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Probiotic cultures for dairy and functional foods

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Probiotic culturesfor dairy and functional foods

Consumers recognise the link betweendiet, lifestyle and good health, whichexplains the rising demand for functionalfood products enriched with ingredientsthat provide a beneficial health effect.Probiotics are one of the fastest growingcategory within functional foods. And, asthe list of health benefits accredited tothem continues to expand, so does theiruse in new dairy and functional foodapplications.

Danisco is a world leader in probioticdevelopment and offers an unparalleledprobiotic culture brand: HOWARU™.Our probiotics are available frozen orfreeze-dried in concentrates or ascustomised formulas. Danisco probioticcultures can be used in your products tohelp customers in their battle against:• Poor digestive health due to stressful

environments or an unbalanced diet• Intestinal disorders caused by eating on

the move• Exposure to harmful bacteria during

extensive travelling• Unbalanced gut flora following

antiobiotic treatment• Day to day agressions which affect our

immune system response

Better health and well-being – naturally

Definition of probiotics:

probiotics are live microorganismswhich, when administered in adequateamounts, confer a health benefit onthe host.

A successful marketing strategy

No matter how strong the documentation thatsupports the health benefit of our strains, the key tomarket success lies in effective communication withconsumers.

The Danisco probiotic offer comprises a uniqueturnkey marketing concept based on a consumer-friendly registered brand, HOWARU™.The concept isbased on top quality probiotic strains ideal for use indairy and other food products.These strains aresupported by a memorable HOWARU™ logo andcharacter and a global consumer educational andpromotional programme:• www.howaru.com, a lively and informative website

to help consumers understand the benefits ofprobiotics in terms of gut health and immunemodulation

• Co-sponsoring of marketing programmes• Participation to international scientific & nutritional

conferences for brand awareness

The brand:an asset for your marketing activities

Meet with our HOWARU™ friendlybacteria, cheerful characters that canbe used for give-aways or all kind of

promotional items. ‘‘‘‘Including HOWARU™ Bifido in all our

yoghurt and smoothies is part of ouroverall effort towards encouragingcustomers to eat more healthily.

Claire Hughes,Nutritionist, Marks & Spencer, UK

A world of scientific expertise

Microbiology is a core competency at Danisco.First, we use upstream molecular biology tools todefine the precise taxonomy, therefore the safetyfeatures of each probiotic strain.Then, our globalteam of experts in microbiology, physical chemistry,bio-processing and human health develop ourprobiotic offer in three major areas:• Health efficacy• Shelf life stability• Stability in various food and nutritional vectors

We have unique expertise in the area of freeze-dried probiotic stability as a result of decades ofresearch in process development in the field of lacticacid bacteria.

Our main centres for probiotic research and devel-opment are located in Madison (USA), Dangé St-Romain (France), Niebüll (Germany), Singaporeand Kantvik (Finland). In the Madison Innovation centre, we use upstream biotechnology tools, such asmicroarrays and functional genomics, which, in collaboration with Dr. Todd Klaenhammer of NorthCarolina State University, have derived a fully annotatedsequence of Lb acidophilus NCFM genome.In Kantvik, our health and nutrition centre has devel-oped its own technology, EnteroMix®, to determinehow functional ingredients work in the gastrointesti-nal tract.With more than 150 scientific papers pub-lished, our scientists are highly experienced in:• Intestinal microbiology• Physiology• Immunology• Biochemistry• Biomathematics

From Kantvik to Madison we also coordinatedifferent human clinical studies in collaboration withdifferent hospitals throughout the world todemonstrate gut health (ie: Irritable Bowel Syndrome,gut transit,…) and immune modulation (InflammatoryBowel Disease). In addition, we work in collaborationwith other divisions as part of Danisco’s Health &Nutrition programme to demonstrate the synbioticeffects between probiotics and other ingredients (ie:non digestible oligosaccharides).

A global quality production

Probiotic quality guaranteed

We maintain well-documented control over eachstep of the production process. Our proprietarystabilisation techniques ensure we deliver live andactive probiotics that can survive highertemperatures and have a longer shelf life.The identity of all our strains is verified by anindependent laboratory, using the most moderngenetic techniques to ensure superior consistencybatch after batch.

Master of the supply chain

We have probiotic culture formulation plants inoperation in the United States, France, Germany andSingapore.That gives you the guarantee of reliable,on-time deliveries – with primary and back-upsupplies all from one supplier.

Your production partner

Looking for a production partner? Turn to Danisco.We offer an expert, efficient and confidential custommanufacturing service to customers who wish toproduce their own proprietary culture.The service iswell suited to customers that require large volumesfor commercial sale or those that seek pilot-scaleculture production for clinical studies or otherdevelopment activities.

For probiotic applications, we use the industryknowledge of our twelve innovation application centresaround the word, ranging from infant formulas in the USAto chocolate bars in Europe or soya beverages in Asia.

In addition, we also benefit from years of collaborationwith the best worldwide scientific experts and researchinstitutes such as North Carolina State University in the USA, Institut Pasteur in France,Turku University inFinland, Beijing University in China or Victoria Universityin Australia.

Danisco actively participates to the IDF1, EFFCA2

assembly, and ISAPP3 where guidelines and claims onprobiotics are discussed between scientists, safetyagencies, regulatory bodies, and official authorities.

1: International Dairy Federation2: European Food & Feed Cultures Association3: International Scientific Association for Probiotics and Prebiotics

Probiotics for dairyproducts, beveragesand functional foods

Yogurts and fermented dairy drinks have long beenconsidered an ideal vehicle for delivering probioticbacteria to the human gastroinstestinal tract which,explains the widespread use of probiotic cultures indairy products. Probiotics are also increasinglyintroduced into non-dairy beverages such as fruit juicesor energy drinks. Cheese is another promising deliveryvehicule of some probiotics to humans. For allapplication developments, Danisco uses its globalynetwork of application specialists. Use our probiotics in:• Yogurts• Fermented milks• Dairy drinks• Cheese• Ice cream• Fruit juice

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‘‘An important goal for Woolworths is to providethe consumer with good food which contributesto health beyond basic nutrition. CombiningHOWARU™ Exclusive Probiotics withWoolworth’s nutritious dairy products illustrateshow we can achieve this goal.

Richard Butt, Food Director,Woolworths, South Africa

HOWARU™ Acidophilus (Lactobacillus acidophilus NCFM®)

HOWARU™ Acidophilus is one of the world’smost extensively studied probiotic strains backed byextensive documentation that proves its outstandinghealth benefits in terms of gut health. In addition to its unique ability to survive passage through thegastrointestinal tract and its extraordinary adherenceto intestinal mucosa, HOWARU™ Acidophilus is thefirst commercially available acidophilus strain to have a complete genome sequence published.

HOWARU™ Bifido (Bifidobacterium lactis HN019) and HOWARU™ Rhamnosus (Lactobacillus rhamnosus HN001)

HOWARU™ Bifido and HOWARU™ Rhamnosushave been specifically selected for their immune-modulating properties, which have been confirmed in human studies in different countries.These studyresults indicate that improved immune function dueto the consumption of HOWARU™ Bifido and HOWARU™ Rhamnosus may reduce the risk ofdifferent types of enteritis and non-gastro-intestinaldiseases and enhance the body’s natural immuneresponse, especially in the elderly.

To complete the range, Danisco also suppliesHOWARU™ Yogurt Blends, carefully selectedcultures including HOWARU™ strains that aredesigned for yogurt applications.

In addition, Danisco provides a wide range ofprobiotic strains and blends for customers who wantto make a content claim or use these strains fortechnological reasons:

• Lactobacillus acidophilus • Bifidobacterium lactis • Lactobacillus casei

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The information contained inthis publication is based on ourown research and developmentwork and is to the best of ourknowledge reliable. Users should,however, conduct their own teststo determine the suitability ofour products for their ownspecific purposes and the legalstatus for their intended use ofthe product. Statementscontained herein should not beconsidered as a warranty of anykind, expressed or implied, andno liability is accepted for theinfringement of any patents.

Danisco develops and producesfunctional ingredients primarilyfor the food and beverageindustry and, to a lesser extent,for the non-food industry.

Produced mainly from naturalraw materials, the broad productrange is backed by top technicalservices, creating innovative, highquality solutions for food andbeverage products.The rangeincludes antimicrobials,antioxidants, emulsifiers,enzymes, flavours, functionalsystems, speciality fats, specialitysweeteners, starter cultures andmedia, and textural ingredients.Danisco is also one of thelargest and most efficient sugarproducers in Europe.

Danisco Cultures20 rue Brunel

75017 Paris, FranceTel: +33 1 56 60 47 00Fax: +33 1 56 60 47 02

[email protected]

Danisco USA Inc.2802 Walton Commons West

Madison,WI 53718, USA Phone: +1 (608) 224-1850

Fax: +1 (608) 224-3130 [email protected]

Danisco Singapore Pte.Ltd.61 Science Park Rd

The Galen 06-16 East WingSingapore Science Park III

117525 SingaporeSingapore

Phone: +65 6511 5600Fax: +65 6776 5055

[email protected]

Danisco Brasil Ltda.Rodovia Raposo Tavares, Km 27.2

BR-06707-000 CotiaSao Paulo

Brazil Phone: +55 (11) 4613 3800

Fax: +55 (11) 4612 1101 [email protected]

www.danisco.com/cultureswww.howaru.com

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