Download - Using the CDD Vault for MM4TB
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Using the CDD Vault for MM4TB Sean Ekins PhD, DSc.
CSO, Collaborative Drug Discovery, IncBurlingame, CA
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The Exploitation pathway…
Research Information system (RIS)
Technology transfer Entrepreneurship Networking
Torbjörn IngemanssonEuropean Commission
Sean EkinsCollaborative Drug Discovery, Inc.
Claire SkentelberyEuropean Biotechnology Network
Bonny HarbingerNational Institutes of Health
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“by provisioning the right amount of storage and compute resources, cost can be significantly reduced with no significant impact on application performance”
Cloud
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CDD- a decade of drug discovery collaborations
2004 - presentSaaS
Easy to use
Used by AcademiaIndustry, Biotech
Private
Selective collaboration
100’s of published datasets
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NIH funded STTR collaboration
Some collaborations outside also
1R41AI088893-012R42AI088893-02
Developing molecules for TBUsing computational data miningNew technologies for TB drug discovery
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From Desktop to Mobile apps – making data accessible
Clark et al., submitted 2014
Predict targets
http://goo.gl/vPOKS
http://goo.gl/iDJFR
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Drug discovery is repetitive and there are 1000s of diseases
Drug discovery is high risk
Do we need robots or just smarter programs that discover the ideas we test?
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24 groups in this project use a single
Participants from India, Russia, South Africa, Europe, USA
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TB Drug AcceleratorAnother example of a big TB collaboration7 Big Pharma and 4 academic institutes will open up targeted sections of their compound libraries and share data with each other.
• Abbott• AstraZeneca• Bayer • Eli Lilly• GlaxoSmithKline• Merck • Sanofi • Infectious Disease Research Institute (IDRI)• NIH National Institute of Allergy and Infectious
Diseases• Texas A&M University • Weill Cornell Medical College
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The Big Picture• This did not happen overnight – 10 years to get here!• Collaboration and selective secure sharing is key – move
ideas and data – to clinical compounds• Domain expertise in drug discovery• Bring scientists together globally• Grants can accelerate / catalyze collaboration• Grants can fund further technology development• Impact how we develop therapies