Simpler and less invasive than biopsy; no donor genotyping required
Suitable for most renal allograft patients across ethnicities
More sensitive and speci�c for clinical and subclinical active rejection than serum creatinine2
Up to 5x more reduction in variability than that of a competitive dd-cfDNA assay1,3
Analytically & clinically validated to be:
266
9.2%
4.5%
NO
Prospera2 ExistingCommercial Assay3
Prospera : Transplant assessment testBroad, highly accurate assessment of active rejection
DIVERSE COHORT
KEY ADVANTAGES
107
0.74
Prospera1 ExistingCommercial Assay4
More SNPs targeted and analyzed2
Precision within run 5x better2
Coef�cient of Variation
Precision across runs 2.3x better2
Coef�cient of Variation
Only assay with evaluatedperformance in related and unrelated donors
T-cell mediated rejection IA/IB/IIBAntibody-mediated rejectionC4d-positive antibody-mediated rejectionAcute rejectionChronic active rejectionMixed rejection
••••••
•
•
•
•
Largest published renal transplant dd-cfDNA validation study1
Highest reported overall accuracy1
AUC
First, only test to identify subclinical rejection1
Sensitivity
Highest reported performance to assess T-cell mediated rejection1
Sensitivity
Broad distribution of rejection types2
Hispanic / Latino (n=50)Caucasian (n=74)African American (n=31)Asian (n=31)
Variety of ethnic and racial demographics2
CAP accredited, ISO 13485, and CLIA certi�ed. © 2019 Natera, Inc. All Rights Reserved.PRO_ESOT_BoothPoster_20190903_NAT-8019995
1 Sigdel, et al. J Clin Med. 2019;8(1):19.2 Altuğ, et al. Transplantation, 20193 Grskovic, et al. J Mol Diagn. 2016;18(6):890-902.4 Bloom RD, et al. J Am Soc Nephrol. 2017 Jul;28(7):2221-2232.
PERFORMANCE COMPARISON
Of 100 active rejection cases, the number of patients who would be missed, and told they are normal*
*Using a 1% dd-cfDNA threshold
NA
27%
™
ANALYTICAL VALIDATION CLINICAL VALIDATION
217
0.87
92%
100%
~ 13,000
1.85%
1.9%
YES
Prospera1 First-generationdd-cfDNA4
Sensitivity Sensitivity89% 59%
11/100 41/100
September 03, 2019 Size: 36”W x 24”H Artwork at 100% 1/4” bleed included all around Poster print on foam board TRIM
