Download - Winnie Svendsen, DTU
www.nanotech.dtu.dk/nabis
Point-of-Care devices
Winnie E. Svendsen
DTU Nanotech
www.nanotech.dtu.dk/nabis
Point of Care - Health
http://www.continuaalliance.org/about-the-alliance
www.nanotech.dtu.dk/nabis
Point of Care – Health
http://health.rush.edu/HealthInformation/Care%20Guides/28/000278.aspx
www.nanotech.dtu.dk/nabis
Point of Care Technology
Ref: Center for Bio photonics Science and technology University of California
www.nanotech.dtu.dk/nabis
Point of Care – Enviroment
Vandforurening i Kalundborg Børnehave ramt af vandforurening på tredje uge Udgivet den 02.01.2013 21:18
Advarsel: Drik ikke vandet i KBH Fredag d. 19. aug. 2011 kl. 17:11
2013
2012
2011
Stadig forbud mod brug af vand i centrum af Kalundborg Udgivet den 20.12.2012 21:09 af TV2 ØST's Redaktion
www.nanotech.dtu.dk/nabis
Point of Care – Enviroment
The Law : Lab test • 30 test per year • 72 hours response time
www.nanotech.dtu.dk/nabis
Nano Bio Integrated Systems (NaBIS )
2012
Micro and Nano Sensor Platforms
Microfluidic Sample handling and manipulation
Bio – Medical Applications
Our vision is to incorporate our research in point of care (POC) technology for diagnostic and monitoring. This is achieved by application-driven research, adapting and refining methodologies to micro- and nanotechnology within bio-medical fields
www.nanotech.dtu.dk/nabis
Nano Bio Integrated Systems (NaBIS )
Micro and Nano Sensor Platforms
Bio – Medical Applications
Microfluidic Sample handling and manipulation
www.nanotech.dtu.dk/nabis
Point of Care – Sensors
Micro and Nano Sensor Platforms
Bio – Medical Applications
Microfluidic Sample handling and manipulation
www.nanotech.dtu.dk/nabis
Point of Care – Sensors
www.nanotech.dtu.dk/nabis
Nano Bio sensors - Health
Biomedical engineering for cancer
and brain disease diagnosis and therapy development
A screenning system for The plasmacytosis virus in Mink
http://www.engcabra.eu
www.nanotech.dtu.dk/nabis
64 chips
4 SiNW on one chip
The Silicon Nano Wires Sensor
300 nm
SiNW h= 50 nm l = 200 µm w= 50 µm
www.nanotech.dtu.dk/nabis
SiNW h= 50 nm l = 200 µm w= 50 µm
Azeem Zulfigar
www.nanotech.dtu.dk/nabis
Semiconducting Nanowire Sensor
+ +
Acceptors Holes (mobile)
=> Get a chage in conductance (DG/G)
+ + + +
+
- - -
Receptors binding a target molecule (negative)
Know and can control charge carriers in the wire
www.nanotech.dtu.dk/nabis
Silicon Nanowire Biosensor
Nanowire
Add a functional layer
Multiple functional layers
www.nanotech.dtu.dk/nabis
Silicon Nanowire Biosensor
www.nanotech.dtu.dk/nabis
SiNW sensor for Aleutian Disease Virus (ADV)
Integration of Silicon Nanowires in Microfluidic Devices
www.nanotech.dtu.dk/nabis
SiNW sensor for Aleutian Disease Virus (ADV)
Aleutian Disease or Mink Plasmacytosis is a highly contagious parvovirus affecting the animals, causing spontaneous abortion and death in minks and ferrets. ADV smallest virus existing d~7 nm Task : Screen blood samples for antibodies
www.nanotech.dtu.dk/nabis
Immobilization of whole virus
Goal : Attach the dead virus on the surface
Detect antibodies in the animal sample
APTES
www.nanotech.dtu.dk/nabis
Test Functionalisation Scheme Immobilization results
12 hours without light
3 hours with P H3CBF4
Conclusion: 1.High selectivity 2.High Yield 3.The catalysts worked as planned
12 hours with light
www.nanotech.dtu.dk/nabis
Screening for ADV virus in Minks sample
Lars Andresen
KU Sund 2010
www.nanotech.dtu.dk/nabis
Michael Jørgensen Msc Martin H. Sørensen MSc
Integration of Silicon Nanowires in Microfluidic Devices
www.nanotech.dtu.dk/nabis www.nanotech.dtu.dk/nabis
Fully automated system
www.nanotech.dtu.dk/nabis
POCT Screening of Cancer
Biomedical engineering for cancer
and brain disease diagnosis and therapy development
CA9 NKG2D ligands
www.nanotech.dtu.dk/nabis
Functionalisation Scheme
APTES
Andrea DTU
Lars KU Sund
www.nanotech.dtu.dk/nabis
Mouse Antibody – Goat Antibody interaction
www.nanotech.dtu.dk/nabis
Sample Handling
Andrea Pfreundt DTU Nanotech
www.nanotech.dtu.dk/nabis
System Engineering/ Embedded Systems
Jan Madsen DTU Compute
Francois Patou DTU NTCH
www.nanotech.dtu.dk/nabis www.nanotech.dtu.dk/nabis
Acnowledgements People NaBIS
Funds
Collaborators
DTU Nanotecth Mads Brandbyge
Kristian Mølhave
KU-life Søren Schou
Lars Andresen
Franziska , Phd student
DTU Farma Åse Uttenthal
DPA Leif Bruun
Rebekka Dam-Tuxen, Phd Stud.
iSAS – Slovakia
Prof. Silvia Patrokova
DTU Compute Prof. Jan Madsen