Download - Zell-Check in daily practice – a spectrophotometrical ... · Dirk Kuhlmann, PhD –2 Zell-Check in daily practice – a spectrophotometrical mineral-and metal analyzing technology

DirkKuhlmann,PhD–Zell-Checkindailypractice–aspectrophotometricalmineral-andmetalanalyzingtechnology.SpecialPrint,PublisherBio-Medoc,2016

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SpecialPrint,PublisherBio-Medoc,12/2016,1-6

Zell-Checkindailypractice–aspectrophotometricalmineral-andmetalanalyzingtechnologyKuhlmann,Dirk;PhDDuring evolution, most living systems have developed a biological oxidation cascade for better energetically balance.Oxidativedegradationofnutritivesubstancesresultinactivatedoxygenspecies,alsoknownasFreeRadicals,whichplayanimportantpathophysiologicalrole.ElevatedconcentrationsofFreeRadicalsaredescribedas„OxidativeStress“.Oxidativestress is a normal phenomenon coming along in nearly allmetabolic pathways like generating and providing energy orrestructuringcellstructures.Butnaturehasprovidedefficientsystemsforprotectingtheownstructuresagainstoxidativedamages.The price that has to payed for high energy output is the small balance between bad and good.By payingattention tonutrition, lifestyleandsupplementationofantioxidants the riskofoxidativedamagescanbeminimizedandpromoteswell-being,healthandvitalityuptoseniorages.

Oxidativeaggression - Oxidativeprotection:Minerals,traceminerals,toxicmetals

Asaconsequenceofoxidativeaggressionsymptomslikereduced performance, energetically deficits, fatigue,susceptibilitiestoinfections,sleepingdisorders,immunedeficiencies,obesity,highbloodpressure,cardiovasculardiseasesandmuchmoreoccur.InGermany,ashiftfromacutetochronicaldiseaseshasbeenobservedduringthelastdecades.

Permanently increasingworkload requiresmore energywork from the metabolism. The magnesium and othertrace mineral depots are rapidly depleted trying tocompensateburnoutandfatigue.Magnesiumcorrelatesdirectlytocellularproductivity.Adeficiencyinpotassium,ifnotanalyzed,slowsdowntherechargingofthecellularbatteries. Heavy metals play an important role ingeneratingdiseasesthatbecomesmanifestandturnintoachronicalstatus.

Oxidative stress will long term provoke a deficit inmicronutrients. To identify a disbalance, deficit or ablockadeofmicronutrientsoranyheavymetaloverload,a reliable and easy-to-handle technology would behelpful.

Subsequentlyanalyticalmethods inblood,urineorhairwill be compared to the Zell-Check technology. Thespectrophotometrical „Zell-Check“ device will bepresentedwithitspotentialindailypractice.

Bloodtesting

Blood testings for analytical purposes are the mainstandardinmedicaldailyworld,inacademicmedicineaswell as naturopathic offices. But interpretation is achallengebecausereferencevaluesmaybecontroversialandthedifferencesinconcentrationofparametersinsideand outside the cells are known. Interaction andmetabolisationbetweenmineralsandenzymaticsystemsorbetweenmineralsandtoxicmetalsmakesitevenmorecomplicate.Normalbloodvaluesdonotalwaysreflectthecellularsituationwherealackorabundancemightbethereality.Sodependingonlyonbloodvaluesbeartheriskofnot identifyinghiddenproblems.Under the still normaldeterminedvalueapotentialpathologicalsituationmaybeunderthesurface.Summarizedithastobenotedthatblood values do not necessarily reflect the currentphysicalormicronutrientsituation.

Twoexamplesofthepoorsignificanceofbloodvaluesarethedeficitsofmagnesiumandcalcium.

Example1:Magnesium

According to Prof Holtmeier (1995) in 50% of all bloodtests a deficit in magnesium was not analyzed. On hisopinion, the blood serum value is inadequate. Theexplanation is the blood homoestasis. Homoestatis isdefined by the physiological balance betweenconcentrations insideandoutside.Thiscanbe inblood,tissue or cells. Normalmeasuredmagnesium values donot necessarilymean a normal status in every physicalregion.


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Example2:Calcium

M.Muhm (2016) describes it very clear: If there is anysubstance,whereanormalbloodvalueisnotaguaranteeofphysiologicalhealth,thenwespeakaboutcalcium.Thismineral shows very clearly that blood values only showhow many of the material circulates in blood not theconcentrationofcalciumincellsortissue.OnthewebsiteLab.TestsonlineoftheAmericanAssociationforClinicalChemistry(AACC)itcanberead:Calciumbloodvaluesdonotreflecttheamountofcaliuminbones,onlyhowmanycalcium is circulating in blood. We may have normalcalium blood values but suffer from a seriousosteoporosis.

Blood testing is thecommonanalyticalmethodbuthasweaknesses specially in analysis of minerals and toxicmetals.

Urineandhairanalysis

Otheranalyticalmethodslikeurineorhairanalysishaveweaknessesaswell.Urinemeasurementsonlyillustratesthe current situation. Urine measurements for heavymetalswill indicate the short-term intake. This point iswell accepted by experts but very often ignored bypractitionersandnaturopaths(DeGroodt,J.2016)

Hairmineralanalysisindicatesenclosuresoverthelast2–3months.Inaddition,unknownexternalfactorsmakeitdifficulttoidentifychronicaldiseases.

TheZell-Checktechnology

With the new Zell-Check technology a method is nowavailableforthefirsttimethatovercomesthedifficultiesdescribedbefore.WhiledevelopingtheZell-Checkdeviceawellknownphysicalmeasurementwasmodulatedthatwaythatitbecameapplicableforbodymeasurements.

Fig1:TheZell-Check

Sofar,thespectrophotometricmeasurementswereusedto investigatemolecularproperties.Differentmoleculescan be identified and quantified. Basis of themeasurements is the Lambert-Beer law describing thelightabsorptionpropertiesofmolecules.Thereflectedor

absorbedlightandultravioletelectromagneticwavesaremeasured.

Fig 2: Chemical compounds absorb light at a differentwavelength. Minerals, trace minerals or toxic metalsabsorbbetween180and1000nm.

The results of the Zell-Check device based onspectrophotometricvalues,sex,age,weight,bloodtype,height of the tested person is evaluated by amathematicalalgorithm.With theZell-Checkdevice theintracellular concentration of more than 20 minerals,trace minerals, metalloids or toxic metals can be memeasuredbydirectskincontact.Thecontactpointsarefour points in the hand palm of the counterhand.Calibration, measurement and online evaluation onlytakes a few minutes. The hand should the thorouglycleanedanddried.

Fig3:Zell-Checkcontactpointsinhandpalm

Differencesbetweenblood-,urine-,hair-andZell-Checkmeasurements

Formicronutrientsortoxicmetalsbloodmeasurementsindicates the circulationof thesematerials.Quantityorconcentrationincellsisextrapolatedorestimated.Urineorhairanalysisshowthequantityexcreted.DieZell-Checktechnology allows an evaluation of current intracellularand tissue situation. According to Ljuba (2013) theadvantages of the Zell-Check technology can besummarized as follows: the level of traceminerals andminerals inepithelialcellsdemonstrates thesubstances


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responsibleforaworkingtissuemetabolism.Deficienciesorlackscanbeseenfirstinepithelcells,monthsoryearsbeforethebloodvaluesturnpathologic.

But thecomparabilitybetweenblood-,urine-,hair-andZell-Checkmeasurements is limitedbecauseof theverydifferent methodological and physiological approacheswhich result in different information or conclusions ordifferentdirectorindirectrelations.Thismeansa„1-to-1“ comparison is hardly possible; a correlation will bepoor.Lookingattheadvantagesordisadvantagesofthesingle methods will help implementing the mostappropriate method or method mix to get the bestdiagnosisandtherapy.

A substantial expertise 2012/2013 about Zell-Checktechnologywas provided byDr.Marion Ljuba, internistand cardiologist. 650 tests were performed followingdifferentquestions:

1. Isthemethodsuitableformedicalpurposesorhealthchecks?

2. Is the non-invasive approach ofspectrophotometryformicronutrientorheavymetal analysis in connective tissue cellspossible?

3. Isreliabilityorreproducibilitysufficient?4. Comparativemeasurements ofmicronutrients

and heavy metals in connective tissue andblood

5. Usability and possibilities following newfindings

6. Otherperceptionsandadvantagescomparedtoothermethodsortechnologies.

Dr. M. Ljuba summarizes the results and resume asfollows:Alltestseriesor-groupshaveindicated,thattheZell-Checksystemmatchesthestatedrequirementsandcan complete the medical diagnostic systems. Thequalitative assessment of the current physiologicalsituationor„first-Look“informationofconcentrationsofmicronutrients or cellular disorders can be performedacceptablysensitivebytheZell-Checkdevice.Ithastobetakenintoaccountthatthetestpersonshadadifferentmicronutrientsituationinbloodandtissuethereforethecomparisontothebloodtestcorrelatesweakerbutthetendencywascomparable.

It canbesummarized,basedontheexperiencesuptonowandthereviewoftheobtainedresults,thatalldatareflectstherealsituationto80-85percentin2012andclimbingto95-97percentin2013.

Thedeviationsaresmallandareduetotheapplications.Ifallcriteriagivenwerefollowedconsequentlyallresultswillbereliable.

Regardingthedeterminationsofminerals,tracemineralsormetalstheuseoftheZell-Checkdeviceoffersseveraladvantages:

- Stable and reproducible results in cells andtissue

- Immediateoutputof results; nodelaysby labanalysis

- No influence of day-time or current mode ofnutrition

- Discoverscurrentandchronicstressloads- Discovers deficiencies, overloads or

intoxications- Givesevidenceofoxidativestresssituation- Monitoring of applied minerals or trace

minerals- Offersimmerdiatewaysoftreatment- Costefficient- Moderatetechnicalinvest

Fig4:Zell-CheckTechnology

Zell-Checkapplicationinthefield

Thecompletemeasurementissplitintofoursessions:

1. Balancingofminerals2. Ratioofminerals3. Balancingoftoxicmetals4. InterdependenciesofZell-Checkresults


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Balancingmineralsandtoxicmetals

Mineralsareessential co factors inmetabolicpathwaysandhavetobedeliveredbydailynutrition.TohighlighttheoutstandingmeaningofmineralsonourhealthsomemetabolicpathwaysandthemainmineralsinvolvedareshowninTbl.1.:

MetabolicPathway Minerals

AntioxidativeCapacity Copper,Manganese,Molybdenum,Selenium

HistaminPathway Copper,Zinc

IntestinalIntegrity Calcium,Magnesium,Selenium,Zinc

ImmuneFunctions Manganese,Molybdenum,Selenium,Zinc

BoneMetabolism Magnesium,Potassium,Calcium,Phosphorus,Zinc,Boron

NeurotransmitterMetabolism

Copper,Magnesium,Zinc

ATPSnythesis Potassium,Copper,Magnesium,Phosphorus

InsulinMetabolism Calcium,Chromium,Potassasium,Manganese

EssentialEndogeneousScavengers

Manganese,Molybdenum,Copper,Selenium,Zinc

Tbl.1Metabolicpathwaysandminerals(Kuhlmannetal.,1991;Burgerstein,2012)

Deficienciesinmineralsareobservedmoreoftenthaninvitamins. One critical point is nutrition: low-calorie,vegetarian,lifestyle,fastfood,drugtreatments,ageetc.Deficiencies can be balanced by supplementation. Butpersisting deficits have to be investigated. The reasoncouldbe insufficient assimilationbye.g. poornutrition,low enzyme levels in pancreatic gland, hypoacidity ofstomach or any intestinal dysbiosis. Insufficientassimilationhastobeinvestigatedandhastoundergoaspecialtreatment.

The meaning of overloads is not that clear than theinterpretationofdeficiencies.OverloadscanbetheresultofametabolicblockadeseealsoBoronFig.5.

Fig.5.:Balanceofminerals(Zell-Checkevaluation)

Supplementation of minerals indicates a look on theirtoxicantagonists.Heavymetalsoccupythebindingsitesofminerals inenzymes intherebyaffecttheirbiologicalfunctionalitye.g.indetoxificationpathways.

Activated immune cells will be endangered when theylosetheiroxidativeprotection.

Interdependenciesbetweenmineralandmetal:

Aluminum–SeleniumAluminum–SiliconArsenic-SeleniumLead–CalciumCadmium–ZincNickel–MagnesiumMercury–Selenium

Toxicmetals induce oxidative stress and inflammations(„silent Inflammations“). Permanent even low doseexposure can cause inflammation of the intestinalepithelialcellswhichmayresultintheso-calledleaky-gutsyndrome. This fact should be considered in adetoxification treatment strategy where the intestineplaysamajorrole.

The illustrationofthe interdependencies inabarorpiechart(e.g.enzymaticstatusorintestinalresorption)easestheinterpretation.

Cellular detoxificationof heavymetals is dependent onthepossibilityofconnectingtomethyl-,acetyl-orsulfurgroups (Phase II enzymes of detoxification phase II).Therefore the evaluation of „Blockage indication ofmissingsulfurcompounds“wasregardedashelpful.Thispoint monitors also the trend of the therapeuticalstrategy.


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Fig.6.Balanceoftoxicmetals(Zell-Checkevaluationsheet)

Other useful information are thedifferent ratios of theminerals likeCalcium (Ca),Magnesium (Mg), Potassium(K),Sodium(Na),Phosphorus(P),Copper(Cu)orZinc(Zn)betweeneachother.

For example: An elevated Cu/Zn ratio indicatesimmunologicalproblems;alowratioCu/Zncardiologicalproblems (Klevey index). Osteoporosis, paradontosis,

hypertherosis or cardiocvascular symptoms are comingvery often along with an elevated Ca/Mg ratio. LowCa/Mg ratios will show up in case of low levels ofmagnesium or vitamin D. Low K/Na ratio indicateshypertension (or treatment with diuretic drugs) orchronical stress (hyperaldosteronism), high K/Na ratiocomesalongwithrenaloradrenalinsufficienciesandlowsaltnutrition.

Fig.7Mineralratios(Zell-Checkevaluation)

The Zell-Check technology provides a rapid look-insightthe quantitative ratios and the physiological andpathologicalsituationofmineralsintissue.


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Fig.8Zell-Checkvaluesandsometherapeuticcomments

SummaryProf.MarcelCapt,managingdirectorof thehospitial inLausanne, Switzerland and since 10 years expert inorthomolecularmedicine,characterizedontheoccasionofthe12thMedicineWorldCongressinMonacotheZell-Checktechnologyasarevolutionindeterminingoxidativestressandothermedicalessentialparameters.InmyownpracticetheZell-Checktechnologyprovedinashorttermas one of the most useful diagnostic methods whichallowstoorganizethedailyworkmoreefficient.TheZell-Check technology offers a quick anamnesis and waythroughthesubsequentdiagnosticsteps.Thetechnologyis a useful completing tool. The broad basis of dataminimizes the risk of ignoring information for e.g. costreasons. The preventive or acute therapy based onorthomolecular medicine therefore has become muchmoreefficient.

Abouttheauthor:

Dirk Kuhlmann, PhD, is a graduated biologist. As anaturopath,hehasbeenleadingapracticeforbiologicalmedicine and naturopathy in Schleswig and Flensburgsince 1983. One of his main areas of practice isorthomolecular medicine. In addition to numerouspublications, he was co-author of the specialist booksOrthomolecular Medicine (1991) and work bookOrthomolecularMedicine(1997)aswellasco-founderoftheorthomolecularlyorientedcompanyOrthim-Pharma.

Download - Zell-Check in daily practice – a spectrophotometrical ... · Dirk Kuhlmann, PhD –2 Zell-Check in daily practice – a spectrophotometrical mineral-and metal analyzing technology

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