Research strategy for RNOH-IOMS
Research strategy for RNOH-IOMS
David Marsh
Professor of Clinical Orthopaedics
Institute of Orthopaedics and Musculoskeletal Science, University College London
Royal National Orthopaedic HospitalStanmore, UK
Trust BoardApril 2008Trust BoardApril 2008
A joint IOMS-RNOH academic strategy is an essential part of the
Outline Business Case
A joint IOMS-RNOH academic strategy is an essential part of the
Outline Business Case
• One of three stipulations in the letter from the SHA inviting submission:“set out a clear commitment to support the work of the university and its partners in achieving AHSC status and strengthening the Orthopaedic Institute”
Academic Health Science CentreAcademic Health Science Centre
• Joint Academic Plan:– integration of UG and
PG education – R&D management
into IOMS– Research strategy
EXCELLENCE,INTEGRATION
EDUCATION
RESEARCH
CLINICAL
How are we going to fund this?
Research StrategyResearch Strategy
• Focused on musculoskeletal system but full spectrum
• Five themes, building on track record and patient needs Innovative implant design Cell therapy and tissue engineering Disability and improvement of quality of life Building the musculoskeletal evidence base Sarcoma medicine
Basic scienc
e
Translational
Experimental
Clinical
trials
Health service
s researc
h
Tapping in to UCLTapping in to UCL
• Five centres in IOMS– Bioengineering– Tissue engineering– Clinical academic– Rehabilitation– Pathology
Basic scienc
e
Translational
Experimental
Clinical trials
Health service
s researc
h Innovative implant
design Cell therapy and tissue
engineering Disability and
improvement of quality of life
Building the musculoskeletal evidence base
Sarcoma medicine Cancer Institute
Centre for Ageing
Engineering
Musculoskeletal Consortium
UKCC
MRC NIHR
Basic scienc
e
Translational
Experimental
Clinical
trials
Health service
s researc
h
ARC, charities
EPSRCBBSR
C
FundingFunding
National Institute for Health Research - the new research environment
National Institute for Health Research - the new research environment
• Concentration of funded clinical research in fewer, larger centres– Large research teams– Epidemiology, health economics vital– Many Trusts giving up and outsourcing research management
• Competition with all other specialities - fierce– Priorities in cancer, neuro, endocrine, mental, children– Role of rheumatology
• Research governance demands tighter
Transform or fade out
NIHR funding streamsNIHR funding streams
• Comprehensive biomedical research centresSpecialist BMRCsBiomedical Research Units– Musculoskeletal in Oxford, Sheffield, Leeds
• Local Comprehensive Research Networks• HTA, RfPB, NEAT, RISC• Applied Research Programme Grants• Technology Support Board
MRC Translational Research CallMRC Translational Research Call
• £241m extra, most on translational research– Bottlenecks
• Pan-UCL bid going in– MRC Centre for Cell and Gene Therapy
• Stanmore hopefully to contribute cell therapy in the musculoskeletal system
Cell-based therapyCell-based therapy
• Clinical trials in ACI• Preclinical work on bone, collagen• Regenerative Medical Systems - UK• Translational teams
– Bone– Tendon– Cartilage
Stanmore Clinical Research FacilityStanmore Clinical Research Facility
• At present a joint venture between RNOHT and UCLB – may change
• Goal is to facilitate rapid study design, costing, governance and conduct
• Both investigator-led and commercial– All must be fully funded
• Building a clinical research network is crucial– eg fragility fractures and drugs that enhance
fracture healing
Research pipeline in cell-based therapyResearch pipeline
in cell-based therapy
Basic scienc
e
Translational
Experimental
Clinical
trials
Health service
s researc
hWhat phenotype of cultured cells produces the best clinical response?
Is it cost-effective to culture-expand cells rather than use bone marrow?
Can we design new way ways of efficiently expanding stem cells?
IOMS RMS-UK SCRF
Integrated Academic Training Programme
Integrated Academic Training Programme
• Four Academic Clinical Fellows• Two Clinical Lecturers
Academic Research
Board
Research Governanc
e Committee
Research Committee
Education Committee
Trust Board
PPI group
UCL and Partners Health
Sciences Research Deanery
UCL Dean and Research Vice-
Provost
Research Support StaffResearch Support Staff
• Academic Clinical Centre of IOMS• MRC Clinical Trial Unit support• Chair of Musculoskeletal Epidemiology
– Alex MacGregor – starting Sep 08
• R&D Director and Manager (Joseph Datukasi)• Nerina – Head of Academic Business Development• SCRF staff• IT systems for research support – Simon Grange
Research GovernanceResearch Governance
• MHRA inspection• Duties of Principal Investigators• Duties of RNOH as a sponsor• Our IT solutions
Support we can offerSupport we can offer
• Training– Executive GCP training– Research Pack– Best methodological practice in musculoskeletal research
• Governance– Integration locally with Risk assessment – Integration with Local Comprehensive Research Network
• Research– Finding Research Partnerships– Developing hypotheses and designing studies– Finding funding sources
05 06 07 08 09 10 11 12
Clinical Sen Lec
My tenure
Team building
MSK epidemiologist
BiostatisticianHealth economist
R&D DirectorR&D Manager
SCRF
Multidisciplinary MSc
Integrated Academic Training Programme
IT/governance supportMedical physics
Regenerative Medical Systems - UK
Joint academic strategy capacity building