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Daniel Brodie
Critical Care Canada Forum
Toronto, Ontario
October 27th, 2015
Research in ECMO: A revolution is coming
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Daniel Brodie
Critical Care Canada Forum
Toronto, Ontario
October 27th, 2015
Research in ECMO: A revolution is coming???
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Faculty DisclosuresDaniel Brodie
Maquet CardiovascularResearch support
Research consulting
ALung TechnologiesMedical Advisory Board
KadenceMedical Advisory Board
International ECMO NetworkChairman, Executive Committee
ECMO is off label
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Advances in technologyPumps
Oxygenators
Biocompatible circuits
Catheters
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Rapid growth of ECMO
2009 to present
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2009 Influenza A (H1N1) pandemic
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Peek G, et al. Lancet 2009
CESAR Trial
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Active ECLS CentersELSO Registry January 2015
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Adult Respiratory CasesELSO Registry January 2015
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Adult Cardiac CasesELSO Registry January 2015
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But wait. . .
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Where’s the evidence?
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Del Sorbo et al. AJRCCM 2012
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0
100
200
300
400
500
600
700
800
900
60 62 64 66 68 70 72 74 76 78 80 82 84 86 88 90 92 94 96 98 0 2 4 6 8 10 12 14
Publication Volume
Pubmed search:Extracorporeal membrane oxygenation OR Extracorporeal carbon dioxide OR Extracorporeal CPR
9,192 references dating back to 1960
Spike 2010 to ~650 (from 300 in ‘09)
2015 annualized to 800 (same as 2014)
2010
1989
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What is the quality of the literature in ECMO?
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Abrams D, Combes A, Brodie D. JACC 2014
*
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Abrams D, Combes A, Brodie D. JACC 2014
*
*Cohort study with propensity analysis
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RCTs
for ECMO in ARDS
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Zapol 1979
Morris 1994
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Advances in technology. . .
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Modern RCT in ECMO
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Peek G, et al. Lancet 2009
CESAR Trial
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Peek G, et al. Lancet 2009
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Where should we go from here?
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Collaboration
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Why is collaboration so important to the future of ECMO research?
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ECMO is. . .
Complex
High risk
Expensive
Wide variations in technique
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We need to settle the most basic questions
Does it work?Who might benefit?
How to use it?How do our patients do long term?
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Need to advance the science of ECMO
Basic
Translational
Clinical questions
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How are we doing?
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ECMO Research
Fragmented across centers, countries, continents
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What should we do?
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First. . .
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Build top quality ECMO centers
Perform quality ECMO
Combes A, et al. AJRCCM 2014
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Why build top quality clinical centers before we even know ECMO works?
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To participate meaningfully in
high quality research
Zapol
Morris
Combes A, et al. AJRCCM 2014
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AJRCCM 2014
Call for research centers
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Do we need “top quality” centers
Or just more centers?
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Volume-outcome in ECMO?
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Retrospective review of ELSO database 1989-2013
290 centers
56,222 patients (30k neonatal, 15k peds, 11k adult)
AJRCCM 2015
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Higher age group-specific ECMO volume associated with lower odds of mortality
in neonatal & adult populations
2008-2013 only held in adults
≥ 30 adult ECMO cases/y OR mortality 0.61 (compared with < 6 cases/y)
AJRCCM 2015
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Not every center should be doing ECMO
in 2015
Regionalization
Highest quality, best practices
Combes A, et al. AJRCCM 2014
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Next. . .
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Drive collaboration
Across centers, countries & continents
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We need a research network in ECMO
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INTERNATIONAL ECMO NETWORK
ECMONet
www.internationalecmonetwork.org
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ECMONet Vision
To serve the ECMO research community
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Foster & support
High-quality, high-impact research ideas by investigators throughout the world
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International ECMO Network
Ongoing & Upcoming Studies
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ECMO to rescue Lung Injury
in severe ARDS
EOLIA
International RCT
PI: Alain Combes
Enrolling December 2011
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ECCO2R for Lung-protection
Moderate to severe ARDS
SUPERNOVA
Pilot Study
International, multicenter, RCT
PI: Alain Combes, Marco Ranieri
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LIFEGARDS
ventiLatIon management oF patients with Extracorporeal membrane
oxyGenation for Acute Respiratory Distress Syndrome
Steering committee
• Matthieu Schmidt (Paris, Melbourne) = PI
• Carol Hodgson (Melbourne)
• Vincent Pellegrino (Melbourne)
• Alain Combes (Paris)
• Eddy Fan (Toronto)
• Daniel Brodie (New York)
An international observational study
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Low-dose heparin in critically ill patients undergoing ECMO –
Single center, unblinded, randomized, feasibility study
The HELP-ECMO Study Investigators:C Aubron, V Pellegrino, D Pilcher, J Sheldrake, D Murphy, J Board,
L Hockings, J Cooper
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What percentage of ICU patients may be candidates for gas eXchange eXtracorporeaL
techniques?
The XXL study
PI: Laurent Brochard & Eddy Fan
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ASAP ECMOAntibiotic, Sedative and Analgesic Pharmacokinetics during ECMO
PI: Kiran Shekar
Multicentre study of population PK models in ECMO
250 subjects
Develop evidence-based guidelines
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International ECMO Network
Proposed Studies
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pRotective vEntilation with venovenouS lung assisTin respiratory failure
REST Study
UK collaborativeMulticentre, RCT
PI: Danny McAuley & James McNamee
ECCO2R for acute hypoxemic respiratory failureNot just ARDS
P:F < 150
1,120 subjects28 day mortality
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ANCHOR
Assessment of ECMO in acute myocardial infarction with Non-reversible, Cardiogenic
shock to Halt Organ failure & Reduce mortality
Prospective, open-label, multicenter, randomized, controlled trial
PI: Alain Combes
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ECMO PTECMO early staged physical training
Carol Hodgson
ANZIC-RC
ACTION CRE
240 subjects
Multicentre, assessor-blinded, RCT
Physical rehab within 48 hours of ECMO vs. no rehab
Outcomes: functional status & muscle strength
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ImmunoDeficiency and ECMO for Acute respiratory failure
IDEA study
Multicenter, retrospective cohort study
Matthieu Schmidt, Vincent Pellegrino, Carol Hodgson, Alain Combes, Eddy Fan, Daniel Brodie
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Multiple other high quality research efforts beyond ECMONet
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ECCO2R for COPD?
Need RCTs
Multiple planned international, multicenter RCTs
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Is a revolution coming?
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Certainly an evolution
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Active ECLS CentersELSO Registry January 2015
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INTERNATIONAL ECMO NETWORK
ECMONet
www.internationalecmonetwork.org
Need for high quality research