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NIHR Programme Grants for Applied Research
Professor Adrian GrantProgramme Director
NIHR Dementia Research Workshop
14 January 2011
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Programme Grants
• Support programmes of research rather than individual studies
• Individual awards for a maximum of £2m over up to five years (average of no more than £400k per year)
• Funding is made to an NHS Organisation in England working in collaboration with appropriate academic partners
• Two-stage assessment process
• Applications and post-award processes managed by team at the NIHR Central Commissioning Facility (NIHR CCF)
Background
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Programme Grants
• Support top quality, collaborative, multidisciplinary teams
• ‘Downstream’, applied research
• Collection of inter-related research activities
• Coherent ‘stream’ of work, where the whole is greater than sum of the individual parts
• Often presented as workpackages, subdivided into discrete activities
Purpose
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Programme Grants
• Dementia care in the communityProf Steve Iliffe, Central & North West London NHS Foundation Trust
• Support at home through psychological and social interventionsProf Martin Orrell, North East London NHS Foundation Trust
• Optimizing care in care homesProf Clive Ballard, Oxfordshire & Buckinghamshire Mental Health NHS
Foundation Trust
• Managing challenging behaviour in dementiaProf Esme Moniz-Cook, Humber Mental Health Teaching NHS Trust
• Preventing acute confusional illnessProf John Young, Bradford Teaching Hospitals NHS Foundation Trust
Some currently funded programmes:
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Programme Grants
• Track record and appropriate mix of skills
• Relevance to priorities and needs of the NHS
• Likelihood of significant benefit to patients and the NHS within 3-5 years of programme’s end
• Quality of the proposed research
• Value for money
Patient and Public Involvement given particular attention
Selection criteria
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Programme Grants
• Fuller details are on the website:
www.pgfar.nihr.ac.uk
• Enquires are welcomed:
The Programme Grants stand in the market place
E-mail: [email protected]
Telephone: 020 8843 8039
Address: NIHR CCFGrange House15 Church StreetTwickenham, TW1 3NL
Further information
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NIHR Research for Patient Benefit
Professor David ArmstrongProgramme Director
NIHR Dementia Research Workshop
14 January 2011
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The RfPB Programme
• Response-mode funding programme with a budget of £25m per year
• Project grants may be: • Up to 36 months in duration • Up to £250k
• Three competitions per year• National Programme with ten
Regional Funding Committees• Open to researchers in the NHS in
England
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The RfPB Programme
• Supports high quality investigator-led research projects which have a clear trajectory into patient benefit
• Includes qualitative or quantitative research which:– Studies the way the NHS services are provided and
used– Evaluates whether interventions are effective and
provide value for money– Supports pilot or feasibility studies leading to major
applications to other NIHR funding streams
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The Application Process
• One stage application process
• Preliminary scrutiny and administrative sift
• External peer and lay review
• Full assessment by one of ten regional funding committees
• Final ratification
• Notification of outcome
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The Scrutiny Stage
Three questions will be asked:
• Is the proposal likely to lead to patient benefit?
• Is the presentation and/or methods appropriate for the research question?
• Is the application form completed according to the instructions described in the guidance?
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BLOOD
CANCER
CARDIOVASCULAR
CONGENITAL DISORDERS
EAR
EYE
INFECTION
INFLAMMATORY
INJURIES
MENTAL HEALTH
METABOLIC AND ENDOCRINE
MUSCULOSKELETAL
NEUROLOGICAL
ORAL AND GASTRO
OTHER
RENAL AND UROGENITAL
REPRODUCTIVE
RESPIRATORY
SKIN
STROKE
GENERIC HEALTHRELEVANCE
Research for Patient BenefitSpend across health category(2009-2010)
Generic Health Relevance
15%
Mental Health 19%Reproductive
8%
Cancer 7%
Oral & Gastro 7% Neurological
6%
Stroke 6%
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Research for Patient Benefit
• Essentially will use existing processes (Scrutiny Committee, scientific and lay review, Regional Funding Committee appraisal)
• Will alert all Regional Committees of the Call and advise them of the strategic need to fund applications in this area, subject to quality thresholds
• Will participate with other Programmes in cross-referring applications
Dementia call
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• For more information, visit
www.rfpb.nihr.ac.uk
• Or call the RfPB helpline
0208 843 8057
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NIHR Evaluation Trials and Studies Programmes
Professor Tom Walley, CBEDirector: NIHR Evaluation Trials and Studies
NIHR Dementia Research Workshop
14 January 2011
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Basic Research
National Institutefor Health Research
This pathway covers the full range of interventions - pharmaceuticals, biologicals, biotechnologies, procedures, therapies and practices - for the full range of health and health care delivery - prevention, detection, diagnosis, prognosis, treatment, care.
Patient Safety and QualityResearch Centres
Research for Patient Benefit
Programme Grants forApplied Research
Health Technology Assessment
Invention for Innovation
Primary Care Trusts Healthcare Commissioning
NHS Providers Patient Care
Research for Innovation,Speculation & Creativity
National Institute for Health & Clinical Excellence Guidance on Health & Healthcare
NHS Institute for Innovation & Improvement Support for the NHS
NHS Purchasing & Supplies Agency Centre for Evidence-based Purchasing
Service Delivery & Organisation
Collabs for Ldrshp in Appl Hlth Res and Care
Ctr for Reviews & Dissemination, Cochrane, TARs
NHS Evidence Access to Evidence
Development Pathway FundingMRC
Biomedical Research Units
Biomedical Research Centres
Public Health Research
Health Services Research
Strategic Health Authorities Duty of Innovation
Efficacy & Mechanism Evaluation
INVENTION EVALUATION ADOPTION DIFFUSION
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NIHR Evaluation, Trials and Studies (NETS) programmes
NETSCC: Established: 2008
Health Services
Research
Established: 2008
Public Health
Research
Established: 2008
Health Technology
Assessment
Established: 1993
Service Delivery
& Organisation
Established: 1999
Efficacy and
Mechanism
Evaluation
Funded by the MRC
Managed by NIHR
Established: 2008
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Efficacy and Mechanism Evaluation programme
Researcher-ledResearcher-led
Types of Research
Primary Research addressing efficacy +/- mechanism
Who defines the question?
Researcher
Frequency Per year
Continuous with 3 submission deadlines
• Purpose and RemitThe EME programme is aimed at supporting ‘science driven’ studies with an expectation of substantial health gain.
• The EME programme works seamlessly with and sits between MRC programmes and the HTA programme
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NIHR Health Technology Assessment programme
• Purpose and Remit
To deliver information about the effectiveness, costs and broader impact of healthcare treatments and tests for those who plan, provide or receive care in the NHS.
Types of Research
Specific technologyassessment
Primary researchFeasibility & pilotEvidence synthesis
Who defines the question?
NICE
Researcher
Frequency Per year
Direct referral toOn-contract teams
Primary researchEvidence synthesis
Theme from HTAprogrammeQuestion from researcher
Continuous with4 closing dates
Researcher LedResearcher Led
Primary researchFeasibility & pilotEvidence synthesis
HTA programme 4 calls
Clinicalevaluation
Clinicalevaluation
Themed CallsThemed Calls 1 call
NICE GuidanceNICE Guidance
CommissionedCommissioned
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HTA Studies currently underway in dementia• Reminiscence groups for people with dementia and their family
care-givers
Professor R Woods, University of Wales
2007-11 £1,536,391
• HTA study of antidepressants for depression in dementia (HTA-SADD)
Professor S Banerjee
The Institute of Psychiatry, 2006-11 £2,210,588
• Individual Cognitive Stimulation Therapy for dementia (iCST Trial)
Professor Martin Orrell, UCL,
2010-14 £1,213,646
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• Effectiveness and cost effectiveness of Collaborative cARE for people with DEMentia in primary care (CARE-DEM trial)
Professor S Iliffe, UCL
2010-15 £2,315,251
• The START (STrAtegies for RelaTives) study: to determine the effectiveness of a manual based coping strategy programme in promoting the mental health of carers of people with dementia
Professor G Livingston UCL
2009-13 £1,521,781
HTA Studies currently underway in dementia
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NIHR Service Delivery and Organisation Programme
• Purpose and Remit
Produces research about the organisation and delivery of healthcare for NHS leaders and decision-makers, commissioners, providers of health care, partner organisations such as local authorities and the voluntary sector, and for users of health care. This evidence is intended to improve practice in relation to the organisation and delivery of healthcare.
CommissionedCommissioned
Researcher-ledResearcher-led
Types of Research
Primary researchEvidence synthesis
Primary researchEvidence synthesisEmpirical studies
Who defines the question?
Researcher
SDO programmePriority AreasPriority Areas
SDO StudiesSDO Studies
Primary researchEvidence synthesisEvaluations
NHSSDO programmeResearcher
NHS EvaluationsNHS Evaluations
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• Better mental health care for older people in general hospitals
Professor J Gladman, Nottingham
2008-11 £473,487
SDO Studies currently underway in dementia
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NIHR Public Health Research programme
• Purpose and Remit
The PHR programme evaluates public health interventions, providing new knowledge on the benefits, costs, acceptability and wider impacts of non-NHS interventions intended to improve the health of the public and reduce inequalities in health.
The scope of the programme is multi-disciplinary and broad covering a range of public health interventions.
CommissionedCommissioned
Researcher-ledResearcher-led
Types of Research
Non-NHSPrimary researchEvidence synthesis
Non-NHSPrimary researchEvidence synthesis
Who defines the question?
Researcher
PHR programme
Frequency Per year
Continuous with3 closing dates
As required
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NIHR Health Services Research programme
• Purpose and RemitThe HSR programme funds research to improve the quality, effectiveness and accessibility of the NHS.
The HSR programme addresses the three dimensions of quality currently of central concern to the NHS: patient safety, patient experience and effectiveness of care.
Types of Research
Any studydesign
Who defines the question?
Researcher
Frequency Per year
Twice yearlyResearcher-ledResearcher-led
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NETS as a system
Facilitating researchers,
speeding review
Transfers between NETS
programmes
Active collaboration between
programmes
Directors' meetings
Joint calls
Meeting with networks
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KeeleKeele Support for CTUs
25 (in England) now
supported by HTA
programme
“pump-priming”
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• Major new opportunity for funding research into dementia– NETS programmes focused on projects with
national reach– Multicentred– Trials and other designs
(Engaging with CTUs)
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For further information, please visit:
www.nihr.ac.uk/research/Pages/Dementia.aspx
NIHR Dementia Research Workshop
14 January 2011
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National Institute for Health ResearchDementia Research Workshop
14 January 2011