Download - Neuroscience
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Housekeeping Notes
Posting lectures online Writing Assignment
Listed as #4 due Monday July 7th July 6th = Monday
Office hours Friday, July 3rd, 5-6 pm, Moran Eye Center 3rd floor lobby By appointment
Test Friday, July 10th
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Physics in Visual Processes
Imaging in the eye Optics
Absorption of light in the eye Quantum mechanics
Nerve conduction Visual Information
Processinghttp://en.wikipedia.org/wiki/File:Gray722.pngGray's Anatomy of the Human Body, 1918
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Neuroscience
Scientific study of the nervous system
Highly interdisciplinary Structure/function Development/Evolution Genetics Biochemistry Physics Physiology Pathology Informatics/Computational
http://en.wikipedia.org/wiki/Image:Sagittal_brain_MRI.JPG
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Objectives
Basic Anatomy of the Nervous SystemOrganizationCells
NeuronsStructureMechanism of function
Modeling neurons
Neurodegenerative Diseases
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Nervous System
Multicellular organisms Specialized cells Complex information processing system
Innervates the entire body Substrate for thought and function Gathers information
External = Organism’s environment Internal = Organism’s self
Processing Response initiated
Perception Muscle activity Hormonal change
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Central Nervous System (CNS) Brain Spinal cord
Peripheral Nervous System (PNS) Cranial and spinal nerves Motor and sensory Somatic NS
“Conscious control” Autonomic NS
“Unconscious control”
http://en.wikipedia.org/wiki/File:Nervous_system_diagram.png
Nervous System Anatomy: Gross Organization
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http://en.wikipedia.org/wiki/File:NSdiagram.png
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Nervous System Anatomy: Cells
Neurons (Nerve Cells)Receive, process, and transmit information
GliaNot specialized for information transferPrimarily a supportive role for neurons
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Neurons
http://en.wikipedia.org/wiki/Neuron
Wei-Chung Allen Lee, Hayden Huang, Guoping Feng, Joshua R. Sanes, Emery N. Brown, Peter T. So, Elly Nedivi
http://en.wikipedia.org/wiki/File:Smi32neuron.jpg
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Neurons
Neuron Doctrine Santiago Ramon y Cajal,
1891 The neuron is the
functional unit of the nervous system
Specialized cell type Very diverse in structure
and function Sensory, interneurons,
and motor neuronshttp://en.wikipedia.org/wiki/Santiago_Ram%C3%B3n_y_Cajal
Above: sparrow optic tectum
Below: chick cerebellum
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Neuron: Structure
Axon hillock
Axon
http://en.wikipedia.org/wiki/File:Neuron-no_labels2.png
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Neuron: Structure/Function
Specially designed to receive, process, and transmit information Dendrites: receive
information from other neurons
Soma: “cell body,” contains necessary cellular machinery, signals integrated prior to axon hillock
Axon: transmits information to other cells (neurons, muscles, glands)
Polarized Information travels in one
direction Dendrite → soma → axon
Axon hillock
http://en.wikipedia.org/wiki/File:Neuron-no_labels2.png
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Glia
Major cell type of the Nervous System ~10X as many glia as neurons
Not designed to receive and transmit information Do influence information transfer by neurons
Glia = “Glue” (Greek) Support neurons
Maintain a proper environment Supply oxygen and nutrients Clear debris and pathogens
Guide development Modulate neurotransmission
Myelination
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Glia: Types
MacrogliaAstrocytes
Regulate microenvironment in CNS Form Blood-Brain Barrier
Oligodendrocytes Myelinate axons of the CNS
Schwann Cells Myelinate axons of the PNS
MicrogliaClean up in the CNS
http://en.wikipedia.org/wiki/File:Neuron-no_labels2.png
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How do neurons work?
Function Receive, process, and transmit information
SignalsChemical Electrical
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Bioelectricity
Electric current generated by living tissue History
http://en.wikipedia.org/wiki/File:Electric-eel2.jpghttp://en.wikipedia.org/wiki/File:Torpedo_fuscomaculata2.jpg
Electric Rays (Torpedos) Electric Eels
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Bioelectricity
Electric current generated by living tissue History
Electric fish"Animal electricity”
Luigi Galvani, 1786 Role in muscle activity Inspiration behind Volta’s
development of the battery
http://en.wikipedia.org/wiki/File:Galvani-frog-legs.PNG
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Bioelectricity
Electric current generated by living tissues Motion of positive and negative ions in the body
Essential for cellular and bodily functions Storage of metabolic energy Performing work Cell-cell signaling Sensation Muscle control Hormonal balance Cognition
Important Diagnostic Tool
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How do neurons work?
Function Receive, process, and transmit informationUnidirectional information transfer
SignalsChemical Electrical
What is the electrical state of a cell?
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Membrane Potential
Difference in electrical potential across cell membrane Generated in all cells Produced by separation of charges across cell membrane
Ion solutions Extracellular fluid Cytoplasm
Cell membrane Impermeable barrier
Ion channels Permit passage of ions through cell membrane Passive (leaky channels) = with gradient Active = against gradient
Resting membrane potential KCl Simple Model
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Driving Forces
Chemical driving forceFick’s First Law of Diffusion Species move from region of high concentration to
low concentration until equilibriumPassive mechanism
Electrical driving forceCharged species in an electric field move
according to chargePassive mechanism
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Nernst Equation
Calculates the equilibrium potential for each ion
R = gas constant, T = temperature, F = Faraday constant, z = charge of the ion
Assumptions: Membrane is permeable to ion Ion is present on both sides of membrane
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Ion Distributions
[Na+] = 15 mM [K+] = 150 mM
[Cl-] = 9 mM [A-] = 156 mM
[Na+] = 145 mM [K+] = 5 mM [A+] = 5 mM [Cl-] = 125 mM [A-] = 30 mM
Cytoplasm Extracellular Fluid
Cell Membrane
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-
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+
+
+
+
+
+
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+
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Driving Forces
Chemical driving force Fick’s First Law of Diffusion Species move from region of high concentration to low concentration
until equilibrium Passive mechanism
Electrical driving force Charged species in an electric field move according to charge Passive mechanism
Na+/K+ pump Active transport pump
3Na+ out of cell 2 K+ into cell
Aids to set up and maintain initial concentration gradients
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Resting Membrane Potential
Actually 4 ions (K+, Na+,Cl-, Ca2+) that strongly influence potential Goldman-Hodgkin-Katz Equation
Takes into account all ionic species and calculates the membrane potential
P = permeability Proportional to number of ion channels allowing passage of the ion
Not specific to the resting membrane potential Can replace p with conductance (G) and [ion]in/[ion]out with Eion
Greater the membrane permeability = greater influence on membrane potential Permeability: PK: PNa: PCl = 1 : 0.04 : 0.45
Cl- typically not pumped, so at equilibrium K+ dominates because greatest conductance Resting membrane potential usually very negative -70 mV
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Electric Signals
Deviation in the membrane potential of the cell Depolarization
Reduction of charge separation across membrane Less negative membrane potential
Hyperpolarization Increase in charge separation across membrane More negative membrane potential
Cause: Ion channels open/close Large change in permeability of ions relative to each other Negligible change in bulk ion concentrations! Induce changes in net separation of charge across cell membrane
Goldman equation only applies to steady state
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Electric Signals
Initiated by discrete eventsSensory neurons
Examples: Vision: photoreceptors - absorb light triggering a chemical
signaling cascade that opens voltage-gated ion channels Touch: mechanoreceptors - mechanical pressure or distortion
opens stress-gated voltage channels
Neuron-neuron, neuron-muscle, neuron-gland Chemical signals open ligand-gated ion channels at the
Synapse
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Synapse
Functional connections between neurons Mediates transfer
of information Allows for
information processing
Axon terminal “talks to” dendrite of another neuron Neurotransmitters
activate ligand-gated ion channels
http://en.wikipedia.org/wiki/File:Synapse_Illustration2_tweaked.svg
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Electric Signals
Deviation in the membrane potential of the cell
Spread according to different mechanismsElectrotonic conduction
Dendrites
Action Potential Axons
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Neuron: Structure
Axon hillock
Axon
http://en.wikipedia.org/wiki/File:Neuron-no_labels2.png
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Electrotonic Conduction
Passive spread of electrical potential Induced point increase in ion concentration
Na+ channels opened Na+ flows into cell Membrane potential shifts
toward Na+ equilibrium potential (positive)
Depolarization Diffusion of ions
Chemical gradient Charge (electrical)
gradient Potential dissipates as distance from source
increases
Na+
Cha
nge
in P
oten
tial
Distance (x)
x = 0
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Electrotonic Conduction
Potential dissipates as distance from source increases“Graded Potentials”Summation
Spatially Multiple sources of ion flux at different locations
Temporally Repeated instances of ion flux at same location
Allows for information processing
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Processing
A single neuron receives inputs from many other neuronsInput locations
Dendrites – principle site Soma – low occurance
Inputs converge as they travel through the neuron Changes in membrane potential sum temporally and
spatially
http://en.wikipedia.org/wiki/File:Neuron-no_labels2.png
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Transmitting Information
Signal inputs do not always elicit an output signal Change in membrane potential must exceed the threshold potential for an action potential
to be produced Mylenated axons
Axon hillock = trigger zone for axon potential Unmyelenated axons
Action potentials can be triggered anywhere along axon
Axon hillock
http://en.wikipedia.org/wiki/File:Action_potential_vert.png
http://en.wikipedia.org/wiki/File:Neuron-no_labels2.png
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Action Potentials
“All-or-none” principle Sufficient increase in
membrane potential at the axon hillock opens voltage-gated Na+ channels
Na+ influx further increases membrane potential, opening more Na+ channels
Establishes a positive feedback loop
Ensures that all action potentials are the SAME size
Also, complete potential is regenerated each time, so does not fade out
Turned off by opening of voltage gated K+ channels
http://faculty.washington.edu/chudler/ap.html
http://en.wikipedia.org/wiki/File:Action_potential_vert.png
Figure: Ion channel openings during action potential
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Action Potential Propagation
VelocityAction potential in one region of axon provides
depolarization current for adjacent region Passive spread of depolarization is not instantaneous Electrotonic conduction is rate-limiting factor
Unidirectional Voltage gated channels take time to recover
Cannot reopen for a set amount of time, ensuring signal travels in one direction
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Transmitting Information
Presynaptic action potential causes a change in membrane polarization at the axon terminals
Votage-modulated Ca2+ channels open
Neurotransmitter is released Activates ligand-
gated ion channels on dendrites of next cell http://en.wikipedia.org/wiki/File:Synapse_Illustration2_tweaked.svg
The Synapse
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Modeling Neurons
Neurons are electrically active Model as an electrical circuit
Battery Current (i) generator
ResistorCapacitor
+
-
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+Battery
Capacitor
Resistori
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+ + + +
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Membranes as Capacitors
Capacitor Two conductors separated by
an insulator Causes a separation of charge
Positive charges accumulate on one side and negative charges on the other
Plasma Membrane Lipid bilayer = insulator Separates electrolyte solutions
= conductors
http://en.wikipedia.org/wiki/File:NeuronCapacitanceRev.jpg
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Ionic Gradients as Batteries
Concentration of ions differ between inside the neuron and outside the neuron Additionally, Na+/K+ pump keeps these ions out of equilibrium
Ion channels permeate the membrane Selective for passage of certain ions Vary in their permeability Always open to some degree = “leaky”
Net Result: each ionic gradient acts as a battery Battery
Source of electric potential An electromotive force generated by differences in chemical potentials
Ionic battery Voltage created is essentially the electrical potential needed (equal and opposite) to
cancel the diffusion potential of the ions so equal number of ions enter and leave the neuron
Establish the resting membrane potential of the neuron
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Ion Channels as Resistors
Resistor Device that impedes current flow
Generates resistance (R) Ion channels vary in their permeability
“Leaky” Always permeable to some degree
Permeability is proportional to conductivity Conductance (g) = 1/R Ion channels modeled as a battery plus a resistor
Leak channels Linear conductance relationship, gL
Voltage-gated channels Non-linear conductance relationship, gn(t,V)
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Neuron modeled as an Electrical Circuit
Ion pump
Created by Behrang Amini http://en.wikipedia.org/wiki/File:Hodgkin-Huxley.jpg
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Cable Equation
Describes the passive spread of voltage change in the membrane of dendrites and axons
Time constant (τ) Capacitor takes time to
rearrange charges Length constant (λ)
Spread of voltage change inhibited by resistance of the cytoplasm (axial resistance)
Spread of voltage limited by membrane resistance (leak channels)
http://en.wikipedia.org/wiki/File:NeuronResistanceCapacitanceRev.jpg
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Hodgkin-Huxley Model
Describes how action potentials in neurons are initiated and propagated
Nrets at en.wikipediahttp://en.wikipedia.org/wiki/File:MembraneCircuit.jpg
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Neuron Design Objectives
Maximize computing powerIncrease neuron densityRequires neurons be small
Maximize response abilityMinimize response time to changes in environmentRequires fast conduction velocities
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Passive Electrical Properties
Limitations to the design objectives Action potential generated in one segment
provides depolarization current for adjacent segmentMembrane is a capacitor
Takes time to move charges
Rate of passive spread varies inversely with the product of axial resistance and capacitance
= raCm
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Passive Electrical Properties
Membrane Capacitance (C) Limits the conduction velocity
ΔV = Ic x Δt / C, where Ic = current flow across capacitor, t = time, and C = capacitance
Takes time to unload the charge on a capacitor when changing potential. Function of surface area of plates (A), distance between plates (d) and
insulator properties (ε)
Lipid bilayer = great insulator properties and very thin = high capacitance
Smaller neuron = smaller area = shorter time to change membrane potential = faster conduction velocity
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Passive Electrical Properties
Axial resistance (ra)Limits conduction velocity
Ohm’s Law: ΔV = I x ra
ra = ρ/πa2
ρ = resistance of cytoplasm, a = cross-sectional area of process
Increases with decreasing axonal radiusLarger axon = smaller axial resistance = larger
current flow = shorter time to discharge the capacitor around axon = faster conduction velocity
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Passive Electrical Properties
Input resistance (Rin) Limits the change in membrane potential
Ohm’s Law: ΔV = I x Rin
Rin = Rm/4πa2
Rm = specific membrane resistance Function of ion channel density and their conductance
Rin = function of Rm and cross sectional area of process
Smaller axon = fewer channels and smaller area = greater resistance = smaller current for a given membrane potential = longer time to discharge capacitor = slower conduction velocities
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Increasing Conduction Velocity
Increase axon diameter Axial resistance decreases in proportion to square of axon
diameter Capacitance increases in direct proportion to diameter Net effect
Increased diameter reduces raCm Increases rate of passive spread
Giant axon of squid Axon diameter = 1 mm
Limitations: Need to keep neurons small so can increase their numbers Energy cost also increases with larger axon diameter
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Increasing Conduction Velocity
Myelination of axons Wrapping of glial membranes around axons Increases the functional thickness of the axonal membrane
100x thickness increase Decreases capacitance of the membrane
Same increase in axonal diameter by myelination produces larger decrease in raCm
More effective increase of conduction velocity
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Myelin
Lipid-rich substance Produced by Schwann cells and
Oligodendrocytes that wrap around axons Gaps between = Nodes of Ranvier
http://en.wikipedia.org/wiki/File:Neuron-no_labels2.png
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Action Potential Propagation
Myelin decreases capacitance Depolarization current moves quickly Current flow not sufficient to discharge capacitance along entire length of axon
Length > 1 m Myelin sheath interrupted every 1-2 mm
Nodes of Ranvier Exposed bare membrane (~2 um)
Increases capacitance Depolarization current slows
High density of Na+ channels Intense depolarization Regenerates full depolarization of amplitude Prevents action potential from dying out
Saltatory Conduction Action potential “hops” from one node of Ranvier to the next, down the axon
Fast in myelinated regions Slow in bare membrane regions
Ion flow restricted to nodes of Ranvier Improves energy efficiency
NS uses >20% of body’s metabolic energy!! High resistance of myelinated membrane reduces current leak Less work by Na+/K+ pump
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Demyelination
Loss of the myelin sheath that insulates axons Examples:
Multiple sclerosis Acute disseminated encephalomyelitis Alexander’s Disease Transverse myelitis Chronic inflammatory demyelinating neuropathy Central pontine myelinosis Guillain-Barre Syndrome
Result: Impaired or lost conduction Neuronal death Symptoms vary widely and depend on the collection of neurons
affected
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Multiple Sclerosis
“multiple scars” Autoimmune condition
Immune system attacks CNS Kills oligodendrocytes
2-150 affected in 100,000 people More prevalent in women
Onset in young adults Physical and cognitive
symptoms Arise from loss of myelination
impairing axon conduction Start as discrete attacks Progress to chronic problems
Symptoms vary greatly Changes in sensation Neuropathic pain Muscle weakness, spasms, or
difficulty moving Difficulty with coordination
and balance Speech, swallowing or visual
problems Fatigue Cognitive impairment
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Innervates every part of the body
Hierarchical organization
http://en.wikipedia.org/wiki/File:Nervous_system_diagram.png
Nervous System Anatomy: Gross Organization
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http://en.wikipedia.org/wiki/File:NSdiagram.png
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Nervous System Anatomy: Gross Organization
Information processing in the brain is highly parallel Localization of function
Parallel streams of information in separate tracts and nuclei
Hierarchical processing scheme Information is relayed serially from one nucleus to the next Each nucleus performs a specific processing step More and more abstract information is extracted from the
sensory inputs
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Neuronal Death
One of few non-regenerating cell populations Axons can re-grow if cell body survives
Target–derived neurotrophic signals Necessary for survival
Barriers to re-growth Scar tissue Absence of appropriate developmental guidance signals
Loss of signal Switch in response to signal
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Neurodegenerative Diseases
Ataxia Conditions causing problems with movements Cerebellar ataxia
Cerebellum affected – coordination of movements Sensory ataxia
Dorsal columns affected – diminished sensitivity to joint and body part position
Vestibular ataxia Vestibular system affected – disequilibrium and vertigo
Dimentia Conditions affecting cognitive function Cortical or subcortical areas affected
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Alzheimer’s Disease
Most common type of dimentia Degenerative disease Terminal Symptoms vary
Memory loss Particularly recent memories
Confusion Anger Mood swings Language problems Long term memory loss Sufferer eventually withdraws as senses decline
Associated with plaques and tangles in the brain
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Parkinson’s Disease
Common type of ataxia Degenerative, chronic and
progressive Insufficient production of the
neurotransmitter dopamine Reduced stimulation of the motor
cortex by the basal ganglia Characteristic symptoms
Muscle rigidity Tremor Slowing or loss of physical
movement Eventually high level cognitive
and language problems
http://en.wikipedia.org/wiki/File:Sir_William_Richard_Gowers_Parkinson_Disease_sketch_1886.jpg