Download - Pedigrees
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PedigreesComplex Inheritance Patterns:Autosomal v. X-Linked
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Pedigree
• Family Tree• Genealogy• Inheritance Diagram
• Relates parents and offspring for numerous generations• Shows relationships between parents, children,
grandchildren…• Aunts, uncles; cousins; second-cousins; distant relatives
• Are useful in tracking complex inheritance traits, genetic disorders, and sex-linked traits
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How to make a pedigree
• Female: Circle• Male: Square• Line between: Parental relationship• Line down: Parent to children• Line over and connecting: Siblings• Chronological order: Left to Right• Left (oldest) to right (youngest)
• Dashed Line: Same person• Shading: Carries/has specific trait
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My Pedigree: Eye Color
Tibbot Csik(bb)
Dottie Csik(Bb)
Jerry Vessey(bg)
Diane Vessey(gg)
Cindy Csik(bb)
Phil Csik(Bb)
Terry Csik(Bb)
Paul Csik(Bb)
Steven Csik(bb)
Genell Csik(gg)
Corinne Popke(bg)
Kirstin Csik(Bg)
Nick Csik(Bg)
Phil Csik(Bb)
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Let’s Practice!
• Please get out Investigation 18: Punnett Square Practice• We already did Parts A, B and C last week
• SKIP the Analysis Questions
• Do Part D now
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Using PedigreesSolving problems for Sex-linked traits, genetic disorders and unknown inheritance
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Sex-linked traits
• A “sex-linked” trait is carried on one of the sex chromosomes
• X-linked traits are far more common in men than women
• Tracking sex-linked traits, particularly when determining if women are carriers, requires use of Pedigrees
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Autosomal v. X-Linked
• Autosomes• 22 homologous chromosome pairs• Autosomal traits occur on one or more of
your AUTOSOMES• Sex Chromosomes• Sex-linked traits occur on a X or Y• Female: XX•Male: XY
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Autosomal Inheritance: Albinism
• Albino: Latin root meaning “white”• Lack of pigment: no colors
• Autosomal, Recessive trait
AA=NormalAa=Carrieraa=Albino
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X-Linked Inheritance: Ocular Albinism
• Ocular: Latin root meaning “Eye”• Lack of pigment in eyes only
• X-Linked, Recessive traitXX=NormalXx=Carrierxx=Ocular Albino
XY=NormalxY=Ocular Albino
http://www.scientificamerican.com/article.cfm?id=cosmetics-animal-testing
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http://ocw.tufts.edu/Content/51/lecturenotes/551169/551383
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Hemophilia
• Genetic bleeding disorder: No clotting factor• IF you have hemophilia:• No clotting proteins to work with platelets
• Recessive• Rare disease
• X-Linked• More common in males• VERY rare in females
http://www.zimbio.com/Hemophilia/articles/Tds3gpcOOph/Hemophilia+Disease
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The Romanova Mystery
• We will be taking on roles today to help solve the mystery of the Russian Royal family, and the would-be heir: Alexei Romanova
• We will construct a pedigree of the Victorian-era royal family to help us investigate the mysterious deaths of royals