• Keeps the neuron
poised for instant action• -70mV• Maintained by constant
active transport of ions
Pumps maintain gradients, channels activate cells
• Which of the following statements about the sodium-potassium pump is false?
• A) It is a membrane protein. • B) It keeps the concentration of sodium low
inside the cell. • C) It moves sodium across the membrane and
into the cell. • D) It helps maintain the resting membrane
potential. • E) It actively transports potassium into the cell
Two kinds of ion channels
Ligand-gated ion channels open when bound to a ligand (a neurotransmitter)
Voltage gated ion channels open when the voltage in the cell changes
Neurons can respond in milliseconds, giving us quick reflexes
Neurotransmitters are the chemical signals with which neurons
communicate across a synapse• Neurotransmitters bind
to gated ion channels in the cell membrane of the next neuron
• Binding opens the ion channel
• Hydrolysis or reuptake removes the neurotransmitter
The Nerve Impulse step by step
Step 1- depolarization causes vesicles to fuse
Step 2- Fused vesicles release neurotransmitter into the synapse
Step 3- Neurotransmitters open gated sodium channels, depolarizing cell
Step 5- Voltage-gated sodium channels pass the signal down the axon
Voltage-gated channels sit at nodes of Ranvier, making the signal travel faster
Step 6- Change in voltage at the axon terminal passes the signal on
Step 7- Potassium channels are opened, re-polarizing the cell for its next response
Step 8- Ion balance is restored using active transport- the Na+/K+ pump
What is the functional unit of the nervous system?
• A) dendrite • B) cell body • C) neuron • D) axon • E) synapse
Depolarization is the activation event
• Depolarization is caused by opening of gated sodium channels
• When depolarized, neurons respond in milliseconds
Action potentials normally travel along an axon
• A) toward the cell body. • B) away from the cell body. • C) in either direction, depending on the needs
of the animal. • D) away from the synapse. • E) from axons into dendrites.
Step 0.5: Vesicles were marched down the axon previously by kinesin
Antidepressants can block reuptake of neurotransmitters
• SSRI- “Selective Serotonin Reuptake Inhibitors”
• Prozac, Paxil, Zoloft, etc.- all SSRI’s
Sarin nerve gas is an Acetylcholinesterase Inhibitor
• How does it work?• How does it kill people?
The reflex arc is the most basic neural circuit
The Ganglion splits the signal to notify the brain
The human brain has 3 major regions
Higher thought is compartmentalized to the cerebrum
Regions of the cerebral cortex are themselves compartmentalized
A homonculus shows the area of the brain devoted to regions of the body