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Alan Hopkins, MDCEO YourLabWork
Using biomarkers to prevent premature aging
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Alan Hopkins, MDAssistant Clinical Professor
Department of Surgery and Perioperative CareDell Medical School
University of Texas at Austin
MD, Loma Linda University Medical CenterAlpha Omega Alpha
Board Certified Emergency Medicine Physician
Former Consultant, Biophysical CorporationNBC’s Biggest Loser, Oprah Show
Former Medical Director, PHDx, Inc. –An Advanced Diagnostic Laboratory
CEO/Founder YOURLABWORK, LLC –Direct Access Lab Testing for the Public
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Only come when you are sick
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Objectives• Fundamentals you need to know• Basics on Hormones and proper testing• Nutrients for proper metabolism• Thyroid testing done right• What science has to say about the latest in blood
vessel health• The value of inflammatory blood tests• How insulin impacts weight loss and predicts future
disease• Special offer for Hormonesbalance
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hs-CRPHomocysteine
A1cGlucoseInsulin
CortisolThyroidSex HormonesFat Hormones
AdvancedLipid Panel
Vitamin DB12FolateFerritinMg
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The Basics on Hormones And Proper Testing
Hormones are measured via blood, urine or swab testing
Best ways to measure some hormones is thru blood:insulinthyroidfat hormones
What about female hormones?DUTCH complete testing (urine)
What about Adrenal Hormones?DUTCH testing (urine), or AM cortisol (blood), or saliva (swab)
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4-5 dried urine specimens throughout the day
Complete assessment of sex hormones
Comprehensive assessment of adrenal hormones and their metabolites
Designed to be optimally effective for most forms of hormone replacement therapy
Also measures neurotransmitter metabolites
DUTCH Complete
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The 3 most common nutrient deficiencies
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90% of Americans are deficient in Omega 3s:
1. Lower inflammation2. Increase HDL cholesterol3. Lower triglycerides4. May lower homocysteine5. Have been shown to lower Lp(a)6. Can help change a LDL Pattern B to a Pattern A7. Protects you from Osteoporosis – chronic inflammation disturbs
bone metabolism
Omega 3:6 Index
Am J of Clinical Nutrition 2000; 71: 1085Diabetes Res Clin Practice 1995:28-35Nature Review Drug Discovery 2012; 11(3), 234-50
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70% of Americans are deficient in Vitamin D:
1. Bone Building (Protection from Osteoporosis)2. Less cancer3. Less autoimmune disease4. Better control of blood pressure5. Less depression6. Increases HDL7. Better function of insulin8. Improved neurological function
Vitamin D
Sources:AMJ Cardiology 2010; 106:963Lancet 1998; 352(9129): 709-710Cancer 2002; 94(6): 1867-75J of Clinical Lipidology 2010; 4:113
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Up to 80% of Americans are deficient in Magnesium:
1. Important in muscles and nerves2. May aid in sleep3. May lower blood pressure4. Less depression5. Less fatigue
Magnesium
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Nutritional Testing
• Omega 3:6 Index• Vitamin D• RBC Magnesium• Vitamin B12• Serum folate (Vitamin B9)• Serum ferritin
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hs-CRPHomocysteine
A1cGlucoseInsulin
CortisolThyroidSex HormonesFat Hormones
AdvancedLipid Panel
Vitamin DB12FolateFerritinMg
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Thyroid Physiology
Feedback by thyroid hormones to regulate TSH
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Thyroid Labs
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hs-CRPHomocysteine
A1cGlucoseInsulin
CortisolThyroidSex HormonesFat Hormones
AdvancedLipid Panel
Vitamin DB12FolateFerritinMg
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Education Center
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Lp (a) Treatment Strategies
• Full biomarker evaluation to assess inflammation, advanced lipid panel, presence of insulin resistance, prediabetes or diabetes
• Fasting glucose < 100• hs-CRP < 1• Control of blood pressure <120/70• Smoking cessation• Family screening• Will go higher after menopause without protective
estrogen
Education Center
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hs-CRPHomocysteine
A1cGlucoseInsulin
CortisolThyroidSex HormonesFat Hormones
AdvancedLipid Panel
Vitamin DB12FolateFerritinMg
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•Diet–Sugar–Trans and saturated fats–Polyunsaturated omega 6 oils (except GLA)–Insufficient fruits and vegetables–Dairy, gluten, coffee
•Stress•Lack of exercise•Toxins (metals, petrochemicals)•Infections – esp. dental•Obesity/ Insulin Resistance
Causes of Inflammation
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•Increase risk for stroke and heart attack
•Increase in autoimmune disease
•Increase in hot flashes in perimenopausal and menopausal women
Problems with Inflammation
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hs-CRP
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hs-CRPHomocysteine
A1cGlucoseInsulin
CortisolThyroidSex HormonesFat Hormones
AdvancedLipid Panel
Vitamin DB12FolateFerritinMg
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Interrelation Between Atherosclerosisand Insulin Resistance
Hypertension
Obesity
Hyperinsulinemia
Diabetes
Hypertriglyceridemia
Small, dense LDL
Low HDL
Hypercoagulability
InsulinResistance Atherosclerosis
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•Fasting insulin: “Insulin Resistance Syndrome”< 2 is optimal
•Fasting glucose (your blood sugar that day):70--85 or less is optimal<100 = normal100-125 = prediabetes>125 = diabetes
•Hemoglobin A1c (3 month sugar measurement):<5.4% optimal<5.7% normal5.7-6.4 prediabetes>6.5% diabetes
Testing sugar metabolism
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“Insulin Resistance Syndrome”Problems with weight loss, especially after menopause
•Blood testing shows:•High fasting insulin•May or may not yet have high blood sugars and A1c levels
•Improved blood sugar control may improve hot flashes
•Insulin resistance syndrome is the #1 cause of PCOS in premenopausal women
•Blood tests show high fasting insulin•Elevated testosterone levels•Abnormal LH/FSH ratio, >2:1 ratio
Problems with Sugar
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Obvious signs for most people
high: increased thirst low: anxious/shakyincreased urination sweatingfatigue moodyblurry vision lack of focus
Premenopausal women:
acne, irritability, missed periods (PCOS)trouble with weight loss
Postmenopausal women:
increased hot flashesincreased belly fat
Signs of Sugar Problems
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Objectives
• Order labs yourself and get educated!• www.yourlabwork.com/hormonesbalance
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Special Offer
https://yourlabwork.com/hormonesbalance
$20 off coupon for you Coupon code: hormonesbalance
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• 5 Hours of Video Lab Review, specific to each Pillar of Health• PowerPoint lecture downloads and evidence-based tools you can
use• In-depth explanations of each individual tests
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Special Offer
includes >60 blood tests
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Special OfferLAB MASTERCLASS
+60 blood tests
+Optimal Value Lab Cheat Sheets
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Special OfferLAB MASTERCLASS
+60+ blood tests
+Optimal Value Lab Cheat Sheets
+Access to Group Lab Review Webinar
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• Learn from others interacting• Understand how conventional doctors look at the labs vs.
functional or anti-aging providers
Group Lab Review
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Quest Draw Station Nearby?