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Women’s HealthGuidelines Update
Mimi Secor, DNP, FNP-BC, FAANP, FAAN
Onset, Massachusetts
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DisclosureMimi Secor, DNP, FNP-BC, FAANP, FAAN
Speaker:
Duchesney: Osphema for VVA, GSM
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Mimi Secor, DNP, FNP-BC, FAANP, FAAN
FNP for 42 years specializing in Women’s Health National Speaker, Educator, Author, Fitness Advocate 2013 Lifetime Achievement Award, (Mass Coalition of NPs) 2018: FELLOW in American Academy of Nursing DNP-2015, Rocky Mountain University, Provo, Utah Coauthor of 2 GYN textbooks, both updated 2018
– The GYN Exam, Advanced Health Assessment: Skills & Procedures
2016, Competed in 1st Bodybuilding show, 2018, (July) Placed 2nd in Over 55 Figure
#1 International Best-Selling Author of“Debut a New You: Transforming Your Life at Any Age”
Passion for helping NPs/PAs become Healthy and FitSecor 2019 copyright 3
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ObjectivesUpon completion of the session attendees will be able to:
Discuss the epidemiology of selected conditions* including risk factors 15 min
Explain key aspects of the most current guidelines and rationale for selected conditions* 30 min
Describe controversies re: these guidelines 15 min
*Cervical Cancer, Breast Cancer, Osteoporosis, Contraception, STIs, Menopause
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Overview Gyn Exam: USPSTF 2017 vs ACOG 2017 Cervical Cancer:
ASCCP 2012, USPSTF 2019 Contraception: CDC 2016 STIs: ………….CDC 2015 Menopause: …NAMS 2018 Osteoporosis: Endocrine Society 2019 Breast Cancer Screening: USPSTF 2019
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Yearly Pelvic Exam: Controversial
ACOG - 2017: Yearly Pelvic Exam With or Without a Cervical Cancer Screening
USPSTF - 2016:- Insufficient Evidence for Pelvic Exams in
Asymptomatic Women- Lack of Research re: Benefits/ Harms of Pelvic
Exam in Asymptomatic Women !!!
Sanchez et al. (2019). Well-women examinations: Beyond cervical cancer screening. JNP, 12(2), 189-194.
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GYN Exam: USPSTF 2016Justified if Clinical Indication !!!
Think Age and Risk of Various Conditions: – STIs, VV, pregnancy, fibroids, AUB, over 50 yr
“Shared Decision” between Clinician & Patient
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Yearly Pelvic Exam:Retrospective, Cohort Study 2019
N = 283 Purpose: Identify types/ frequency of gynecologic conditions in women > 40 years old, in a large urban county, mostly Hispanic.- 54.8% had GYN conditions !!! - Uterine Prolapse 16.2%, Incontinence 12%, Pelvic Masses
11.9%, VVA 11.3%- Other: Abnormal Uterine Bleeding (AUB), Vaginitis, UTIs
Sanchez et al. (2019). Well-women examinations: Beyond cervical cancer screening. JNP, 12(2), 189-194.
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HPV 2019 Update: What’s New?
Vaccine Update: NEW v9 Gardasil Cervical Cancer Screening Guidelines: New 2012 Primary HPV Screening 2018 F/u of Abnormal Pap Guidelines: New 2013
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HPV: Introduction Most common STI in US Cause of cervical cancer
Associated with external genital warts, and cancer of the penis, vagina, vulva, anus & oropharynx !
Munoz N. Vaccine. 2006; ASCCP Website 2006; Anhang R. CA Cancer J Clin. 2004; American Cancer Society. Cancer Facts and Figures. 2006; Soper D. Inf Dis Obstet Gynecol. 2006; Trottier H. Vaccine. 2006. Secor 2019 copyright 10
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Epidemiology of Cervical Cancer:
• ~ 12,900 NEW cases invasive cervical cancer • About 4,100 deaths from cervical cancer • 266,000 deaths worldwide (2012)• Hispanic Women: #1 cause of cancer deaths• Most common - in women < 50 years old
http://www.cancer.org/cancer/cervicalcancer/overviewguide/cervical-cancer-overview-key-statistics#top
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HPV Associated Cancers: 2004-2008CDC, MMWR 2012;61(15):258–261.
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2019 Cervical Cancer: Screening Guidelines
21-29 years: Pap = every 3 years (Level A recommendation) < 21 = DO NOT SCREEN>25-29: hrHPV = every 3 years (Level B) Alternative ASCCP 2016
30-65 years: Pap/ HPV = every 5 years (Level A) Preferred per ACOG Pap ONLY = every 3 years (WHY?) hrHPV = every 5 years (Level A) USPSTF 2018>65: May continue (NEW 2018)
www.asccp.org, www.acs.org, www.uspstf.org
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2019: HPV Testing as Primary Screen for Cervical Cancer
In U.K. Pilot Program, n= 678,547 women (ages 24-64)
HPV testing had higher sensitivity than Cytology for CIN 2-3
Lower incidence of subsequent disease
Rebolj, M et al. Primary cervical screening with high risk HPV testing: Observational study. BMJ 2019 Feb 6;364:1240. (https://doi.org/10.1136/bmj.1240)
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New 2019: HPV Vaccine*9v Gardasil
9-14 years = 2 doses, (6 months apart)
2019 NEW CDC Recommendations: > 15-26 years = 3 doses, (0, 1-2, 6 months)
If 1 dose < 15 years = give 2 more doses 9-26 years, If immune compromised = 3 doses 27-45 years, NOT routinely recommended
BUT may benefit if not vaccinated earlierNOTE: Give PRIOR to sexual activity (Coitarche) because Vaccinemore effective if Naïve (not exposed to HPV) vs Non-naïve
*2019 CDC/ACIP, ACOG recommendations
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Surveillance for Cervical Precancer in the Era of the HPV Vaccine!
NEW 2019 Decline:• 21% reduction in CIN2+ (from 2008-2014)!!!
• Declines greatest in younger vaccinated women• Declines also in unvaccinated = Herd Immunity!
Mcclung NM, et al. Trends in HPV types 16 and 18 in cervical precancers, 2008-2014. Cancer Epidemiol Biomarkers Prev 2019 Mar;28:602.
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The HPV Vaccine: Is Making a Difference!
• HPV prevalence has declined steeply !!!Even though vaccine coverage remains incomplete
Decline:• 64% in 14-19 year olds (from 2003-06 vs 2009-12)
from 11.5% to 4.6%• 34% in 20-24 year olds
from 18.5% to 12.1%• Vaccinated: prevalence declined 91% !!!• Unvaccinated: decline ONLY 13%
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Atypical Squamous Cells (ASC):by Age
ASC-US (of undetermined significance): 21-24 y repeat PAP in 12 months
(no HPV or HPV+) if NEGATIVE = Routine screeningif POSITIVE = Colposcopy
ASC-US: > 24 yearsreflex HPV: if POSITIVE = Colposcopy
ASC-H: Colposcopy & Endocervical Sampling!!!Secor 2019 copyright 18
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Follow-up: ASC-H: COLPO FOR ALL LSIL (low grade squamous intraepithelial lesion)
If < 24 years - OBSERVE, REPEAT 1 year, WHY?If > 24 years – COLPO
HSIL (high grade squamous intraepithelial lesion) Mod or severe dysplasia, CIN 2 or 3, and
carcinoma in situ: COLPO ALL Atypical glandular cells (AGC): Favor neoplasia
COLPO FOR ALL
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App ”CDC Contraception 2016”Contraception Guidelines
MEC = Medical Eligibility Criteria By condition By methodSPR = Selected Practice Recommendations Initiation Exams and tests Routine f/u Missed doses Bleeding abnormalities
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CDC STIs 2015: Updates NEW Cervicitis: Rx = Chlamydia
– HIV - Universal screening– HSV - IGG serology (No Universal screening)– Chlamydia, GC: NAAT– Trich -Teens and > 40 yr, (7 days for men, HIV+)– BV - x 7 days Rx, Pregnancy- Oral or Vaginal
NEW: Secnidazole (Solosec) Oral Single Dose– PID - Low threshold for diagnosis– Sexual Assault – STI testing update– Syphilis- Increasing esp. in WOMEN
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Menopause Guidelines: 2019North American Menopause Society- NAMS,
“Menopro” App
Within 10 years of LMP (FMP) Vasomotor Symptoms (VMS)- Systemic E2 Vulvovaginal Atrophy (VVA) –Local E2= Genitourinary Syndrome of Menopause Estrogen: cream, tablets, ring, “Imvexxy”Ospemifene (Osphena), DHEA (Intrarosa), Mona Lisa Touch (Laser x3, expensive)
New FDA Warning- AVOID!!!Secor 2019 copyright32
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OsteoporosisDisease of low bone mass with
microarchitectural disruption
T-score: -1.0 to -2.5 (Osteopenia) -2.5 and below (Osteoporosis)
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Osteoporosis: Risk Factors
Caucasian, Asian Advanced age Previous fracture!!! Long-term glucocorticoid therapy Low body weight (< 127 lbs) Cigarette smoking Excess alcohol intake
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Osteoporosis Screening:Guidelines
DXA scan: dual x-ray absorptiometry
Age 65: START screening !!!
NO Pre-menopausal Screeningunless risk factors
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OsteoporosisT-score: -1.0 to -2.5 (Osteopenia)
–Possibly Treat if Risk Factors
-2.5 or lower (Osteoporosis)
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Frax Calculator (App) Determines if treatment is necessary 10 year estimate of fracture risk Easy Step by step process
Based on the following RISK Estimates: Hip fracture risk >3% in 10 years All fracture risk >30% in 10 years
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Osteoporosis ManagementWeight bearing exerciseResistance training!!! (wt lifting)Stop cigarette smokingAvoid excess alcoholAvoid corticosteroids,
anticonvulsants
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Osteoporosis Management Calcium: Daily intake 600-1500 mg/day Preferred calcium source: FOOD !!!
Vitamin D deficient: Vitamin D3- 1000- 2000 iu (or 4,000) day
- varies re: reference
National Osteoporosis Foundationwww. NOF.org
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Osteoporosis: MedicationsInhibits Osteoclasts: Bisphosphonates: Alendronate (Fosamax 70 mg q d),
Ibandronate (Boniva), Risedronate (Actonel): Take w 8 oz water, sit 60 mins, ~5 yr max duration
Zoledronic acid (Reclast): 5 mg IV x 1 yearly Denosumab (Prolia): 60 mg SC q 6 months (forever) Calcitonin (Miacalcin): 200 iu spray altern. nostrils q d Stimulates Osteoblasts: Teriparatide (Forteo): 20 mcg SC daily x 2 y
Builds bone, used > 5 yrs postmenopause Raloxifene (Evista): 60 mg oral daily, hx DVT !
– SERM estrogen-like effects on bone, protects breast, uterus
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Endocrine Society: NEW 2019Osteoporosis Guidelines
Postmenopausal Women at High Risk,TREAT w/ Bisphosphonates (Not Boniva)
Reassess Risk after 3- 5 years, if now LOW RISK, consider Drug Holiday
Denosumab is an Alternative to Bisphosphonates for Initial Therapy
Assess Risk in 5-10 years
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Full guideline in the Journal of Clinical Endocrinology & Metabolism (Free PDF) http://response.jwatch.org/t?ctl=5207C:293E88F1177CBE119E197495A878D422D2B71D9A95FA21D3&List of guideline recommendations (Free) http://response.jwatch.org/t?ctl=5207D:293E88F1177CBE119E197495A878D422D2B71D9A95FA21D3&
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Oral Bisphosphonates: First line for most patients
Inhibits bone resorption: Remains active in bone for weeks, months, maybe years !!!
Increases bone mass: Reduces risk of fracture:
Alendronate (Fosamax®) weekly Risedronate (Actonel®) weekly
AVOID Ibandronate (Boniva®) monthlyDoes NOT reduce hip Fx risk
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Breast CancerMalignant tumor of the breast
ALERT: 85% of breast cancer occurs in women > 50 yearsSecor 2019 copyright 43
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Breast Cancer: Risk Factors Age, Gender: (Women > Men) Obesity: NEW - Dense Breasts: 3D, or Tomosynthesis Family History/ Genetic risk: Ontario tool
- BRCA 1, 2 genetic mutations REFER Reproductive History: (low parity) Estrogen Exposure:
- Early menarche <12 years- Late menopause >55 years
Estrogen Meds: (vaginal estrogen NO incr. risk)- Combo OC- very low risk
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IncidenceAge of woman Risk of Breast Cancer
By age 30 1 in 2,212By age 40 1 in 235By age 50 1 in 54By age 60 1 in 23By age 70 1 in 14By age 80 1 in 10
Ever 1 in 8Secor 2019 copyright 45
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Breast Masses Most common:
Fibroadenomas, Cysts
Benign complaints: CAN mimic breast cancerAnd vice versa!
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Diagnostic StudiesUS: < 30 years
- for female/male < 30 years, w focal mass, or symptom
- first line in pregnancy, or < 30 years
- to assess mass identified on mammography
Mammography: > 30 years (3D best!!)- for any female/male > 30 yr w/ breast complaint Tomosynthesis: f/u if dense breasts on mammo
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Screening: Average or High Risk Average Risk Women – Mammogram* (3D best): CONTROVERSIAL
- ACS: 45-54 = every year (may screen 40-44)55+ = every 2 years* (yearly may be offered)75+ = If ~10 year survival =>> May continue screening
- USPSTF 2016/2018: (12,070 studies, 5 systemic rev of 62 studies)!50-74 = every 2 years (may start earlier!!!)
o Clinical Breast Exam/ Self-breast Exam: NOT Recommended (ACS)- BUT consider performing and teaching SBE: WHY?
High Risk Women: (USPSTF 2019 (JAMA)- Personal OR Family History Breast /Ovarian/ Tubal cancer - Ontario Family History Assessment tool (in Primary Care)!!- If positive, REFER for Genetic testing (BRCAPRO, etc.)- Consider Annual MRI Screening AND Clinical Breast Exam- US if <30 yrs
https://www.cdc.gov/cancer/breast/pdf/BreastCancerScreeningGuidelines.pdf
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Resources and “Apps” “CDC Contraception 2016” Medications/contraceptives: “MPR” Pap F/u: “ASCCP mobile”, ASCCP.org “CDC STD 2015” Menopause: “Menopro”, Menopause.org Osteoporosis: “FRAX”, NOF.org Breast Cancer: ACS.org ARHP. Org, NPWH.org, ACOG.org for my App, text “DrMimi” to 36260
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Summary of ObjectivesUpon completion of the session attendees will be able to:
Discuss the epidemiology of selected conditions* including risk factors
Explain key aspects of the most current guidelines/rationale for selected conditions* (Pharm 25%)
Describe controversies re: these guidelines
*Cervical Cancer, Breast Cancer, Osteoporosis, Contraception, STIs, Menopause
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Thank you and Questions
Mimi Secor, DNP, FNP-BC, FAANP, FAAN
MimiSecor.com
For my App, text “Dr Mimi” to 36260 Secor 2019 copyright 51