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SUPPORTING INFORMATION
Solution-Phase Synthesis of Pyrrole-Imidazole Polyamides
David M. Chenoweth, Daniel A. Harki, and Peter B. Dervan* Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125
Table of Contents for Supporting NMR Spectra
Compound Page 1H NMR of HCl•H2N-Py-CO2Me (10) S2 13C NMR of HCl•H2N-Py-CO2Me (10) S3 1H NMR of BocHN-PyPy-CO2Me (11) S4 13C NMR of BocHN-PyPy-CO2Me (11) S5 1H NMR of HCl•H2N-PyPy-CO2Me (12) S6 13C NMR of HCl•H2N-PyPy-CO2Me (12) S7 1H NMR of BocHN-PyPyPy-CO2Me (13) S8 13C NMR of BocHN-PyPyPy-CO2Me (13) S9 1H NMR of HCl•H2N-PyPyPy-CO2Me (4) S10 13C NMR of HCl•H2N-PyPyPy-CO2Me (4) S11 1H NMR of ImPyPyPy-CO2Me (14) S12 13C NMR of ImPyPyPy-CO2Me (14) S13 1H NMR of ImPyPyPy-CO2H (3) S14 13C NMR of ImPyPyPy-CO2H (3) S15 1H NMR of BocHN-(R) -CbzHN -Im-CO2Et (15) S16 13C NMR of BocHN-(R) -CbzHN -Im-CO2Et (15) S17 1H NMR of HCl•H2N-(R) -CbzHN -Im-CO2Et (5) S18 13C NMR of HCl•H2N-(R) -CbzHN -Im-CO2Et (5) S19 1H NMR of ImPyPyPy-(R) -CbzHN -Im-CO2Et (16) S20 13C NMR of ImPyPyPy-(R) -CbzHN -Im-CO2Et (16) S21 1H NMR of ImPyPyPy-(R) -CbzHN -Im-CO2H (17) S22 13C NMR of ImPyPyPy-(R) -CbzHN -Im-CO2H (17) S23 1H NMR of ImPyPyPy-(R) -CbzHN -ImPyPyPy-CO2Me (2) S24 13C NMR of ImPyPyPy-(R) -CbzHN -ImPyPyPy-CO2Me (2) S25 1H NMR of ImPyPyPy-(R) -CbzHN -ImPyPyPy-CO2H (22) S26 13C NMR of ImPyPyPy-(R) -CbzHN -ImPyPyPy-CO2H (22) S27 1H NMR of BocHN-(+)-BnOIPA (20) S28 13C NMR of BocHN-(+)-BnOIPA (20) S29 1H NMR of ImPyPyPy-(R) -CbzHN -ImPyPyPy-(+)-BnOIPA (23) S30 13C NMR of ImPyPyPy-(R) -CbzHN -ImPyPyPy-(+)-BnOIPA (23) S31 1H NMR of ImPyPyPy-(R) -H2N -ImPyPyPy-(+)-IPA (1) S32 13C NMR of ImPyPyPy-(R) -H2N -ImPyPyPy-(+)-IPA (1) S33
S1
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NH2•HCl
NMeO2C
S2
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NH2•HCl
NMeO2C
S3
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NHBoc
NO
HN
NMeO2C
S4
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NHBoc
NO
HN
NMeO2C
S5
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NH2•HCl
NO
HN
NMeO2C
S6
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NH2•HCl
NO
HN
NMeO2C
S7
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NHBoc
NO
HN
NO
HN
NMeO2C
S8
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NHBoc
NO
HN
NO
HN
NMeO2C
S9
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NH2•HCl
NO
HN
NO
HN
NMeO2C
S10
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NH2•HCl
NO
HN
NO
HN
NMeO2C
S11
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MeO2C
N
NO
HN
NO
HN
NO
HN
N
S12
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MeO2C
N
NO
HN
NO
HN
NO
HN
N
S13
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HO2C
N
NO
HN
NO
HN
NO
HN
N
S14
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HO2C
N
NO
HN
NO
HN
NO
HN
N
S15
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N
NEtO2C
HN
O
NHBocNHCbz
S16
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N
NEtO2C
HN
O
NHBocNHCbz
S17
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N
NEtO2C
HN
O
NH2•HClNHCbz
S18
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N
NEtO2C
HN
O
NH2•HClNHCbz
S19
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N
NEtO2C
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
NHCbz
S20
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N
NEtO2C
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
NHCbz
S21
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N
NHO2C
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
NHCbz
S22
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N
NHO2C
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
NHCbz
S23
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N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
MeO2C
NHCbz
S24
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N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
MeO2C
NHCbz
S25
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N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
HO2C
NHCbz
S26
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N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
HO2C
NHCbz
S27
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BocHN N NH
O
OBn
O
S28
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BocHN N NH
O
OBn
O
S29
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N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
HN
O
NHCbz
N
HN
O
O OBn
S30
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dmso
N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
HN
O
NHCbz
N
HN
O
O OBn
S31
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N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
NH3
O
HNHN
HN
O
O O
CF3CO2H salt
S32
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N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
NH3
O
HNHN
HN
O
O O
CF3CO2H salt
S33