drug delivery systems carb acid ch
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Drug Delivery Systems
Mullner, M.; Schallon, A.; Walther, A.; Freitag,
R. Biomacromolecules, 2010, 11, 390-396.
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Problem with cancer drugs
Most not water soluble
Toxic to healthy cells
Do not just target cancerous cells
Cause harmful side effects
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New Design
Nanoparticle Template:
Use a micelle that makes drug water soluble
Micelle has hydrophilic outer layer and hydrophobic coreDrug is incorporated into hydrophobic coreNot harmful to body and allows careful delivery of medicine
http://www.uic.edu/classes/bios/bios100/f05pm/micelle.jpg
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Bind a dye that can be used for imaging
Organic dye or quantum dot
Helps scientist track drug
Attach cancer targeting agent on outside of nanoparticle
Allows the drug to target specifically cancer cells
Almost no harm to healthy cells
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Benefits
Longer circulation of drug
Targeting of cancerous cells = less harm to healthy cells
Target allows for more harm to cancerous cells
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Cancer and chiropracticsJ Manipulative Physiol Ther 2001 (Jan); 24 (1): 52–57
A chiropractor can help provide noninvasive and non-pharmacologic options for decreasing pain and improving function.
Treatment may benefit those patients experiencing pain from the side effects of treatment or from the disease process itself
The chiropractor's treatment may include manipulation, soft tissue techniques, physiotherapeutic modalities, exercise, and ergonomic counseling.