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Pioneer in Natural Health- since 1923
Bioforce Canada Inc.66 Brunswick Blvd., Dollard-des-Ormeaux
QC, Canada H9B 2L3 • 1-800-361-6320 www.avogel.ca
Points to Remember1. Echinaforce is the only product approved by Health Canada for both
prevention and treatment of cold and flu.
2. Echinaforce can be safely taken for up to 4 months to effectively prevent cold and flu.1
3. For maximum effectiveness you need both root and herb: Antiviral properties are located in the herb and anti-inflammatory properties are located in the roots.
Echinaforce is composed of 5% root and 95% herb extract.5
4. Fresh plant extract is more effective.5-8
5. Acute Treatment with Echinaforce: Start at first signs of infection and use the higher indicated dosage.
6. Echinaforce Hot Drink has the same concentration as Echinaforce Extra, with the added benefit of organic elderberry.
7. Having a hot drink is in itself an effective treatment for common cold symptoms.9
References(1) Jawad M et al. Safety and Efficacy profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double
Blind, Placebo-Controlled Trial. eCAM 2012(2) Schapowal A.Efficacy and safety of Echinaforce® in respiratory tract infections. Wien Med Wochenschr.2013;163(3-4):102-5(3) Shah SA, et al. Evaluation of Echinacea for the prevention and treatment of the common cold: a meta-analysis. Lancet
Infect Dis. 2007;7(7):473-80.(4) Brinkeborn R, et al. Echinaforce and other Echinacea fresh plant preparations in the treatment of the common cold: A
randomized, placebo controlled, doubleblind clinical trial. Phytomedicine. 1996(1):1-6.(5) Vimalanathan S, et al. Optimisation of Echinacea purpurea extraction and processing to yield high potency antiviral activity.
2013 (poster).(6) Vimalanathan S, et al. (2005). Pharm. Biol 12;43(9):740-745.(7) Chicca A, et al. Synergistic immunopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. Int
Immunopharmacol. 2009;9(7-8):850-8.(8) Tobler M, et al. Swiss J Integr Med. 1994;5:257-266.(9) A. Sanu and R. Eccles. The effects of a hot drink on nasal airflow and symptoms of common cold and flu. Rhinology, 46,
271-275, 2008.
New Echinaforce Extra “Hot Drink”
The cold and flu relief you need. The comfort you crave.
Same medicinal concentration as Echinaforce Extra (1200 mg) with the added benefit of tasty elderberry
Scientific Evidence
In addition to the clinical proof of safety and efficacy of Echinaforce, there is actual evidence of the efficacy of a hot drink.
A 2008 study conducted by the Common Cold Centre at Cardiff University concluded that there was evidence to support the folklore that “A hot tasty drink is a beneficial treatment for relief of most symptoms of common cold and flu”.
The study showed that subjects with cold infections who consumed a hot drink showed a subjective but significant improvement in their symptoms (runny nose, cough, sore throat, fatigue) versus subjects given the same drink at room temperature.
700
476
11
Minute Training
Echinaforce® Latest News!
Echinaforce is the only product approved by Health Canada for both prevention and treatment of cold and flu.
For professional use only
NEw StudiES, NEw product,
NEw claim
caution:Consult a healthcare practitioner prior to use if taking an immunosuppressant (including Imuran, Simulect, Neoral, Sandimmune, Zenapax, OKT3, Orthoclone OKT3, CellCept, FK506, Prograf, Rapamune, prednisone and other corticosteroids) or if you have a progressive systemic disease such as tuberculosis, leucosis, collagenosis or multiple sclerosis. Discontinue immediately in case of hypersensitivity/allergic reaction. Do not use if you have an allergy to Asteraceae/Compositae (daisy) family or elderberries or in case of known allergy to any of the ingredients in the product. Consult a healthcare practitioner if symptoms persist or worsen.
medicinal ingredients:
EACH TEASPOON (5 ML) CONTAINS: Fresh organic Echinacea (Echinacea purpurea) - Herb tincture (ratio 1:12) - 1,140 mg, equivalent to 95 mg of dried herb - Root tincture (ratio 1:11) - 60 mg, equivalent to 5.5 mg of dried root Fresh organic European Elderberry (Sambucus nigra) - Fruit extract (ratio 1.4:1) - 1,370 mg, equivalent to 1 910 mg of dried fruit.
N.B. there is no danger of cyanogenic toxicity, which results in weakness, dizziness, numbness and stupor with Echinaforce Extra Hot drink. it is made with the ripe fruit of Elderberry, which does not contain cyanogenic glycosides.
Freshly harvested Echinacea herb contains 10 times more anti-viral activity than dried ones.
Max
imum
Inhi
bito
ry
Dilu
tion
(1/x
)
9000
8000
7000
6000
5000
4000
3000
2000
1000
0
Table 2. Superiority of fresh Echinacea preparations
The anti-viral activity of Echinacea is located in the herb (green plant parts).
Max
imum
Inhi
bito
ry
Dilu
tion
(1/x
)
9000
8000
7000
6000
5000
4000
3000
2000
1000
0
Table 1. Localization of the anti-viral activity in Echinacea
above-ground plant parts
green plant parts
flowerheadspetalsroots
dried roots Echinaforce® from dried
plants
fresh roots Echinaforce®
from fresh plants
fresh herbdried herb
Table 3
pg/m
l
LPS = Lipopolysaccharide
LPS control
Herba tincture
Roots tincture 1:20 dilution
Echinaforce® (95% Herba, 5% Roots)
4500
4000
3500
3000
2500
2000
TNF-α
*
Echinaforce® is the only medicine licensed by Health Canada for both the prevention and the treatment of the common cold Largest study on Echinacea completed in 20121
Scientists at the Common Cold Centre at Cardiff University’s School of Biosciences conducted the world’s largest clinical study on Echinacea purpurea. The double-blind, placebo-controlled study unequivocally demonstrates that Echinaforce is effective both in the prevention and treatment of colds and flu and that it is safe even for long-term use. In particular, Echinaforce offers much-needed support to those whose immune systems may be depleted from stress, insufficient sleep or smoking.
proven long-term prevention.755 subjects were treated with either Echinaforce or placebo over 4 months.
Latest research in EchinaceaResearch in plant extracts is quite different from pharmaceutical research. The base material is a complex of many molecules in various concentrations which depend on weather, time of harvest, the particular section of the plant being used/analyzed and freshness. In some cases, known benefits are linked to specific plant parts; for example: it is the fatty acid content in the fruit of the saw palmetto plant that helps with prostate hyperplasia, hypericin in the flower heads of St-John’s Wort is responsible for its anti-depressant action. In the case of Echinacea Purpurea, a plethora of products are available, some containing dry extract, root only extract, whole fresh plant, mixed varietals of echinacea, and so on. The picture has never been clear… until now.
Antiviral activity in EchinaceaIn their latest study, Vimalanathan S et al., evaluated different types of echinacea purpurea extracts for relative antiviral activities.5
The authors separately investigated ethanol extracts (65% V/V) of roots, herb (aerial part without flowers), flower heads and petals. Minimal inhibitory concentrations (MIC) were measured quantitatively by means of standard plaque assays with influenza virus type A, H3N2.6
No antiviral activity was found in the roots and the petals (MIC > 1 mg/ml); but extracts of the herb and of the flower heads were active (MIC < 26.5μg/ml). (Table 1)
In addition there was a substantial difference between the freshly processed herb providing tinctures with MIC < 2.3 μg/ml in comparison to dried herb tincture with MIC equal to 16.8 μg/ml. (Table 2)
Anti-inflammatory activity in EchinaceaIn 2009, Chicca A, et al. demonstrated that alkylamides are the key to the anti-inflammatory effect of echinacea purpurea.7 Their study showed how alkylamides regulate inflammation by influencing the levels of immune mediators (e.g. TNF-a) (Table 3)
Get Real! When choosing an Echinacea product, look for a fresh plant extract, combining root and herb.
« Combination of anti-viral and anti-inflammatory therapies is the best hope for intervention after the onset of cold symptoms »
Johnston SL. Trends in Microbiology. 1997;5(2):58-63
The plant’s roots hold the highest concentration of alkylamides. In a previous study, Tobler et al. showed that fresh plant extract contains significantly more alkylamides than dried plant extract.8 (Table 4)
90
80
70
60
50
40
30
20
10
0
+32%
+66% +68%
+82%
Risk
of
plac
ebo
grou
p vs
. Ec
hina
forc
e® (
%)
> 2 colds/year
Stress Lack of sleep Smoking
Higher risk of cold episodes without Echinaforce
60
50
40
30
20
10
0
+26%
+59%+52%
Risk
of
plac
ebo
grou
p vs
. Ec
hina
forc
e® (
%)
Cold episodesCold days
Recurrentinfections
Risk without Echinaforce
Co-medication episodes
New evidence for stressed immune systems5-2
Effective treatment Significant reduction of symptoms and symptom duration3-4
For acute treatment with Echinaforce: • Start at first signs of infection (itchy/sore throat, sneezing, runny nose)• Use the higher indicated dosage
Sym
ptom
sev
erity
Symptom duration
Placebo Echinaforce®
Schematic illustration of Echinaforce® effects
–62.7%reduction
of symptom severity7
–1.5 daysreduction of
symptom duration6
Freshly harvested Echinacea herb contains 10 times more anti-viral activity than dried ones.
Max
imum
Inhi
bito
ry
Dilu
tion
(1/
x)
9000
8000
7000
6000
5000
4000
3000
2000
1000
0
Table 2. Superiority of fresh Echinacea preparations
The anti-viral activity of Echinacea is located in the herb (green plant parts).
Max
imum
Inhi
bito
ry
Dilu
tion
(1/
x)
9000
8000
7000
6000
5000
4000
3000
2000
1000
0
Table 1. Localization of the anti-viral activity in Echinacea
above-ground plant parts
green plant parts
flowerheadspetalsroots
dried roots Echinaforce® from dried
plants
fresh roots Echinaforce®
from fresh plants
fresh herbdried herb
Freshly harvested Echinacea herb contains 10 times more anti-viral activity than dried ones.
Max
imum
Inhi
bito
ry
Dilu
tion
(1/
x)
9000
8000
7000
6000
5000
4000
3000
2000
1000
0
Table 2. Superiority of fresh Echinacea preparations
The anti-viral activity of Echinacea is located in the herb (green plant parts).
Max
imum
Inhi
bito
ry
Dilu
tion
(1/
x)
9000
8000
7000
6000
5000
4000
3000
2000
1000
0
Table 1. Localization of the anti-viral activity in Echinacea
above-ground plant parts
green plant parts
flowerheadspetalsroots
dried roots Echinaforce® from dried
plants
fresh roots Echinaforce®
from fresh plants
fresh herbdried herb
The anti-viral activity of Echinacea is located in the herb (green plant parts).
Freshly harvested Echinacea herb contains 10 times more anti-viral activity than dried ones.
Table 3
pg/m
l
LPS = Lipopolysaccharide
LPS control
Herba tincture
Roots tincture 1:20 dilution
Echinaforce® (95% Herba, 5% Roots)
4500
4000
3500
3000
2500
2000
TNF-α
*
table 4. Fresh plant/dried plant comparison for Echinacea purpurea herbs (in Echinaforce)
Alkylamide (VC = 0.9%)
mg/
100g
cal
cula
ted
on th
e ba
sis
of th
e dr
ied
plan
t
80
70
60
50
40
30
20
10
0Fresh
79.9
dried
30