Download - Spasmolitic Muscle Relaxants
7/21/2019 Spasmolitic Muscle Relaxants
http://slidepdf.com/reader/full/spasmolitic-muscle-relaxants 1/12
MUSCLE RELAXANTSMUSCLE RELAXANTS
SPASMOLITICSPASMOLITIC
OlehOleh
Wiwik KusumawatiWiwik Kusumawati
7/21/2019 Spasmolitic Muscle Relaxants
http://slidepdf.com/reader/full/spasmolitic-muscle-relaxants 2/12
A CASE
A 25-year-old paraplegic man whohad sustained a T3/T4 erte!ralcompression "racture 3 years
preiously presented with seere#pain"ul spasm o" the le"t hamstringmuscle group o" 2 hours$ duration%
This spasm produced e&treme knee'e&ion o" a degree which held the le"t"oot posterior to the right !uttock%
7/21/2019 Spasmolitic Muscle Relaxants
http://slidepdf.com/reader/full/spasmolitic-muscle-relaxants 3/12
SPASMOLITIK SPASMOLITIK
(pastisitas(pastisitas(pinal cord in)ury# *+#(pinal cord in)ury# *+#
sklerosis# strokesklerosis# stroke
,uscle spasm,uscle spasmTendon in)ury# in'ammationTendon in)ury# in'ammation
7/21/2019 Spasmolitic Muscle Relaxants
http://slidepdf.com/reader/full/spasmolitic-muscle-relaxants 4/12
SPASMOLITIK SPASMOLITIK
(pastisitas(pastisitasia.epamia.epam
aclo"enaclo"en
antroleneantrolene
Ti.anidineTi.anidine
7/21/2019 Spasmolitic Muscle Relaxants
http://slidepdf.com/reader/full/spasmolitic-muscle-relaxants 5/12
DIAZEPAMDIAZEPAM
en.odiasepineen.odiasepine
0AA 0AA A A
1ndikasi semua !entuk1ndikasi semua !entuk
ke)ang otot tu!uhke)ang otot tu!uh
osis 4 mg/hr mg/hrosis 4 mg/hr mg/hr6( sedasi6( sedasi
7/21/2019 Spasmolitic Muscle Relaxants
http://slidepdf.com/reader/full/spasmolitic-muscle-relaxants 6/12
BACLOFENBACLOFEN
Agonis 0AA Agonis 0AA // (pasmolitik akti" (pasmolitik akti"
,engurnagi nyeri dengan,engurnagi nyeri denganmengham!at rilis su!stansi +mengham!at rilis su!stansi +
6"ekti7tas sama dg dia.epam# e"ek6"ekti7tas sama dg dia.epam# e"ek
sedasi kurangsedasi kurang
7/21/2019 Spasmolitic Muscle Relaxants
http://slidepdf.com/reader/full/spasmolitic-muscle-relaxants 7/12
BACLOFENBACLOFEN
+O# a!sor!si cepat# T 8 3 sd 4 )am+O# a!sor!si cepat# T 8 3 sd 4 )am
9+6# 1ntratekal:9+6# 1ntratekal:
osis 2& ;5 mgosis 2& ;5 mg <ati-hati pada p& epilepsi<ati-hati pada p& epilepsi
7/21/2019 Spasmolitic Muscle Relaxants
http://slidepdf.com/reader/full/spasmolitic-muscle-relaxants 8/12
TIZANIDINETIZANIDINE
0olongan clonidin0olongan clonidin Agonis adrenoceptor- Agonis adrenoceptor-==22 ,eningkatkan ham!atan prasinaps dan,eningkatkan ham!atan prasinaps dan
pascasinaps pada cordapascasinaps pada corda ,engham!at transmisi nosisepti" pada,engham!at transmisi nosisepti" pada
cornu dorsalis medula spinaliscornu dorsalis medula spinalis 67kasi se!anding dengan dia.epam#67kasi se!anding dengan dia.epam#
!aclo"en dan dantrolen!aclo"en dan dantrolen 6( kantuk# hipotensi# mulut kering dan6( kantuk# hipotensi# mulut kering dan
asteniaastenia
7/21/2019 Spasmolitic Muscle Relaxants
http://slidepdf.com/reader/full/spasmolitic-muscle-relaxants 9/12
DANTROLENEDANTROLENE
eriat hydantoineriat hydantoin
1ntracellular calcium release1ntracellular calcium release
+O hanya ;/3 dia!sor!si+O hanya ;/3 dia!sor!si
Waktu paruh > )amWaktu paruh > )am
osis 25 mg/hr s!g dosis tunggalosis 25 mg/hr s!g dosis tunggal
6( kelemahan otot menyeluruh# sedasi#6( kelemahan otot menyeluruh# sedasi#
hepatitishepatitis Hipertermia maligna – IV 1mg/kg sd 10 Hipertermia maligna – IV 1mg/kg sd 10
mg/kgmg/kg
7/21/2019 Spasmolitic Muscle Relaxants
http://slidepdf.com/reader/full/spasmolitic-muscle-relaxants 10/12
SPASMOLITIK SPASMOLITIK
,uscle spasm,uscle spasm+rimary treatment+rimary treatment
*entrally acting skeletal*entrally acting skeletal
muscle rela&antmuscle rela&ant
7/21/2019 Spasmolitic Muscle Relaxants
http://slidepdf.com/reader/full/spasmolitic-muscle-relaxants 11/12
MUSCLE SPASMMUSCLE SPASM
*arisoprodol mepro!amate*arisoprodol mepro!amate9!usu:9!usu:
*hlorphenesin kehamilan #*hlorphenesin kehamilan #!usu# gg lier# kurang > minggu!usu# gg lier# kurang > minggu
*hlor.o&a.one *hlor.o&a.one
agranulositosis# hepatotoksisagranulositosis# hepatotoksis*yclo!en.aprine - tricyclic*yclo!en.aprine - tricyclic
antidepressantantidepressant
7/21/2019 Spasmolitic Muscle Relaxants
http://slidepdf.com/reader/full/spasmolitic-muscle-relaxants 12/12
MUSCLE SPASMMUSCLE SPASM
,ata&alone anemia,ata&alone anemiahemolitik# hepatotoksikhemolitik# hepatotoksik
,ethoca!amol p& tetanus,ethoca!amol p& tetanusOrphenadrine antihistamineOrphenadrine antihistamine
anticholinergic e?ect anticholinergic e?ect