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Platelet Platelet DisordersDisorders
Dr.Leni Lismayanti, SpPK
Dept of Clinical Pathology
RSHS/FKUP Bandung
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Reference book:
- Denise M Harmening. Clinical Hematology and Fundamental of Hemostasis. 5th edition. Philadelphia: FA Davis Co, 2009.
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Introduction• Primary hemostasis platelet + vessel
• Disorders of primary hemostasis inability to perform platelet plug.
• Defect: quantitative & qualitative
• Inherited, congenital, acquired
• Clinical manifestation
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4
Hemostasis Primer (Sumbat trombosit)
Hemostasis Sekunder (Sumbat hemostasis)
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Clinical Manifestation of Primary Hemostasis Disorders:Ecchymosis:
• Petechiae
• Purpura
Mucosal Bleeding:• Epistaxis
• Gingival bleeding
• Gastrointestinal bleeding
• Menorrhagia
• Hematuria
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Laboratory Tests to Assess Disorders of Primary Hemostasis
• Platelet count• Peripheral blood
smear• Ivy bleeding time or
PFA-100• von Willebrand
study• Platelet antibody
testing
• Flowcytometry• Platelet aggregation
study• BM aspiration &
biopsy
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Any Questions?Any Questions?
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Platelet Disorders:
1. Number:
Decreased (Thrombocytopenia)
Increased (Thrombocytosis/
Thrombocythemia)
2. Function:
• Adhesion
• Release reaction
• Aggregation
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Thrombocytopenia
Etiology:
1. Deficient platelet production
2. Abnormal platelet distribution
3. Increased platelet destruction
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Deficient Platelet Production
1. Myelophthisic (marrow infiltratif processes)
2. Aplasia
3. Ineffective erythropoiesis
4. Congenital Disoders
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Abnormal Platelet Distribution
1. Hypersplenism (splenomegaly)
2. Hemangioma (Kasabach-Merrit syndrome)
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Increased Platelet Destruction
1. Immune (primary) (ITP)
2. Immune (secondary) (SLE, Infection)
3. Microangiopathic thrombocytopenia (TTP, HUS, DIC)
4. Pregnancy-associated thrombocytopenia (HELLP syndrome)
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Qualitative Platelet Disorders
1. Congenital:
• Platelet Membrane Defects
• Platelet Release (secretion) Defects
• Platelet Coagulant Defects
• Von Willebrand Disease
2. Acquired
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Acquired Qualitative Platelet Disorders
1. Renal disease (Uremia)
2. Liver disease
3. Paraproteinemia
4. Myeloproliferative diorders
5. Acquired von Willebrand disease
6. Cardiopulmonary bypass
7. Acquired storage pool deficiencies
8. Drug therapy
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Vascular Disorders (purpura)
Results from another disease process and is just one of the manifestations of the disease process.
1. Primary purpura (Senile Purpura)
2. Secondary Purpura (Allergic)
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Thank You Thank You for Your for Your AttentionAttention