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Using bioinformatics for better understanding of
genes
Becky SeipeltKarla Marriott
Arlin ToroVilma Martinez
Roger Luihttp://artedi.ebc.uu.se/course/BioInfo-10p-2006/projects/katarzyna/bioinformatics.jpg
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DNA RNA PROTEIN Function phenotype
PromotersGene finding
Variation Probability
DOGMA
TranscriptionSplicingEditingModifications
Human Gene Variation
TranslationEditingModificationsStructureComplexes
TRANSLATE
StructureComplexes
1. Gene finding 2. Case study using a normal and a known mutant gene
Ideas
A FEW Resources
Proposed activities
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Becky Seipelt, Middle Tennessee State [email protected]
• Active learning activity– Perhaps animation comparison
• Give a small sequence file with 2-5 genes within.
• Ask students to figure out how the cell “knows” where a gene is, i.e., where to start and stop transcription, and where to start and stop translation.
• Introduce ‘gene finding’ algorithms for comparison (DOGMA)
• Ask students to compare how “we” and nature differ?
•Honors Genetics (BIOL3250H) •2 blocks of 3 hours•Sophomore-seniors, mostly sophomores•Transcription and translation “learned” at least twice, perhaps more•Goals:
•deeper understanding of processes and regulation•more engaged students
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Lab exercise-Mitochondrial DNA Analysis
http://www.edvotek.com/images/332.jpg
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Students will use DOGMA to identify
genes that they amplify with PCR
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Working with the Sequence
Blast and other analysisevolutionary problems
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How this project using DOGMA will help me teaching my genetics course
The next time I teach the part of genomes and proteomes in my genetics course, in the explanation of comparative genomics, I can show similarities between different genomes and introduce them the evolutionary relationships between organisms of different species and the information that some species are more related than others.
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Ideas for my courseComputational and systems biology
7-week course.For comp. bio. part, either do sequence alignment problem if more math majors
OR bioinformatics using data and software available on the web like what I have
learned in this conference.
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Forensic Biology
• Development of new course targeting seniors and juniors
• Involves lecture and laboratory• Research- DNA sequencing, translation and
transcription to protein• Using software such as DOGMA, Translate, BLAST