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Opportunities at the Alexander von
Humboldt Foundation (AvH)
Prof. Dr. Alessandra Sussulini
University of Campinas
Institute of Chemistry
Department of Analytical Chemistry
Campinas, September 26th 2016
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CAPES-Humboldt Research Fellowship
For Brazilian Researchers: Joint fellowship program
(until 31 July 2017).
Postdoctoral Researchers: If you are at the beginning of
your academic career and completed your doctorate less
than 4 years ago. Duration: 6-24 months.
Experienced Researchers: If you are a scientist (Assistant
Professor or Junior Research Group Leader) and completed
your doctorate less than 12 years ago. Duration: 6-18
months (flexible).
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Humboldt Research Fellowship for Postdoctoral Researchers
German course: up to 4 months
prior to the research fellowship
(including accompanying spouse)
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My research experience in Germany:
Metallomics in the study of brain
diseases
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BrainMet - Bioimaging of Metals in
Brain and Metallomics
Forschungszentrum Jülich - BrainMet
Dr. habil. J. Sabine Becker
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What is Metallomics?
Genomics
Transcriptomics
Proteomics
Metabolomics
DNA
RNA
Proteins
Lipids Sugars Amino
acids
Nucleotides
Metallomics Metalloproteins Free elements
Systems biology
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Degenerative disorder of the central
nervous system:
Loss of dopamine in substantia nigra
Protein accumulation (Lewy bodies)
in brain cells
Causes:
Genetic or environmental
factors
Diagnosis:
Medical history and
neurological examination
Treatment:
Only management
(levodopa)
http://nihseniorhealth.gov/parkinsonsdisease/
Parkinson’s Disease
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Forschungszentrum Jülich in collaboration
with Philipps Universität Marburg
Study of mouse models of Parkinson’s disease induced by
6-hydroxydopamine (6-OHDA):
Only PD induced, n = 6
Treated with L-DOPA (L-3,4-dihydroxyphenylalanine), n = 12
6-OHDA injection
(PD)
Control
(without PD)
Parkinson’s Disease Metallomics
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Parkinson’s Disease Metallomics
Animal
experiment
LA-ICP-MS
(Elemental
MS imaging)
Forschungszentrum Jülich in collaboration
with Philipps Universität Marburg
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Higher concentration in animals without
L-DOPA treatment (control):
Fe in striatum
Mn in cortex and ventral forebrain nucleus
Zn in agranular insular cortex posterior (AIP)
Cu in hypothalamus and periventricular zone
Parkinson’s Disease Metallomics
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Impact of the AvH fellowship in my carreer
During the fellowship period (2011-2012): 2 papers
(Metallomics and Biomedical Spectroscopy & Imaging), 5
conferences (3 in Germany, 1 in Brazil, 1 in the USA).
After the fellowship period: 3 papers: Mass Spectrometry
Reviews (2016), Talanta (2015), and Contrast Media &
Molecular Imaging (2013). Book chapter in progress:
Methods in Molecular Biology (Springer).
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Impact of the AvH fellowship in my carreer
“Once a Humboldtian, always a Humboldtian”
AvH Alumni Programs:
Return fellowships (for reintegration at home country)
Book donations (donation of academic literature)
Participation in specialist conferences in Germany
Equipment subsides (purchase of scientific equipments)
And others… Please visit: www.avh.de
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Special Thanks
Dr. Sabine Becker