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Environmental risk assessment Dr Stuart Dobson Centre for Ecology & Hydrology, United Kingdom

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Page 1: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

Environmental risk assessmentDr Stuart DobsonCentre for Ecology & Hydrology, United Kingdom

Page 2: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

Reasons for doing international environmental risk assessment:

• high exposure or tonnage production• regional or national contamination• local “hot spots”• transboundary concerns• susceptible populations• “problem” chemicals • global contamination or key ecosystem dysfunction

Page 3: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

“the ultimate key aim of [environmental]risk assessment is to prevent further chemicals from becoming major problems by applying lessons learnt at the population and ecosystem end of the spectrum to the lower, screening stages”

Page 4: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

Information needed for a full risk assessment:

• population effects data• community effects data• ecosystem effects data

In practice, we have few if any of these

• measured exposure concentrations from a range of habitats/ecosystems

• field studies to give us ….• chronic multiple endpoint/species effects data• acute and sub-acute multiple endpoint/species effects data

Page 5: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

Achievable objectives:• international harmonisation on the basic approach (OECD)

• screening of chemicals against a basic set of information

• an estimated “no-observed-effect” concentration

• a predicted “protective” concentration for populations/communities (PNEC)

• a predicted environmental concentration (PEC)

• expression of risk as a ratio PEC/PNEC

Page 6: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

Concentration

EXPOSURE EFFECTS

Simple principle of environmental risk assessment

Neither the exposure distribution nor the effects distribution are straightforward to determine

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Default exposure estimation:

Refined exposure estimation:

• initial estimate based on tonnage in a region• simple models for degradation• worst case dilution factors• partition models• bioaccumulation models

• base on specific industrial plants or receptors• specific models for region• geographical information incorporated• monitoring

Page 8: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

0.01

0.1

1

10

100

1,000

10,000C

once

ntra

tion

µg/li

tre

(µg/

kg)

St Su M E Se

St: surface water (effluent in area is treated) Su: surface water (effluent untreated or unknown)M: estuarine and marine water E: sewage effluent (treated or untreated) Se: sediment

Concentrations of nonylphenol measured in water and sediment

Predicted

Environmental

Concentration

Page 9: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

Estimated exposure distribution

Actual exposuredistribution

Exposure distributionrelevant to particularorganisms

• mostly our estimates of environmental concentration are substantially higher than reality

• we can predict locally better than regionally or nationally

• regulators use the conservative worst case to encourage industry to measure levels in the environment

• very little monitoring of chemicals in water, soil etc. is performed globally

• of the monitoring which is done, much of the information is not readily available to IPCS

Page 10: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

1

10

100

1,000

Con

cent

ratio

n µg

/litr

ePlot of acute lethal toxicity studies in fish for nonylphenolcompared to sub-lethal NOECs for oestrogenicity

lethal sub-lethal

The effects distribution:• we more usually have acute than longer-term data

• it is a distribution of effects on a limited range of common test species

• it is strongly biased towards temporate climates

• we usually have few data points

Page 11: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

1

10

100

1,000

Con

cent

ratio

n µg

/litr

ePlot of acute lethal toxicity studies in fish for nonylphenolcompared to sub-lethal NOECs for oestrogenicity

lethal sub-lethal

Acute to chronic and lethal to sublethal:• commonly we know little of the chronic effects of chemicals

• few endpoints are studied in standard testing

• when sub-lethal endpoints are measured, there are often highly significant effects at concentrations much lower than lethal

Page 12: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

We deal with limited data by applying uncertainty factors:• internationally agreed schemes require basic test data for three trophic levels – algae, invertebrates and fish

• lack of any part of the data set attracts an uncertainty factorranging from 10 to 1000 depending on the data

• an uncertainty factor of 10 is always applied because of the very limited data set required

Page 13: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

0.01

0.1

1

10

100

1,000

10,000C

once

ntra

tion

µg/li

tre

(µg/

kg)

St Su M E Se

St: surface water (effluent in area is treated) Su: surface water (effluent untreated or unknown)M: estuarine and marine water E: sewage effluent (treated or untreated) Se: sediment

Concentrations of nonylphenol measured in water and sediment

Lowest acute EC50

Lowest chronic NOEC

Predicted noobserved effect (PNEC)

PEC

Page 14: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

With these limitations, what can we achieve?• can we even be confident about risk assessment for well studied chemicals?

• what is the real risk from nonylphenol, for example?

• can we help countries world wide to inform their risk management?

• what have we attempted to do in the IPCS Programmes to overcome the limitations?

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Multiple scales

Page 16: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

1E-005

0.0001

0.001

0.01

0.1

1

10

100

1,000

10,000

Con

cent

ratio

n m

g/lit

re

PECs LC50

Plot of estimated and measured concentrationsin surface waters and reported acute toxicity values for 2- butoxyethanol

• only a single measured concentration available

• information on all manufacturing sites in the USA

• the range of toxicity can be compared to modelled concentrations for all sites to give a range of risk factors

• we are still only estimating true risk but increase our confidence in the result

Expanding a limited dataset on exposure ……

Page 17: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

Log-logistic distribution of median lethal dose of 10 specieswith determined TLD5

from Baril et al. (1994)

We can use probabilistic methods where the dataset is adequate

Page 18: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

c

once

ntra

tion

µg/li

tre

algaeinvertebratesfishupstreamdownstreambioavailablebioavailable

Cu Cr As CCA

1

10

100

1000

10000

100000

.1

Large datasets establish more reliable no-effect-concentrations …

• the large datasets for copper, chromium and arsenic can establish “true” NOECs

• we can combine measured concentrations to establish risk of copper chrome arsenate wood preservatives

• estimates from the IPCS documents allow us to calculate likely bioavailability to organisms

Page 19: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

Incorporation of biology and ecology into the risk assessment …

Beryllium

0.80.1245144.61Grass12.44.435.5vole, field

0.70.1335134.91Grass13.33.224vole, bank

1.60.0632284.81Grass6.3101.11600rabbit

1.70.0572314.61Grass5.7160.22800hare, mountain

1.80.0555324.51Grass5.5184.73330hare, brown

0.30.346651.910Tree shoots3.51620.446750goat, feral

0.30.393545.710Tree shoots3.9902.122925deer, sika

0.30.393045.810Tree shoots3.9907.723100deer, roe

0.40.267667.310Tree shoots2.75352.0200000deer, red

0.20.432441.610Tree shoots4.3583.713500deer, muntjac

0.30.336253.510Tree shoots3.41865.855500deer, fallow

0.20.424942.410Tree shoots4.2633.014900deer, Chinese water

WORST CASE CHRONIC TERb

WORST CASE DIETARY CONSUMPTION (mg/kg/day)

WORST CASE ACUTE TOXICITY/EXPOSURE RATIO (TER)

EXPECTED MAXIMUMCONCENTRATION IN DIET (mg/kg dry weight) c

DIETARY COMPONENT

ESTIMATED FOOD AS % BODY WEIGHT *

ESTIMATED FOOD CONSUMPTION (g dry weight)*

BODY WEIGHT (g fresh weight)

SPECIES

Page 20: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

If we have a large enough dataset ….

• we can estimate which species are affected at particular concentrations

• we can define what effects are likely to be seen on communities

Page 21: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324
Page 22: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324
Page 23: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

Concentration

EXPOSURE EFFECTSNOT

ADAPTED

As

ADAPTED

Species adapt to natural high concentrations of chemicals over time …..

Some communities of species with unique characteristics exist inconcentrations of chemicals which would be lethal to un-adapted communities – they may be of great conservation interest

Page 24: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

There are limitations on what advice we can give from the international programmes …

• we might have the range of effects data to estimate toxicity

• we often don’t have enough local exposure data to estimate risk

Page 25: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

10-1

100

101

102

103

C

once

ntra

tion

(mg

fluor

ide/

litre

)

Algae: EC50Algae: LOECAlgae: NOECInvertebrates: LC50Invertebrates: LOECInvertebrates: NOECInvertebrates -"Safe concentration"Fish: LC50Fish: LOECFish: NOECFish - "Safe concentration"* - chronicFish behaviour LOEC

Figure 9: Reported toxicity of fluoride to fresh water organisms

***

Page 26: Dr Stuart Dobson Centre for Ecology & Hydrology, United ... · deer, red 200000 5352.0 2.7 Tree shoots 10 67.3 0.2676 0.4 deer, muntjac 13500 583.7 4.3 Tree shoots 10 41.6 0.4324

10-3

10-2

10-1

100

101

102

C

once

ntra

tion

(mg

fluor

ide/

litre

)

seawaterfresh water; backgroundfresh water; geothermal/volcanicfresh water; local industrial

Figure 5: Reported concentrations of fluoride in surface waters

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10-2

10-1

100

101

102

103

104

C

once

ntra

tion

(mg

fluor

ide/

kg)

Natural: totalNatural: water solubleAnthropogenic: totalAnthropogenic: water soluble

Figure 7: Reported concentrations of fluoride in soil

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Conclusions …..

• we can aid countries globally with information to aid risk assessment and risk management

• we could provide better assessment with local information from a range of countries

• exposure data are particularly difficult to obtain

• collaboration to make local information available to the international programmes is invaluable