Download - Parmentier 02
![Page 1: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/1.jpg)
Primary Care Mental HealthAnxiety disorders
Dr Henk Parmentier
24th January 2011
![Page 2: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/2.jpg)
Introduction
Dr Henk Parmentier
General Practitioner
• Wonca: http://www.globalfamilydoctor.com/
• Wonca Mental Health: http://www.WWPOMH.ning.com
• Mental Health in Family Medicine Journal: http://www.radcliffe-oxford.com/journals/J20_Mental_Health_in_Family_Medicine/default.htm
![Page 3: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/3.jpg)
objectives
Learn about: Anxiety Disorders Definitions Recognition treatment
![Page 4: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/4.jpg)
The Role of Mind & Body Separation
Since Hippocrates, conditions currently regarded as mental illness were treated by general physicians for 2000 years
The idea of insanity as a disease of the mind, different from other illnesses, emerged in the 18th century from Cartesian dualism
4
![Page 5: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/5.jpg)
Public Attitudes ‘Unfortunately, the linguistic distinction
between mental and physical illnesses, and the mind/body distinction from which this was originally derived, still encourages many lay people, and some doctors and other health professionals, to assume that the two are fundamentally different.’ (Kendell 2001)
5
![Page 6: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/6.jpg)
Mind and Body: dump Descartes !
![Page 7: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/7.jpg)
Mind – Body “The only way to separate the mind from the
bodyis with an axe.”
![Page 8: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/8.jpg)
Primary Care Mental Health
mental disorders are found in all countries, in women and men, at all stages of life, among the rich and poor, and in both rural and urban settings
up to 60% of people attending primary care clinics have a diagnosable mental disorder.
![Page 9: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/9.jpg)
Primary Care Mental Health
effective treatments exist for mental health disorders and can be successfully delivered in primary care
![Page 10: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/10.jpg)
The Size Of The Problem
(Andrews et al, J Ment Health Policy Econ, 2000 Dec 1;3(4):175-186)
prev disability days total (million) % of total
depression 3.9% 11.6 6.0 24%
anxiety 6.5% 9.0 7.8 31%
psychosis 0.4% 7.7 0.4 2%
Disability days by diagnosis
![Page 11: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/11.jpg)
depression
WHO predicts that by the year 2020 depression will be the second most important cause of disability after ischaemic heart disease
Murray & Lopez 1997
![Page 12: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/12.jpg)
Excess Consultation Rate UK Anti-Depressants (Centre for Innovation in Primary Care 2001)
12
![Page 13: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/13.jpg)
Extra Consultations (Centre for Innovation in Primary Care 2001)
Condition Extra consults per patient per condition
per year
Extra consults per patient per year allowing for co-
morbidity
Diabetes 1.32 0.62
Hypertension 1.51 1.12
CHD 1.95 0.99
Ulcer healing drugs 2.9 1.92
Asthma/COPD 2.44 2.04
Antidepressants 4.21 3.60
Antipsychotics < 60 5.32 5.32
13
![Page 14: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/14.jpg)
Depression
Cardiovascular disease
Depression has been associated with increased risks of MI and mortality
(Barefoot & Schroll 1996)
Cause or effect?Cause or effect?
Many patients who are free of depression following an acute MI experience an episode
of depression within a year. (Ranga KR et al 2002)
Major depressive disorder occurs in between15% and 23% of patients with acute coronarysyndromes and constitutes an independentrisk factor for both morbidity and mortality
(Glassman et al. 2002)
![Page 15: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/15.jpg)
Wonca WPoMH
Depression and Cardiovasular Mortality Post-MI:6 and 18 month outcomeDepression and Cardiovasular Mortality Post-MI:6 and 18 month outcome
Frasure-Smith N, et al. JAMA 1993;270:18191825. Frasure-Smith N, et al. Circulation 1995;91:9991005.
3%
6.4%
17%
20%
0
5
10
15
20
25
6 months 18 months
% o
f cor
onar
y de
aths
Non-depressed patients
Depressed patients
![Page 16: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/16.jpg)
Previously Identified Risk Factors for Coronary Artery Disease
Genetic Factors Diabetes Hypertension Thrombocyte
Dysfunction Hyperlipidemia Smoking Obesity
![Page 17: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/17.jpg)
Major depression – CV risk
![Page 18: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/18.jpg)
Depressionindependent risk factor for myocardial infarction
Platelets: upregulation of platelet imidazoline and
serotonin receptors and enhanced intraplatelet calcium mobilization seen in patients with depression resulting in increased platelets activation
Sauer,Berlin,Kimmel:Selective serotonin reuptake inhibitors and myocardial infarction:Circulation. 2001 Oct 16;104(16):1894-8
![Page 19: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/19.jpg)
![Page 20: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/20.jpg)
Prevalence of unexplained symptoms in consecutive new attendees to medical clinics at a UK Teaching Hospital
Nimnuan and Wessely, 2000
Clinic Prevalence (95% CI)ChestCardiologyGastroenterologyRheumatologyNeurologyDentalGynaecology
59% (46-72)56% (46-67)60% (45-73)58% (47-69)55% (45-65)49% (37-61)57% (50-68)
Total 56% (52-60)
![Page 21: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/21.jpg)
Unexplained symptoms
Depression Anxiety
Abdominal pain 63% 53%
Chest pain 66% 49%
Dizziness 58% 52%
Short of breath 63% 46%
Headache 53% 46%
Back pain 54% 46%
Kroenke et al, Arch Fam Med, 1994
![Page 22: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/22.jpg)
Stress is normal
![Page 23: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/23.jpg)
Primary care for mental healthPrimary care for mental health
Primary care for mental health forms an essential part of both:
• comprehensive mental health care • general primary care.
General health care
Primary care
Mental health care
Primary care for mental health
![Page 24: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/24.jpg)
Primary care for mental health must be supported by other levels of care including : community-based and
hospital services, informal community care
services, and self-care.
WHO pyramid of care for mental healthWHO pyramid of care for mental health
![Page 25: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/25.jpg)
![Page 26: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/26.jpg)
Generalized Anxiety Disorder: DSM-IV Diagnostic Criteria
– Excessive anxiety and worry present most of the time for > 6 months
– Difficult to control worry– Associated with (at least 3 items):
• Restlessness • Being easily fatigued • Concentration difficulties• Irritability• Muscle tension• Sleep disturbance
– Focus of anxiety and worry not confined to features of an Axis I disorder
– Causes clinically significant distress or functional impairment– Not due to medication, illness, or substance abuse
DSM-IV-TR. APA 2000
![Page 27: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/27.jpg)
Generalized Anxiety Disorder: ICD-10 Summary
– Anxiety is generalized and persistent and not associated with a particular environmental circumstance (i.e. it is free-floating)
– Anxiety present most days for at least several weeks at a time and usually for several months
– Symptoms should involve elements of:• Apprehension
– E.g. Worry about future, feeling “on edge”, difficulty concentrating• Motor tension
– E.g. Restlessness, fidgeting, tension headaches, trembling• Autonomic overactivity
– E.g. Light-headedness, sweating, tachycardia, epigastric discomfort
– Must not meet full criteria for depressive episode, phobic anxiety disorder, panic disorder, or obsessive-compulsive disorder
ICD-10, WHO 1992
![Page 28: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/28.jpg)
DSM-IV and ICD-10 GAD Diagnostic Criteria: Some Differences
DSM-IV ICD-10
Diagnostic classification
Independent category
Residual category
Worry/anxiety symptom
Excessive anxiety and worry
Persistent free-floating anxiety
Duration ≥6 months Several months
Autonomic hyper-activity and physical symptoms
Not essential Must be present
Functional impairment Must be present Not specified
Rickels & Rynn. J Clin Psychiatry. 2001;62(suppl 11):4-12Starcevic. Anxiety Disorder in Adults. Oxford University Press. 2005:102-140
![Page 29: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/29.jpg)
The epidemiology of generalized anxiety disorder in Europe.Lieb R, Becker E, Altamura C.
Eur Neuropsychopharmacol. 2005 Aug;15(4):445-52.Max-Planck-Institute of Psychiatry, Unit Clinical Psychology and Epidemiology, München, Germany.
The objective of this paper is to provide a review on available data to date on the epidemiology of GAD in Europe, and to highlight areas for future research. MEDLINE searches were performed and supplemented by consultations with experts across Europe to identify non-published reports. Despite variations in
the design of studies, available data suggest that
(a) about 2% of the adult population in the community is affected (12-month prevalence),
(b) GAD is one of the most frequent (up to 10%) of all mental disorders seen in primary care,
(c) GAD is a highly impairing condition often comorbid with other mental disorders,
(d) GAD patients are high utilizers of healthcare resources, and
(e) despite the high prevalence of GAD in primary care, its recognition in general practice is relatively low.
![Page 30: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/30.jpg)
Anxiety: dictionary
Feeling anxious Full of mental distress because of fear of
danger or misfortune; greatly worried
![Page 31: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/31.jpg)
Anxiety: symptom
anxiety
Anxiety disorders
affective disorders
![Page 32: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/32.jpg)
Anxiety&
Depression
Financial worries
Relationship worries
Bereavement
Housing
Work
Illness
Acute Illness
Chronic Illness
Illness in family
Gender&
sexuality
Side effectsmedication
Terminal Illness
Pain syndromes
Personalitydisorders
Alcohol&
drugsThe law
![Page 33: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/33.jpg)
33
Finding GAD in the Symptom “SOUP”
Stress
Insomnia
Irritable
Nervy
Jumpy
Weight Angry
Wake up
Feel Bad
Sad
Crying
SadAppetite Antisocial
Frightened
WorriedGuilty Fatigue
No energySuicidal
Heart Race
Forget
Can’t think
Shy
Loner
Panicky
Useless
Worthless
Depressed
Anxious
HeadachesTense
GI pain
BuzzyFlat
Pain
Breathless
Dizzy
Off sex
Restless
Edgy
Sweaty
Shaky
Cramps
IBS
Need a drink
Always Most of the time Sometimes Most of my life Since I lost my job
Etc…..Hot flashes
Worry
![Page 34: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/34.jpg)
Overlap Between Anxiety Disorders and Depression Can Make Diagnosis Difficult
Stahl's Essential Psychopharmacology Online © 2009 Cambridge University Press.
Comorbidity of depression and anxiety disorders can also confound diagnosis
![Page 35: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/35.jpg)
Anxiety Continuum
Worried / anxious but NO somatic symptoms
Worried / anxious but WITH somatic symptoms
Cardiovascular symptoms
Respiratory symptoms
Gastro-Intestinal / Genito-urinary symptoms
Mysterious pains
How GAD usually presents to PCPs….
![Page 36: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/36.jpg)
Unexplained Medical Symptoms & Misdiagnosis of GAD… a Viscous Cycle
Misdiagnosed, untreated Persistent
GAD
Unexplained medical symptoms
Medical consequencesHPA, cytokines
Exacerbation of Existing chronic illness
Development of new illnesses
Investigations-ve findings
![Page 37: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/37.jpg)
Screening Tools
• Alert the physician to the possibility a disorder might exist– Trigger further investigation using diagnostic
criteria and instruments
• Examples– GAD-7
– ASQ-15
![Page 38: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/38.jpg)
GAD 7
†Score >10 indicates possibility of GAD
![Page 39: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/39.jpg)
![Page 40: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/40.jpg)
![Page 41: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/41.jpg)
![Page 42: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/42.jpg)
42
Anxiety-causing medicinal substances
• Anticholinergics• Some blood pressure
medicine• Caffeine• Digitalis (toxic doses)• Sympathomimetic
drugs (ephedrine)
• Levodopa • Neuroleptics (akathisia)• Bronchodilators• Thyroid hormones• Anti-inflammators• SSRI’s• Withdrawal from
alcohol and benzodiazepine use
![Page 43: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/43.jpg)
hyperventilation
![Page 44: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/44.jpg)
Hyperventilation (over-breathing)
• About 60% of attacks are accompanied by hyperventilation and many panickers overbreathe even whilst relaxed.
![Page 45: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/45.jpg)
hyperventilation
• The most important thing to understand about hyperventilation:– it can feel as if you don’t have enough oxygen, the
opposite is true. It is a symptom of too much oxygen.– With hyperventilation, your body has too much
oxygen. To use this oxygen (to extract it from your blood), your body needs a certain amount of Carbon Dioxide (CO2).
– When you hyperventilate, you do not give your body long enough to retain CO2, and so your body cannot use the oxygen you have. This causes you to feel as if you are short of air, when actually you have too much.
![Page 46: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/46.jpg)
hyperventilation and panic attack symptoms
• Light headiness • Giddiness • Dizziness • Shortness of breath • Heart palpitations • Numbness • Chest pains • Dry mouth • Clammy hands • Difficulty swallowing • Tremors • Sweating • Weakness • Fatigue
![Page 47: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/47.jpg)
Breathing exercises• Hold your breath. Holding your breath for as long as you comfortably
can will prevent the dissipation of carbon dioxide. If you hold your breath for a period of between 10 and 15 seconds and repeat this a few times that will be sufficient to calm hyperventilation quickly.
• Breathe in and out of a paper bag. This will cause you to re-inhale the carbon dioxide that you exhaled. Naturally there are many times when this would be inappropriate and may appear a little strange. It really helps though.
• Thirdly you can take vigorous exercise while breathing in and out through your nose. A brisk walk or jog whilst breathing through the nose will counter hyperventilation. Regular exercise will decrease general stress levels decreasing the chance of panic attacks.
• If you find that your breathing pattern is irregular or uncomfortable a lot of the time, the best way to ‘reset’ it is by exercising. Start off gradually and check with your doctor if you are not used to exercise.
![Page 48: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/48.jpg)
Management and Treatment
of GAD
Treatment Guidelines
![Page 49: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/49.jpg)
The WFSBP Guidelines for the Pharmacological Treatment of Anxiety Disorders, OCD and PTSD - First Revision
www.wfsbp.org
Bandelow B, et al. (2008) World J Biol Psychiatry 9: 248-312
![Page 50: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/50.jpg)
![Page 51: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/51.jpg)
Presentation in A&E or other settings with a panic attack• If a patient presents with a panic attack, he or she should:
• Be asked if they are already receiving treatment for panic disorder
• undergo the minimum investigations necessary to exclude acute physical problems
• not usually be admitted to a medical or psychiatric bed• be referred to primary care for subsequent care, even if
assessment has been undertaken in A&E• be given appropriate written information about panic
attacks and why they are being referred to primary care• be offered appropriate written information about sources of
support, including local and national voluntary and self-help groups.
Nice anxietyA&E
![Page 52: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/52.jpg)
Treatments for Anxiety Disorders – Evidence From Controlled Studies
Effective
SSRIs (escitalopram etc.) SNRIs venlafaxine,
duloxetine Tricyclic antidepressants Benzodiazepines Pregabalin (only GAD) Buspirone (only GAD) Irreversible MAOIs Moclobemide (only SAD) Quetiapine (only GAD)-------------------------- Cognitive/behavior therapy Psychoanalysis -1 study
Insufficient Proof Typical Neuroleptics
Lack of Evidence or Negative Studies
Beta blockers Herbal preparations Other psychological
treatments Hypnosis
In God we trust.Everybody else needs to provide evidence.
AnonBandelow et al. World J Biol Psychiatry.2008;9(4):248-312.
![Page 53: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/53.jpg)
Advantages and Disadvantages of Anti-anxiety Drugs (I)
Drug Advantages Disadvantages
SSRIs No dependency Sufficient evidence from clinical studies for all anxiety disordersRelatively safe in overdose
Latency of effect 2–6 weeks, initial jitteriness, nausea, restlessness, sexual dysfunctions and other side effects. Some risk of discontinuation syndromes
SNRIs No dependency Sufficient evidence from clinical studiesRelatively safe in overdose
Latency of effect 2–6 weeks, nausea, possible increase in blood pressure and other side effects. Some risk of discontinuation syndrome
Pregabalin No dependency Sufficient evidence from clinical studiesRapid onset of effect
Dizziness, sedation and other side effects
Quetiapine No dependency Preliminary evidence from clinical studiesRapid onset of effect
Somnolence, weight gain and other side effects
TCAs No dependency Sufficient evidence from clinical studies (exception: SAD, PTSD)
Latency of effect 2–6 weeks, anticholinergic effects, cardiac side effects, weight gain and other side effects, may be lethal in overdose
Bandelow et al. World J Biol Psychiatry. 2008;9(4):248-312.
![Page 54: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/54.jpg)
Advantages and Disadvantages of Anti-Anxiety Drugs (II)
Drug Advantages Disadvantages
Benzodiazepines Rapid onset of action Sufficient evidence from clinical studiesRelatively safe in overdose
Dependency possible; sedation, slow reaction time and other side effects. Paradoxical reactions in elderly patients.
Moclobemide No dependency Benign side effect; relatively safe in overdose
Latency of effect 2–6 weeks, inconsistent study results in SAD, no efficacy proofs for other anxiety disorders
MAOIs No dependency Few supporting studies in PD and SAD; latency of effect 2–6 weeks; potentially dangerous side effects and interactions
Buspirone No dependencyRelatively safe in overdose
Latency of effect 2–6 weeks; efficacy proofs only for symptoms of GAD; lightheadedness, nausea and other side effects
Hydroxyzine No dependency Efficacy proofs only for GAD; sedation and other side effects; no experience with long-term treatment
Bandelow et al. World J Biol Psychiatry. 2008;9(4):248-312.
![Page 55: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/55.jpg)
WFSBP Recommendations: Generalized Anxiety Disorder
Treatment Examples Category of Evidence
RecommendationGrade
Recommended Daily Dose for
Adults
SSRIs Escitalopram A 1 10–20 mg
Paroxetine A 1 20–50 mg
Sertraline A 1 50–150 mg
SNRIs Venlafaxine A 1 75–225 mg
Duloxetine A 1 60–120 mg
Calcium channel modulator
Pregabalin A 1 150–600 mg
Atypical antipsychotic
Quetiapine A 1 50–300 mg
TCA Imipramine A 2 75–200 mg
Benzodiazepines Diazepam A 2 5–15 mg
Lorazepam A 2 2–8 mg
Antihistamine Hydroxyzine A 2 37.5–75 mg
Tricyclic Anxiolytic
Opipramol B 3 50–150 mg
Azapirone Buspirone D 5 15–60 mg
Bandelow et al. World J Biol Psychiatry. 2008;9(4):248-312.
![Page 56: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/56.jpg)
WFSBP 2008 GAD Treatment Guidelines
FIRST-LINEPregabalin
SSRIs SNRIs
4-6 Weeks
Continue
No
Partial
Yes
Response?Further
4-6 weeks
Change dose or
switch• Benzodiazepines (2nd line because of
abuse potential)– Treatment-resistant patients with no
history of dependence– Add-on to SSRIs/SNRIs in first few
weeks until onset of efficacy of antidepressant
• TCAs– Imipramine effective, but potentially
lethal in overdose and tolerability less than first-line
World Federation of Societies of Biological Psychiatry Bandelow B, et al. The World Journal of Biological Psychiatry. 2008; 9(4): 248-312
Sec
on
d l
ine
![Page 57: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/57.jpg)
![Page 58: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/58.jpg)
![Page 59: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/59.jpg)
![Page 60: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/60.jpg)
![Page 61: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/61.jpg)
![Page 62: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/62.jpg)
![Page 63: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/63.jpg)
![Page 64: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/64.jpg)
![Page 65: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/65.jpg)
![Page 66: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/66.jpg)
![Page 67: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/67.jpg)
QOF
Bibliotherapy Preferred reading list
CBT Local “primary care counselling service” CBT online
www.livinglifetothefull.com
![Page 68: Parmentier 02](https://reader036.vdocument.in/reader036/viewer/2022062617/54bee2084a79598e4b8b4585/html5/thumbnails/68.jpg)
68
Finding GAD in the Symptom “SOUP”
Stress
Insomnia
Irritable
Nervy
Jumpy
Weight Angry
Wake up
Feel Bad
Sad
Crying
SadAppetite Antisocial
Frightened
WorriedGuilty Fatigue
No energySuicidal
Heart Race
Forget
Can’t think
Shy
Loner
Panicky
Useless
Worthless
Depressed
Anxious
HeadachesTense
GI pain
BuzzyFlat
Pain
Breathless
Dizzy
Off sex
Restless
Edgy
Sweaty
Shaky
Cramps
IBS
Need a drink
Always Most of the time Sometimes Most of my life Since I lost my job
Etc…..Hot flashes
Worry