References 1. Addison GM, et al (1972) An immunoradiometric assay for ferritin
in the serum of normal subjects and patients with iron deficiency and iron overload. J Clin Patho125: 326-329
2. Arosio P, Levi S, Gabri E, et al (1984) Heterogeneity of ferritin II: immunological aspects. In: Albertini A, Arosio P, Chiancone E, Drysdale J (eds) Ferritins an isoferritins as biochemical markers. Elsevier, Amsterdam New York Oxford, pp 33-47
3. Basset ML, Halliday JW, Bryant S, Dent 0, Powell LW (1988) Screening for hemochromatosis. Am NY Acad Sci 526: 274-289
4. Batho A(l983) Clinical applications of atomic spectroscopy. Instrumentation Laboratory: 3.9-3.11; Warrington UK
5. Bavakat RM, Ekins P (1961) Asay vitamin Bl2 in blood: a simple method. Lancet i: 25-26
6. Beguin Y (1992) The soluble transferrin receptor: biological aspects and clinical usefulness as quantitative measure of erythropoiesis. Haematologica 77: 1-10
7. Beguin Y, et al (1993) Quantitative asessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin. Blood 81: 1067
8. Bentley DP (1985) Iron metabolism and anaemia in pregnancy. Clin Haematol 14: 613-628
9. Bernard A, Lauwerys R (1984) Turbidimetric latex immunoassay for serum ferritin. J Immunol Methods 71: 141-147
10. Bernat I (1981) Eisenresorption. In: Bernat I (Hrsg) Eisenstoffwechsel. Gustav Fischer, Stuttgart New York, S 36-37
11. Bernat I (1981) Der Eisentransport. In: Bernat I (Hrsg) Eisenstoffwechsel. Gustav Fischer, Stuttgart New York, S 68-84
12. Berson SA, Yalow RS, et al (1958) Isotopic tracers in the study of diabetes. Adv BioI Med Phys 6: 349
13. Bobbio-Pallavicini F, Verde G, Spriano P, Losi R, et al (1989) Body iron status in critically ill patients: significance of serum ferritin. Int Care Med 15: 171-178
114 References
14. Barch K (1986) Epidemiologic, clinicopathologic and economic aspects of gastroscopic screening of patients with pernicious anemia. Scand J Gastroenterol21: 21-30
15. Bothwell TH (1979) Iron metabolism in man. Blackwell Scientific Publications, Oxford
16. Bothwell TH, Baynes RD, MacFarlane BJ, MacPhail AP (1989) Nutritional iron requirements and food iron absorption. J Intern Med 226: 357-365
17. Braun HJ (1971) Eigenschaften, Funktion und Serumkonzentration des menschlichen Hamopexins. K1in Wochenschr 49: 445
18. Buffone GJ, Lewis SA, Josefson M, et al (1978) Chemical and immunochemical measurement of total iron-binding capacity compared. Clin Chern 24: 1788-1791
19. Bunn HF (1991) Anemia associated with chronic disorders. In: Harrison's principles of internal medicine, 12th ed. McGraw-Hill, New York, pp 1529-1531
20. Cavanna T, et al (1983) An immunaradioactive assay for human heart ferritin using a specific monoclonal antibody. Clin Chern 29: 1245-1246
21. Chanarin J (1987) Megaloplastic anaemia, cobalamin and tolate. J Clin Pathol 40: 978-984
22. Chen JW, Sperling MJ, Heminger LA (1989) Vitamin B\2. In: Pesce AJ, Kaplan LA (eds) Methods in clinical chemistry. CV Mosby Company, St. Louis Washington Toronto, pp 1127-1129
23. Chiancone E, Stefanini F (1984) Heterogeneity offerritin I structural and functional aspects. In: Albertini A, Arosio P, Chiancone E, Drysdale J (eds) Ferritins and isoferritins as biochemical markers. Elsevier, Amsterdam New York Oxford, pp 23-31
24. Cook JD, Skikne BS, Baynes RD (1993) Serum transferrin receptor. Annu Rev Med 44: 63
25. Cotes PM, Dore CJ, Yin Yal (1986) Determination of serum immunoreactive protein in the investigation of erythrozytosis. N Engl J Med 315: 283-287
26. Covell AM, Worwood M (1984) Isoferritins in plasma. In: Albertini A, Arosio P, Chiancone E, Drysdale J (eds) Ferritins and isoferritins as biochemical markers. Elsevier, Amsterdam New York Oxford, pp 49-65
27. Dallman PR (1989) Iron deficiency: does it matter? J Intern Med 226: 367-372
28. Dati F, Sauder U (1990) Immunchemische Methoden im klinischen Labor. GIT Labor Medizin 7-8: 357-372
References 115
29. Deinhard AS, List A, Lindgren B, Hunt JV, Chang PN (1986) Cognitive deficits in iron-deficient and iron-deficient anaemic children. J Paediatr 108: 681-689
30. de Jong G, von Dijk IP, van Eijk HG (1990) The biology of transferrin. C1in Chim Acta 190: 1-46
3l. Dietzfelbinger H (1993) Korpuskulare hamolytische Anamien. In: Begemann H, Rastetter J (Hrsg) Klinische Hamatologie, 4. Aufl. Thieme, Stuttgart New York, S 248
32. Donnelly SM, Smith EK (1990) The roll of aluminium in the functional iron deficiency of patients treated with erythropoietin: case report of clinical characteristics and response to treatment. Am J Kidney Dis 16: 487-490
33. Doss M (1992) Porphyrie. In: Thomas L (Hrsg) Labor und Diagnose. Medizinische Verlagsgesellschaft, Marburg, S 549
34. Deutsch E, Gever G, Wenger R (1992) Folsaure-Resorptionstest. In: Laboratoriumsdiagnostik. Wissenschaftliche Buchreihe, Schering, S 91
35. Drysdale JW (1977) Ferritin phenotypes: structure and metabolism. In: Jacobs A (ed) Iron metabolism. Ciba Foundation Symposium 51 (excerpta medica). Elsevier, Amsterdam, pp 41-57
36. Dubois S, McGovern M, Ehrhardt V (1988) EisenstoffwechselDiagnostik mit Boehringer MannheimlHitachi-Analysesystemen: Ferritin, Transferrin und Eisen. GIT Labor-Medizin 9: 468-471
37. Dunn RT, Foster LB (1973) Radioassay of serum folate. Clin Chern 19: 1101-1105
38. Ebrich J, Foellmer H, Krull F, Winnecken H, Wurster U (1984) Aussagen, Fehlerquellen und Grenzen der Proteindiagnostik im Urin. Monatsschr Kinderhei1k 132: 136
39. Engvall E, Perlmann P (1971) Enzyme linked immunosorbent assay (ELISA): a quantitative assay of immunoglobin G. Immunochemistry 8: 871-874
40. Eriksson S (1981) Pernicious anemia as a risk factor in gastric cancer. The extent of the problem. Acta Med Scand 210: 481
4l. Erslev AJ (1991) Erythropoietin. N Engl J Med 324: 1339-1344 42. Eschbach JW, Haley NR, Adamson JW (1990) The anemia of chro
nic renal failure: pathophysiology and effects of recombinant erythropoietin. Contrib Nephrol 78: 24-37
43. Eschbach JW, Adamson JW (1989) Guidelines for recombinant human erythropoietin therapy. Am J Kidney Dis [No 2, Suppl 1] 14:2-8
116 References
44. Fahey JL, McKelvey EM (1965) Quantitative determination of serum immunoglobulins in antibody-agar plates. J Immunol 94: 84-90
45. Fateh-Moghadam A, Wick M (personliche Mitteilung)
46. Ferguson BJ, Skikne BS, Simpson KM, Baynes RD, Cook JD (1992) Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J Lab Clin Med 19: 385-390
47. Finch CA, Huebers HA, Cazzila M, Bergamaschi G, Bellotti V (1984) Storage iron. In: Albertini A, Arosio P, Chiancone E, Drysdale J (eds) Ferritins and isoferritins as biochemical markers. Elsevier, Amsterdam New York Oxford, pp 3-21
48. Finlayson NDC (1990) Hereditary (primary) hemochromatosis. BMJ 301: 350-351
49. Fisher J, Nathashima J (1992) The role of adnosine hypoxic regulation of kidney production of erythropoietin. In: Pagel H, Weiss Ch, Jelkman W (eds) Pathophysiology and pharmacology of erythropoietin. Springer, Berlin Heidelberg New York Tokyo, pp 29-51
50. Ferro chern, serum iron and total iron binding capacity. Analyzer, Bedford, MA, Environmental Sciences Associated, Inc
51. Flowers CH, Skikne BS, Covell AM, Cook JD (1989) The clinical measurement of serum transferrin receptor. J Lab Clin Med 114: 368
52. Forman DT, Parke SL (1980) The measurement and interpretation of serum ferritin. Ann Clin Lab Sci 10: 345-349
53. Forman DT, Vye MV (1980) Immunoradiometric, serum ferritin concentration compared with stainable bone marrow iron as indices to iron stores. Clin Chern 26: 145-147
54. Franco RS (1987) Transferrin. In: Pesce AJ, Kaplan LA (eds) Methods in clinical chemistry. CV Mosby Company, St. Louis Washington Toronto, pp 1279-1280
55. Franco RS (1987) Ferritin. In: Pesce AJ, Kaplan LA (eds) Methods in clinical chemistry. CV Mosby Company, St. Louis Washington Toronto, pp 1240-1242
56. Garry PJ (1984) Ferritin. In: Hicks JM, Parker KM (eds) Selected analytes in clinical chemistry. American Association for Clincal Chemistry Press, Washington, pp 149-153
57. Givas JK, Gutcho S (1975) pH dependence of the binding of folates to milk binder in radioassay of folates. Clin Chern 21: 427-428
References 117
58. Gregory JF (1989) Folacin. Chromatographic and radiometric assays. In: Pesce AJ, Kaplan LA (eds) Methods in clinical chemistry. CV Mosby Company, St. Louis Washington Toronto, pp 1131-1132
59. Goldberg MA, Dunning SP, Bunn HF (1988) Regulation of the erythropoietin gene: evidence, that the oxygen sensor is a hemo protein. Science 24w: 1412-1415
60. Gressner AM (1990) Entwicklungstendenzen nephelometrischer und turbidimetrischer Immunoassays. GIT Labor-Medizin 9: 419-429
61. Griitzmacher P, Ehmer B, Messinger D, et al (1991) Therapy with recombinant human erythropoietin (rEPO) in hemodialysis patients with transfusin dependent anemia. Report of an European multicenter trial. Nephrologia 11: 58-65
62. Goodnough LT, Price TH, Friedmann DK, et al (1994) A phase III trial of recombinant humen erythropoietin therapy in nonanemic orthopedic patients subjected to aggressive removal of blood to antologous use. Tranfusion (Philadelphia) 34: 66-71
63. Gosling JP (1990) A decade of development in immunoassay methodology. Clin Chern 36: 1408-1427
64. Gundermann KD (1978) Chemiluminescence: current status. In: Schramm E, Stanley P (eds) Proceedings of the International Symposium on Analytical Applications of Bioluminescence and Chemiluminescence. State Printing and Publishing Westlake Village, California, p 37
65. Gutcho S, Mansbach L (1977) Simultaneous radioassay of serum vitamin B12 and folic acid. Clin Chern 23: 1606-1614
66. HammiHi J (1985) Fluoroimmunoassays and immunofluorometric assays. Clin Chern 31: 359-370
67. Harjn E, Pakarmen A, Larmi T (1984) A comparison between serum concentration and the amount of bone marrow stainable iron. Scand J Clin Lab Invest 44: 555-556
68. Haupt H, Baudner S (1990) Chemie und klinische Bedeutung der Human Plasma Proteine. Behring Institut Mitteilungen 86: 1-66
69. Heidelberger M, Kendall FE (1935) The precipitin reaction between type III pneumococcus polysaccharide and homologous antibody III. A quantitative study and theory of the reaction mechanism. J Exp Med 61: 563-591
70. Heinrich HC (1980) Diagnostischer Wert des Serumferritins flir die Beurteilung der Gesamtkorper-Eisenreserven. In: Kaltwasser JP, Werner E (Hrsg) Serumferritin. Springer, Berlin Heidelberg New York, S 58-95
118 References
71. Helman AD, Darnton-Hill I (1987) Vitamin and iron status in new vegetarians. Am J Clin Nutr 45: 785-789
72. Henderson DR, Friedmann SF, Harris JD, Manning WB, Zoccoli MA (1986) CEDIATM, a new homogeneous immunoassay system. Clin Chern 32 (9): 1637-1641
73. Henry DH, Abels RI (1994) Recombinant human erythropoietin in the treatment of cancer and chemotherapy-induced anemia: results of double blind and open-label follow-up studies. Semin Oncol 21 [2 Suppl 3]: 21-28
74. Henry DH, Beall GN, Benson CA, et a1 (1992) Ann Int Med 117: 739-748
75. Henry DH (1992) Changing patterus of care in the management of anemia. Semin Oncol [Suppl8] 19: 3-7
76. Henry DH (1990) Erythropoietin therapy in AIDS. Prog Clin BioI Res 338: 113-120
77. Herbert V (1966) Aseptic addition method for actobacillus casei assay of folate activity in human serum. J Clin Pathol 19: 12-16
78. Herbert V (1977) The five possible causes of all nutrietent deficiency, illustrated by defiencies of vitamin B J2 and folic acid. Am J Clin Nutr 26: 17
79. Herbert V (1985) Megaloblastic anemias. Lab Invest 52: 3-19 80. Hershko Ch, Konijin AM (1981) Serum ferritin in hematologic dis
orders. In: Albertini A, Arosio P, Chiancone E, Drysdale J (eds) Ferritins and isoferritins as biochemical markers. Elsevier, Amsterdam New York Oxford, pp 143-158
81. Herrmann U (1990) Personliche Mitteilung; siehe auch: Del Cura J, Maside C, Rus A, Ruiz R, Borque L, et al (1990) Evaluation of an improved colorimetric iron assay on Boehringer MannheimlHitachi analyzers. Poster presented at the 4th ANT, Barcelona
82. Huebers HA, Beguin Y, Pootrakne P, Einspahr D, Finch CA (1990) Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood 75: 102-107
83. Hytten FE, Cheyne CA, Klopper AI (1964) Iron loss at menstruation. J Obstet Gynaecol Br Cwlth 71: 255
84. International Committee for Standardisation in Haematology (1988) Recommendations for measurement of serum iron in blood. Ind J Hematol 6: 107-111
85. International Committee for Standardisation in Haematology (1978) Recommendations for measurement of serum iron in human blood. Br J Haematol38: 291-194
References 119
86. International Committee for Standardisation in Haematology (1985) Proposed international standard of human ferritin for the serum ferritin assay. Br J Haematol61: 61
87. Jacobella C, Ghielmi S, Belloli S, et al (1984) Use of a reference standard to improve the accuracy and precision of seven kits for determination of ferritin in serum. Clin Chern 30: 298-301
88. Jacobs A, Hodgetts J, Hoy TG (1984) Functional aspects ofisoferritins. In: Albertini A, Arosio P, Chiancone E, Drysdale J (eds) Ferritins and isoferritins as biochemical markers. Elsevier, Amsterdam New York Oxford, pp 113-127
89. Jacobs A, Worwood M (1975) Ferritin in serum. N Engl J Med 292: 951-956
90. Jelkman W, Wiedemann G (1990) Erythropoietinbestimmung im Serum. Klin Lab 37: 229-234
91. Johannsen H, Gross AJ, Jelkmann W (1989) Erythropoietinproduction in malignancy. In: Jelkmann W, Gross AJ (eds) Erythropoietin. Springer, Berlin Heidelberg New York Tokyo, pp 80-91
92. Johnson AM (1987) Nephelometric immunoassay. J Pharm Biomed Anal 5: 803-809
93. Kaltwasser JP, Werner E (Hrsg) (1980) Serumferritin: Methodische und klinische Aspekte. Springer, Berlin Heidelberg New York
94. Kaltwasser JP, Werner E (1980) Serumferritin als Kontrollparameter bei der Therapie des Eisenmangels. In: Kaltwasser JP, Werner E (Hrsg) Serumferritin: Methodische und klinische Aspekte. Springer, Berlin Heidelberg New York, S 137-151
95. Karlsson FA, Burman P, Loof L (1987) Enzyme-linked immunosorbent assay of H+/K + ATPase, the parietal cell antigen. Clin Exp Immunol 70: 604
96. Keller H (1986) Klinisch-chemische Labordiagnostik flir die Praxis. Analyse, Befund, Interpretation. G Thieme, Stuttgart New York
97. Keller H (1980) EinflUsse auf klinisch-chemische MeBgroBen. In: Lang H, Rick W, BUttner H (Hrsg)ValidiHit klinisch-chemischer Befunde. Springer, Berlin Heidelberg New York
98. Kero WC, Fisher JW (1986) Serum, erythropoietin concentrations in patients with hepatocellular carcinoma. Cancer 58: 2485-2488
99. Kleeberg UR (1975) Pathophysiologie und Diagnostik hamolytischer Anamien. Dtsch Med W ochenschr 100: 1400
120 References
100. Kolhouse JF, Kondo H, Allen NC (1978) Cobalamin analogues are present in human plasma and can mask cobalamin deficieny because current radioisotope dilution assays are not specific for true cobalamin. N Engl J Med 299: 785-792
10l. Knoll E (1989) Radioimmunoassay. In: Borsdorf R, Fresenius W, Gtinzler H, et al (Hrsg) Analytiker-Taschenbuch, Bd 8. Springer, Berlin Heidelberg New York Tokyo, S 93-125
102. Konijn AM, et al (1982) Serum ferritin employing a fluorogenic substrate. J Immunol Methods 54: 297-307
103. Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495
104. Krainer M, Fritz E, Kotzmann H, et al (1990) Erythropoietin modulates lipid metabolism. Blut 61: Abstr No 81
105. Kreutzer HJH (1976) An immunological turbidimetric method for serum transferrin determination. J Clin Chern Clin Biochem 14: 401-406
106. Levy A, Vitacce P (1961) Direct determination and binding capacity of serum iron. Clin Chern 7: 241-248
107. Lindenbaum J (1988) Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 318: 1720-1728
108. Linke R, Ktippers R (1989) Nicht-isotopische Immunoassays - Ein Uberblick. In: Borsdorf R, Fresenius W, Gtinzler H, et al (Hrsg) Analytiker-Taschenbuch, Bd 8. Springer, Berlin Heidelberg New York Tokyo, S 127-177
109. Linkesch W (1979) Serumferritin - diagnostische und klinische Bedeutung. Acta Med Austr 5: 169-171
110. Linkesch W (1986) Ferritin bei malignen Erkrankungen. Springer, Wi en New York
11l. Linkesch W (1984) Physiologie und Pathophysiologie des Eisenstoffwechsels. Wien Med Wochenschr 134: 59-63
112. Lipschitz DA, Cook JD, Finch CA (1974) A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med 290: 1213-1218
113. Ludwig H, Chott A, Fritz E (1995) Increase of bone-narrow cellurarity during erythropoietin treatment in myeloma. Stem Cells (Dayton) 13: [Suppl 2] 77-87
114. Ludwig H, Fritz E, Leitgeb C, Pecherstorfer M, et al (1994) Prediction of response to erythropoietin treatment in chronic anemia of cancer. Blood 84: 1056-1063
115. Ludwig H, Komek G, Krainer M, et al (1991) Eur J Cancer Clin Oncol27 [SuppI2]: Abstr No 1425
References 121
116. Ludwig H, Leitgeb C, Pecherstorfer M, et al (1994) Recombinant human erythropoietin for the correction of anemia in various cancers. Br J Haematol 87 [Supp1 1]: 158 (Abstr No 615)
117. Mac Dougall IC, Roberts DE, Neubert P, et al (1989) Pharmacokinetics of intravenous, intraperitoneal and subcutanous recombinant erythropoietin in patients on CAPD - A rationale for treatment. Contrib Nephrol 76: 112-121
118. Matthews DM (1962) Observations on the estimation of serum vitamin B 12 using Lactobacillus leichmannii. Clin Sci: 10 1-111
119. Mancini G, Carbonara AO, Heremans JF (1965) Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2: 235-243
120. Mazza J, Barr RM, MacDonald JWD, Valberg LS (1978) Usefulness of the serum ferritin concentration in the detection of iron deficiency in an general hospital. CMA 19: 884-886
121. Mc Mahon FC, Vargas R, Ryan M, et al (1990) Pharmacokinetics and effects of recombinant human erythropoietin after intravenous and subcutaneous injections in healthy volunteers. Blood 76: 1718-1722
122. McNeely MDD (1987) Folic acid. In: Pesce AJ, Kaplan LA (eds) Methods in clinical chemistry. CV Mosby, St. Louis Washington Toronto, pp 1131-1134
123. Metzmann E (1989) Plasmaproteinbestimmungen. In: Borsdorf R, Fresenius W, Gtinzler H, et al (Hrsg) Analytiker-Taschenbuch, Bd 8. Springer, Berlin Heidelberg New York Tokyo, S 179-198
124. Miles LEM, et al (1974) Measurement of serum ferritin by a 2-site immunoradiometric assay. Anal Biochem 61: 209-224
125. Milmann N, Sondergaard M, Sorensen CM (1985) Iron stores in femal blood donors evaluated by serum ferritin. Blut 51: 337-345
126. National Committee for Clinical Laboratory Standards (1980) Guidelines for evaluating a B12 (cobalamin) assay. Villanova, PA
127. Nickerson HJ, Holubets MC, Weiler BR, Hass RG, et al (1989) Causes of iron deficiency in adolescent athletes. J Pediatr 114: 657-663
128. Nowrousian MR (1996) Pathophysiologie und Therapie tumorbedingter Anamie. In: Klaschik E (Hrsg) Supportive Tumortherapie. Boehringer-Mannheim, Mannheim, S 16-17
129. Nyman M (1959) Serum haptoglobin methodological and clinical studies. Scand J Clin Lab Invest 11 [Suppl 39]
130. O'Connor B, Manganello J, Pcholski J, et al (1989) Performance of the Kodak iron and total iron-binding capacity methods [Tech Brief]. Clin Chern 35: 2250-2251
122 References
131. Oellerich M (1984) Enzyme-immunoassays: a review. J Clin Chern Clin Biochem 22: 895
132. O'Neil-Cutting MA, Crosby WH (1986) The effect of antacids on the absorption of simultaneously ingested iron. JAMA 255: 1468-1470
133. Perrotta G (1987) Iron and iron-binding capacity. In: Pesce AJ, Kaplan LA (eds) Methods in clinical chemistry. CV Mosby, St. Louis Washington Toronto, pp 1258-1261
134. Pollitt E, Saco-Pollitt C, Leibel RL, Viteri FE (1986) Iron deficiency and behavioural development in infants and preschool children. Am J Clin Nutr 43: 555-565
135. Packungsbeilage, Enzymun-Test®-Ferritin, Boehringer Mannheim, Mannheim, Germany. Immundiagnostica fUr ES 600, ES 300, ES 22, ES II/manuell, Februar 1989
136. Packungsbeilage, Tina-quant®-a Transferrin, Boehringer Mannheim, Mannheim, Germany. September 1988
137. Packungsbeilage, Eisen ohne EnteiweiBung, Boehringer Mannheim, Mannheim, Germany. Juni 1988
138. Packungsbeilage, Tina-quant®-a Ferritin, Boehringer Mannheim, Mannheim, Germany. Mlirz 1990
138a. Pinggera W (1996) personliche Mitteilung 139. Punnonen K, Irjala K, Rajamaki A (1994) Iron deficiency anemia is
associated with high concentrations of transferrin receptor in serum. Clin Chern 40: 774-776
140. Ramsey WNM (1958) Plasma iron. Adv Clin Chern 1: 1 141. Refsum AB, Schreiner BEl (1984) Regulation of iron balance by
absorption and excretion. Scand J Gastroenteroll9: 867-874 142. Rich IN (1991) Erythropoietin production - a personal view. Exp
Hematoll9: 985-990 143. Rich IN, Noe G, Vogt C, Lemke C (1990) Erythropoietin is produ
ced in the tubules of the renal cortex (Abstr). Blood 76 [Suppl 1]: 162a
144. Ritchey AK (1987) Iron deficiency in children. Update of an old problem. Postgrad Med 82: 59-63
145. Robinson SH (1990) Degradation of hemoglobin. In: Williams WJ, Beutler W, Erslev AI, Lichtman MA (eds) Hematology, 4th ed. McGraw-Hill, New York
146. Rosenberg IH, Alpers DH (1983) Nutrional deficiencies in gastrointestinal disease. In: Sleisenger MH, Fordtran JS (eds) Gastrointestinal disease, 3rd ed. Saunders, New York, pp 1810-1819
References 123
147. Rosenmund A, Caponovo F, Koechli HP (1986) Der EinfluB hormone1ler Kontrazeptiva und der Schwangerschaft auf Eisenstoffwechsel, Plasmalactoferrinkonzentration und Granulozytenzahl der Frau. Schweiz Med Wochenschr 116: 1411-1414
148. Rossander L (1987) Effect of dietary fiber on iron absorption in man. Scand J Gastroenterol [SuppI129]: 68-72
149. Roth D, Smith RD, Schulman G, et al (1994) Effects of recombinant human erythropoietin on renal function in chronic renal failure predialysis patients. Am J Kidney Dis 24: 777-784
150. Rotheberg SP, DaCosta M, Rosenberg BS (1972) A radioassay for serum fotale: use of a two-phase sequential incubation, ligand-binding system. N Engl J Med 285 (25): 1335-1339
151. Rowland TW, Kelleher JF (1989) Iron deficiency in athletes. Insights from high school swimmers. Am J Dis Child 143: 197-200
152. Rowland TW, Black SA, Kelleher JF (1987) Iron deficiency in adolescent endurance athletes. J Adolesc Health Care 8: 322-326
153. Ruggeri G, Jacobello C, Albertini A, et al (1984) Studies of human isoferritins in tissues and body fluids. In: Albertini A, Arosio P, Chiancone E, Drysdale J (eds) Ferritins and isoferritins as biochemical markers. Elsevier, Amsterdam New York Oxford, pp 67-78
154. San Diego Declaration (1995) Erythropoietin use and response in end-stage renal disease. The American Society of Nephrology, Annual Meeting. San Diego, J Am Soc Nephrol 3: 35P
155. Sassa S (1990) Synthesis of heme. In: Williams WJ, Beutler E, Erslev AJ, Lichtman MA (eds) Hematology, 4th ed. McGraw-Hill, New York, p 332
156. Savage D, Lindenbaum J (1986) Anemia in alcoholics. Medicine 65: 322
157. Schrocksnadel W, Gabl F (1984) Die Diagnostik des gestOrten Eisenstoffwechsels. Wien Med Wochenschr 3/4: 63-68
158. Schultz BM, Freedman ML (1987) Iron deficiency in the elderly. Baillieres Clin Haematol 1: 291-313
159. Scott JM, Weir DG (1980) Drug induced megaloblastic change. Clin Haematol 9: 587-606
160. ScigaUa P, Ehmer B, Woll EM, et al (1990) Zur individuellen Ansprechbarkeit terminal niereninsuffizienter Patienten auf die RH-EPO-Therapie. Nieren-Hochdruckerkrankungen 19: 178-183
161. Schurek HJ (1992) Oxygen shunt diffusion in renal cortex and its physiological link to erythropoietin production. In: Pagel H, Weiss C, Jelkmann W (eds) Pathophysiology and pharmacology of erythropoietin. Springer, Berlin Heidelberg New York Tokyo, pp 53-55
124 Recommended Reading
162. Schuster-Kolbe I, Ludwig H, Fritz E, et al (1994) Serum levels of cytokines and acute-phase proteins in anemic cancer patients receiving treatment with recombinant human erythropoietin. Onkologie 138 [SuppI2]: Abstr No 550
163. Selby GB, Eichener ER (1986) Endurance swimming, intravascular hemolysis, anemia and iron depletion. Am J Med 81: 791-794
164. Seligman PA, et al (1987) In: Stamatoyannopoulos G, Nienhuis A W, Leder P, Majerus PW (eds) The molecular basis of blood diseases. Saunders, Philadelphia, pp 219-244
165. Shackleton PJ, Fish DI, Dawson DW (1989) Intrinsic factor antibody tests. J Clin Pathol42: 2lO
166. Shih YJ, et al (1990) J BioI Chern 265: 19-77 167. Short LF, Murray GF, Uptografft WR, et al (1984) Transferrin
levels derived from total iron-binding capacity: is it a reliable relationship? Am J Surg 148: 621-623
168. Siedel J, Wahlefeld A W, Ziegenhorn J (1984) A new iron ferro zine-reagent without deproteinisation. Clin Chern 30: 975 (AACCMeeting-Abstract)
169. Strant PW (1975) Alkoho1wirkung auf das Blut. Schweiz Med Wochenschr105: 1072
170. Thaler E, Balzar E, Kopsa H, Pinggera WF (1978) Erworbener Antithrombin-III-Mangel bei Patienten mit glomeruHirer Nephropathie. Haemostasis 7: 257
171. Thomas AJ, Bunker VW, Stansfield MF, Sodha NK, Clayton BE (1989) Iron status of hospitalized and housebound elderly people. QJ Med 70: 175-184
172. Thomas L, Kaltwasser JP, Kuse R, Pinggera W, Scheuermann EH, Wick P (1996) Konsensus-Konferenz: Eisensubstitution bei Dialysepatienten unter Erythropoietintherapie, Frankfurt (unveroffentlichte Mitteilung)
173. Thorstensen K, Romslo I (1993) The transferrin receptor: its diagnostic value and its potential as therapeutic target. Scand I Clin Lab Invest 53 [SuppI215]: 113-120
174. Tompson WG (1988) Comparison of tests for diagnosis of iron depletion in pregnancy. Am J Obstet Gynaecol 159: 1132-1134
175. Tosker PP, Deren JJ (1973) Vitamin Bl2 absorption and malabsorption. Gastroenterology 65: 662
176. Uchida T, Kokubun K, Abe R, Kimura H, et al (1988) Ferrokinetic evaluation if erythropoiesis in patients with myelodysplastic syndroms. Acta Haematol (Basel) 79: 81-83
Recommended Reading 125
177. Valcour AA, Krzymowski G, Onoroski M, et a1 (1990) Proposed reference method for iron in serum used to evaluate two automated iron methods. Clin Chern 36: 1789-1792
178. VanLente F, Marchand A, Galen RS (1979) Evaluation of a nephelometric assay for haptoglobin and its clinical usefulness. Clin Chern 25: 2007
179. Vogt C, Noe G, Rich IN (1990) Normal steady-state haemopoiesis assay of erythropoietin by regulator molecules in the bone marrow. In: Sachs L, Abraham NG, Wiedermann CJ, Levine AS, Konwalinka G (eds) Molecular biology of haematopoiesis. Intercept, Andover, pp 401-412
180. Wagner HA (1987) Haufigkeit und Friiherkennung des Eisenmangels bei Blutspendern. Arztl Lab 33: 93-98
181. Weigert M (1990) (personliche Mitteilung) 182. Whicher JT, Price CP, Spencer K (1983) Immunoephelometric and
immunoturbidimetric assays for proteins. CRC Crit Rev Clin Lab Sci 18: 213-260
183. Weiss TL, Kavinsky CJ, Goldwasser E (1982) Characterization of a monoclonal antibody to human erythropoietin. Proc Natl Acad Sci USA 79: 5465-5469
184. Wick M, Pinggera W (1994) (personliche Mitteilung) 185. Wognum A W, Lansdorp PM, Eaves AC (1989) An enzyme-linked
immunosorbent assay for erythropietin using monoclonal antibodies, tetrameric immune complexes, and substrate amplification. Blood 74: 622-628
186. Worwood M (1980) Serum ferritin. In:. Jacobs A, Worwood M (eds) Iron in biochemistry and medicine II. London, p 204
187. Yanagawa S, Hirade K, Ohnota H (1984) Isolation of human erythropoietin with monoclonal antibodies. J BioI Chern 259: 2707-2710
188. Oxford, March 1996, Consensus conference: Iron Replacement in Dialysis Patients (unpublished)
Recommended Reading
Albertini A, Arosio P, Chiancone E, Drysdale J (eds) (1984) Ferritins and isoferritins as biochemical markers. Elsevier, Amsterdam New York Oxford
Basset ML, Halliday JW, Bryant S, Dent 0, Powell LW (1988) Screening for hemochromatosis. Ann NY Acad Sci 526: 274-289
126 References
Begemann H, Rastetter J (1993) Klinische Hamatologie, 4. Aufl. Thieme, Stuttgart New York
Bernat I (1981) Eisenstoffwechsel. G Fischer, Stuttgart New York de Jong G, von Dijk JP, von Eijk HG (1990) The biology of transferrin.
Clin Chim Acta 190: 1-46 Garry PJ (1984) Ferritin. In: Hicks JM, Parker KM (eds) Selected ana
lytes in clinical chemistry. American Association for Clinical Chemistry Press, pp 149-153
Greiling H, Gressner AM (Hrsg) (1989) Lehrbuch der klinischen Chemie und Pathobiochemie, 2. Aufl. Schattauer, Stuttgart New York
Finlayson NDC (1990) Hereditary (primary) hemochromatosis. BMJ 301: 350-351
Forth W (1993) Iron, bioavailability, absorption, utilization. Wissenschaftsverlag, Mannheim
Huber H, Laffler H, Pastner D (1992) Diagnostische Hamatologie -Laboratoriumsdiagnose hamatologischer Erkrankungen, 3. Aufl. Springer, Berlin Heidelberg New York Tokyo
Kaltwasser IP, Werner E (Hrsg) (1980) Serumferritin: Methodische und klinische Aspekte. Springer, Berlin Heidelberg New York
Keller HL (1986) Klinisch-chemische Labordiagnostik flir die Praxis. Analyse, Befund, Interpretation. Thieme, Stuttgart New York
Linke R, Ktippers R (1989) Nicht-isotopische Immunoassays - Ein Uberblick. In: Borsdorf R, Fresenius W, Gtinzler H, et al (Hrsg) Analytiker-Taschenbuch, Bd 8. Springer, Berlin Heidelberg New York Tokyo, S 127-177
Schracksnadel W, Gabl F (1984) Die Diagnostik des gestarten Eisenstoffwechsels. Wien Med Wochenschr 3/4: 63-68
Thomas L (Hrsg) (1988) Labor und Diagnose, 3. Aufl. Medizinische Verlagsgesellschaft, Marburg
Williams WJ, Beutler E, Ersler AJ, Lichtman MA (eds) (1990) Hematology, 4th ed. McGraw-Hill, New York
Subject Index
Anemias 94 hemolytic 83, 86 hypochromic microcytic macrocytic 80, 81 normocytic 82, 86 renal 92 pernicious 81, 82 sideroachrestic 35, 97 tumor related 27,93
Antibodies 44 monoclonal 44 polyclonal 44
Antigen-antibody reaction 45 Antigen excess 46 Anulocytes 71 Auto-antibodies 37
against intrinsic factor 85 against parietal cells 84 cold antibodies 37 warm antibodies 37
Bilirubin 20, 111 Blood transfusion 76, 79 Bone-marrow diseases 98 Burr cells 29, 89
Cell necroses 80 CRP (C-reactive protein) 80, 104 Cofactors of erythropoiesis 97
Erythropoiesis 15 ineffective 76, 80 co-factors 29, 98
deficiencies 29 physiological 15
Erythropoietin 17, 62, 90 as tumor marker 91, 105 deficiency 103 therapy 103
Erythrocytes 15 degradation 17, 19 maturation 15 morphology 31
Ferritin 10, 13,47 apoferritin 10 isoferritins (acidic, basic) 10 organ-specific 12 structure 11
Ferritin concentration decreased 68 increased, non-representative
80 increased, representative 76, 77 merits, according to Mazza 63
Ferritin, determinations automation 49,67 reference range 51
Ferro Zine Method 39 Folic acid 29, 57, 60, 98
absorption test 84 deficiency 29, 81 requirement reference range 61 therapy 106
128 Subject Index
Frankfurt, Consesus Conference, January 1996 104
Haptoglobin 35, 55 Heidelberger and Kendall curve
46 Hematological Diagnosis 94, 96 Heme Iron 13 Hemochromatosis 77
idiopathic 79 primary, hereditary 78 secondary, acquired 79
Hemoglobin 17, 20, 66 degradation 20 free 36 HbAo, A2, Hb Bart's 17,30 HbF, HbH, HbS 17,31 synthesis 17
Hemoglobinopathies 30 Hemolysis 35, 36
auto-immune 38 corpuscular 37 extracorpuscular 37 intravascular 37 mechanical 37 toxic 38
Hemopexin 57 Hemosiderin 10, 12, 69 Hepatocytes 2, 11 Hypermenorrhea 72
Immunoassay methods 44 direct 45 indirect 45
Immunoassays 45 enzyme 45, 59 fluorescence 45 latex immunoagglutination 45 luminescent 45,49,60 nephelometric 45 radial immunodiffusion 45 turbidimetric 45, 56
Iron 39 active iron 64 day-to-day fluctuations 42 depot iron 64 Transport iron 5
Iron binding capacity (TIBC) 5,43 Iron determination 39 in bone marrow aspirate 68
determination without 39 with deproteinization 40
reference range 42 Iron deficiency 22, 70, 72
latent 70 manifest 70 pre latent 70 blood donation 21, 76 breast-feeding 73 competitive athletes 74 growth 22, 74 menstruation 23, 74 pregnancy 23, 74 unbalanced diet 23, 75
Iron distribution in the body 12, 64
Iron fraction in serum 42 Iron metabolism
absorption 64 distribution 64 disturbances 25, 26 losses 15 requirement 12 transport 4, 11
Iron saturation 7 Iron status 65 Iron storage 9 Iron storage proteins 44 Iron transport proteins 44 Iso-electric focusing 12,48
Lead poisoning 30 LDH 87, 82,111
Macrocytes 29,82
Subject Index 129
Malignant neoplasia 80 Myelodysplastic syndromes 105 Myoglobin 66, 68
Oxford, Consensus-Conference, March 1996 1 04
Porphyrias 31, 32
Renal failure 104 Reticulo-endothelia1 system
(RES) 10, 17,79
San Diego Declaration 104, 112 Schilling-Test 84 Sickle cells 37 Sickle cell anemia 32, 34 Spherocytes 32, 37 Spherocytosis 37
Target cells 32 Thalassemia 30 Therapeutic approaches in
anemias 101 Iron deficiency 101 Oral administration 101 Parenteral administration of
iron 102
Erythropoeitin deficiency 103 Renal failure 104 Tumour-induced anemias 105 Vitamin Bl2 deficiency 105 Folic acid deficiency 106 Autologous blood donors 107
Transferrin 5, 52, 96 isotransferrin 51, 52
Transferrin methods 52 clinical interpretation 96 clinical significance 97 reference range 53
Transferrin receptor 7,55,96 Transferrin saturation 7,53,97 Transferrin, TIBC 53 Tumors 93, 105
Uremic anemia 85, 89,92
Vitamin B6 deficiency 31 Vitamin Bl2 29, 57, 58, 98
absorption 8 deficiency 29, 81, 84 reference range 59 requirement 59 therapy 105
Zinc-protoporphyrin 26, 32
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