![Page 1: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/1.jpg)
Psoriatic Arthritis
Preeti Tuladhar MD
![Page 2: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/2.jpg)
Psoriatic Arthritis
Seronegative spondyloarthropathy associated with psoriasis
HLA-B27 positive in 50%
![Page 3: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/3.jpg)
Seronegative Spondyloarthropathies
1. Ankylosing spondylitis
2. Psoriatic arthritis
3. Reiter’s syndrome
All 3 produce abnormalities at:
– Cartilaginous Joints and Enthesis
– Bursae and Tendon Sheaths (tenosynovitis and
periostitis)
– Synovial Joints
![Page 4: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/4.jpg)
Psoriatic Arthritis
Affects up to 1-2% US population
Reported in up to 20% of patients with psoriasis
Majority: skin manifestations precede joint involvement
Although in 15-20% joint involvement precedes skin involvement (2)
![Page 5: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/5.jpg)
Moll and Wright Original Diagnostic Criteria
The original criteria are the simplest and most frequently used
Criteria:
– An inflammatory Arthritis (peripheral arthritis and/or sacroiliitis or spondylitis)
– The presence of psoriasis
– The (usual) absence of rheumatoid factor
![Page 6: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/6.jpg)
5 Patterns (Moll and Wright)
Asymetric Oligoarticular type ( 4 or fewer joints) *most common
Polyarticular type (5 or more joints)
Predominant DIP involvement
Arthritis Mutilans
Psoriatic Spondylitis (2) Some have symmetric seronegative polyarthritis
simulating RA (vs Predominant DIP type, Polyarticular and DIP are grouped together
![Page 7: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/7.jpg)
Skin and Nail Involvement
Skin lesions of psoriasis: sharply marginated salmon pink papules and plaques with silver white scale (1)
Scalp, Genital and Nail involvement (pitting, oil spots, onycholysis(separation from nail bed)
Nail Pitting
onycholysis
![Page 8: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/8.jpg)
(Resnick 3)
Pathogenesis
![Page 9: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/9.jpg)
Radiologic Pathologic Correlation of Synovial Joint Abnormalities Soft tissue swelling and
widening joint space
Narrowing of joint space
Marginal erosion
Bone erosion and sunchondral cyst formation
Bony ankylosis
Marginal “whiskering”, periostitis and subchondral sclerosis
Cortical Atrophy, osteolysis
Synovial Inflammation and production of fluid
Pannus destruction of cartilage
Pannus destruction of unprotected bone and joint margin
Pannus destruction of subchondral bone
Fibroplasia, cartilaginous metaplasia, chondral and capsular ossification
Bony proliferation in response
to damage
Noninflam proliferation of
periosteum
![Page 10: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/10.jpg)
Radiographic Features
Productive changes with Erosions *distinguishes from RA
PsA erosions occur at “bare areas” vsErosive Osteoarthritis
– (subchondral cortex is primarily affected)
![Page 11: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/11.jpg)
Radiographic Features
Bone Production:
– Mouse ears- bone production adjacent to erosions
– Ivory Phalanx- sclerosis of distal phalanx
Erosions: aggressive
– Pencil in cup deformity
– Acroosteolyisis- resorption of terminal tufts
![Page 12: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/12.jpg)
Psoriatic Arthritis
Joint inflammation ranges from axial to peripheral
Synovial and adjacent soft tissue inflammation
Severe osteolysis
![Page 13: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/13.jpg)
Psoriatic Arthritis
Distinguishing radiographic feature of psoriasis enthesis related changes include:
– entheseal new bone formation
– enthesitis
– osteitis, periostitis
– entheseal erosions (4, Ann Rheum Dis 2005;64)
![Page 14: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/14.jpg)
Psoriatic Arthritis
Scintigraphy, arthroscopy, ultrasonography, and MRI indicate these features are more common than evident on clinical grounds (4, Ann
Rheum Dis 2005;64)
![Page 15: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/15.jpg)
Enthesitis: cardinal feature of
spondyloarthropathies
Enthesis: insertion of ligament, tendon or joint capsule to bone
Enthesitis: focal insertional inflammation
![Page 16: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/16.jpg)
Enthesitis: cardinal feature of
spondyloarthropathies
Unlike RA where disease centers on synovium, PsA also centers on the enthesis organ (includes adjacent tendons, periosteum and underlying bone at attachment sites)(4 Ann Rheum
Dis 2005)
![Page 17: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/17.jpg)
Male with PsA : Osteitis (asterisk)
SI joints behave like functional entheses, due to high shear and compressive stress
Similar MRI pattern to areas of insertion --> extensive bone disease independent of synovitis
Extracapsular inflammation (*)
Bone edema at distal capsular enthesis (arrow)
MCP head edema in region of synovium (arrow head)
![Page 18: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/18.jpg)
T1 pre and post gad in pt with PsA
Synovitis at 3rd and 4th PIP and DIP joints (large arrows).
Joint space narrowing with bone proliferation at the third PIP joint
Erosions at the fourth DIP joint (white circle).
Enthesitis (extracapsular enhancement : small arrows) medial to 3rd and 4th
PIP (8)
MRI Findings
![Page 19: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/19.jpg)
Hand Manifestations
Sausage digit
Pencil in cup deformity
Ivory phalanx
Acroosteolysis
Bony Ankylosis
Erosions (DIP) (often affected 1st)
Bone formation
![Page 20: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/20.jpg)
Sausage DigitTenosynovitis
and soft tissue swelling
![Page 21: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/21.jpg)
PsA With Flexor Tenosynovitis on MRI
T1 pre T1 post
Flexor tenosynovitis at 2nd digit with enhancement and thickening of the tendon sheath (large arrow)
Synovitis in 4th IP Joint (small arrow) (8)
![Page 22: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/22.jpg)
Arthritis Mutilans
Bony ankylosis IP joints
Pencil in cup
![Page 23: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/23.jpg)
Ivory Phalanx
Gentili.net
Bony Proliferation and endosteal bone formation as exaggerated healing response
Unique and specific to PsA, but uncommon finding
![Page 24: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/24.jpg)
“Whiskering” or Mouse Ears (Bony Proliferation)
(Resnick 3)
![Page 25: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/25.jpg)
“Whiskering” or Mouse Ears (Bony Proliferation)
Marginal Erosions: Pannus destruction of unprotected bone at joint margins Erosions and Subchondral cyst formation: Pannus destruction of subchondral boneNarrowing of joint space: Pannus destruction of cartilage
(TH)
![Page 26: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/26.jpg)
Shaft Periostitis
(TH)
![Page 27: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/27.jpg)
Progressive Erosion of DIP Joint
No erosionBare area erosion3 years later
Diffuse subchondal destruction
![Page 28: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/28.jpg)
Erosions
(TH)
![Page 29: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/29.jpg)
Psoriatic Arthritis Vs. Erosive Osteoarthritis
PsA typical “bare area” erosions
EOA Typical subchondral erosions “gull wings”
![Page 30: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/30.jpg)
Pencil Cup Osteolysis Gross Osteolysis
Osteolysis
![Page 31: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/31.jpg)
Acroosteolysis
Resorption of terminal tufts of distal phalanges
Noninflammatory proliferation of the periosteum
Arthritritis DIP, 3rd and 4 digits
![Page 32: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/32.jpg)
Hand Distribution
![Page 33: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/33.jpg)
Foot
Erosive changes and bone proliferation in feet usually involves the IP and MTP joints,
*IP joint of great toe most often affected
![Page 34: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/34.jpg)
Erosive Changes Great Toe IP Joint
![Page 35: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/35.jpg)
Calcaneus
New bone formation at attachment of achilles and plantar aponeurosis
Erosions superior margin of calcaneus
![Page 36: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/36.jpg)
Calcaneus
![Page 37: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/37.jpg)
Calcaneus
(a) (STIR) image:
Enthesitis at the Achilles tendon insertion ( thick arrow)
Bone marrow edema (short thin arrow)
Synovitis (long thin arrow)
(b,c) T1 weighted images pre and post gad :
Enthesitis (large arrow)
Bone erosion at tendon insertion (short thin arrows).(8)
![Page 38: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/38.jpg)
Pt with symmetrical polyarthritis type of Psoriasis with multiple sites of fusion, fibular deviation and pencil in cup deformity left fifth toe (4)
![Page 39: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/39.jpg)
Axial Skeleton
Sacroiliitis (up to 25% in 2 series, and in up to 78% in another series) (5)
Spondylitis
Frequent asymptomatic involvement of spine and SI joints in association with PsA
![Page 40: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/40.jpg)
Sacroiliitis
Bilateral Symmetric– Ankylosing Spondylitis– Enteropathic Arthropathy– Late RA
Bilateral Asymmetric– Psoriatic arthritis– Reiters– Juvenile RA
Unilateral– infection– OA from abnormal mechanical stress
![Page 41: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/41.jpg)
Sacroiliitis
T1 pre and post gad showing enhancement right SI joint indicating active sacroiliitis (8)
MRI findings: bone edema (common), SI erosions, more chronic: periarticular fat accumulation and sclerosis
![Page 42: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/42.jpg)
Spinal Involvement
Atlantoaxial subluxation and odontoid abnormalities
![Page 43: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/43.jpg)
Spinal Involvement
Bulky asymmetric non-marginal / paramarginal syndesmophytes
Erosions on surface of vertebrae and syndesmophytes form at site of erosion or in adjacent soft tissue
Paravertebral ossification (rare)
Apopyseal joint ankylosis
![Page 44: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/44.jpg)
“Bulky” SyndesmophyteWhy?
De Vlam postulates that sydesmophytemorphology is the result of the amount of motility at zygoapophysealjoint
De Vlam demonstrated association between zygoaphyseal fusion and classic marginal syndesmophytes and “bulky” syndesmophyes where posterior fusion had not occurred(6)
![Page 45: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/45.jpg)
Psoriatic Syndesmophytes
![Page 46: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/46.jpg)
MRI Imaging
MRI may have advantage of detecting abnormalities earlier than plain radiography
Response to treatment and disease activity may be measured before structural damage occurs.
![Page 47: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/47.jpg)
52 year old male with psoriasis T1 fat sat post gad: enhancement demonstrating periostitis of proximal phalanxRadiograph 2 months later: No evidence of periostitis (7)
![Page 48: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/48.jpg)
Uses of MRI Imaging
MRI enhancement has been used to measure synovial vascularity in RA wrist following initiation of therapy
Same approach employed in PsA trials with antitumor necrosis factor (infliximab) (5)
– Reduced enhancement parallels reduced inflammation
![Page 49: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/49.jpg)
Ultrasonography
Can be used to assess disease activity in inflammatory joint disease
Assess synovial tissue, joint effusions, erosions, hyperemia (with doppler), tenosynovitis and enthesitis (identified at Achilles tendon by U/S in much higher frequency than on clinical exam, however U/S findings are nonspecific and can be seen with OA, RA and PsA) (5)
![Page 50: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/50.jpg)
Summary
Clinical findings
Pathophysiology of Radiographic features
Disease processes of the synovium and enthesis
Small Joints of the Hand and Foot
Spondylitis, Sacroilliitis
![Page 51: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/51.jpg)
References: 1. Jones, J. et al. Pictorial Review: Radiological Associations with
Dermatological Disease. The British Journal of radiology, 78(2005), 662-671.
2. Kataria, RJ. Et al. Spondyloarthropathies. American Family Physician 2004; 69: 2853-60.
3. Resnick, D. Common Disorders of Synovium-Lined Joints: Pathogenesis, Imaging Abnormalities, and Complications. AJR:151, December 1988
4. McGonagle, D. Imaging the Joint and Enthesis: Insights into Pathogenesis of Psoriatic Arthritis. Ann Rheum Dis 2005;64(Suppl II).
5. Ory, PA et al. Psoriatic arthritis and Imaging. Ann Rheum Dis 2005;64(Suppl II).
6. Helliwell, PS et al. Classification and Diagnostic Criteria for Psoriatic Arthritis. Ann Rheum Dis 2005;64;3-8.
7. Schoellnast, H. et al. Psoriatic Arthritis and Rheumatoid Arthritis: Findings in Contrast-Enhanced MRI. AJR 2006; 187: 351-357
8. McQueen, F. Magnetic Resonance Imaging in Psoriatic Arthritis: A Review of the Literature. Arthritis Research and Therapy 2006, 8:207
![Page 52: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/52.jpg)
Spinal Involvement
Spondylitis, may be difficult to distinguish from ankylosing spondylitis
Syndesmophytes (bony outgrowths) in both
![Page 53: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/53.jpg)
Spinal Involvement
T1 and STIR
active inflammation (arrows)
Anterior Spondylitis L1/L2
Inflammatory Anderson lesion upper endplate of L3 (8)
![Page 54: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/54.jpg)
![Page 55: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/55.jpg)
Radiographic Features
Asymmetric paravertebral ossification of thoracolumbar junction (from vertebral body to body vs AS, corner to corner)
Sacroiliitis usually bilateral (more asymetretic vs Ank spond)
![Page 56: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/56.jpg)
Seronegative Spondyloarthropathies vs. Rheumatoid arthritis
Synovial articulations:
– 1.Absence of periarticular osteoporosis
– 2. Intr-articular bony ankylosis
– 3. Bony proliferation (Whiskering: irregular excescences and Pereostitis of shafts in small bones of the hands and feet) in sernegative arthropathies. (Resnick)
![Page 57: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/57.jpg)
![Page 58: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/58.jpg)
Radiographic Features
Usually no osteoporosis (unlike RA)
Severe joint space loss
Sausage digit: soft tissue swelling of entire digit
Ankylosis: most common in the hands and feet (10%)
![Page 59: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/59.jpg)
Periosteal Bone Apposition causing widening of affected bones
4th and 5th DIP affected
widening multiple phalanges
![Page 60: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/60.jpg)
Radiographic Assessment
Radiographic features of PsA
– Soft tissue swelling
– Relative lack of periarticular osteopenia
– Erosions and joint space narrowing
– Pencil-in-cup of DIPs
– Bone proliferation common, including peri-articular and shaft periostitis
– Ankylosis (most common hands and feet)
– Osteolysis of digit tufts
![Page 61: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/61.jpg)
MRI Imaging
An international Outcome Measures in Rhematologic Clinical Trials (OMERACT) MRI in working group has been developing scoring system to assess synovitis, bone edema, and erosions in hands and wrists.
Since pts with Psa share same clinical features as pts with RA, this MRI scoring sysem may have potential outcome measure in pts with PsA
![Page 62: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/62.jpg)
![Page 63: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/63.jpg)
Conclusions:
Distribution of psoriatic arthritis is variable, a polyarticular disorder of the synovial joints of the axial skeleton with prominent involvement of the of the interphalangeal articulations of the hand and foot, combined with synovial and cartilagenous joints of the axial skeleton and enthesis of the axial and appendicular skeleton is distinctive. (Resnick)
![Page 64: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/64.jpg)
Ivory Phalanx
![Page 65: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/65.jpg)
Seronegative Spondyloarthropathies vs. Rheumatoid arthritis Sites of tendon and ligament
attachments to bone: inflammatory enthesopathy leading to osseous destruction and repair is characteristic of the spondyloarthropathies (Resnick)
Enthesopathy- derived from Enthesis
Enthesis- site of ligamentous or tendinous attachment to bone
![Page 66: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/66.jpg)
Arthritis mutilans
Nail pitting
![Page 67: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/67.jpg)
![Page 68: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/68.jpg)
Pencil in Cup Deformity
![Page 69: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/69.jpg)
Sausage Digit
![Page 70: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/70.jpg)
Marginal Bony Erosions, Subchondral Cysts and Narrowing of Joint Space Narrowing
Pannus destruction of unprotected bone at joint margins (marginal erosions)Pannus destrucion of subchondral bone (erosions and subchondral cyst formation)Pannus destruction of cartilage (narrowing of joint space)
![Page 71: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/71.jpg)
Seronegative Spondyloarthropathies vs. Rheumatoid arthritis
Cartilagenous joints: extent of osseous erosion and bone proliferation in seronegative arthropathies. (Resnick)
![Page 72: Psoriatic Arthritisbonepit.com/Lectures/Psoriatic arthritis talk Preeti Tuladhar.pdfImaging Abnormalities, and Complications. AJR:151, December 1988 4. McGonagle, D. Imaging the Joint](https://reader034.vdocument.in/reader034/viewer/2022042309/5ed57d8a276f240580269103/html5/thumbnails/72.jpg)
Outline
Pathogenis
Manifestations
– hand,
– foot
– calcaneus
– SI
– spine
MRI