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actin
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actin troponin
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actin troponin
tropomyosin
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actin troponin
tropomyosin
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actin troponin
tropomyosinmyosin binding site
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Ca2+Ca2+ Ca2+ Ca2+
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Ca2+Ca2+ Ca2+ Ca2+
Calcium ions are released from the sarcolemma after stimulation from the T system
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Ca2+Ca2+
Ca2+
Ca2+
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Ca2+Ca2+
Ca2+
Ca2+
the calcium ions bind to the troponin and changes its shape
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Ca2+Ca2+
Ca2+
Ca2+
the calcium ions bind to the troponin and changes its shape
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Ca2+Ca2+
Ca2+
Ca2+
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Ca2+Ca2+
Ca2+
Ca2+
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Ca2+Ca2+
Ca2+
Ca2+
the troponin displaces the tropomyosin and exposes the myosin binding sites
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Ca2+Ca2+
Ca2+
Ca2+
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Ca2+Ca2+
Ca2+
Ca2+
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Ca2+Ca2+
Ca2+
Ca2+
the bulbous heads of the myosin attach to the binding sites on the actin filaments
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Ca2+Ca2+
Ca2+
Ca2+
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Ca2+ Ca2+
Ca2+
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Ca2+ Ca2+
Ca2+
the myosin heads change position to achieve a lower energy state and slide the actin filaments past the stationary myosin
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Ca2+ Ca2+
Ca2+
APi PiPiAPi PiPiAPi PiPi
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Ca2+ Ca2+
Ca2+APi PiPi
APi PiPi
APi PiPi
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Ca2+ Ca2+
Ca2+APi PiPi
APi PiPi
APi PiPi
ATP binds to the bulbous heads and causes it to become detached
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Ca2+ Ca2+
Ca2+
APi PiPiAPi PiPi
APi PiPi
ATP binds to the bulbous heads and causes it to become detached
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Ca2+ Ca2+
Ca2+
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
hydrolysis of ATP provides the energy to “re-cock” the heads
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Ca2+ Ca2+
Ca2+
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
hydrolysis of ATP provides the energy to “re-cock” the heads
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Ca2+ Ca2+Ca2+
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
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Ca2+ Ca2+Ca2+
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
calcium ions are re-absorbed back into the T system
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APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
calcium ions are re-absorbed back into the T system
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APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
the troponin reverts to its normal shape and the tropomyosin move back to block the myosin binding sites
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APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
the troponin reverts to its normal shape and the tropomyosin move back to block the myosin binding sites
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APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
the troponin reverts to its normal shape and the tropomyosin move back to block the myosin binding sites
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APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
phosphocreatine regenerates ATP
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APi Pi
PiAPi PiPi
APi PiPi
phosphocreatine regenerates ATP
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APi PiPiAPi PiPi
APi PiPi
phosphocreatine regenerates ATP