dr motlalepula g. matsabisa indigenous knowledge systems [health] medical research council – south...
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Dr Motlalepula G. MatsabisaDr Motlalepula G. Matsabisa
Indigenous Knowledge Systems [Health] Indigenous Knowledge Systems [Health]
Medical Research Council – South AfricaMedical Research Council – South Africa
Portfolio Committee on HealthPortfolio Committee on Health
April 11April 11thth 2004 2004
Our Mission and Vision
To promote and advance indigenous knowledge systems through research and development by making it a valued health model in the global environment and to redress health traditions, which until now have neglected health research priorities and issues.
To be a centre of excellence in traditional medicines research regionally and to be competitive globally
Objectives Objectives
Coordination and development of health research in indigenous knowledge
Institutional and community networks
Development of an enabling clinical trial environmentDevelopment of an enabling clinical trial environment
Innovations and commercialization in traditional health systems. Innovations and commercialization in traditional health systems.
Policies governing intellectual property and benefit-sharing Policies governing intellectual property and benefit-sharing
Research programmes that are appropriate & relevant Research programmes that are appropriate & relevant
Support academic researchSupport academic research
FundingFunding
CEO Interim: Prof AD Mbewu
Research Directorate
IKS Lead ProgrammeDirector Dr MG Matsabisa
IKS Knowledge Management
IKS Research and Development
IKS Utilization SBU
IKS Laboratory IKS Resource Centre IKS Production Facility & Quality Control Laboratory
DELFT: MRC’s Core IKS Facilities
Drug Discovery
Clinical Trials
Toxicity
New Research Methodologies
DatabasesNational Reference CentreHealth PromotionPolicyAdvocacyHealer Liaison
Poverty Eradication Programmes
Pilot Farms
Horticulture
Production GMP
MALARIA
HYPERTENSION
TUBERCULOSIS
IKS RESEARCH GUIDELINES
Research Policy
TRAMED III
NHKN
Database
DELFT CENTRE
Special Projects
CLIN
ICA
L TRIA
LS PLATFO
RM
IP POLICY
IK TRUST
•Medicinal Garden Project•Training Programme
POVERTY ALLIVIATION
TOXICOLOGY
CANCER
DIABETES
TRADITIONAL HEALERS
MONONGRAPHS
School outreach program
FARM
TRADITIONAL HEALTH CLAIMS
TDr Program
NATIONAL REFERENCE CENTRE for ATM
MCC - ATMC
IKS Research and Development IKS Knowledge Management IKS Utilization (SBU)
PAIN
ACCESS & BENEFIT-SHARING
Current Projects
HIV AND AIDS
MalariaMalaria
Preclinical studiesPreclinical studies
Clinical studiesClinical studies
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14 5
67
8
910
1112
13
15
14
1'
2'4'
6'
8'9'
11'
12'
13'
15'
14'
C30H28O7
C30H28O6
Resistance Modulators
Cancer
Antibiotics
Malaria
HIV and AIDS
AnticancerAnticancer
MAS1 aqueous
0
20
40
60
80
100
0.025 0.25 2.5 25 250
micrograms/ml
% I
nh
ibit
ion
HT29
HeLa
MCF7
MAS2 aqueous
0
20
40
60
80
100
0.025 0.25 2.5 25 250
micrograms/ml
% In
hibi
tion HT29
HeLa
MCF7
MAS3 aqueous
0
20
40
60
80
100
0.025 0.25 2.5 25 250
micrograms/ml
% In
hibi
tion HT29
HeLa
MCF7
MAS3 methanol
0
20
40
60
80
100
0.025 0.25 2.5 25 250
micrograms/ml
% In
hibi
tion HT29
HeLa
MCF7
Antidiabetic Antidiabetic
Toxicity assay on Chang liver cells
0.2
0.4
0.6
0.8
0 50 100 150
[Extract] (ug/ml)
A540n
m
Glucose utilisation in Chang liver cells
0
20
40
60
80
100
120
140
160
180
Control Insulin Extract Metformin
% o
f co
ntr
ol
Acute
Chronic
Toxicity assay on C2C12 muscle cells
0.2
0.4
0.6
0.8
0 50 100 150
[Extract] (ug/ml)
A540n
m
Glucose utilisation in C2C12 muscle cells
0
20
40
60
80
100
120
140
160
180
Control Insulin Extract Metformin
% o
f co
ntr
ol
Acute
Chronic
HIV and AIDSHIV and AIDS
Assessment of Traditional Assessment of Traditional Claims for curesClaims for cures
Safety, Efficacy studiesSafety, Efficacy studies
Value additionValue addition
Clinical TrialsClinical Trials
EthicsEthicsEthics:Ethics: Informed consent for screeningInformed consent for screening Informed consent for HIV testingInformed consent for HIV testing Informed consent for participation in the studyInformed consent for participation in the study Information leaflet for the screeningInformation leaflet for the screening Information leaflet for participation in the studyInformation leaflet for participation in the study Counseling:Counseling:
Integrated approach: To whole familyIntegrated approach: To whole family
Pre-screening HIV counselingPre-screening HIV counseling
1 post screening counseling (referral of those that are HIV+, but not meeting the inclusion criteria to 1 post screening counseling (referral of those that are HIV+, but not meeting the inclusion criteria to appropriate & accredited centres for support) appropriate & accredited centres for support)
Ethical approval: Ethical approval: (scientific and ethical merits)(scientific and ethical merits)
Protocols are peer-reviewedProtocols are peer-reviewed Submitted to MRC & MCC’s Clinical Trials Committee (CTC) for ethical evaluationSubmitted to MRC & MCC’s Clinical Trials Committee (CTC) for ethical evaluation
ToxicologyToxicology
90-day sub chronic study on a non-human 90-day sub chronic study on a non-human primate modelprimate model
Clinical Human TrialsClinical Human Trials
Both Phase I and II/III Both Phase I and II/III Are double blind, randomized, placebo controlled Are double blind, randomized, placebo controlled
dose elevation parallel group studiesdose elevation parallel group studies
Case StudiesCase Studies
199
-79
23
-100
-50
0
50
100
150
200
% In
crease
/Decr
ease
1 2 3
n = 62
8696
86
0
20
40
60
80
100
% Inh
ibitio
n
In vitro HIV Protease Inhibition
Extract Extract A SO A SO 86% 86%Extract Extract B PTB PT 96% 96%Extract Extract C Cm & gC Cm & g 86% 86%
HIV and AIDSHIV and AIDS
TrainingTraining
School OutreachSchool Outreach
Community PartnershipCommunity Partnership
Medicinal Herb GardenMedicinal Herb Garden
MRC Delft Community Project
• Provide enabling environment for healers and scientists to interact
• Formal structure for healers to interact, develop policy and develop communication products
• Provide healers access to scientific infrastructure (Information, Library, Internet access, database, medicinal plant cultivation, drug discovery, Resource Centre)
• Provide a forum for structured health education and promotion (Herb garden)
• Develop skills in growing, processing, packaging and marketing of herbal products
School out-reach Program and TDr Training Program
[photos not included]
IKS UtilizationIKS Utilization
Strategic Business UnitStrategic Business Unit
Socio-economic DevelopmentSocio-economic Development
Poverty EliminationPoverty Elimination
ManufacturingManufacturing
Poverty EliminationPoverty Elimination
Organizational StructureOrganizational Structure
DST
MRC
Municipality
Community Commercial Partner
Land Infrastructure
Nursery Commercial farming
Markets
Skills transfer
Agriculture
Skills transfer
Health Education
Entrepreneurial skills development
Business development
Skills transfer
MethodologyMethodology
THE VALUE ADDED CHAINTHE VALUE ADDED CHAIN
Creation (Patents, Innovations) Creation (Patents, Innovations)
KnowledgeKnowledge
Point of entry Existing IndustriesPoint of entry Existing Industries ServicesServices
__________________________________________________________________________________________________
IndustriesIndustries
Point of entry Emerging Industries Point of entry Emerging Industries
AgricultureAgriculture
Theoretical modelTheoretical model
MARKETMARKET
Commercial viability(2)
Commercial viability(2)
Technical viability(3)
Technical viability(3)
Entrepreneurial viability(4)
Entrepreneurial viability(4)
INDUSTRY(5)
• Partnerships
INDUSTRY(5)
• Partnerships
INSTITITONALSUPPORT (1)•MRC•Municipalities•Private sector
INSTITITONALSUPPORT (1)•MRC•Municipalities•Private sector
Kimberley
Municipality: TsolwanaPlace: Hofmeyer/ Tarkastad
Municipality: SenquPlace: Sterkspruit
Anticipated ImpactAnticipated Impact
Job creation
Sustainable use of medicinal plants
Application of scientific research developed by the IKS Lead Programme
Capacity building for institutions (municipalities)
Training and promotion of the culture of entrepreneurship
The promotion of registered business ventures fully owned by emerging entrepreneurs
Horizontal and vertical integration of the area surrounding the projects.
IKS TechnologiesIKS Technologies
Systems – Mechanisms of Systems – Mechanisms of ActionAction
Analytical analysisAnalytical analysis
Quality ControlQuality Control
ManufacturingManufacturing
ProteomicsProteomics
GenomicsGenomics
MetabolimicsMetabolimics
Cytochrome P540Cytochrome P540 1a21a2 2a2a 2c19 2c19 2d62d6 2c82c8 2c92c9 2e12e1 3a43a4
How to Contact UsHow to Contact Us
Indigenous Knowledge Systems Indigenous Knowledge Systems [Health] Lead Programme[Health] Lead Programme
Dr MG MatsabisaDr MG Matsabisa – Director – Director
Tel. +27 21 938 0475Tel. +27 21 938 0475Fax. +27 21 938 0410Fax. +27 21 938 0410
E-mail. E-mail. [email protected]@mrc.ac.za
Website:Website: www.mrc.ac.za www.mrc.ac.za
“Going back to our roots for innovative health solutions”