Download - Tolstoy Target,Mult Obj,Evolving Enzymes
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Tolstoy Targets for Evaluating Multiple Objectives
in Arrays of Candidates
Dennis E Sweitzer, Ph.D.
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Tolstoy?
Failure in a few ways Failure of the whole⇒
Happy families are all alike; Every unhappy family is unhappy in its own way.
--Leo Tolstoy, Anna Karenina
Successful projects are all alike; Every unsuccessful project fails in its own way.
--Someone else…….
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BasicsEach Axis: An AttributeEach target:• Green: Go (acceptable)
Red: (STOP) (unacceptable)• Yellow: (SLOW) (marginal/uncertain)
The Waterline Convention:• Below: Any Red Sinks the Candidate• Above: Need >1 Green
36 Candidates at a glance:
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Subsequent GenerationsWeed: Pick the BestSeed: Base next on Best
Array of Tolstoy Targets allow rapid identification of best
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Dominate Candidates(1) Superior to ≥1 other in all
attributes (2) No other candidate dominates it
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Focus on Dominant Candidates
• Below the waterline: Must have ALL Green (Any Red Sinks the Candidate)• Above the waterline: Must have ONE Green