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Opening plenary
• Chair:
• Andrew Morris, Director, Health Data Research UK
• Welcome address:
• Patrick Vallance, Government Chief Scientific Adviser and Co-Chair, Scientific Advisory Committee for Emergencies (SAGE)
This session will start at 09:30BST.Please use the Q&A function to ask questions to speakers. You are welcome to comment using the chat function, but we cannot guarantee this will be monitored.
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How UK health data research has pivoted for COVID-19
• Andrew Morris, Director, Health Data Research UK
• Caroline Cake, Chief Executive Officer, Health Data Research UK
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HDR UK’s mission is to unite the UK’s health data to enable discoveries that improve people’s lives
Our 20-year vision is for large scale data and advanced analytics to benefit every
patient interaction, clinical trial, biomedical discovery and enhance public health.
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To achieve this our strategy focuses on uniting, improving and using health data….
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…delivering through the Gateway, Alliance and Hubs…
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…and through 6 national research priority areas
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….and the institute is continuing to evolve to deliver this strategy
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2017 2018 2019
INCEPTION• 10 funders
SUBSTANTIVE SITES• 6 Research sites with
20 research organisations
GROWTH• >20 Alliance members• 8 hubs with > 100 partners • 11 Sprints• 10 training sites• Public Advisory Group
10FUNDERS
10FUNDERS
6RESEARCH
SITES
20RESEARCH
ORGANISATIONS
6RESEARCH
SITES
8HUBS
>20ALLIANCEMEMBERS
PUBLICADVISORY
GROUP
10FUNDERS
78RESEARCH
ORGANISATIONS
10TRAINING
SITES
100ORGANISATIONS
11SPRINTS
2020
GROWTH• 30 Alliance members• 8 Research sites• 78 research organisations• 4 Catalyst projects • 60 patients on COVID group
8RESEARCH
SITES
8HUBS
>30ALLIANCEMEMBERS
PUBLICADVISORY
GROUP
12FUNDERS
78RESEARCH
ORGANISATIONS
10TRAINING
SITES
100ORGANISATIONS
60 COVID patient advisors
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We are now an institute made up of 86 organisations in 56 offices across 32 locations
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HEALTH DATA RESEARCH HUBS
BREATHE
DATA-CAN
Discover-NOW
Gut Reaction
INSIGHT
PIONEER
NHS DigiTrials
BHF Data Science Centre
TRAINING LOCATIONS (Masters and PhD)
Belfast
Birmingham
Bristol
Cambridge
Edinburgh
Exeter
Leeds
London
Manchester
Oxford
CENTRAL TEAM OFFICES
Wellcome Trust
Great Ormond Street DRIVE Unit
RESEARCH LOCATIONS
HDR UK Cambridge
HDR UK London
HDR UK Midlands
HDR UK North
HDR UK Oxford
HDR UK Scotland
HDR UK South-West
HDR UK Wales and Northern Ireland
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With a growing community of researchers, innovators, technologists, clinicians, patients, & public across industry, NHS, academia and charities working together…
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Key senior leadership appointments made
in February –December 2018
Founding partner of UK Health Data Research Alliance announced in
December 2018
New Masters programmes announcedJune 2019
One Institute Strategy
launched – April 2019
7 Hubs launched inSeptember 2019 and started October 2019 Milestone 1 met
by all HubsDecember 2019Industry
engagement events UK, US, Europe October 2019 onwards
Gateway MVP launch with >400
datasetsFebruary 2020
Alliance grows to 27 members January 2020
2018 2019 2020
Gateway Rapid Development
TaskJanuary – March
2020
2017
HDR UK incorporatedas a company limited by guarantee in July
2017
BHF and HDR UK start work in
partnership to develop BHF Data
Science CentreAugust 2018
Substantive Site call launched to form HDR UK’s research base in
August 2017
Successful applicants announced forming our
first six Substantive Sites in February 2018
Interim funding received and six
Substantive Sites start in April 2018
First appointments made to the Board in
November 2017
HDR UK chosen to lead development of
4-year Digital Innovation Hubs
programme in July 2018
DIH Programme Design & dialogueSeptember 2018 –
April 2019
Core Funding starts and Call for
National Implementation
Projects launchedAugust 2018
Further appointments
made to the Board in November 2018
Collaboration with KQ Labs announced
November 2018
UK Health Data Research Alliance
launched with nine member in
February 2019
11 Sprint Exemplars
operationalJanuary 2019 –December 2019
DIH prospectus launched May 2019
First round of National
Implementation Projects
announcedJune 2019
Partnership with NICE
announcedJuly 2019
2018/19 Annual Review
launchedJuly 2019
Plans for Gateway MVP
announcedJuly 2019
Successful Wellcome PhD Programme
announced inSeptember 2019
HDR UK’s 100th
Open Access output
published inSeptember
2019
BHF Data Science Centre and inaugural Director announced
in October 2019
Chair of International
Advisory Board announced inOctober 2019
Gateway MVP developed
October 2019 -January 2020
Call for new Substantive Sites and Better Care
Catalysts launched inDecember 2019
HDR UK Public Advisory Board
announced –January 2019
2020 /21 strategic delivery plan and
governance structures announced in March
2020
HDR UK implements research question
prioritisation process to support COVID-19
response in April 2020
New Substantive Sites and Better Care Catalysts announced in
April 2020
First phase of fully functional Gateway
delivered in June 2020
Andrew Morris announced as
Director in March 2017
…to deliver at pace…
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…and make impact at scaleOur highlights from the past year
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Working in Partnership to respond to COVID-19
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“Covid-19 — A Once-in-a-Century Pandemic?”
Bill Gates
New England Journal of Medicine, April 2020
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We are mobilising resources and championing the use of health data to respond to COVID-19
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1
2
3
Co-ordinate and connect national data sciencedriven research efforts related to COVID-19
Accelerate access to UK-wide priority data relevant to COVID-19 for research
Leverage the best of the UK’s health data science capability to address the wider impact of the COVID-19 pandemic, supporting vulnerable groups that will be hardest hit
Our three key priority areas are:
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We are operating a prioritisation process for health data research questions for SAGE – accelerating the ‘fittest’ questions…
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Questions from
researchers
106 health data research questions identified
36 prioritised for support and data access
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…and reporting new research insights transparently…
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100 pre-print publications
86 active research studies in the national Trusted Research Environments
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…making it easier to discover and request access to COVID-19 relevant datasets via the Gateway
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https://healthdatagateway.org/
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…ensuring the views of patients and public are heard and taken on board and we are transparent with our work
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We are receiving input from the 62 members of our COVID-19 public advisory group, our Public Advisory Board and new lay members on our delivery groups.
• Prioritising COVID-19 data research questions• Shaping our advise to SAGE• Advising on COVID-19 research projects – e.g.
the risk calculator ‘OurRisk.CoV’• Sharing questions and concerns on accelerated
data access
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Increasing our knowledge of this devastating disease and how to treat it
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Examples
Data from the Symptom Study App identified loss of sense of smell and taste as a recognised symptom of COVID-19, influencing UKgovernment policy
Use of data has shown the impact of COVID-19 on vulnerable people with health conditions, including those with cancer and heart disease
The RECOVERY trial has used data to establish there is no clinical benefit of hydroxychloroquine in hospitalised patients
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Scaling this up to a global responseLaunching today: International COVID-19 Data Research Alliance and Workbench
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VisionTo unite data from international clinical trials, biomedical and health research to enable discoveries that benefit all people, everywhere, by reducing the harm of the COVID-19 pandemic.
To build a trustworthy international partnership and enduring data infrastructure to support a rapid response to the current COVID-19 and future pandemics across the world.
Mission
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Initial partners“start small, think big, move fast”
FUNDERS
Bill and Melinda Gates FoundationChan Zuckerberg FoundationMastercardMinderoo FoundationWellcome
ALLIANCE PARTNERS
African Academy of SciencesBREATHE Health Data Research HubGeneration Scotland Genomics EnglandGlobal Alliance for Genomic HealthHDR Network CanadaInfectious Diseases Data Observatory (IDDO)
TECHNICAL EXPERTISE
AridhiaMastercard Novartis PharmaSAILSeRP (Secure eResearch Platform)
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International approaches to combatting the COVID-19 pandemic – how have data and technology been harnessed?
Chairs:
• Rhos Walker, Chief Science Strategy Officer, Health Data Research UK
Panellists:
• Andreas Poensgen, Managing Partner, Turgot Venture
• Effy Vayena, Chair of Bioethics, Swiss Institute of Technology
• Teo Yik Ying, Dean of Saw Swee Hock School of Public Health, National University of Singapore
Please use the Q&A function to ask questions to speakers. You are welcome to comment using the chat function, but we cannot guarantee this will be monitored.
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Responding to an international pandemic
Germany’s response to COVID-19
Dr. Andreas Poensgen
Health Data Science in the COVID-19 Era: HDR UK ‘One Institute’ Conference
June, 16th 2020
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The first wave and government interventions: overview
27Source: Statista, RKI, Johns Hopkins, WHO, Handelsblatt
Real infection curve
minus 5 to 12 days
It 2000 new
cases
The story
19.1 - 27.2 Limited outbreak (Webasto / China)
27.2. New Cases : Skiing /Italy
Citizen Level
4.3. Many businesses start home office
City & Federal State level
10.3 No large events > 1000
11.3 Isolation for skiing tourist
16.3. State of emergency
German national level
12.3 No large events > 1000
16.3 Closing of bars, restaurants, most shops
19. 3 Merkel televised Speech
22.3. Lock down: 2 persons to meet, home
2.4. !!! Stopping flights from Iran etc.
#
Registered new cases p.d
Germany
ItalyState of
Emergency
Public PolicyInterventions
Pro-longation
Steps to
reopen
The probable peak
NextPhase
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Insights
1. The success - not result of grand design & strategy or full readiness
2. Probably a combination
• Outside chock: the „Italian tragedy“
• Access to Asian experience (SK, T, S, Ch): clear what needed to be done
• Early change of behaviour: physical distancing
• Some federal states acting early
• Angela Merkel & Robert Koch Institute
3. After the„Hammer“, society started to learn „dancing“, slowly, trial and error: How to…
• interrupt transmissions opening up
• test-trace-isolate
• protect elderly and feeble
• ramp up supplies & capacity
• improve hospital treatment strategies
28
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The power of decentral decision-making & initiativeExample: independent laboratories
29
0
20000
40000
60000
80000
100000
120000
140000
March 6 March 15 March 23 March 30 Early April
86 48 97 86 ~100# of labs
Development a surprise for political decision makersMany similar stories: e.g. ramp up of hospital capacity, getting masks, organizing test stations, etc..
> 600 % increase within a month
• Independent laboratories
• Direct relation with physicians
• Adaptive to local needs
• No government intervention
Testing capacity per day#
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Learning: You win on the local level
• Understanding infection rates & dynamics
• Learning physical distancing and appropriate behaviour
• Testing, tracing, isolating
• Protecting nursing homes etc.
• Providing care / intensive care
• Supply & procurement
30
Key success factors
• Adaptation to local situation
• Targeted local task forces in charge
• Flexible availability of resources
• Fast data availability & transparency
• Operational effectiveness
• Involving all shareholders
• Communication
But support needed: central competence hubs & government:
Nat. & int. know how & best practice sharing, benchmarking, scientific insights, data infrastructureAccess to int. purchasing & procurement
Financial resources, laws & regulation, law enforcement, corrective actions if the local level fails
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The role of science, data and technology: leverage focussed strategiesPrincipal approach to stay focussed
31
Monitor &
Evaluate /
Benchmark
Implement
Operate
Share
R&D
Understand
Innovate
Develop
Test
Key areas of activitiesto fight COVID 19
Monitor infection rates & dynamics
Measures of physical distancing/ Behavioural change
Test, trace, isolate
Protecting elderly & feeble
Providing care / intensive care
Ensure supplies
Seek & useleverage
Value chainper area
Real time data
Social Media & Apps & UX
Access to & analytics of data pools
Open Source & Crowd Sourcing
AI & decision support algorithms
Insight / knowledge scouting & KM hubs
Connectivity
Studies / Research
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32
Thank you
Dr. Andreas Poensgen
Managing Partner Turgot Ventures AG
https://www.linkedin.com/in/andreas-
poensgen-51903951/
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||
Prof. Effy Vayena
Health Ethics and Policy Lab
@EffyVayena
6/25/2020 33
COVID19
A perspective from Switzerland and the WHO
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|| 34
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||https://www.corona-data.ch/ 35
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||[email protected] 36
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▪ Science, policy and
politics
▪ The Swiss science task
force
▪ Subgroups
▪ Policy briefs
▪ Public engagement
6/2
5/2
020
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WHO guidance
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||
▪ 31 131 infections
▪ 1677 deaths
▪ New infections on June 15 - 14
▪ “Extraordinary situation” to end on June 19th
▪ Contact tracing and testing
▪ App
▪ Cantonal responsibilities
40
At this point
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Turning Discovery into Healthier Communities 41Turning Discovery into Healthier Communities
YY Teo
Professor, Dean
Saw Swee Hock School of Public Health
How will the world adapt to challenges
from COVID-19: a case study of
Singapore’s response
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42/49
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43/49
Situation in Singapore
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44/49
Situation in Singapore
Importations
Community cases
Total
Migrant Workers in Dormitories
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Key Principle 1:
Find, Trace, Test, Isolate
• 50 teams of 10, 2 shifts, 7
days
• 13,000 tests/day to 40,000
test/day in July
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Key Principle 2:
Evidence-guided Policies
(Reducing contact transmission in both communities and schools at different times and for durations)
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Key Principle 2:
Evidence-guided Policies
• Commissioned by Chief Health Scientist to Public Health
Translational Unit in School of Public Health
• Weekly synthesis of latest scientific and media reports on
key topics
• http://sph.nus.edu.sg/covid-19/
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Key Principle 3:
Clear Public Communications
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Border Control Measures
Border Restrictions
• 24 Mar: Border closures to all short-
term visitors*
• 9 Apr: All returning locals mandatory
14-days quarantine in government-
appointed hotels
• Strict digital and in-person enforcement
meted penalties include fines,
deportations and imprisonments
* Not applicable to citizens, PRs and long-
term pass holders (study, work)
• “Fast lane” (air bridges) arrangements
with China for essential business travel
• TBC: New Zealand, Australia, South
Korea, Malaysia
Temperature Screening
• 24 Jan: All land and sea checkpoints
• 29 Jan: All flights into Singapore
Forfeiture of Health Insurance
• Locals who voluntarily travel for non-
essential purpose forfeit COVID-19
coverage
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COVID-19: Global Public Health
• Commonalities in Public Health strategies, but important
context differences in implementation
• Contextual elements:
▪ Historical (e.g. SARS, MERS, H1N1, etc.)
▪ Social and cultural (e.g. trust, community-spirited)
▪ Capacity and capability (testing, tracing, isolation,
treatment)
▪ Economic (e.g. fiscal measures to protect livelihoods)
▪ Political (i.e. long-term outlook vs. short-term impact)
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Summary
• Embarking on both aggressive PCR and serology
testing, and increased capability for contact tracing
• Calibrated and phased easing of lockdown measures
• Constant risk assessments and possibly sectoral
closures if resurgence
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Turning Discovery into Healthier Communities 52
Turning Discovery into Healthier Communities
Thank you!
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International approaches to combatting the COVID-19 pandemic – how have data and technology been harnessed?
Chairs:
• Rhos Walker, Chief Science Strategy Officer, Health Data Research UK
Panellists:
• Andreas Poensgen, Managing Partner, Turgot Venture
• Effy Vayena, Chair of Bioethics, Swiss Institute of Technology
• Teo Yik Ying, Dean of Saw Swee Hock School of Public Health, National University of Singapore
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Format & programme for the day
Rhos Walker, Chief Science Strategy Officer, Health Data Research UK
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Delegate pack:
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Programme for the day:
Stream 1 Stream 2
10:45 Breakout 1: How do we make the UK world leading for COVID-19 clinical trials?
Breakout 2: COVID-19 Data – data definitions and new data types in a crisis
11:45 Breakout 3: Understanding the causes of disease & COVID 19 – Harnessing multi-omic cohorts & the COVID-19 Genomics UK Consortium
Breakout 4: How are Health Data Research Hubs & BHF
Data Science Centre supporting COVID-19 Research?
PLENARY
12:45 Rapid Fire Early Career Lightning Talks
13:15 LUNCH BREAK
Stream 1 Stream 2
13:50 Breakout 5: Better care – role of data at the frontline of the COVID-19 response
Breakout 6: Responding to the Public Health Emergency of COVID-19
14:50 Breakout 7: What do national and international health data researchers need in a post-COVID-19 world?
Breakout 8: Relationship of trust: Realising patient and NHS benefits in times of COVID-19
PLENARY
15:50 Fireside chat: How will data and technology influence the future of clinical and regulatory science?
16:25 Celebrating partnership in health data science across the UK: Prize for ‘Impact of the Year’, ‘Team of the Year’ & Lightning Talks
16:35 Closing remarks
16:45 CLOSE
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Delegate pack:
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Accessing the sessions:
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Additional support:
• If you have any problems accessing any sessions, please email [email protected] and the team will be able to help
• Sessions will be recorded and where possible we will share the recordings and slides on our website after the conference
• We aim for the event will be as interactive as possible.
• Please submit questions via the Q+A function. More details on how to submit questions are included in your Delegate pack
• Please tweet their thoughts and contributions using #HDRUKcon20
• Enjoy the day!
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Break
The next session will start at 10:45BST.