drug delivery in nano metal organic frameworks
TRANSCRIPT
INTRODUCTION TO
DRUG DELIVERY SYSTEMS
Tony FrancisDepartment of Chemistry
St. Mary’s college Manarkadu
WHY IS DRUG DELIVERY IMPORTANT?
By using DD the ability to engineer controlled localized delivery of drugs might contribute to the :-
1) Efficiency of the treatment and 2) Reduces the side effects.
ENHANCED PERMEABILITY AND RETENTION (EPR) EFFECT & DD It is the property by which certain sizes of
molecules tend to accumulate in tumor tissue much more than they do in normal tissues.
This is because the tumors can induce blood vessel growth (angiogenesis) by secreting various growth factors which helps in tumor expansion.
Chem. Soc. Rev., 2012, 41, 2623–2640
REQUIREMENTS FOR AN EFFICIENT DRUG DELIVERY
VEHICLETHEY SHOULD BE :- NON-TOXIC BIOCOMPATIBLE HIGH DRUG LOADING CAPACITY CONTROL RELEASE AND AVIOD THE
“BURST EFFECT” CONTROL MATRIX DEGRADATION AND
ENGINEER ITS SURFACE BE DETECTABLE BY VARIOUS IMAGING
TECHNIQUES
IMPORTANT DD SYSTEMS
POLYMERIC NANOPARTICLES QUANTUM DOTS METALLIC NANOPARTICLES POLYSACCHARIDES LIPOSOMES CERAMIC NANOPARTICLES CARBON NANOPARTICLES DENDRIMERS
ALL THESE SYSTEMS CAN BE DIVIDED
ORGANIC POLYMERIC NPS LIPOSOMES POLYSACCHARIDES DENDRIMERS CARBON NPS
INORGANIC QUANTUM DOTS METALLIC NPS CERAMIC NPS
THE ORGANIC ROUTE
IN THIS CASE A WIDE RANGE OF DRUG CAN BE ENCAPSULATED BUT A CONTROLLED RELEASE IS DIFFICULT TO ACHIVE IN THE ABSENCE OF A WELL DEFINED POROSITY.
THE INORGANIC ROUTE
IN THIS CASE RELESE IS PERFORMED BY GRAFTING ORGANIC MOLECULES ON THE PORE WALLS BUT IMPLIES A DECREASE IN THE DRUG LOADING CAPACITY
HYBRID ROUTE
THIS IS A COMBINATION OF HIGH AND REGULAR POROSITY WITH THE PRESENCE OF ORGANIC GROUPS WITHIN THE FRAMEWORKS.
ADVANTAGES HIGH DRUG LOADING CONTROLLED RELEASE
WHY MOFS ??
HIGH DRUG LOADING CAPACITY BIODEGRADABILITY TUNABILITY
FIRST DD MOF DENOTED BY MIL-100 & MIL-101 LARGE PORE SIZE(25-34Å) SURFACE AREA(3100-5900m2\g) DENOTED BY—M3X(H2O)2Ln (M3=Cr ,
X=F,OH) L=1,3,5-benzene tricarboxylic acid(BTC) & n=2 FOR MIL-100 or
L=1,4-benzenedicarboxylic acid (BDC) & n=3 MIL-101
Nanoparticles of the mesoporous iron aminoterephthalateMIL-101 synthesised by the hydrothermal microwave-assisted method
ISSUES REGARDING MOFS
STABILITY TOXICOLOGY
THANK YOU…