Wehrens et al. 2001. Circulation. 102:584-90

Abriel et al. 2001. Circ. Res. 88:740-5

Rivolta et al. 2001. JBC. 276(33):30623-30630

WT Simulation

Veldkamp et al. 2000. Circ. Res. 86:e91-97

Supplemental Figure 1

P2/

P1

P1-P2 interval (ms)

A

B

C

D

E

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

1

1 10 100 1000

Kambouris et al. 2000. JCI. 105:1133-40

F

WT

WT

WT

WT

WT

Recovery time (ms)

WT simulation

Chandra, Starmer and Grant. 1998. AJP. 274. H1643-54.

See also Rook et.al. 1999. Cardiovascular Res. 44. 507-17

Makita et. al. 2000. Circulation. 101:54-60.

Rivolta et. al. 2001. JBC. 30623-30630.

Membrane potential (mV)

-120 -80 -40 0

0

0.2

0.4

0.6

0.8

1A

vaila

bilit

y/co

nduc

tanc

e

Supplemental Figure 2

A

B

C

D

Abriel et. al. 2001. Circ. Res. 88:740-45.

Wehrens et. al. 2000. Circulation. 102:584-590.

WT

WT

WT

availabilityactivation