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Reaqua BT99
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1.Reaqua BT99 Reaqua BT99 is a betaine,betaine is discovered by the Scheibler, an
d separated from the sugar beet, It is a completely natural, edible am
ino acids. Since 1939, DU Vigneaud found its nutritional function,it
has become a hot topic of research, and is widely used in the pharma
ceutical, food, additives, chemical reagents, chemical raw materials,
livestock breeding, aquaculture and other fields.
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❀ White crystalline powder❀ Sweet and bitter taste❀ Soluble in water, ethanol, PG and glycerin❀ Solubility:
160g Reaqua BT99 / 100g water8,7g Reaqua BT99 / 100g ethanolslightly soluble in ether
❀ Compatible with anionic, cationic and nonionic materials❀High temperature resistant❀Heated to 310°decomposition❀Loss on drying(105℃, 2 hours) ≤1.0%❀Reaqua BT99 Content ≥99.0%❀Residue on ignition ≤0.1%❀PH Value (5%) 5.0-7.0❀Sulphate ≤20 ppm❀Heavy metal(Pb) < 10 ppm❀Arsenic < 2 ppm
The Physical properties
of Reaqua BT99
CH3
CH3
CH3
N+
CH2
COO-
. H O2
Chemical structure :
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2.The function of Reaqua BT99
2.1 Reaqua BT99 is a major osmolyte
K+
Sugars
Amino Acids
Reaqua BT99
H2O
• Water follows osmotically active compounds such as potassium and organic osmolytes
• Water doesn`t move alone
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Disturbance
Original cell volume
Swell
Shrink
Original cell volume
Recovery
Osmolyte efflux
Osmolyte uptake
Cells regulate their volume and water balance by absorbing or effluxing osmolytes
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2.2 Maintain moisture balance• Water is common base to all biological solutions and thus to life itself• All cells are 85-95% water
Reaqua BT99 attracts water but does not immobilize it as a moisturizer
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2.3 Solubilization of insoluble material, such as salicylic acid and allantoin• Salicylic acid
– Use levels from 2 to 10 %.– Solubility in water is 0.2 % at room
temperature – Reaqua BT99 was found to increase the
solubility of salicylic acid to 5 %
• Allantoin -solubility in water 0.7 % at RT
-Reaqua BT99 was found to increase the solubility of allantoin
to 2 %
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2.4 Buffering properties of Reaqua BT99
pH values after addition of HCl 1N to 100 mls of 1M Reaqua BT99 aqueous solution
0
1
2
3
4
5
6
7
0 2 4 6 8 10 12
HCl 1N (ml)
pH
Betaine 1M Water
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2.5 Polymers swelling
• Viscosity values during the swelling phase of 1% water and water- Reaqua BT99 dispersions of Sodium• carboxymethylcellulose
0,14% Na CARBOMER aq
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2.6 Reaqua BT99 ability to reduce the irritating effects of detergents
0
0,5
1
1,5
2
2,5
3
3,5
4
4,5
5
0 2 3,5 5 7
Betaine(%)
Irrita
tion
Scor
e
24 h
48 h
Human patch test SLES/Reaqua BT99 on 25 volunteers
1. Test solution: 10.3 % SLES 0 - 7 % Reaqua BT992. 25 µL of the test solution was applied on the forearm in a „Finn chamber“(sealed Al-chamber)3. Removal of the Finn chamber after 24 and 48h, respectively.4. Dermatologists assessed skin irritation 1 hour after removal
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0
200
400
600
800
SLES mix SLES/DLSS mix+3,5 Betaine Betaine
Irritant
Slightly Irritant
Non irritant
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Increased Reaqua BT99, Inositol, & Taurine uptakes
(Warskulat et al. 2004)
InositolReaqua BT99
Taurine
Oxidative Stress Opening of K+ channels Cell shrinkageIncreased Reaqua BT99, Inositol and Taurine transporters & uptake
2.7 Osmotic Stress : UV radiation
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2.8 Sensory properties
Reaqua BT99 modifies the feelof aq. Solutions and emulsions with 3-4 %
❀ Glycerol❀ Sorbitol❀ Propylene glycol
Best performer❀ 50/50 glycerol/ Reaqua BT99 3-4 %
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2.9 Improving the performance of foamFoam texture when 0% Reaqua BT99 included
Foam texture when 5% Reaqua BT99 included
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Thank you !