Download - Theories of aging, anti aging
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Dr Ling Sien Ngan
Anti Aging, Aesthetic Medical Practitioner
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Theories of Ageing
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Edith Cowan UniversityFaculty of Communications, Health & Science
Post Graduate Study in Andrology & Men’s Health
5 December 2004
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
• Every single day, as we age , more and more people are dying of
cancer, or simply of old age
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
•Are you doing something about it?
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Lowel Anti Aging + Aesthetic Clinic , SS2 ,PJ
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Mission:
to enhance QoL
through comprehensive & integrated
anti aging & aesthetic healthcare services.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
1) Anti aging medicine• Balanced diet• Nutritional supplementations + antioxidants• Detoxification ( chelation, colon hydrotherapy, FIR
sauna, ozoniser okamizu• Correct, moderate exercise.• Weight management• Syndrome X + Mx of chronic deg dse -CDD• Osteoporosis• Bio –identical hormones• Occupational health noise , chemical• Stress Mx: relaxation meditation , yoga
• Chemoprevention & cancer
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Wellness IndustryWellness Industry
Sickness IndustrySickness Industry
Anti Aging Medicine is
Even here can still anti age !
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Visible Oxidation damage in action• Free radical damage/oxidative
stress, same process causing:
-Iron to rust
-Cut apple turning brown
-Underlying initiator of diseases, e.g.:
Pigmentation, wrinkle repairable by cream
CAD Multiple sclerosis
Cancer Alzheimer’s dementia
Stroke Macular degeneration
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Theories of Ageing
• Biologic, epidemiologic, + demographic data – an attempt to identify a cause or process;
• Ageing: an extremely complex, multifactorial process;
• Different theories not mutually exclusive;• Definition of ageing: open to various
interpretations.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Summary of Presentation
• Life span and Life expectancy.• Definition of Ageing.• What causes ageing?• Clinical approach to ageing.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Theories of Ageing
• Life span and Life expectancy.• Definition of Ageing.• What causes ageing?• Clinical approach to ageing.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Life Span
• Maximum life span is the theoretic species specific, longest duration of life, excluding premature unnatural life.– Jeanne Calment, died July 1997 at age of
122.
Lowland gorilla: 47 yrsHorse: 35 yrs
American hookworm: 15 yrsEarthworm: 6 yrs
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Life Expectancy
• Life expectancy is the average number of additional years expected for a member of a population, regardless of cause of death.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Theories of Ageing
• Life span and Life expectancy. • Definition of Ageing.• What causes ageing?• Clinical approach to ageing.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
What is Ageing?
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Ageing vs Senescence
• “Senescence”:– deteriorative processes that constitute
natural causes of death.
• “Ageing”:– processes of accruing maturity with the
passage of time, including...
George Martin. In: The ageing process, 1984
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Ageing vs Senescence
Positive aspects like:- becoming wiser
- mellow
- evolution of life style
… “just like wine, improves as it ages but not as it senesces”.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Stages of Lifespan• Prenatal life
• Birth
• Postnatal life
– neonatal
– infancy
– childhood
• early
• middle
• late
– adolescence
– adulthood
– senescence
• Death
fertilisation-10months
• birth thru’week 23 wks - 1st birthday
2 - 6 yrs7 - 10 yrsprepubertal
6 yrs following puberty20 - 65 yrs from 65 yrs
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LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
What is Ageing?
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• A ubiquitous biologic process, characterised by a progressive, inevitable evolution and maturation until death.
Susan A Gaylord, Mark E Williams. In: Geriatrics Review Syllabus, 1990
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Theories of Ageing
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• Life span and Life expectancy.• Definition of Ageing.• What causes ageing?• Clinical approach to ageing.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Ageing Process
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• primary ageing• secondary ageing
True primary ageing is an ongoing normal process.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Environmental hazards
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• Ionising radiation?• Pollutants?• Chemicals• Diet?• Ambient temperature?• Diseases?
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Theories of Ageing
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“The scientific study of ageing has been an odd mixture of the accumulation of mountains of dismal evidence that shows that almost anything you can think of goes wrong with age, and proposals of simplistic theories that try to explain ageing in terms of single processes, ranging from defective testicles to shortened telomeres.”
Brian Charlesworth, an evolutionary biologist
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Theories of Ageing
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• Research in ageing:– Traditional gerontologist– Evolutionary biologist
• 300 over theories till date!
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Theories of Ageing
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• “Programmed” theories – the biological clocks.
• “Error” theories – identify environmental insults.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Theories of Ageing
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• Evolutionary
• Molecular
• Cellular
• Systemic
Brian T. Weinert and Poala S. Timiras . Theories of Ageing.
J Appl Physiol 95: 1706-1716, 2003.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Evolutionary Theoriesof Ageing
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• Mutation accumulation
• Disposable soma
• Antagonistic pleiotropy
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Molecular Theoriesof Ageing
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• Gene regulation• Codon restriction• Error catastrophe• Somatic mutation• Dysdifferentiation
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Cellular Theoriesof Ageing
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• Cellular senescence – Telomere theory
• Free radical
• Wear-and-tear
• Apoptosis
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
System Theoriesof Ageing
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• Neuroendocrine
• Immunologic
• Rate-of-living
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Theories of Ageing
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• Biological theories– genotropic– environmental
• Psycho-social theories:– Disengagement – Exchange – Labelling– Social Stratification– Political economy– Continuity
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Summary of Presentation
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• Life span and Life expectancy.• Definition of Ageing.• What causes ageing?• Clinical approach to ageing.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Clinical Approach to Ageing
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True ageing vs disease statesBiologic ageing vs chronologic ageing
Promoting positive ageing
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Positive Ageing: Pre-requisites
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• Ageing is not denied;• Perceptions and understanding of
ageing are not disempowering;• Differences between people are
acknowledged.
Mary Davies
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Reconceptualisation of Ageing?
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Ageing exclusively characterised by declines in function & in health?
Substantial heterogeneity?
Existence of positive trajectories of ageing?
Possible avoidance of age-related diseases and disabilities?
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
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Mechanisms of successful ageing
• Persistence of normal function and plasticity• Compensatory responses to restore function • Interventions to replace deficient function• Changing of health outcome by modifying risk
profiles• Prevention of diseases• Strengthening of social interactions and
support
Brian T. Weinert and Poala S. Timiras .
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
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Promote Positive Ageing
• Acceptance of ageing• empowerment• individuality• physical activity• social contact/friendship• developing coping skills• valuing experience,
knowledge etc.
• Denial of ageing• disempowerment• being stereotyped• sedentary lifestyle• social withdrawal• psychological stress• overvaluing paid work
Brendan Kennelly
Encourage Avoid
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Conclusion
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• Ageing process is multifactorial and complex;
• Research is still ongoing to determine the cause(s) or explain the process of ageing;
• None is conclusive;• One important goal: how does intervention
signals the body to delay ageing?• “Successful” ageing is possible.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Reading List
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• Brian T. Weinert and Poala S. Timiras . Theories of Ageing. J Appl Physiol 95: 1706-1716, 2003.
• Ageing: A natural history; 1995, RE Ricklefs, CE Finch (WH Freeman & Co).
• Evolutionary biology of aging; 1991, MR Rose (New York: Oxford University Press).
• The Aging Process: therapeutic implications; 1984, RN Butler, AG Bearn (Raven Press).
• Geriatrics Review Syllabus: A core curriculum;1989, JC Beck (American Geriatrics Society).
• Aging as a biological phenomenon: Review in Clinical Gerontology, Vol 1, No. 1, 1991.
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
How to choose Miss universe supplements ?
• GMP --Supp manufacturing : poorly regulated --Pharm factory adherence > food factory pharm grade OTC
sure better• Label, full disclosure + address --Contain actual amount stated
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Choose Ms universe supplement
• Where products marketed ? --Only locally in USA , < stringent --To Canada, Australia, Europe >
stringent send on-site inspection regularly
--3rd party certification on Quality of manufacturing
• QC testing ( dissolvability ) --3/9 prenatal Vit ever dissolved – Uni
of marryland
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Antioxidant help good cell• Side effect of chemo, radio = oxidative stress to
normal cell• Taking ^ dose antioxidant ^ defense of normal
cell while on chemowhile chemo work at peak, side effect @
minimal--- win-win• Cancer cell receive double whammy
– Oxidative stress from antioxidant (now pro-oxidant)– Chemo stress
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Vit E
Co Q10
B-carotene+ vit A
Against damage by chemo to lung, liver, kidney, heart, skin
Against damage by Adriamycin to heart
< side effect of chemo + radio Rx
All these antioxidant protect against damage to DNA of normal cell
From chemo + Radio Rx
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
INTERNAL BEAUTY CARE
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
If ageing can be halted...
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Would you choose to be in it?
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
SEEKING A GOOD LIFE
STYLE? Physically and
emotionally strong
Age gracefully
Feel good factor
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
Be all that you are Show it off
• VIBRANT
• RADIANT
• VITALITY
Thank you
LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant
My contact
• E mail; [email protected]
• Web; www.aestheticandyou.com
• You tube; www.youtube.com/lowelantiaging
• Face book; www.facebook.com/drdavidling