Download - Osteomalacia
Osteomalacia
Zaryab GhauriBatch E
What is Osteomalacia?
Osteomalacia means soft bones often develops because of vitamin D deficiency.
Who gets Osteomalacia?
Elder PeopleFamily History of RicketsBlack RaceSouth Asian Origin
Bone Mineralization
Bone Mineral Hydroxyapatite[Ca10(PO4)6(OH)2]
Vitamin D(Metabolism)
Vitamin D(Functions)
*Intestinal Calcium absorption
*Re-absorption of Calcium from Kidneys
*Interaction with PTH in regulation of blood Calcium
*Mineralization of Bone
OsteoclastsOsteoblastsOsteocytesLining Cells
Pathology in Osteomalacia
Inadequately mineralized Osteoid
Causes Of Osteomalacia
1. Vitamin D deficiencyDietSun Exposure
2. Gastrointestinal CausesGastricIntestinalBilliary
3. Renal CausesChronic Renal FailureRenal Tubular AcidosisLong term Renal DialysisFanconi Syndrome(Poisoning)
4. Tumor Induced Osteomalacia5. Drugs
Phenobarbital (Pubmed)Acetazolamide(JAMA, Journal of the American Medical Association)
Ammonium Chloride (http://press.endocrine.org/doi/abs/10.1210/jcem-16-5-599)
Disodium Etidronate(http://www.ncbi.nlm.nih.gov/pubmed/10883448)
Flouride(http://fluoridealert.org/studies/osteoid02/)
Symptoms
>50yrs ageBone PainMuscle WeaknessEasy Fractures
Investigations
CBCElectrolytesLevels Of CalciumPhosphorusCalcium Phosphorus IndexVitamin DALPPTH
Looser’s Zone
Codfish Vertebrae
Trefoil Pelvis
Bone Scan
Treatment
Sun ExposureDietVitamin D supplementation
Prevention
References
http://painreliveonlypt.blogspot.com/2014/10/osteomalacia-causes-risk-factors.html
http://www.arthritisresearchuk.org/arthritis-information/conditions/osteomalacia/what-is-osteomalacia.aspx
http://www.vitaminsestore.com/osteomalacia-causes-treatments-symptoms-and-risk-factors/