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19/09/2016 MANCOZEB | C8H12MnN4S8Zn PubChem
https://pubchem.ncbi.nlm.nih.gov/compound/3034368 1/67
NIH U.S. National Library of Medicine National Center for Biotechnology Information
O P E NCHEMISTRYD A T A B A S E
Search Compounds
PUBCHEM COMPOUND MANCOZEB
MANCOZEB Cite this Record
Vendors
Pharmacology
Literature
Bioactivities
PubChem CID: 3034368
Chemical Names:MANCOZEB; Dithane; 8018017; Carmazine; Kascade;
Mancomix; More...
Molecular Formula: C H MnN S Zn
Molecular Weight: 541.045725 g/molInChI Key: CHNQZRKUZPNOOHUHFFFAOYSAJSafety Summary: Laboratory Chemical Safety Summary (LCSS)Modify Date: 20160917Create Date: 20050808
8 12 4 8
Compound Summary for CID 3034368
https://www.nih.gov/https://www.nlm.nih.gov/https://www.ncbi.nlm.nih.gov/https://pubchem.ncbi.nlm.nih.gov/https://pubchem.ncbi.nlm.nih.gov/https://www.ncbi.nlm.nih.gov/pccompoundhttps://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C8H12MnN4S8Zn&sort=mw&sort_dir=asc
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Contents1 2D Structure
2 3D Conformer
3 Names and Identifiers
4 Chemical and Physical Properties
5 Related Records
6 Chemical Vendors
7 Agrochemical Information
8 Pharmacology and Biochemistry
9 Use and Manufacturing
10 Identification
11 Safety and Hazards
12 Toxicity
13 Literature
14 Biological Test Results
15 Classification
16 Information Sources
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from PubChem
1 2D Structure
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from PubChem
2 3D Conformer
3D Conformer of Parent Compound ETHYLENEBISDITHIOCARBAMIC ACID (CID 3000605)
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https://pubchem.ncbi.nlm.nih.gov/compound/3000605
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3 Names and Identifiers
3.1 Computed Descriptors
zinc;manganese(2+);N[2(sulfidocarbothioylamino)ethyl]carbamodithioate
from PubChem
3.1.1 IUPAC Name
InChI=1S/2C4H8N2S4.Mn.Zn/c2*73(8)51264(9)10;;/h2*12H2,(H2,5,7,8)(H2,6,9,10);;/q;;2*+2/p4
from PubChem
3.1.2 InChI
CHNQZRKUZPNOOHUHFFFAOYSAJ
from PubChem
3.1.3 InChI Key
C(CNC(=S)[S])NC(=S)[S].C(CNC(=S)[S])NC(=S)[S].[Mn+2].[Zn+2]
from PubChem
3.1.4 Canonical SMILES
C H MnN S Zn
from PubChem
3.2 Molecular Formula
8 12 4 8
3.3 Other Identifiers
8018017
from ILOICSC
3.3.1 CAS
6169955
from ECHA
3.3.2 EC Number
0754
from ILOICSC
3.3.3 ICSC Number
https://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=C8H12MnN4S8Zn&sort=mw&sort_dir=aschttp://www.ilo.org/dyn/icsc/showcard.display?p_card_id=0754
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19/09/2016 MANCOZEB | C8H12MnN4S8Zn PubChem
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ZB3200000
from ILOICSC
3.3.4 RTECS Number
2210
from ILOICSC
3.3.5 UN Number
Title Mancozeb
Description chemical compound
from Wikipedia
3.3.6 Wikipedia
3.4 Synonyms
1. ethylenebisdithiocarbamate manganesezinc2. mancozeb
from MeSH
3.4.1 MeSH Synonyms
1. MANCOZEB2. Dithane3. 80180174. Carmazine5. Kascade6. Mancomix7. Mancozi8. Manoseb9. Milcozebe10. Nemispor
11. Penncozeb12. Vondozeb13. Zimanat14. Zimaneb15. Manzeb16. Marzin17. Fore18. Liro manzeb19. Manebzinc20. ZimanDithane
21. Karamate N22. Greendaisen M23. Tritogol MZ24. Indofil M 4525. Manzate 20026. Novozir MN 8027. Agrox 16D28. Othane M 4529. UNIIR0HY55EB9E30. Zinc manganese ethylenebisdithiocarbamate
31. F 296632. Karamate33. Mancofol34. Mancozebe35. Mancozin36. Marzidan37. Sandozebe38. Manzin39. Dithane ultra40. Vondozeb plus
41424344454647484950
from PubChem
3.4.2 DepositorSupplied Synonyms
http://www.cdc.gov/niosh-rtecs/ZB30D400.htmlhttps://en.wikipedia.org/wiki/Mancozebhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22MANCOZEB%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Dithane%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%228018-01-7%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Carmazine%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Kascade%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Mancomix%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Mancozi%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Manoseb%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Milcozebe%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Nemispor%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Penncozeb%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Vondozeb%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Zimanat%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Zimaneb%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Manzeb%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Marzin%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Fore%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Liro%20manzeb%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Maneb-zinc%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Ziman-Dithane%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Karamate%20N%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Green-daisen%20M%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Tritogol%20MZ%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Indofil%20M%2045%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Manzate%20200%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Novozir%20MN%2080%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Agrox%2016D%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Othane%20M%2045%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22UNII-R0HY55EB9E%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Zinc%20manganese%20ethylenebisdithiocarbamate%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22F%202966%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Karamate%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Mancofol%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Mancozebe%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Mancozin%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Marzidan%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Sandozebe%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Manzin%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Dithane%20ultra%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5Dhttps://www.ncbi.nlm.nih.gov/pcsubstance/?term=%22Vondozeb%20plus%22%5BCompleteSynonym%5D%20AND%203034368%5BStandardizedCID%5D
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4 Chemical and Physical Properties
Molecular Weight 541.045725 g/mol
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 6
Exact Mass 538.749952 g/mol
Monoisotopic Mass 538.749952 g/mol
Topological Polar Surface Area 181 A^2
Heavy Atom Count 22
Formal Charge 0
Complexity 108
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
CovalentlyBonded Unit Count 4
from PubChem
4.1 Computed Properties
4.2 Experimental Properties
GREYISHYELLOW POWDER.
from ILOICSC
4.2.1 Physical Description
Greyishyellow freeflowing powderTomlin CDS, ed. Mancozeb (8018017). In: The ePesticide Manual, 13th Edition Version 3.1 (200405). Surrey UK, British CropProtection Council
from HSDB
Blue to green powdered solidMeister, R.T., Sine, C; Crop Protection Handbook Volume 94. Meister Media Worldwide, Willoughby, OH 2008, p. D 279
from HSDB
4.2.2 Color
Practically odorlessMeister, R.T., Sine, C; Crop Protection Handbook Volume 94. Meister Media Worldwide, Willoughby, OH 2008, p. D 279
4.2.3 Odor
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from HSDB
Decomposes at 172 deg CTomlin CDS, ed. Mancozeb (8018017). In: The ePesticide Manual, 13th Edition Version 3.1 (200405). Surrey UK, British CropProtection Council
from HSDB
4.2.4 Melting Point
137.8 deg C (tag open cup)Tomlin, C.D.S. (ed.). The Pesticide Manual World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p.635
from HSDB
138°C o.c.
from ILOICSC
4.2.5 Flash Point
Insoluble in waterO'Neil, M.J. (ed.). The Merck Index An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co.,Inc., 2006., p. 988
from HSDB
In water, 6.2 ppm, pH 7.5, 25 deg CTomlin CDS, ed. Mancozeb (8018017). In: The ePesticide Manual, 13th Edition Version 3.1 (200405). Surrey UK, British CropProtection Council
from HSDB
Insoluble in most organic solvents; dissolves in solutions of powerful chelating agents but cannot be recovered fromthem
Tomlin CDS, ed. Mancozeb (8018017). In: The ePesticide Manual, 13th Edition Version 3.1 (200405). Surrey UK, British CropProtection Council
from HSDB
in water: none
from ILOICSC
4.2.6 Solubility
1.92Tomlin CDS, ed. Mancozeb (8018017). In: The ePesticide Manual, 13th Edition Version 3.1 (200405). Surrey UK, British CropProtection Council
from HSDB
(water = 1): 1.92
from ILOICSC
4.2.7 Density
1.32X1010 mm Hg at 25 deg C
4.2.8 Vapor Pressure
https://pubchem.ncbi.nlm.nih.gov/compound/water
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US Dept Agric; The Pesticide Properties Database. Available from on Mancozeb (8018017) as of Dec 17, 2009:http://www.ars.usda.gov/Services/docs.htm?docid=14199
from HSDB
Vapour pressureat 20°C: negligible
from ILOICSC
log Kow = 1.33US Dept Agric; The Pesticide Properties Database. Mancozeb (8018017). Available from, as of Dec 17, 2009:http://www.ars.usda.gov/Services/docs.htm?docid=14199
from HSDB
1.33
from ILOICSC
4.2.9 LogP
Stable under normal, dry storage conditions. Slowly decomposed by heat and moisture.Tomlin, C.D.S. (ed.). The Pesticide Manual World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p.635
from HSDB
4.2.10 Stability
The substance decomposes slowly on heating or on contact with acids and moisture producing toxic and irritating fumesincluding sulfur oxides, nitrogen oxides, zinc oxide, manganese oxide, hydrogen sulfide, carbon sulfide, ethylene thiuramsulfide, ethylene bisisothiocyanate, ethylene urea and 2mercaptoimidazoline.
International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card onMancozeb (November 2003). Available from, as of March 10, 2010: http://www.inchem.org/pages/icsc.html
from HSDB
4.2.11 Decomposition
No corrosive propertiesMeister, R.T., Sine, C; Crop Protection Handbook Volume 94. Meister Media Worldwide, Willoughby, OH 2008, p. D 279
from HSDB
4.2.12 Corrosivity
http://www.ars.usda.gov/Services/docs.htm?docid=14199http://www.ars.usda.gov/Services/docs.htm?docid=14199https://pubchem.ncbi.nlm.nih.gov/compound/zinc%20oxidehttps://pubchem.ncbi.nlm.nih.gov/compound/hydrogen%20sulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/carbon%20sulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/ethylenethiuram%20sulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/ethyleneureahttps://pubchem.ncbi.nlm.nih.gov/compound/2-mercaptoimidazolinehttp://www.inchem.org/pages/icsc.html
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5 Related Records
Parent Compound ETHYLENEBISDITHIOCARBAMIC ACID (CID 3000605)
from PubChem
5.1 Parent Compound
Same Parent, Connectivity 82 records
Same Parent, Exact 80 records
Mixtures, Components, andNeutralized Forms 3 records
Similar Compounds 10 records
from PubChem
5.2 Related Compounds
5.3 Substances
Same 26 records
from PubChem
5.3.1 Related Substances
Chemical Vendors (7)
Curation Efforts (5)
Governmental Organizations (6)
Journal Publishers (1)
NIH Initiatives (4)
Research and Development (7)
Subscription Services (5)
Legacy Depositors (1)
from PubChem
5.3.2 Substances by Category
5.4 Entrez Crosslinks
Download
https://pubchem.ncbi.nlm.nih.gov/compound/3000605https://www.ncbi.nlm.nih.gov/pccompound?cmd=Link&LinkName=pccompound_pccompound_parent_connectivity_pulldown&from_uid=3034368https://www.ncbi.nlm.nih.gov/pccompound?cmd=Link&LinkName=pccompound_pccompound_parent_pulldown&from_uid=3034368https://www.ncbi.nlm.nih.gov/pccompound?cmd=Link&LinkName=pccompound_pccompound_mixture&from_uid=3034368https://www.ncbi.nlm.nih.gov/pccompound?cmd=Link&LinkName=pccompound_pccompound&from_uid=3034368https://www.ncbi.nlm.nih.gov/pcsubstance/?term=3034368[StandardizedCID]
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PubMed 69 records
Taxonomy 5 records
OMIM 9 records
Gene 65 records
from PubChem
https://www.ncbi.nlm.nih.gov/sites/entrez?LinkName=pccompound_pubmed&db=pccompound&cmd=Link&from_uid=3034368https://www.ncbi.nlm.nih.gov/sites/entrez?LinkName=pccompound_taxonomy&db=pccompound&cmd=Link&from_uid=3034368https://www.ncbi.nlm.nih.gov/sites/entrez?LinkName=pccompound_omim&db=pccompound&cmd=Link&from_uid=3034368https://www.ncbi.nlm.nih.gov/sites/entrez?LinkName=pccompound_gene&db=pccompound&cmd=Link&from_uid=3034368
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Vendor/Supplier Purchasable Chemical PubChem SID
3B_SCI_CORP
DR003213 253680599
LP113097 254720550
OR192026 254410079
OR211332 254148826
ChemFrog 888478104 125501243
Finetech Industry Limited FT0628143 164811972
ChemTik CTK8G0735 163135635
from PubChem
6 Chemical Vendors Refine/Analyze Download
http://www.3bsccorp.com/http://3bsccorp.com/drug-like-molecules-and-api/DR003213https://pubchem.ncbi.nlm.nih.gov/substance/253680599http://3bsccorp.com/lipids/LP113097https://pubchem.ncbi.nlm.nih.gov/substance/254720550http://3bsccorp.com/organic-chemicals/OR192026https://pubchem.ncbi.nlm.nih.gov/substance/254410079http://3bsccorp.com/organic-chemicals/OR211332https://pubchem.ncbi.nlm.nih.gov/substance/254148826http://www.chemfrog.com/http://www.chemfrog.com/getPSupply/VHGMNV/https://pubchem.ncbi.nlm.nih.gov/substance/125501243http://www.finetechnology-ind.com/http://www.finetechnology-ind.com/product_detail.shtml?catalogNo=FT-0628143https://pubchem.ncbi.nlm.nih.gov/substance/164811972http://www.chemtik.com/http://www.chemtik.com/pro_result/860726/https://pubchem.ncbi.nlm.nih.gov/substance/163135635
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7 Agrochemical Information
Fungicide
from EU Pesticides Database, EPA Office of Pesticide Programs
7.1 Agrochemical Category
EU Pesticides Data: 1 of 1
Substance Mancozeb
Status Approved on 01/07/2006 Expired on 31/01/2018
ADI 0.05 mg/kg bw/day
ARfD 0.6 mg/kg bw
AOEL 0.035 mg/kg bw/day
from EU Pesticides Database
7.2 EU Pesticides Data
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8 Pharmacology and Biochemistry
Fungicides, IndustrialChemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, inswimming pools, etc. See a list of PubChem compounds matching this category.
from MeSH
8.1 MeSH Pharmacological Classification
Ethylenethiourea is a decomposition product and metabolite of the ethylenebis(dithiocarbamate) group of fungicides.Following administration of single oral doses of (14)C ethylenethiourea to pregnant rats, maternal blood maintainedpeak radioactivity for 2 hr, and the radioactivity was dispersed uniformly between the RBC and plasma. The level ofradioactivity was distributed equally among several maternal tissues but was present in lower amounts in embryos. 24 hrafter treatment all tissues examined, except blood, were relatively clear of radioactivity, and 72.8% of the totalradioactivity given had been excreted in the urine. Elution patterns of metabolites for Sephadex separation suggestedthat ethylenethiourea was degraded very little. /Ethylenebis(dithiocarbamate) group of fungicides/ Abstract: PubMed
Ruddick JA et al; Teratology 13 (1): 35 (1976)
from HSDB
Mancozeb appears to be rapidly absorbed from the gastrointestinal tract, distributed to target organs and excretedalmost totally by 96 hr.
Purdue University; National Pesticide Information Retrieval System, Mancozeb Fact Sheet No. 125 (1987)
from HSDB
Rats dosed via a stomach tube with 20 mg (14)Cmancozeb per day for 7 days (equivalent to approx 100 mg/kg bodyweight) were killed one day after the last dose and the radioactivity in excreta and organs was measured. In the feces,urine, organs and tissues, and carcass, 71%, 16%, 0.31%, and 0.96% of the total radioactivity was detected,respectively. Specifically, the liver contained 0.19%, the kidneys, 0.076%, the thyroid gland, 0.003%, and all otherorgans,
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In oral rat metabolism studies conducted with radiolabeled parent /ethylenebisdithiocarbamate compounds (EBDC)/,there was an average 7.5% in vivo conversion of the EBDC to ETU, on a weighttoweight basis.
USEPA/Office of Pesticide Programs; Mancozeb: Human Health Risk Assessment p.29. Identification No. EPAHQOPP200501760002 (June 2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
In plants, the principal metabolite is ethylenethiourea, which undergoes further metabolism. Ethylenethiurammonosulfide, ethylenethiuroum disulfide, and sulfur are also metabolites.
Tomlin, C.D.S. (ed.). The Pesticide Manual World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p.636
from HSDB
The major metabolite is ethylene thiourea comprising almost 24% of the bioavailable dose in urine and bile. Ethylenethiourea residues in the thyroid and the liver were less than 1 ppm and were nondetectable after 24 hr.
Purdue University; National Pesticide Information Retrieval System, Mancozeb Fact Sheet No. 125 (1987)
from HSDB
Environmental and mammalian degradation of the ethylenebisdithiocarbamate compounds into ethylene thiourea, aknown mutagen, teratogen, and carcinogen, as well as an antithyroid compound, has raised suspicions about theseagents and fostered requests for more indepth studies. There is also evidence that ethylene thiourea may be formedwhile processing and cooking ethylenebisdithiocarbonatecontaminated products. Few additional, definitive, and morerecent studies have yielded any evidence of consequence concerning health hazards. /Ethylenebisdithiocarbamatecompounds/
Klaassen, C.D., M.O. Amdur, Doull J. (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons. 5th ed. New York, NY:McGrawHill, 1995., p. 679
from HSDB
The weight of evidence supports grouping of mancozeb, maneb, and metiram by a common mechanism of toxicity forthyroid effects. Thyroid toxicity induced by the ethylenebisdithiocarbamates (EBDCs) has been attributed to themetabolism of these chemicals to ETU /Ethylene thiourea/. Although the dimethyldithiocarbamates (DMDC) ziram andferbam, and perhaps thiram, also produce thyroid effects in the rat, these chemicals are not metabolized to ETU, andthe mechanism by which they induce thryoid effects has not been established. Thus, /USEPA/ concludes that there issufficient evidence to support grouping only EBDCs mancozeb, maneb, and metiram based on a common mechanismfor the induction of thyroid effects. The weight of evidence does not support grouping the dithiocarbamates by acommon mechanism of toxicity for neuropathy because: a) the pattern of neuropathology that is produced by differentdithiocarbamates is not consistent; b) although the neuropathy produced by diethyldithiocarbamate has been linked withthe formation of CS2, the neuropathy produced by disulfiram is not mediated by the formation of CS2; c) there are nodata showing that the EBDCs are metabolized to CS2 in vivo; and d) NaDMDC and ferbam are metabolized to CS2,but these dithiocarbamates do not produce neuropathy.
USEPA/Health Effects Division/Office of Pesticide Programs: The Determination of Whether Dithiocarbamate Pesticides Share aCommon Mechanism of Toxicity (December 2001). Available from, as of March 29, 2010:http://www.epa.gov/oppsrrd1/cumulative/dithiocarb.pdf
from HSDB
... The human promyelocytic cell line THP1 was used as in vitro model to study the effects of mancozeb and its mainmetabolite ethylenthiourea (ETU) on lipopolysaccharide (LPS)induced tumor necrosis factoralpha (TNF) release.Mancozeb, but not ETU, at noncytotoxic concentrations (1100 ug/mL), induced a dose and timedependent inhibitionof LPSinduced TNF release, reflecting in vivo data. The modulatory effect observed was not limited to mancozeb butalso other ethylenebisdithiocarbamates (EBDTCs), namely zineb and ziram, /which/ showed similar inhibitory effects.Mancozeb must be added before or simultaneously to LPS in order to observe the effect, indicating that it acts on earlyevents triggered by LPS. It is known that nuclear factorkappaB (NFkappaB) tightly regulates TNF transcription. Wecould demonstrate that mancozeb, modulating LPSinduced reactive oxygen species generation, prevented IkappaBdegradation and NFkappaB nuclear translocation, which in turn resulted in decreased TNF production. To furtherunderstand the mechanism of the effect of mancozeb on TNF transcription, THP1 cells were transfected with NFkappaB promoterluciferase construct, and the effect of mancozeb on luciferase activity was measured. Cellstransfected with promoter constructs containing kappaB site showed decreased LPSinduced luciferase activity relativeto control after mancozeb treatment, confirming NFkappaB binding as an intracellular target of mancozeb. Abstract:PubMed
Corsini E, et al; Toxicol Appl Pharmacol 212 (2): 8998 (2006). Available from, as of March 22, 2010:
from HSDB
8.4 Mechanism of Action
https://pubchem.ncbi.nlm.nih.gov/compound/EBDChttps://pubchem.ncbi.nlm.nih.gov/compound/EBDChttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/ethylenethioureahttps://pubchem.ncbi.nlm.nih.gov/compound/Ethylenethiuram%20monosulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/sulfurhttps://pubchem.ncbi.nlm.nih.gov/compound/ethylene%20thioureahttps://pubchem.ncbi.nlm.nih.gov/compound/Ethylene%20thioureahttps://pubchem.ncbi.nlm.nih.gov/compound/ethylene%20thioureahttps://pubchem.ncbi.nlm.nih.gov/compound/ethylene%20thioureahttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/metiramhttps://pubchem.ncbi.nlm.nih.gov/compound/Ethylene%20thioureahttps://pubchem.ncbi.nlm.nih.gov/compound/ziramhttps://pubchem.ncbi.nlm.nih.gov/compound/ferbamhttps://pubchem.ncbi.nlm.nih.gov/compound/thiramhttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/metiramhttps://pubchem.ncbi.nlm.nih.gov/compound/diethyldithiocarbamatehttps://pubchem.ncbi.nlm.nih.gov/compound/disulfiramhttps://pubchem.ncbi.nlm.nih.gov/compound/ferbamhttp://www.epa.gov/oppsrrd1/cumulative/dithiocarb.pdfhttps://pubchem.ncbi.nlm.nih.gov/compound/lipopolysaccharidehttps://pubchem.ncbi.nlm.nih.gov/compound/zinebhttps://pubchem.ncbi.nlm.nih.gov/compound/ziramhttps://pubchem.ncbi.nlm.nih.gov/compound/oxygenhttp://www.ncbi.nlm.nih.gov/pubmed/16112155?dopt=Abstract
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9 Use and Manufacturing
Mancozeb is a polymeric mixture of a zinc salt and the chemical maneb.Tomlin CDS, ed. Mancozeb (8018017). In: The ePesticide Manual, 13th Edition Version 3.1 (200405). Surrey UK, British CropProtection Council
from HSDB
Mancozeb is produced by reaction of a concentrated solution of zinc sulfate with a suspension of maneb in water.Muller F et al; Ullmann's Encyclopedia of Industrial Chemistry 7th ed. (2008). NY, NY: John Wiley & Sons; Fungicides, Agricultural.Online Posting Date: January 15, 2010.
from HSDB
9.1 Methods of Manufacturing
Mancozeb (Dithane M45) is essentially a combination of maneb and zineb.Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology Diagnosis and Treatment of Human Poisoning. New York, NY: ElsevierScience Publishing Co., Inc. 1988., p. 1100
from HSDB
Mancozeb is a complex of zinc and maneb containing 20% of manganese and 2.55% of zinc. Chemical name ismanganese ethylenebis(dithiocarbamate) (polymeric) complex with zinc salt.
Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985to Present., p. VA12 (89) 92
from HSDB
A complete list of currently registered active pesticide products can be found in the National Pesticide InformationRetrieval System's USEPA/OPP Registered and Cancelled Pesticide Product Database. These pesticide products areregistered for use in the U.S. but approved products may change periodically and so federal, state and local authoritiesmust be consulted for currently approved products.
National Pesticide Information Retrieval System's USEPA/OPP Registered and Cancelled Pesticide Product Database. Mancozeb(8018017). Available from, as of March 15, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Acrobat MZ Fungicide (BASF): Mancozeb 60%, Morpholine, 3(3(4chlorophenyl)3(3,4dimethoxyphenyl)1oxo2propenyl) 9%
National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Cuprofix MZ Disperss (United Phosphorus): Mancozeb 30.4%, Basic cupric sulfate 22.1%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Dithane DF Rainshield (Dow): Mancozeb 75%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Dithane F45 Flowable Mancozeb Agricultural Fungicide (Dow): Mancozeb 37%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Dithane M45 Fungicide (Dow): Mancozeb 80%
9.2 Formulations/Preparations
https://pubchem.ncbi.nlm.nih.gov/compound/zinchttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/zinc%20sulfatehttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/zinebhttps://pubchem.ncbi.nlm.nih.gov/compound/zinchttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/manganesehttps://pubchem.ncbi.nlm.nih.gov/compound/zinchttps://pubchem.ncbi.nlm.nih.gov/compound/manganese%20ethylenebis%28dithiocarbamate%29https://pubchem.ncbi.nlm.nih.gov/compound/zinchttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Morpholinehttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Phosphorushttps://pubchem.ncbi.nlm.nih.gov/compound/cupric%20sulfatehttp://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/
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National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Drexel Mancozeb Technical: Mancozeb 88%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Duosan WSB Wettable Powder Turf and Ornamental Fungicide (ScottsSierra): Mancozeb 64%, Thiophanatemethyl15.6%
National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Dupont Mankocide fungicide: Mancozeb 15%, Copper hydroxide 46.1%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Dupont Manzate 80WP: Mancozeb 80%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Dupont Manzate Flowable: Mancozeb 37%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Dupont Manzate Prostick: Mancozeb 75%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Evolve Potato Seed Piece Treatment Fungicide (Bayer): Mancozeb 6%, Thiophanatemethyl 2.5%, Cymoxanil 1%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Formec 80 Turf & Ornamental Fungicide (PBI/Gordon): Mancozeb 80%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
GauchoMZ potato seedpiece treatment (Gaucho): Mancozeb 6%, Imidacloprid 1.25%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Gavel 75 DF Agricultural Fungicide (Gowan): Mancozeb 66.7%, Zoxamide 8.3%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Grain Guard (Chemtura): Mancozeb 50%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Junction (Sepro): Mancozeb 15%, Copper hydroxide 46.1%
http://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Duosanhttps://pubchem.ncbi.nlm.nih.gov/compound/Thiophanate-methylhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Copper%20hydroxidehttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Manzatehttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Manzatehttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Manzatehttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Thiophanate-methylhttps://pubchem.ncbi.nlm.nih.gov/compound/Cymoxanilhttp://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Imidaclopridhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Zoxamidehttp://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Copper%20hydroxide
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National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Mancozeb seed protectant fungicide (Ellis): Mancozeb 6%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Maxim MZ (Syngenta): Mancozeb 5.7%, Fludioxonil 0.5%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Moncoat MZ (Nichino): Mancozeb 6%, Flutolanil 1.5%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Penncozeb Technical (United Phosphorus): Mancozeb 88%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Penncozeb Turf and Ornamentals Fungicide (United Phosphorus): Mancozeb 80%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Pentathlon (Sepro): Mancozeb 37%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Pentathlon DF Fungicide Dispersible Granules (Sepro): Mancozeb 75%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Potato Seed Protector PS (Ellis): Mancozeb 8%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Potato Seed Treater AStrep (Ellis): Mancozeb 8%, Streptomycin sesquisulfate 0.02%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Protect DF (Cleary): Mancozeb 75%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
P.S.T. Plus Bark (Simplot): Mancozeb 6%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
RH0611 (Dow): Mancozeb 60%, Myclobutanil 2.25%
http://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Fludioxonilhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Flutolanilhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Penncozebhttps://pubchem.ncbi.nlm.nih.gov/compound/Phosphorushttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Penncozebhttps://pubchem.ncbi.nlm.nih.gov/compound/Phosphorushttp://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Streptomycin%20sesquisulfatehttp://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Myclobutanil
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National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Ridomil Gold MZ (Syngenta): Mancozeb 64%, MetalaxylM 4%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Ridomil Gold MZ WG (Syngenta): Mancozeb 64%, MetalaxylM 4%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
SA50 Dithane M45 (Southern Agricultural Insecticides): Mancozeb 80%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Tops MZ Potato seedpiece treatment fungicide (Bayer): Mancozeb 6%, Thiophanatemethyl 2.5%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
TopsMZGaucho potato seedpiece treatment (Bayer): Mancozeb 6%, Thiophanatemethyl 2.5%, Imidacloprid 1.25%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Wingman (Phoenix Environmental): Mancozeb 75%National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Mancozeb (8018017). Availablefrom, as of March 3, 2010: http://npirspublic.ceris.purdue.edu/ppis/
from HSDB
Blecar MN, powder for seed treatment (480 g/kg); Dithane LF, suspension concentrate (flowable) (455 g/L); Acarie M,Crittox MZ, Dithane M45, Dithane 945, Manzate, wettable powder (600 or 800 g mancozeb/kg); Dithane M 45Poudrage, dustable powder (60 g/kg).
Worthing, C.R. and S.B. Walker (eds.). The Pesticide Manual A World Compendium. 8th ed. Thornton Heath, UK: The British CropProtection Council, 1987., p. 511
from HSDB
... Dispersible powder, suspension concentrate, and powder for dry seed treatment. Mixtures; (mancazeb +) metalaxyl;benalaxyl; oxadixyl; cymoxanil; carbendazim; captan; fosetylaluminum; zineb; copper oxychloride; sulfur; dinocap;folpet; myclobutanil; fenpropimorph; Bordeaux mixture; pyrifenox; penconazole; and many others.
Tomlin, C.D.S. (ed.). The Pesticide Manual World Compendium, 11 th ed., British Crop Protection Council, Surrey, England 1997, p.762
from HSDB
Dust, flowable suspension, liquid flowable, water dispersible granules, wettable powder.Meister, R.T., Sine, C; Crop Protection Handbook Volume 95. Meister Media Worldwide, Willoughby, OH 2009, p. 350
from HSDB
3465 tons are used annuallyHalfon E et al; Chemosphere 33: 154362 (1996)
from HSDB
9.3 Consumption
http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Ridomil%20Goldhttps://pubchem.ncbi.nlm.nih.gov/compound/Metalaxyl-Mhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Ridomil%20Goldhttps://pubchem.ncbi.nlm.nih.gov/compound/Metalaxyl-Mhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Dithane%20M-45http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Thiophanate-methylhttp://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Thiophanate-methylhttps://pubchem.ncbi.nlm.nih.gov/compound/Imidaclopridhttp://npirspublic.ceris.purdue.edu/ppis/http://npirspublic.ceris.purdue.edu/ppis/https://pubchem.ncbi.nlm.nih.gov/compound/Crittoxhttps://pubchem.ncbi.nlm.nih.gov/compound/Dithane%20M-45https://pubchem.ncbi.nlm.nih.gov/compound/Manzatehttps://pubchem.ncbi.nlm.nih.gov/compound/metalaxylhttps://pubchem.ncbi.nlm.nih.gov/compound/benalaxylhttps://pubchem.ncbi.nlm.nih.gov/compound/oxadixylhttps://pubchem.ncbi.nlm.nih.gov/compound/cymoxanilhttps://pubchem.ncbi.nlm.nih.gov/compound/carbendazimhttps://pubchem.ncbi.nlm.nih.gov/compound/captanhttps://pubchem.ncbi.nlm.nih.gov/compound/zinebhttps://pubchem.ncbi.nlm.nih.gov/compound/sulfurhttps://pubchem.ncbi.nlm.nih.gov/compound/folpethttps://pubchem.ncbi.nlm.nih.gov/compound/myclobutanilhttps://pubchem.ncbi.nlm.nih.gov/compound/fenpropimorphhttps://pubchem.ncbi.nlm.nih.gov/compound/Bordeaux%20mixturehttps://pubchem.ncbi.nlm.nih.gov/compound/pyrifenoxhttps://pubchem.ncbi.nlm.nih.gov/compound/penconazolehttps://pubchem.ncbi.nlm.nih.gov/compound/water
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In the United Kingdom, mancozeb is used on wheat, winter barley, spring barley, and oats at 253, 12, 1, and 1 tons peryear, respectively.
Harris GL; in Pesticide Loss to Water A Review of Possible Agricultural Management Opportunities to Minimize PesticideMovement. BCPC Mongr, Vol 62 pp. 3718 (1995)
from HSDB
Mancozeb use on various fruits and vegetables, including apples, potatoes, tomatoes, and wheat, in 1987 was8,660,507 lbs active ingredient per year.
Gianessi LP; US Pesticide Use Trends: 19661989. Resources for the Future, Washington, DC (1992)
from HSDB
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10 Identification
Product analysis /is/ by decomposition with acid and measuring the carbon disulfide liberated, either by gas liquidchromatography or by a titrimetric method. Residues /may be/ determined by reaction with acid of the liberated carbondisulfide which is measured by standard methods.
Tomlin, C.D.S. (ed.). The Pesticide Manual World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p.636
from HSDB
EMSLC Method 630. The Determination of Dithiocarbamate Pesticides in Municipal and Industrial Wastewater by UVVIS Spectrophotometry.
USEPA; EMMI. EPA's Environmental Monitoring Methods Index. Version 1.1. PC# 4082. Rockville, MD: Government Institutes(1997)
from HSDB
10.1 Analytic Laboratory Methods
https://pubchem.ncbi.nlm.nih.gov/compound/carbon%20disulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/carbon%20disulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/Dithiocarbamate
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11 Safety and Hazards
11.1 Hazards Identification
Signal: WarningGHS Hazard StatementsH317: May cause an allergic skin reaction [Warning Sensitization, Skin Category 1]H320: Causes eye irritation [Warning Serious eye damage/eye irritation Category 2B]H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity,repeated exposure Category 2]H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard Category 1]H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, longtermhazard Category 1]Precautionary StatementsP260: Do not breathe dust/fume/gas/mist/vapors/spray.P261: Avoid breathing dust/fume/gas/mist/vapors/spray.P264: Wash ... thoroughly after handling.P272: Contaminated work clothing should not be allowed out of the workplace.P273: Avoid release to the environment.P280: Wear protective gloves/protective clothing/eye protection/face protection.P302+P352: IF ON SKIN: wash with plenty of water.P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present andeasy to do continue rinsing.P314: Get medical advice/attention if you feel unwell.P321: Specific treatment (see ... on this label).P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.P337+P313: IF eye irritation persists: Get medical advice/attention.P363: Wash contaminated clothing before reuse.P391: Collect spillage.P501: Dispose of contents/container to ...
from NITECMC
View GHS Classification from all (3) sources.
11.1.1 GHS Classification
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
from ILOICSC
11.1.2 Fire Hazard
Finely dispersed particles form explosive mixtures in air.
from ILOICSC
11.1.3 Explosion Hazard
CombustibleInternational Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card onMancozeb (November 2003). Available from, as of March 10, 2010: http://www.inchem.org/pages/icsc.html
11.1.4 Fire Potential
https://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.inchem.org/pages/icsc.html
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from HSDB
The substance is irritating to the eyes and the respiratory tract, and is mildly irritating to the skin.International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card onMancozeb (November 2003). Available from, as of March 10, 2010: http://www.inchem.org/pages/icsc.html
from HSDB
11.1.5 Skin, Eye, and Respiratory Irritations
11.2 Safety and Hazard Properties
Dust explosion possible if in powder or granular form, mixed with air.
from ILOICSC
11.2.1 Physical Dangers
Decomposes on heating and on contact with acids and moisture. This produces toxic and irritating fumes includingsulfur oxides, nitrogen oxides, zinc oxide, manganese oxide, hydrogen sulfide, carbon sulfide, ethylene thiuram sulfide,ethylene bisisothiocyanate, ethylene urea and 2mercaptoimidazoline.
from ILOICSC
11.2.2 Chemical Dangers
Finely dispersed particles form explosive mixtures in air.International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card onMancozeb (November 2003). Available from, as of March 10, 2010: http://www.inchem.org/pages/icsc.html
from HSDB
11.2.3 Explosive Limits and Potential
11.3 First Aid Measures
Fresh air, rest. Refer for medical attention.
from ILOICSC
11.3.1 Inhalation First Aid
Remove contaminated clothes. Rinse and then wash skin with water and soap.
from ILOICSC
11.3.2 Skin First Aid
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medicalattention.
from ILOICSC
11.3.3 Eye First Aid
http://www.inchem.org/pages/icsc.htmlhttps://pubchem.ncbi.nlm.nih.gov/compound/zinc%20oxidehttps://pubchem.ncbi.nlm.nih.gov/compound/hydrogen%20sulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/carbon%20sulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/ethylenethiuram%20sulfidehttps://pubchem.ncbi.nlm.nih.gov/compound/ethyleneureahttps://pubchem.ncbi.nlm.nih.gov/compound/2-mercaptoimidazolinehttp://www.inchem.org/pages/icsc.htmlhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/water
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Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!).
from ILOICSC
11.3.4 Ingestion First Aid
Powder, water spray, foam, carbon dioxide.International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card onMancozeb (November 2003). Available from, as of March 10, 2010: http://www.inchem.org/pages/icsc.html
from HSDB
11.4 Fire Fighting Measures
Use water spray, powder, foam, carbon dioxide.
from ILOICSC
11.4.1 Fire Fighting
11.5 Accidental Release Measures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilledsubstance into sealable containers. Carefully collect remainder. Then store and dispose of according to localregulations. Do NOT wash away into sewer.
from ILOICSC
11.5.1 Spillage Disposal
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sitesshould be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shallbe lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to apermitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that"pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation,dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage thechemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in orderto determine the appropriate local, state and federal requirements for disposal.
from HSDB
Do NOT wash away into sewer. Sweep spilled substance into sealable containers. Carefully collect remainder, thenremove to safe place.
International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card onMancozeb (November 2003). Available from, as of March 10, 2010: http://www.inchem.org/pages/icsc.html
from HSDB
11.5.2 Cleanup Methods
Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numberU114, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
40 CFR 240280, 300306, 702799 (7/1/2008)
from HSDB
11.5.3 Disposal Methods
https://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/carbon%20dioxidehttp://www.inchem.org/pages/icsc.htmlhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/carbon%20dioxidehttp://www.inchem.org/pages/icsc.html
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19/09/2016 MANCOZEB | C8H12MnN4S8Zn PubChem
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A potential candidate for liquid injection incineration at a temperature range of 650 to 1,600 deg C and a residence timeof 0.1 to 2 seconds. A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 deg C andresidence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bedincineration at a temperature range of 450 to 980 deg C and residence times of seconds for liquids and gases, andlonger for solids. /Ethylenebisdithiocarbamate/
USEPA; Engineering Handbook for Hazardous Waste Incineration p.313 (1981) EPA 68033025
from HSDB
Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless inaccordance with the requirements of a National Pollutant Discharge Eliminations System (NPDES) permit and thepermitting authority has been notified in writing prior to discharge. ... For guidance, contact your State Water Board orRegional Office of the Environmental Protection Agency.
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 1045 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personalcontact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of thecleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by theworkers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place ofwork for cleaning.
from HSDB
SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits ordetrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including theform of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and thehygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such thatthe wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn.In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
from HSDB
Avoid long term exposure, even to small quantities. Keep away from flames and sparks.Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook. 2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry,1987., p. A251/Aug 87
from HSDB
Manufacturers of products formulated as wettable powders must prohibit application of wettable powder products to turfon sod farms and application of wettable powder formulations to turf unless packaged in water soluble packaging
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 104 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
Manufacturers of products formulated as liquids must prohibit application of liquids by aerial or chemigation methods togolf courses and application of liquids aerially to sod farms.
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 104 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
Manufacturers of products formulated as dusts must require closed systems for commercial seedpiece treatment.USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 104 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
Human flagging is prohibited. Flagging to support aerial application is limited to use of the Global Positioning System(GPS) or mechanical flaggers.
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 110 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
11.5.4 Other Preventative Measures
https://pubchem.ncbi.nlm.nih.gov/compound/Waterhttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#home
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Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, usedetergent and hot water. Keep and wash PPE separately from other laundry. Discard clothing or other absorbentmaterials that have been drenched or heavily contaminated with this product's concentrate. Do not reuse them.
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 110 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
Users should wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet. Users should removeclothing/ PPE immediately if pesticide gets inside, then wash thoroughly and put on clean clothing. Users shouldremove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible,wash thoroughly and change into clean clothing
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 111 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 24 hours.USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 111 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Onlyprotected handlers may be in the area during application.
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 111 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
This pesticide is toxic to aquatic organisms. Do not apply directly to water, or to areas where surface water is present, orto intertidal areas below the mean high water mark. Do not contaminate water when cleaning equipment or disposingof equipment washwater or rinsate.
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 113 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
11.6 Handling and Storage
Provision to contain effluent from fire extinguishing. Separated from acids and food and feedstuffs. Dry. Keep in a wellventilated room.
from ILOICSC
11.6.1 Safe Storage
Provision to contain effluent from fire extinguishing. Separated from acids, food and feedstuffs. Dry. Keep in a wellventilated room.
International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card onMancozeb (November 2003). Available from, as of March 10, 2010: http://www.inchem.org/pages/icsc.html
from HSDB
11.6.2 Storage Conditions
11.7 Exposure Control and Personal Protection
Workplace Environmental Exposure Level (WEEL): 8hr Timeweighted Average (TWA) 1 mg/cu m, dermalsensitization.
11.7.1 Other Occupational Permissible Levels
https://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#homehttp://www.inchem.org/pages/icsc.html
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American Industrial Hygiene Association; Emergency Response Planning Guidelines & Workplace Enviromental Exposure Levels.Fairfax, VA 2009, p. 41
from HSDB
TLV (NOTESTABLISHED):.
from ILOICSC
11.7.2 Occupational Exposure Limits
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly whendispersed.
from ILOICSC
11.7.3 Inhalation Risk
The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin.
from ILOICSC
11.7.4 Effects of Short Term Exposure
Repeated or prolonged contact may cause skin sensitization. See Notes.
from ILOICSC
11.7.5 Effects of Long Term Exposure
OPP RfD= 0.003 mg/kg; WHO RfD= 0.05 mg/kgUSEPA/OPP; Health Effects Div RfD/ADI Tracking Report p.36 (8/26/91)
from HSDB
11.7.6 Acceptable Daily Intakes
Tolerances for residues of a fungicide which is a coordination product of zinc ion and maneb (manganous ethylenebisdithiocarbamate) containing 20 percent manganese, 2.5 percent zinc, and 77.5 percent ethylenebisdithiocarbamate(the whole product calculated as zinc ethylenebisdithiocarbamate), are established as follows:
Commodity Parts permillion
Apple 7
Asparagus (negligible residue) 0.1
Banana 4.0
Banana, pulp 0.5
Barley, bran 20
Barley, flour 20
Barley,grain 5
Barley, pearled barley 20
Barley, straw 25
11.7.7 Allowable Tolerances
https://pubchem.ncbi.nlm.nih.gov/compound/zinchttps://pubchem.ncbi.nlm.nih.gov/compound/manebhttps://pubchem.ncbi.nlm.nih.gov/compound/manganesehttps://pubchem.ncbi.nlm.nih.gov/compound/zinchttps://pubchem.ncbi.nlm.nih.gov/compound/zinc%20ethylenebisdithiocarbamate
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Beet, sugar, roots 2
Beet, sugar, tops 65
Carrot, roots 2
Cattle, kidney 0.5
Cattle, liver 0.5
Celery 5
Corn, field, forage 5
Corn, field, grain 0.1
Corn, field, stover 5
Corn, pop, grain 0.5
Corn, pop, stover 5
Corn, sweet, forage 5
Corn, sweet, kernel plus cob with husks removed 0.5
Corn, sweet, stover 5
Cotton, undelinted seed 0.5
Crabapple 10
Cranberry 7
Cucumber 4
Fennel 10
Goat, kidney 0.5
Goat, liver 0.5
Grape 7
Hog, kidney 0.5
Hog, liver 0.5
Horse, kidney 0.5
Horse, liver 0.5
Melon 4
Oat, bran 20
Oat, flour 20
Oat, grain 5
Oat, groats/rolled oats 20
Oat, straw 25
Onion, bulb 0.5
Papaya (whole fruit with no residue present in the edible pulp after the peel is removed anddiscarded) 10
Peanut 0.5
Peanut, hay 65
Pear 10
Poultry, kidney 0.5
Poultry, liver 0.5
Quince 10
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Rye, bran 10
Rye, grain 5
Rye, straw 25
Sheep, kidney 0.5
Sheep, liver 0.5
Squash, summer 4
Tomato 4
Wheat, bran 20
Wheat, flour 20
Wheat, germ 20
Wheat, grain 5
Wheat, middlings 20
Wheat, shorts 20
Wheat, straw 25
40 CFR 180.176(a) (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations.Available from, as of February 24, 2010: http://www.gpoaccess.gov/ecfr
from HSDB
A timelimited tolerance is established for combined residues of the fungicide mancozeb, calculated as zincethylenebisdithiocarbamate and it's metabolite ETU in connection with use of the pesticide under a section 18emergency exemption granted by EPA. The tolerance will expire and is revoked on the dates specified. Commodity:ginseng; Parts Per Million: 2.0; Expiration/Revocation Date: 12/31/10
40 CFR 180.176(b) (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations.Available from, as of March 2, 2010: http://www.gpoaccess.gov/ecfr
from HSDB
NO open flames.
from ILOICSC
11.7.8 Fire Prevention
Closed system, ventilation, explosionproof electrical equipment and lighting. Prevent deposition of dust.
from ILOICSC
11.7.9 Explosion Prevention
PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!
from ILOICSC
11.7.10 Exposure Prevention
Use local exhaust or breathing protection.
from ILOICSC
11.7.11 Inhalation Prevention
http://www.gpoaccess.gov/ecfrhttps://pubchem.ncbi.nlm.nih.gov/compound/zinc%20ethylenebisdithiocarbamatehttp://www.gpoaccess.gov/ecfr
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Protective gloves. Protective clothing.
from ILOICSC
11.7.12 Skin Prevention
Wear safety goggles or eye protection in combination with breathing protection.
from ILOICSC
11.7.13 Eye Prevention
Do not eat, drink, or smoke during work. Wash hands before eating.
from ILOICSC
11.7.14 Ingestion Prevention
EndUse Products Intended for Occupational Use (WPS and nonWPS). Personal Protective Equipment (PPE) forLiquid Concentrate. Mixers, loaders, applicators, and other handlers must wear: longsleeved shirt, long pants, shoesand socks, and chemicalresistant gloves (except pilots, groundboom applicators, and airblast applicators). In addition,mixers/loaders supporting chemigation applications to turf on sod farms must wear a NIOSHapproved respirator with adust/mist filter with MSHA/NIOSH approval number prefix TC21C or any N*, R, P, or HE filter. *Instruction toregistrant: Drop the "N" type filter from the respirator statement if the pesticide product contains or is used with oil.
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 105 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
EndUse Products Intended for Occupational Use (WPS and nonWPS). Personal Protective Equipment (PPE) forLiquid Concentrate, Liquid ReadyToUse, and Dry Flowable Formulations. Mixers, loaders, applicators, and otherhandlers must wear: longsleeved shirt, long pants, shoes and socks, and chemicalresistant gloves (except handlerswho are bagging the treated seed or sewing the bags).
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 1056 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
EndUse Products Intended for Occupational Use (WPS and nonWPS). Personal Protective Equipment (PPE) forWettable Powder (WP) Formulations that are not packaged in water soluble packaging. (For all uses except seed andseed piece treatment). Mixer, loaders, applicators, and other handlers must wear: longsleeved shirt, long pants, shoesand socks. In addition, all handlers except pilots, groundboom applicators, and airblast applicators must wear: chemicalresistant gloves, and a NIOSHapproved respirator with a dust/mist filter with MSHA/NIOSH approval number prefix TC21C or any N*, R, P, or HE filter. Instruction to Registrant: Drop the "N" type filter from the respirator statement if thepesticide product contains, or is used with, oil.
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 106 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
EndUse Products Intended for Occupational Use (WPS and nonWPS). Personal Protective Equipment (PPE) forWettable Powder (WP) Formulations that are not packaged in water soluble packaging. (For products with directions foruse as a seed treatment). Mixer, loaders, applicators, and other handlers must wear: longsleeved shirt, long pants,shoes and socks. In addition, all handlers (except handlers who are bagging the treated seed or sewing the bags) mustwear: chemicalresistant gloves, and a NIOSHapproved respirator with a dust/mist filter with MSHA/NIOSH approvalnumber prefix TC21C or any N*, R, P, or HE filter. *Instruction to Registrant: Drop the "N" type filter from the respiratorstatement if the pesticide product contains, or is used with, oil.
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 1067 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
11.7.15 Protective Equipment and Clothing
http://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#home
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EndUse Products Intended for Occupational Use (WPS and nonWPS). Personal Protective Equipment (PPE) for (WP)Formulations that are packaged in water soluble packaging. Mixers, loaders, applicators, and other handlers must wear:longsleeved shirt, long pants, shoes and socks, and chemicalresistant gloves (except pilots, groundboom applicators,and airblast applicators). In addition, handlers performing tasks, such as spill cleanup, that involve contact with the drywettable powder must wear: a NIOSHapproved respirator with a dust/mist filter with MSHA/NIOSH approval numberprefix TC21C or any N*, R, P, or HE filter. *Instruction to Registrant: Drop the "N" type filter from the respiratorstatement if the pesticide product contains, or is used with, oil.
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 1078 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
EndUse Products Intended for Occupational Use (WPS and nonWPS). Personal Protective Equipment (PPE) for DustFormulation and Wettable Powder Formulations (applied dry). "Loaders, applicators, and other handlers must wear:longsleeved shirt, long pants, shoes and socks, chemicalresistant gloves, and a NIOSHapproved respirator with adust/mist filter with MSHA/NIOSH approval number prefix TC21C or any N*, R, P, or HE filter. *Instruction toRegistrant: Drop the "N" type filter from the respirator statement if the pesticide product contains, or is used with, oil.
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 108 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
Watersoluble packets when used correctly qualify as a closed mixing/loading system under the Worker ProtectionStandard for Agricultural Pesticides [40 CFR 170.240(d)(4)].
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 110 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
Engineering Controls: Pilots must use an enclosed cockpit that meets the requirements listed in the Worker ProtectionStandard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)].
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 110 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involvescontact with anything that has been treated, such as soil or water, is: Coveralls, Shoes and socks, and Chemicalresistant gloves made of any waterproof material.
USEPA/Office of Pesticide Programs; Mancozeb: Reregistration Eligibility Decision. EPAHQOPP200501760001, pg. 111 (June2005). Available from, as of March 3, 2010: http://www.regulations.gov/search/Regs/home.html#home
from HSDB
11.8 Transport Information
No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person isregistered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, andin condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171177)./
49 CFR 171.2 (7/1/99)
from HSDB
The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA DangerousGoods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to befollowed by all IATA Member airlines when transporting hazardous materials.
IATA. Dangerous Goods Regulations. 40th Ed. Montreal, Canada and Geneva, Switzerland: International Air Transport Association,Dangerous Goods Regulations, 1999., p. 216
from HSDB
The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals.Detailed recommendations for individual substances and a number of recommendations for good practice are includedin the classes dealing with such substances. A general index of technical names has also been compiled. This index
11.8.1 Shipment Methods and Regulations
https://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/Waterhttp://www.regulations.gov/search/Regs/home.html#homehttp://www.regulations.gov/search/Regs/home.html#homehttps://pubchem.ncbi.nlm.nih.gov/compound/waterhttp://www.regulations.gov/search/Regs/home.html#home
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should always be consulted when attempting to locate the appropriate procedures to be used when shipping anysubstance or article.
IMDG; International Maritime Dangerous Goods Code; International Maritime Organization p.3270, 6219, 6220, and 6221 (1998)
from HSDB
Airtight. Do not transport with food and feedstuffs. Marine pollutant.
from ILOICSC
11.8.2 Packaging and Labelling
Symbol: Xi; R: 3743; S: (2)824/2546
from ILOICSC
11.8.3 EC Classification
UN Hazard Class: 4.2; UN Subsidiary Risks: 4.3; UN Pack Group: III
from ILOICSC
11.8.4 UN Classification
Transport Emergency Card: TEC (R)42S2210.
from ILOICSC
11.8.5 Emergency Response
11.9 Regulatory Information
(AZ) ARIZONA 21 ug/lUSEPA/Office of Water; FederalState Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal DrinkingWater Standards and Guidelines (11/93) To Present
from HSDB
(ME) MAINE 6 ug/lUSEPA/Office of Water; FederalState Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal DrinkingWater Standards and Guidelines (11/93) To Present
from HSDB
11.9.1 State Drinking Water Guidelines
Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject toeffluent limitations. /Zinc and compounds/
40 CFR 401.15 (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Availablefrom, as of March 2, 2010: http://www.gpoaccess.gov/ecfr
from HSDB
11.9.2 Clean Water Act Requirements
11.9.3 CERCLA Reportable Quantities
https://pubchem.ncbi.nlm.nih.gov/compound/Waterhttps://pubchem.ncbi.nlm.nih.gov/compound/Zinchttp://www.gpoaccess.gov/ecfr
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Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, whenthere is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantityof 5000 lb or 2270 kg. The toll free number of the NRC is (800) 4248802. The rule for determining when notification isrequired is stated in 40 CFR 302.4 (section IV. D.3.b). /Ethylenebisdithiocarbamic acid, salts and esters/
40 CFR 302.4 (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Availablefrom, as of March 2, 2010: http://www.gpoaccess.gov/ecfr
from HSDB
U114; As stipulated in 40 CFR 261.33, when ethylenebisdithiocarbamic acid, salts and esters, as a commercialchemical product or manufacturing chemical intermediate or an offspecification commercial chemical product or amanufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or Statehazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or otherdebris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of thiswaste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5). /Ethylenebisdithiocarbamicacid, salts and esters/
40 CFR 261.33 (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Availablefrom, as of March 2, 2010: http://www.gpoaccess.gov/ecfr
from HSDB
11.9.4 RCRA Requirements
Tolerances for residues of a fungicide which is a coordination product of zinc ion and maneb (manganous ethylenebisdithiocarbamate) containing 20 percent manganese, 2.5 percent zinc, and 77.5 percent ethylenebisdithiocarbamate(the whole product calculated as zinc ethylenebisdithiocarbamate), are established as follows:Commodity
Apple
Asparagus (negligible residue)