dr. kevin ahern - oregon state...
TRANSCRIPT
Metabolic Energy
Dr. Kevin Ahern
Metabolic Energy
Metabolic Energy
Metabolic Energy
Metabolic Energy
Metabolic Energy
Metabolic Energy
Metabolic Energy
For aA ⇄ bB
Metabolic Energy
For aA ⇄ bB
∆G = ∆G°’ + RTln([B]b/[A]a)
Metabolic Energy
For aA ⇄ bB
∆G = ∆G°’ + RTln([B]b/[A]a)
For aA + cC ⇄ bB + dD
Metabolic Energy
For aA ⇄ bB
∆G = ∆G°’ + RTln([B]b/[A]a)
For aA + cC ⇄ bB + dD
∆G = ∆G°’ + RTln{([B]b[D]d)/([A]a[C]c)}
Metabolic Energy
For aA ⇄ bB
∆G = ∆G°’ + RTln([B]b/[A]a)
For aA + cC ⇄ bB + dD
∆G = ∆G°’ + RTln{([B]b[D]d)/([A]a[C]c)}
∆G = ∆G°’ + RTln({Products}/{Reactants})
Metabolic Energy
For A <=> B
Metabolic Energy
For A <=> B
if ΔG is negative, A->B is favored
Metabolic Energy
For A <=> B
if ΔG is negative, A->B is favoredif ΔG is positive, B-> A is favored
Metabolic Energy
For A <=> B
if ΔG is negative, A->B is favoredif ΔG is positive, B-> A is favored
if ΔG is 0, B-> A and A-> B are equally favored
Metabolic Energy
For A <=> B
if ΔG is negative, A->B is favoredif ΔG is positive, B-> A is favored
if ΔG is 0, B-> A and A-> B are equally favoredAt ΔG = 0, the system is at equilibrium
Metabolic Energy
Metabolic Energy
Metabolic Energy
Muscle Energy
Metabolic Energy
Muscle EnergyCreatine Kinase
Metabolic Energy
Muscle EnergyCreatine Kinase
Creatine + ATP <=> Creatine Phosphate + ADP
Metabolic Energy
Muscle EnergyCreatine Kinase
Creatine + ATP <=> Creatine Phosphate + ADP
ΔG0' = +12 kJ/mol
Metabolic Energy
Metabolic Energy
Metabolic Energy
Metabolic Energy
Metabolic EnergyNicotinamide
Metabolic EnergyNicotinamide
Adenine
Metabolic EnergyNicotinamide
Adenine
Din
ucle
otid
e
Din
ucle
otid
e
Din
ucle
otid
e
Din
ucle
otid
e
Metabolic Energy
Coupled Reactions
Glucose + Pi <=> Glucose-‐6-‐Phosphate ΔG°’ = +14 kJ/mol Glucose + ATP <=> Glucose-‐6-‐Phosphate ΔG°’ = -‐16.5 kJ/mol
Metabolic Energy
Metabolic Pathways
Metabolic Pathways
Metabolic Pathways
Metabolic Pathways
ΔG°’ Values of Hydrolysis (kJ/mol)
PEP = -‐61.9 1,3 BPG = -‐49.4
Creatine Phosphate = -‐43.1 ATP to ADP = -‐30.5
G1P = -‐20.9 Pyrophosphate = -‐19.3
Metabolic Pathways
Metabolic Melodies
Metabolic Melodies
Oh Delta G (To the tune of "Oh Danny Boy")
Copyright Kevin Ahern
Oh Delta G (To the tune of "Oh Danny Boy")
Copyright Kevin Ahern
Oh Delta G - the change in Gibbs free energy Can tell us if a process will advance
'Cause if the value's less than naught it translates that Reverse reactions haven't got a chance
But when the sign is plus it is the opposite
And then the backwards happens all the time A factor is the standard Gibbs free energy
So don't forget about the delta G naught prime
Metabolic Melodies
Metabolic Melodies
The Muscle Energy Song
(to the tune of “I Will”) Copyright © Kevin Ahern
The Muscle Energy Song
(to the tune of “I Will”) Copyright © Kevin Ahern
For running and for jumping
You need some energy
Chemically the body stores it
In the form of ATP
If backup should be needed
Reserves are there in wait
Muscles brimming with supplies of
Tiny creatine phosphate
Ready whenever cells are ever
Needing to exercise
Steady as ever when whatever
Energy needs arise
The action is exacting
For leaping in the air
Myofibrils all contracted
Using energy extracted
From reactions that react in me
Using A-T-P
You see