PRKD2

clv. PARP

b-actin

PARP

clv. caspase 9

U251

PU-H71

0 0.1 0.5 1.00 0.01 0.1 1.0

STA-9090

µM

PU-H71STA-9090

PRKD2

clv. PARP

b-actin

PARP

clv. caspase 9

µM0 0.1 0.5 1.00 0.01 0.1 1.0

SW480

PU-H710 0.1 0.5 1.00 0.01 0.1 1.0

STA-9090

Panc1

µM

PRKD2

clv. PARP

b-actin

PARP

clv. caspase 9

S.1

B

A shScr shHSP90a shHSP90b

A54

9Pa

Tu2

Scr

shHSP90

a

shHSP90

b

0

2

4

6

8

10

TU

NE

L -

po

siti

ve c

ells

(%

)

Scr

shHSP90

a

shHSP90

b

0

3

6

9

12

TU

NE

L -

po

siti

ve c

ells

(%

) p=0.0396

p=0.0241

p=0.0001

p=0.0041A549 PaTu2