Download - Unit 5 Part 2: CANCER – CELLS GONE WILD!
Unit 5 Part 2: CANCER CELLS GONE WILD!
The summary color on the following slides is red; vocabulary words
are underlined! Adapted from PPt by Karobi Moitra (Ph.D) NCI
Frederick , NIH Cancer Inflammation Program Human Genetics Section
Frederick MD. Dreams I look to the sky and what do I see?A castle,
a rainbow, and dreams for me,An end to this battle that I must
fight,To rid my feelings of depression and fright,An end to cancer
is not far away,It will be here someday... someday. ~ Anonymous Has
cancer ever touched your life? Turn and talk with your neighbor.
Animation 1 - What is Cancer?
Image Earliest Mention of Cancer
1600 BC The earliest written description of cancer known to exist
is an ancient Egypt papyrus.It describes eight cases of breast
tumors or ulcers. Papyrus Interactive Link Image Origin of The Word
Cancer
The origin of the word cancer is credited to the Greek physician
Hippocrates (460377 B.C.), considered the "Father of Medicine."
Hippocrates used the terms "carcinos" and carcinoma to describe
tumors. In Greek, these words refer to "crab", most likely applied
to the disease because the finger-like spreading projections from
cancer called to mind the shape of a crab. "Hippocrates Examining
an Animal Skull."History of Modern Science and Mathematics. Charles
Scribner's Sons, 2002.Science in Context. Web. 2 Nov Origin Cont.
The Roman physician, Celsus (25-50 B.C.), later translated the
Greek term into "cancer", the Latin word for crab. Image
https://upload.wikimedia.org/wikipedia/commons/6/6a/Aulus_Cornelius_Celsus.jpg
Origin Cont. Galen (A.D ), another Greek physician, used the word
"oncos" (Greek for swelling) to describe tumors. Galen's term is
now used as a part of the name for cancer specialists --
oncologists. Image Cancer & the Cell Cycle During the cell
cycle, there is a complicated series of checkpoints to ensure that
everything is going according to plan. When something happens to
the genes for these checkpoints, cancer can develop. Cancer is a
group of related diseases which are characterized by uncontrolled
cellular growth and division. Fourth or later mutation Third
mutation Second First Cell Suicide or Apoptosis Cell damage no
repair Cancerous cells divide when they should not divide and they
lack the normal control systems to shut off unwanted cell division.
Animation 2 Image
http://www.nature.com/nrc/journal/v4/n9/images/nrc1430-f3.jpg
Turn and talk with your neighborabout the photographs on the screen
what do you see are clear differences between the normal cells in A
and the cancerous cells in B and C. R Cell death = Cell growth In
most cases, cancer forms a cell mass called a tumor.
Lung Carcinoma Image Breast Mammogram Image R Types of Tumors
Benign tumor has restricted growth and tends to remain in one area.
EX wart. Malignant tumor -does not remain localized but invades
other tissue and gives rise to secondary tumors in other parts of
the body (metastasis). R What is Metastasis? Metastasis when a
cancer travels to different parts of the body, usually through the
blood stream R Causes of Cancer Carcinogen -substances and
exposures that can lead to cancer Radiation including the sun
Alcohol Engine exhaust Tobacco smoke Certain chemicals Cancer can
also be caused by random mutations and exposure to certain viruses.
R Cancer of the Young Turn and talk with your neighborabout the
graph and the details on adolescent cancer between 15 and 24 years
old. Video
Imagehttp://www.cancer.gov/research/progress/snapshots/adolescent-young-adult