1. Seattle Trip ReportData Integration Company Engagement BigDataDenis C. Bauer | Research Scientist19 November 2012CMIS

2. About me BSc (Germany) Bioinformatics + Hons (ITEE, UQ) In Silico Protein Design Machine Learning PhD (IMB, UQ) Quantitative models of Transcriptional regulation Optimization PostDoc (IMB, UQ) Sorting the intranuclear proteom Bayesian Networks PostDoc (QBI, UQ) Bioinformatics for the Sequencing Facility Operation Research Scientist (CSIRO) Data integration of Omics data in CRC Develop protocols for data generation Develop pipelines for analysis Research ways for data integration pHealth (Garry Hannan) 3. Seattle: Future hub for life sciences?Seattle Trip Report | Denis C. Bauer | Page 3 4. Primary Goal: Collaboration withWilliam NobleBayesian Network for automaticgrouping of genomic functional elements(TSS, gene) by learning simultaneously frommeasured genomic features (histone Bill Noblemodifications) Michael HoffmanSeattle Trip Report | Denis C. Bauer | Page 4 5. Segway: predictions Histone Modifications H2M3 x0x00x0xx00x00x000x000x00x000000x00x00xxxxx00xx0x00xxxx0x00x0xx00x00x000x000x00x000000x00x00xxxxx00xx0x00xxxx0x00x0xx00x00x000x000x00x0 H3M4 x0x00x0xx00x00x000x000x00x000000x00x00xxxxx00xx0x00xxxx0x00x0xx00x00x000x000x00x000000x00x00xxxxx00xx0x00xxxx0x00x0xx00x00x000x000x00x0 H3M4 0x0xx00x00x000x000x00x000000x00x00xxxxx00xx0x00xxxx0x00x0xx00x00x000x000x00x000000x00x00xxxxx00xx0x00xxxx0x00x0xx00x00x000x000x00x00000 Bayesian Network Train Segmentation & Classification AnnotationPresentation title | Presenter name | Page 5 6. Institute for Systems Biology: case studyfor BigDataTCGA has 20 different cancertypes with up to 900 sampleseach. Faster computers Better approachesAmazon: machine learning method for uncovering Ilya Shmulevichmultivariate associations from large and diverse data sets.Google: Use 10.000 600.000 cores and benefit fromGoogle expertise in compute and storage.Seattle Trip Report | Denis C. Bauer | Page 6 7. ISB App Engine Presentation at Google IO 2012http://popcorn.webmadecontent.org/4d3Seattle Trip Report | Denis C. Bauer | Page 7 8. Focusing on large scale and tactile interactive experiences that engross and envelope the visitor, Philip Worthington (1977-) created Shadow Monsters, a digital version of the traditional shadow puppet.Seattle Trip Report | Denis C. Bauer | Page 8 9. Can CSIRO use outline-detection to do cool stuff ?Seattle Trip Report | Denis C. Bauer | Page 9 10. Road Trip to Pacific Northwestern National LaboratoryPresentation title | Presenter name | Page 10 11. Road Trip to PNNLPresentation title | Presenter name | Page 11 12. Road Trip to PNNLPresentation title | Presenter name | Page 12 13. Road Trip to PNNLPresentation title | Presenter name | Page 13 14. Road Trip to PNNLPresentation title | Presenter name | Page 14 15. Road Trip to PNNLPresentation title | Presenter name | Page 15 16. Enterprise-wide multidisciplinarycollaborationsPNNL predicts from sensor data if and whenradioactive material hits ground water.Mathematical and visual prediction methods ofcompute-intensive expert systemsIans team develops a framework that allowsenterprise wide collaboration Data sharing/annotation/provenance Computational expert pipelines -> graphical programming -> domain experts Developed for computer-grid infrastructure Ian GortonSeattle Trip Report | Denis C. Bauer | Page 16 17. Commoditize parallelizationComputer Science & EngineeringUniversity of WashingtonCurrently: Expert-system if !(embarrassingly parallel) Deciding how to most efficiently bundle for parallel execution and how to resolve The appropriate method can change with the actual load at runtimeParallelization needs to become something thecompiler at run time works out for us(just like we dont write assembly code anymore) SciDB SKEWTUNE (better load for Hadoop) HaLoop (Iterative parallele Data Processing) Magdalena BalazinskaPresentation title | Presenter name | Page 17 18. Commoditize parallelization (andvisualization)HDInsight Hadoop on windows Server and Azure Integration with excelPowerView Interactive graphicsSeattle Trip Report | Denis C. Bauer | Page 18 19. Collaboration options GS (Bill): Bayesian Network ISB (Ilya): Variant association CS (Magda): Iterative parallelization PNNL (Ian): Graphical programming FrameworkThank youCMISDenis C. BauerResearch Scientistt +61 2 9325 3174E Denis.Bauer@csiro.auw www.csiro.au/cmisCMIS