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#NACFC
Preston W. Campbell, III, MD President and Chief Executive Officer
Cystic Fibrosis Foundation
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#NACFC
Presenter DisclosurePreston W. Campbell, III, MD
The following relationship(s) exist(s) related to this presentation
To advance drug development and a search for a cure, the CF Foundation has contractual agreements with several companies to receive royalties related to drugs that are developed as a result of CFF funding. Any royalties we receive are used in support of our mission. More information about our model is available at cff.org/industry.
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#NACFC
Cam C. McLoudChair, Board of Trustees
Cystic Fibrosis Foundation
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#NACFC
Preston W. Campbell, III, MD President and Chief Executive Officer
Cystic Fibrosis Foundation
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#NACFC
Chris Penland, PhD Vice President of BioPharma Programs
Cystic Fibrosis Foundation
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NACFC 2018 PROGRAM PLANNING COMMITTEECo-chairs: Heather Hathorne, PhD, MAE, RRT, CCRC and Ronald C. Rubenstein, MD, PhD
Margarida D. Amaral, PhD Debbie Benitez, RN, MSN,
ACNP
Scott M. Blackman, MD, PhD
Jennifer Bomberger, PhD
André M. Cantín, MD
James F. Chmiel, MD, MPH
J.P. Clancy, MD
Cori L. Daines, MD
Brian R. Davis, PhD
Mitchell L. Drumm, PhD
Christina Duncan, PhD
Jordan M. Dunitz, MD
Kristin M. Dunn
Marie Egan, MD
Robert E. Fowler, MA,
CCRC
Antoinette Gardner, BSN,
MEd, AEC, CCRC
John W. Hanrahan, PhD
Heather Hathorne, PhD,
MAE, RRT, CCRC
Manu Jain, MD, MSc
Katie Larson-Ode, MD
Amanda R. Leonard, MPH,
RD, CDE
John J. LiPuma, MD
Marcus Mall, MD
Paul McCray, Jr., MD
A.P. Naren, PhD
Kecia L. Nelson, MSW,
LCSW
Matthew Nippins, PT,
DPT, CCS
Raymond J. Pickles, PhD
Felix Ratjen, MD, PhD,
FRCPC
Clement L. Ren, MD
Kathleen Richards, RRT
Steven M. Rowe, MD,
MSPH
Ronald C. Rubenstein, MD,
PhD
Kathryn A. Sabadosa, MPH
Lisa Saiman, MD, MPH
Gregory Sawicki, MD
Sarah Jane Schwarzenberg, MD
Richard H. Simon, MD
Beth Smith, MD
Eric J. Sorscher, MD
Anne Stephenson, MD, PhD
David A. Stoltz, MD, PhD
Patrick Thibodeau, PhD
Philip Thomas, PhD
Valerie J. Waters, MD, MSc
Jeffrey J. Wine, PhD
Marlyn S. Woo, MD
David C. Young, PharmD
Edith T. Zemanick, MD
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NACFC 2018 Program Planning Committee Conference Co-Chairs
Ronald C. Rubenstein, MD, PhD Professor of Pediatrics
Perelman School of Medicine at the University of PennsylvaniaRichard B. Johnston, Jr. Endowed Chair in Pediatrics
Director, Cystic Fibrosis CenterThe Children’s Hospital of Philadelphia
Heather Hathorne, PhD, RRTManager, Cystic Fibrosis Clinical Research Unit
University of Alabama at Birmingham
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NACFC 2018 EXHIBITORS AND SUPPORTERSAbbVieAccredoAlcresta TherapeuticsAllerganAzurRx BiopharmaceuticalsBriovaRxCallionCeltaxsys, Inc.Chiesi USA, Inc.Corbus PharmaceuticalsCVS SpecialtyCystic Fibrosis & Freedom PharmaciesDKBMedDymedso, Inc.Electromed, Inc.ELITechGroupEloxx PharmaceuticalsFairview Specialty Pharmacy
Folia HealthFoundation CareFunctional FormulariesGenentechGileadGlycosBio Food Sciences, Inc.HealthWell FoundationHill-RomHorizon PharmaInfocare Healthcare Services (USA) LLCInternational Biophysics CorporationKate FarmsKroger Specialty PharmacyMaxor Specialty/IV Solutions/Pharmaceutical SpecialtiesMonaghan Medical
MVW NutritionalsNational Jewish HealthNationwide Children's Hospitalndd Medical TechnologiesNovabiosisPARI Respiratory Equipment, Inc.Physiologic Instruments, Inc.Proteostasis Therapeutics, Inc.PulmoTraceRespirTechRho, Inc.STEMCELL TechnologiesUniversity of Florida HealthVertex PharmaceuticalsVitalographVIVUS, Inc.WalgreensWestmedWiley
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#NACFC
William R. Skach, MD Senior Vice President of Research Affairs
Cystic Fibrosis Foundation
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#NACFC#NACFC
Improving outcomes of infections in the age of CFTR modulators
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#NACFC
Presenter DisclosureWilliam R. Skach, MD
• Dr. Skach has no relationships to disclose but is an employee of the CF Foundation and participates in programmatic funding decisions.
• To advance drug development and a search for a cure, the CF Foundation has contractual agreements with several companies to receive royalties related to drugs that are developed as a result of CFF funding. Any royalties we receive are used in support of our mission. More information about our model is available at cff.org/industry.
• Special thanks to Genevieve Maul, Jenna Vince, and Stephanie McDermott.
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CF advances through the ages
1955 1989 2012
Early Days
Care and Discovery
CFTR Gene
CFTR Modulators Cure
Ivacaftor (2012)Luma/Iva (2015)Tez/Iva (2018)
<5 yrs ~30 yrs ~40 yrsMedian Survival 60, 70, 80 yrs
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Triple combination therapy is highly effective in people with a single copy of ∆F508
VX-659 + Tez/Iva with one ∆F508 (n=63)
• 13% absolute improvement in FEV1
• 51 mmol/L drop in sweat chloride
• Improved quality of life (+19.8 CFQ-R)
VX-445 + Tez/Iva achieved similar results
February 2018 Phase II results:
ppFEV1 Sweat chlorideAbsolute change from baseline in F/MF
Placebo VX-659 80 mg QD + TEZ/IVAVX-659 240 mg QD + TEZ/IVA VX-659 400 mg QD + TEZ/IVA
Data provided courtesy of Vertex Pharmaceuticals See Posters #213, #216
ppFE
V1LS
Mea
n (+
/-SE
)
Swea
t Chl
orid
eLS
Mea
n (+
/-SE
) (m
mol
/L)
ppFEV1 p-values*: +13.3 p<0.001, +12.0 p<0.001, +10.2 p<0.001, +0.4 p=0.90*p-values are within group p-values based on a mixed effects model† Absolute change through day 29. Values expressed as “Through Day 29” are the average of Day 15 and Day 29 measures
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Vertex triple combinations move into phase III trials
Genotype Study(s) Status
AURORA & ECLIPSE:
Data Availability: VX-659 in late 2018, VX-445 in Q1 2019Submission Plan: no later than mid-2019
Provided courtesy of Vertex Pharmaceuticals
VX-659 + Tez/IvaVX-445 + Tez/Iva
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Additional triple combinations are also advancing
Proteostasis Therapeutics:Amplifier + Potentiator + CorrectorPTI-428 PTI-808 PTI-801
Multiple trials ongoing in ∆F/∆F• Dual Combination (801/808)• Triple Combination (428/801/808)
Data provided courtesy of PTI Therapeutics
Ussing Chamber activity in primary ∆F508/∆F508 lung cells
See Posters #38, #54, #261, #816
0
3 0
6 0
9 0
1 2 0
% N
orm
al
CF
TR
Ac
tiv
ity
TEZIVA
107%
69%56%
29%
PTI-801PTI-808
TEZIVAOLA
PTI-801PTI-808PTI-428
Doublets Triplets
% n
orm
al C
FTR
act
ivity
0
60
30
90
120
Galapagos: Potentiator + Corrector + CorrectorGLPG2451 GLPG2222 GLPG2737
FALCON trial now registered for subjects with 1 or 2 ∆F mutations (Europe) See Posters #14, #42, #186, #269, #271
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20
30
40
50
60
70
80
90
100
6 16 26 36 46 56 66 76 86
G551D With Ivacaftor
F508del/F508del
Age in Years
Lung Transplant
See: Sawicki et al. AJRCCM 2015Konstan et al. Lancet Resp Med 2017
∆F/∆F with Luma/Iva
Effect of CFTR modulators on lung function decline
0
?Effective Modulator
FEV1
%
Pred
icte
d
No Modulator
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End of 2016 ~5 year vision ~10 year vision ~20 year vision
Healthy
Some decline in lung function
Advanced disease/lung transplant
57%61%
68% Adults
Continued need
52% Adults
Note: Healthy = FEV1 >90%, Moderate =FEV1 40-90%, and Advanced disease =FEV1 <40%Source: Revised Model for July 2018 CFF Medical Strategy Retreat
Effect of CFTR modulators on population health
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Future challenges
• Not everyone will respond to modulators• Some people have existing lung disease • Infections may not be eradicated• Lung function may still decline
• Preventing CF complications to maintain health remains a top priority– Respiratory infections are the greatest concern– Inflammation remains a major cause of lung damage
5%
90%+(Highly Effective
Therapy)1+ copy of ∆F and
Gating
2%
No ProteinRare Unresponsive
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• CFF is committing $100M over the next 5 years
• To improve detection, diagnosis, treatment, and outcomes of infections for people with CF
Introducing theINFECTION RESEARCH INITIATIVE
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#NACFC#NACFC
Improving outcomes of infections in the age of CFTR modulators
Lisa Saiman, MD MPH
Professor of Pediatrics, Department of Pediatrics, Columbia University Irving Medical Center, New York, NYHospital Epidemiologist, Department of Infection Prevention and Control, NewYork-Presbyterian Hospital, New York, NY
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#NACFC
Presenter DisclosureLisa Saiman, MD, MPH
The following relationships exist related to this presentation:
• CF Foundation, Grant funding• CF Foundation, Data Safety Monitoring Board• Teva Pharmaceuticals, Advisory Board• Gilead, Advisory Board• ABComm, Inc., Honorarium
Today, I have the privilege and responsibility of presenting the research and insights of countless individuals from the CF community.
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Objectives for Today’s Plenary• Identify ongoing challenges in the treatment of
infections in people with CF and discuss the potential impact of CFTR modulators on infections
• Update you on the results of ongoing work to improve our understanding of CF microorganisms including detection, diagnosis, and optimal treatment
• Discuss current strategies that will result in the new anti-infective therapies of tomorrow
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Objectives for Today’s Plenary• Identify ongoing challenges in the treatment of
infections in people with CF and discuss the potential impact of CFTR modulators on infections
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#NACFC
DATA
Care Centers CF Foundation Registry Report
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CF Microbial Burden and Treatment Challenges
0
20
40
60
91 93 95 97 99 01 03 05 07 09 11 13 15 17
Perc
enta
ge o
f Ind
ivid
uals
with
CF
Year
MSSA
P. aeruginosa
MRSA
H. influenzae
S. maltophilia
NTM
MDR-PA
Achromobacter
B. cepacia complex
Prevalence of Respiratory Microorganisms, 1991–2017
B. cepacia complex
’91 ’93 ’95 ’97 ’99 ’01 ’03 ’05 ’07 ’09 ’11 ’13 ’15 ’17
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Nontuberculous mycobacteria (NTM) is increasing.
0
2
4
6
8
10
12
14
16
18
91 93 95 97 99 01 03 05 07 09 11 13 15 17
Perc
enta
ge o
f Ind
ivid
uals
with
CF
Year
H. influenzae
S. maltophilia
NTM
MDR-PA
Achromobacter
B. cepacia complex
Prevalence of Respiratory Microorganisms, 1991–2017
’91 ’93 ’95 ’97 ’99 ’01 ’03 ’05 ’07 ’09 ’11 ’13 ’15 ’17
B. cepacia complex
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Different microorganisms are problematic in different age groups.
0
10
20
30
40
50
60
70
<2 2 to 5 6 to 10 11 to 17 18 to 24 25 to 34 35 to 44 ≥45
Perc
enta
ge o
f Ind
ivid
uals
with
CF
Age (Years)
P. aeruginosa H. influenzae B. cepacia complex MRSA
MSSA Achromobacter S. maltophilia MDR-PA
Prevalence of Respiratory Microorganisms by Age Cohort, 2017
B. cepacia complex
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M. abscessus as common as M. aviumthrough young adulthood
0
1
2
3
4
5
6
7
8
9
10
<2 2 to 5 6 to 10 11 to 17 18 to 24 25 to 34 35 to 44 ≥45Perc
enta
ge o
f Ind
ivid
uals
with
CF
Age (Years)
M. Abscessus M. Avium M. fortuitum M. gordonae
M. kansasii M. marinum M. terrae Other Mycobacteria
Prevalence of Non-tuberculous Mycobacteria by Age Cohort, 2017
M. abscessus M. avium
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What questions are emerging for treating infections in the era of CFTR modulators?• What will happen to microbiology
among individuals with: – established lung disease already infected– less severe lung disease and positive
cultures – without documented infections
• Some individuals may not tolerate or respond to existing modulators.
• Some may not have effective modulators available.
• All need monitoring of microbiology to guide treatment.
• We still need antimicrobials!!!
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#NACFC
What have we learned so far about the impact of CFTR modulators on CF microbiology?
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Rowe SM et al. Am J Respir Crit Care Med. 2014 ;190(2):175-84
p < 0.001
IvacaftorstartedP.
aer
ugin
osa
dete
cted
Restoring CFTR function associated with decreased P. aeruginosa
• Participants >6 years old
• G551D mutation• Decreased
P. aeruginosa– 6 months– 12 months
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Restoring CFTR function associated with other microbiology changes
• Decreased P. aeruginosa, mucoid P. aeruginosa, and Aspergillus
• Decreased frequency of isolation of P. aeruginosa
Heltshe SL, et al Clin Infect Dis 2015; 60(5):703–12
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#NACFC
Restoring CFTR function associated with decreased density of P. aeruginosa -> rebounded within 2 years
• Adult participants • G551D• 8/12 chronic P. aeruginosa • Initially density decreased• Rebounded within 2 years
Hisert KB et al. Am J Resp Crit Care Med 2017;195:1617-28.
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#NACFC
Video 1: Chronic Infection
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79%
45%
57%
44%
42%
29%
44%
39%
29%
25%
34%
30%
78%
56%
53%
28%
18%
29%
6%
18%
6%
12%
6%
0%
Respiratory microorganism detection and treatment
Mental health
Reducing treatment burden
Gastrointestinal symptoms
CF-related diabetes
Lung transplantation
CF-related liver disease
Diet and nutrition
Sinus disease
Pain management
Exercise
Alternative/Holistic treatments and therapies
Community members(n=39-107)
Clinicians(n=18)
Prioritization Survey of Research
Topics
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InfectionResearchInitiative
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Objectives for Today’s Plenary
• Update you on the results of ongoing work to improve our understanding of CF microorganisms including detection, diagnosis, and optimal treatment
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#NACFC
A decade ago…
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Inflammation and Infection: Update on the CF Pipeline
NACFC 2009
Michael W. Konstan, MD and James Chmiel, MD MPHCase Western Reserve University
Rainbow Babies and Children’s Hospital
Lisa Saiman, MD MPHColumbia University
NewYork-Presbyterian Hospital
NACFC 2009; Plenary Session II
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Persistently Pa +cultures
Chronic infection
Mucoid P. aeruginosa
Birth1st Pa + culture
Pa negative culture
Intermittent infection
2nd Pa + culture
Eradication
PulmonaryExacerbations
Chronic Suppressive Therapy
Natural History of Acquisition of Pseudomonas aeruginosa
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CF lung is a complex microbial ecology
• Unique growth conditions, available nutrition, metabolism – Can affect activity of antibiotics– Can affect mode of growth
o Biofilmso S. aureus small colony variants
• Microorganisms interact, and microbial community may be ‘pathogenic unit’
• These interactions may impact progression of CF, response to therapy, and clinical outcomes
Wolter DJ et al. Clin Infect Dis. 2013;;57(3):384-91.
UnderstandingCF
Microorganisms
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Microbial and host interactions that could impact CF progression P. aeruginosa biofilm enhanced by RSV co-infectionWhat is the proposed mechanism? • Dysregulation of host nutritional immunity• Normally, host sequesters iron• RSV infection: induces release of iron-
bound transferrin by airway epithelial cells mediated by interferon (IFN)
• More iron -> increased biofilm growthW26.2: Abstract 326Hendricks MR et al. Prot Nat Acad Sci 2016;113:1642-7
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#NACFC
Improving Detection and Diagnosis
• Conventional microbiology identifies single organisms• New molecular, rapid diagnostic methodologies could:
– Identify microorganisms directly from specimens – Improve eradication by earlier identification of lower airway
infections – More rapid turnaround time for management of exacerbations– Could decrease the treatment burden
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New methodologies have revealed potentially more complex polymicrobial community
• Must sort out role of community members
• Correlate structure(microbiome) and activity(metabolome/ transcriptome/ proteome) and clinical course
• Use translational science to study altering these parameters to improve outcomes
Huang YJ, et al. Clin Chest Med. 2016; 37:59–67
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Improving detection of microorganisms in non-sputum producers
2-D gas chromatography time-of-flight mass spectroscopy
• Can detect volatile metabolites • Biomarkers to identify CF microorganisms
Al-Saleh S et al. J Pediatr 2010;157:1006-11. Nasir M et al. Science Rep 2018;8:82 .
Induced sputum
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#NACFC
Imagine with me: Precision Medicine for CF Infections
• Abandoning conventional microbiology in favor of rapid molecular detection using point of care devices
• Integrating information about polymicrobial community to guide therapy
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#NACFC
A decade ago…
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Early Eradication Clinical Trials
• ELITE – EarLy Intervention TOBI Eradication
• EPIC – Eradication of PseduomonasInfection Control
For more information:Plenary III – Early Airway Infection in Young Children with CF –What is the Optimal Therapy?
Konstan and SaimanNACFC 2009; Plenary Session II
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Optimizing Current Treatments: The OPTIMIZE Trial• Reduce exacerbations in
children undergoing eradication of P. aeruginosa
• Add azithromycin to inhaled tobramycin
• Azithromycin group– 44% reduction in exacerbations– 1.27 kg weight gain– No impact on microbiology Mayer-Hamblett N et al. Am J Resp Crit Care Med June 11 2018
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Heltshe SL, et al. Contem Clin Trials. 2018;64:35-40.
STOP 2 Underway: Compares Antibiotic Treatment Duration for Exacerbations
Safety and effectiveness of different treatment durations based on response to therapy• Regimen 1 & 2: early robust
responders (ERR)* treat 10 vs. 14 days
• Regimen 3 & 4: non-early robust responders (NERR) treat 14 days vs. 21 days
* FEV1 5-10% and CRISS improved >11 units
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STOP 2 Current Enrollment: 10/1/18
880 Sample Size:570 NERR310 ERR
NCT02781610
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Improving the Management of NTM
• Clinical observations– NTM can be transient– Remain indolent– Accelerate progression of
lung disease• International effort to write
and disseminate diagnostic and treatment consensus guidelines
Nick JA, et al. Current Opinion Pulm Med. 2016:22:629-636
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• Prospective, observational study at Pediatric and Adult Colorado CF Care Center
• Use algorithm in consensus guideline to diagnose NTM disease
• Address NTM cultures, radiology, disease course, other microorganisms, and comorbidities
Prospective Evaluation of NTM Disease in Cystic Fibrosis (PREDICT Study)
NCT02073409
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PREDICT Preliminary Conclusions
• 42% of PREDICT subjects met criteria for NTM disease after median of 5 months
• Participants diagnosed with NTM disease had:– Significantly lower FEV1 at enrollment – Significant and rapid decline in FEV1
– More frequent constitutional symptoms, severe exacerbations, and acute decline in BMI
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• Open-label, treatment study at Colorado Pediatric and Adult CF Care Center
• Use single NTM treatment algorithm from consensus guideline • Algorithm guides selection of therapy, obtaining NTM cultures,
monitoring, and managing toxicity and intolerance Inclusion: • Age > 7 years • MAC or M. abscessus• Judgment of CF physician that person with CF may benefit • Person with CF and/or parent agrees with proposed treatment
Prospective Algorithm for Treatment of NTM in Cystic Fibrosis (PATIENCE)
NCT02419989
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PATIENCE Preliminary Conclusions
Improved culture conversion rates (compared to historic rates) may in part be due to optimizing CF care first (PREDICT).
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Seattle
UTSWUAB
UNC
University of Michigan
Colorado
ColumbiaUniversity
Johns HopkinsUniversity
• Increase enrollment, improve “power” to support findings
• Test and refine protocols • Greater geographic
diversity and distribution• Benefits more individuals
with CF
Expanding PREDICT and PATIENCE to Other CF Centers
• Test feasibility and build “infrastructure” for future studies
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IMAGINE with me…
These studies provide framework for future investigations.
– Standardize approach to diagnosing different disease-causing microorganisms
– Serve as comparator arm for investigating new treatment approaches
– Support biomarker discovery
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Evaluating Long-Term Antimicrobial Use
• Important to revisit long term impact of drugs we use chronically
• Inadvertent drug interactions, intolerance, toxicity• Only target single microorganisms, but may impact
other microorganisms • Could improve care through improving personalized
medicine
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Is there antagonism between azithromycin and tobramycin?Secondary analysis of clinical trial• Participants on tobramycin +
azithromycin had less improvement in lung function than those on inhaled aztreonam + azithromycin
Biologic plausibility for antagonism• Azithromycin upregulated MexXY
efflux pumpNeed for clinical trial Nichols DP et al. J Cyst Fibros. 2017 May;16(3):358-366.
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Testing the Effect of Adding CHronic Azithromycin to Inhaled Tobramycin: TEACH Enrollment: 10/1/18
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Objectives for Today’s Plenary
• Discuss current strategies that will result in the new anti-infective therapies of tomorrow
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Video 2: Clinical Trial Experience
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A decade ago…
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TOBI (TSI)
AZLI
KB001
TIP (TOBRAMYCIN INHALED POWDER)
ARIKACE
BAY Q3939
PRE-CLINICAL PHASE 1 PHASE 2 PHASE 3 TO PATIENTS
AZITHROMYCIN
MP-376
GS 9310/11
Cystic Fibrosis Foundation Anti-Infective Therapeutics Pipeline, 2009
CAYSTON
QUINSAIR (Europe)
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Funded ID Therapeutic Portfolio
Discovery Preclinical Phase 1 Phase 2 Phase 3
Gallium CitrateAridis
AerovancSavara
Encochleated Amikacin Matinas
QRM-003Qrumpharma
Nitric Oxide (inhaled)Novoteris
Bismuth-thiolsMicrobion
Lactoferrin + OSCNAlaxia
SPI-3005 ebselenSound Pharma
Itraconazole inhalationPulmatrix
Pseudomonas
MRSA
NTM
Other (multi-pathogen)
FungalOtotoxicity
Key:
Last Updated: 3 Oct 2018
In discussions with an additional 17 companies on
potential therapeutics.
Diagnostic toolViTi
Intravenous GalliumCFF
SNSP113Synspira
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What are some approaches to developing new therapies?• Borrow agents from other infectious diseases
– MDR-TB agent Bedaquiline for NTM • Alter existing agents to become inhaled agents
– Inhaled itraconazole for ABPA – Inhaled vancomycin for MRSA
• Repurpose drugs used for non-infectious conditions with unique mechanisms of action – Gallium for Pseudomonas and others– Ca-EDTA for several pathogens– Inhaled NO for Pseudomonas and NTM – GM-CSF for NTM
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Mechanism of Action for Gallium• Bacteria use iron for DNA synthesis,
oxidative stress response, other metabolic functions
• Gallium and iron are same size (ionic radius)
• Fool bacteria to use Gallium instead of iron
• Proof-of-concept Phase 1b Study– 20 adults with CF and chronic Pseudomonas– Improved lung function that persisted
• W17.6: Abstract 307Goss et al., Sci. Transl. Med. Sept 28 2018
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What are future questions for treating infections with increasing access to CFTR modulators?• If CFTR modulators are used prior
to infection:– Will people remain infection-free?– Will infections occur later? – Will emerging pathogens become
problematic?• Our current treatment paradigms
may change. • Our research and clinical
approaches to infections will evolve.
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A prospective study to evaluatebiological and clinical effects of significantly
corrected CFTR function
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Study Design, Objectives, Population • 2 year prospective observational study of short- and long-term
clinical effectiveness of next generation modulators• Objectives:
• Impact on lung function, sweat Cl-, symptoms, BMI• Focused sub-studies, e.g., microbiology, inflammation, gastrointestinal
issues • Biobank for future studies
• 400 people with CF• >12 years of age• F508del heterozygote/minimal function allele (~60%)• F508del homozygous (~40%)• Stable health• Willing to maintain current therapies for > 6 months
Study Design, Objectives, Population
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• Highly motivated partners: individuals with CF, families, and care centers
• Research Tools• Collaborations• Funding resources • Industry partnerships• Infrastructure to conduct studies• Biobanks• New ideas
Amazing Tool Box Available
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It Takes a VillagePatrick FlumeNicole HamblettLuke HoffmanJohn LiPumaDave NicholsJerry NickLynne QuittellPradeep SinghValerie Waters
Team at CF Foundation:Aliza Fink, Genevieve Maul, Stephanie McDermott, Susan Schept, Jenna Vince
OPTIMIZE Study TeamSTOP Trial Study TeamTEACH Trial Study TeamPATIENCE Study TeamPREDICT Study TeamPROMISE Trial Study TeamDublin Study GroupSCVSA Study Group
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Symposia• S12 – Microbial Adaption in the CF Airway• S21 – Controversies in Airway InfectionWorkshops• W11 – Airway Innate Defense Defects in CF• W17 – Epidemiology & Management of Infections• W27 – Microbial Ecology of CF Airways
Infection-related posters
Infection-related Symposia, Workshops, and Posters
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Presented at the Cystic Fibrosis Foundation’s NACFC 2018