Alice T. LimBSN IIB DRUG STUDY Aug. 9, 2010

Carbocisteine

Aflem/Aflem Forte® [cap]

MIMS Class : Cough & Cold Preparations

IndicationsCough including those associated w/ excessive & tenacious bronchial secretions as in acute & chronic bronchitis, bronchiectasis & emphysema.

DosageAflem cap 1 cap tid-qid.

AdministrationShould be taken with food

Contraindications Active ulceration.

Special Precautions Elderly patient w/ severe resp insufficiency, asthma.

Adverse Drug Reactions Bronchospasms, nausea, vomiting, stomatitis & rhinorrhea. Occasionally chills & fever.

ATC ClassificationR05CB03 - Carbocisteine ; Belongs to the class of mucolytics. Used in the treatment of wet cough.

Poison Schedule Non-Rx Presentation/Packing

Form Packing/PriceAflem/Aflem Forte capsule Aflem/Aflem Forte 500 mg x 100's (P896)

ParacetamolBiogesic® [tab]

United Lab [ Biomedis ] MIMS Class: Analgesics (Non-Opioid) & Antipyretics

Contents

ParacetamolIndications

Relief of fever, minor aches & pains.

Dosage Tab Adult & childn >12 yr 1-2 tab every 4-6 hr as needed. Max: 8 tab in 24 hr.

Administration May be taken with or without food

Contraindications Anemia, cardiac & pulmonary disease. Hepatic or severe renal disease.

Special Precautions

Pain of >5 days for children & 10 days for adults. Fever of >3 days.

Adverse Drug Reactions

Allergic skin reactions & GI disturbances.

Drug Interactions Anticonvulsants, aspirin, INH, phenothiazines, alcohol.

Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not

demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

MIMS Class Analgesics (Non-Opioid) & Antipyretics

ATC Classification

N02BE01 - Paracetamol ; Belongs to the class of anilide preparations. Used to relieve pain and fever.

Poison Schedule Non-Rx

Presentation/Packing

Form Packing/Price Photo

Biogesic tablet Biogesic 500 mg x 20'sBiogesic 500 mg x 500's (P2.9/tab)

AmoxicillinBradoxil® [cap]

Singapore Pharmawealth Lifesciences [ Phil Pharmawealth ] MIMS Class : Penicillins

Contents

Amoxicillin (cap: trihydrate, vial: Na)Indications

Treatment of infections caused by susceptible strains of gm+ve & gm-ve microorganisms eg actinomycosis, biliary tract, bone & joint infections, bronchitis, endocarditis, gastroenteritis, gonorrhea, mouth infections, otitis media, pneumonia, spleen disorders, typhoid & paratyphoid fever & UTI. Lyme disease.

Dosage Cap 250-500 mg 8 hrly.

Administration May be taken with or without food (May be taken w/ meals for better absorption & to reduce GI discomfort.).

Contraindications Hypersensitivity to penicillins.

Special Precautions

History of allergy or asthma, hay fever or urticaria. Severe renal failure.

Adverse Drug Reactions

Skin rash, GI effects, pseudomembranous colitis. Reversible blood & lymphatic reactions eg anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia & agranulocytosis.

Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not

demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

MIMS Class Penicillins

ATC Classification

J01CA04 - Amoxicillin; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.

Poison Schedule Rx

Presentation/Packing

FormPacking/Price

Bradoxil capsule

Bradoxil 250 mg x 100's

Bradoxil 500 mg x 100's

Glibenclamide Gluban® [tab]Vendiz [ Metro Drug ]

MIMS Class : Antidiabetic Agents

Contents Glibenclamide

Indications NIDDM or type II-maturity-onset diabetes.

Dosage Initially 2.5-5 mg once daily, may be increased in increments of ≤2.5 mg at wkly intervals until diabetic control is obtained. Max: 20 mg/day.

Administration Should be taken with food

Contraindications IDDM, diabetic ketoacidosis, serious impairment of renal hepatic or adrenocortical function, surgical operation, pregnancy.

Adverse Drug Reactions

Mild GI or allergic skin reactions, reversible leukopenia & thrombocytopenia, transient changes in liver function tests.

Drug Interactions Hypoglycemic effect may be enhanced by dicoumarol, MAOI, β-blockers, sulfonamides, phenylbutazone, chloramphenicol, cyclophosphamide, salicylates or diminished by adrenaline, corticosteroids, OC or thiazide diuretics.

Pregnancy Category (US FDA) Category C: Either studies in animals have revealed adverse effects

on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.

MIMS Class Antidiabetic Agents

ATC Classification

A10BB01 - Glibenclamide ; Belongs to the class of sulfonamides, urea derivatives. Used in the treatment of diabetes.

Poison Schedule Rx

Presentation/Packing Form Packing/PriceGluban tablet Gluban 5 mg x 100's (P700)

MetforminInsunex® [tab]

Medopharm [ NextChem ] MIMS Class: Antidiabetic Agents

Contents Metformin HCl

Indications NIDDM; primary or secondary sulfonylurea failure, where it may replace or be combined w/ sulfonylureas as an adjunct to therapy in IDDM.

Dosage 1 tab bid-tid, increased up to 2-3 g daily.

Administration Should be taken with food (Take w/ or after meals.).

Contraindications Diabetic coma, severe ketoacidosis, severe renal or hepatic insufficiency, cardiac failure, severe thyroid function impairment, dehydration, acute or chronic alcoholism. Trauma & post-op.

Special Precautions

Hepatic & renal disease. Pregnancy.

Adverse Drug Reactions

Anorexia, nausea, vomiting.

Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not

demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

MIMS Class Antidiabetic Agents

ATC Classification

A10BA02 - Metformin ; Belongs to the class of biguanides. Used in the treatment of diabetes.

Poison Schedule Rx

Presentation/Packing Form Packing/PriceInsunex tablet Insunex 500 mg x 100's (P350)

Aluminum HydroxideKremil-S (Reformulated)® [tab]

United Lab [ Therapharma ] MIMS Class : Antacids, Antireflux Agents & Antiulcerants

Contents Al(OH)3 178 mg, Mg(OH)2 233 mg, simethicone 30 mg

Indications Symptomatic relief of hyperacidity associated w/ peptic ulcer, gastritis, esophagitis & dyspepsia. Supplement to H2-blockers or proton pump inhibitors for rapid relief of ulcer symptoms. Antiflatulent to alleviate the symptoms of gassiness, including post-op gas pain, associated w/ hyperacidity.

Dosage Adult 1-2 tab 1 hr after each meal and at bedtime.

Administration Should be taken on an empty stomach (Take 1 hr after each meal & at bedtime. Break/ chew before swallowing.).

Contraindications Patients with renal failure. Partial intestinal obstruction, appendicitis, fecal impaction, gastric outlet obstruction & constipation. Phosphate depletion, low serum phosphate & osteomalacia.

Special Precautions

Risk of Al accumulation & toxicity w/ advanced renal failure. Prolonged use of Al-containing antacids in patients w/ renal failure may result in or worsen dialysis osteomalacia.

Adverse Drug Reactions

Diarrhea or constipation may occur to patients taking antacids containing Mg & Al. The following occur rarely: Due to Al(OH)3: Proximal myopathy; encephalopathy & dementia may occur in patient w/ renal failure; intestinal obstruction; fecal impaction; osteomalacia.

Drug Interactions Alkalinization of gastric content decreases the bioavailability of Fe, ketoconazole & tetracyclines. The absorption of tetracyclines is further reduced by its chelation with Al & Mg ions.

MIMS Class Antacids, Antireflux Agents & Antiulcerants

ATC Classification

A02AF02 - Ordinary salt combinations and antiflatulents ; Belongs to the class of antacids with antiflatulents.

Poison Schedule Non-Rx

Presentation/Packing Form Packing/Price

Kremil-S (Reformulated) tablet

Kremil-S (Reformulated) 8's (P33.2)Kremil-S (Reformulated) 100's (P415)Kremil-S (Reformulated) 500's (P2075)Kremil-S (Reformulated) (P4.15/tab)

LoperamideDiatabs (Reformulated)® [cap]

United Lab [ Biomedis ] MIMS Class : Antidiarrheals

Contents Loperamide HCl

Indications Symptomatic control of acute & chronic diarrhea. Ileostomy.

Dosage Adult Acute diarrhea 2 cap followed by 1 cap after each unformed stool. Do not use for >5 days. Chronic diarrhea 2 cap then adjust dose until 1-2 solid stools/day are obtained. Max: 16 mg/day.

Administration May be taken with or without food

Contraindications Constipation. Acute ulcerative colitis, pseudomembranous colitis, acute dysentery.

Special Precautions

Hepatic dysfunction, persistent diarrhea, patients receiving anti-infectives. Childn <12 yr. Pregnancy & lactation.

Adverse Drug Reactions

Constipation, nausea, vomiting, tiredness, drowsiness or dizziness, dry mouth.

Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not

demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

MIMS Class Antidiarrheals

ATC Classification

A07DA03 - Loperamide ; Belongs to the class of antipropulsives. Used in the treatment of diarrhea.

Poison Schedule Non-Rx

Presentation/Packing Form Packing/Price

Diatabs (Reformulated) capsule

Diatabs (Reformulated) 2 mg x 8's (P54)Diatabs (Reformulated) 2 mg x 100's (P675)Diatabs (Reformulated) 2 mg x 500's (P3375)Diatabs (Reformulated) 2 mg (P6.75/cap)

Diclofenac SodiumDifenax® [tab]

GXI [ Metro Drug ] MIMS Class : Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Contents Diclofenac Na

Indications Inflammatory & degenerative forms of rheumatism, ankylosing spondylitis, osteoarthritis & spondylarthritis. Painful post-traumatic & post-op inflammation & swelling.

Dosage 50 mg bid.

Overdosage View Difenax overdosage for action to be taken in the event of an overdose.

Administration Should be taken with food (Take immediately after meals.).

Contraindications Peptic ulcer.

Special Precautions

Close monitoring necessary in patient w/ GI disorders. Severe impairment of hepatic function.

Adverse Drug Reactions

Epigastric pain, nausea, vomiting, diarrhea, headache & dizziness, rashes or skin eruptions.

Drug Interactions May increase plasma levels of warfarin, lithium, methotrexate, digoxin.

Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not

demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). in 3rd trimester or near delivery.

Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Storage View Difenax storage conditions for details to ensure optimal shelf-life.

Description View Difenax description for details of the chemical structure and excipients (inactive components).

Mechanism of Action

View Difenax mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

ATC Classification

M01AB05 - Diclofenac ; Belongs to the class of acetic acid derivatives and related substances of non-steroidal antiinflammatory and antirheumatic products.

Poison Schedule Rx

Presentation/PackingForm Packing/Price PhotoDifenax tablet Difenax 50 mg x 100's (P5.57/tab)

Mefenamic AcidMefenax® [susp]

One Pharma [ One Pharma ] MIMS Class : Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Contents Mefenamic acid

Indications Headache, muscular & traumatic pain; post-op, post-extraction & postpartum pain; relief of primary dysmenorrhea.

Dosage Susp 25 mg/kg body wt daily in 3 divided doses. Treatment should not exceed 7 days.

Administration Should be taken with food (Take immediately after meals.).

Contraindications Ulceration or inflammation of GIT.

Special Precautions

Renal or liver impairment.

Adverse Drug Reactions

GI irritation, diarrhea (high doses/long-term therapy), skin rash. Rarely, thrombocytopenia & reversible hemolytic anemia.

Side Effects Side effects are few and mild at the recommended dosage for analgesic use and are readily detected and easily controlled when encountered with high dosage and long-term use. Gastric irritation is infrequent and may be minimized by taking Mefenax with meals.

Diarrhea has been observed when mefenamic acid was given in higher than recommended doses and/or long-term continuous therapy. Skin rash has occurred but disappeared upon withdrawal of medication. Rarely, thrombocytopenia and reversible hemolytic

anemia have been reported with mefenamic acid.

Drug Interactions May enhance effects of coumarin anticoagulants.

Pregnancy Category (US FDA) Category C: Either studies in animals have revealed adverse effects

on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus. in 3rd trimester or near delivery.

Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Storage View Mefenax storage conditions for details to ensure optimal shelf-life.

Mechanism of Action

View Mefenax mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

ATC Classification

M01AG01 - Mefenamic acid ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, fenamates.

Poison Schedule Rx

Presentation/PackingForm Packing/PriceMefenax suspension Mefenax 50 mg/5 mL x 60 mL (P80)

Ascorbic AcidCeelin® [syr]

Pediatrica [ United Lab ] MIMS Class : Vitamins & Minerals (Pediatric)

Contents Ascorbic acid

Indications Prevention & treatment of vit C deficiency.

Dosage Syr Childn 7-12 yr 5-10 mL (1-2 tsp), 2-6 yr 5 mL (1 tsp). To be taken once daily for supplementation, bid-qid for therapeutic use.

Administration May be taken with or without food

Adverse Drug Reactions

Nausea, abdominal cramps, diarrhea, nose bleeds.

Drug Interactions

Avoid in phenylketonurics as tab contains phenylalanine.

MIMS Class Vitamins & Minerals (Pediatric)

ATC Classification

A11GA01 - Ascorbic acid (vit C) ; Belongs to the class of ascorbic acid (vitamin C). Used as dietary supplements.

Poison Schedule Non-Rx

Presentation/Packing Form Packing/Price

Ceelin syrup

Ceelin 100 mg/5 mL x 60 mL (P54.5)Ceelin 100 mg/5 mL x 120 mL (P116)Ceelin 100 mg/5 mL x 250 mL (P196.75)Ceelin 100 mg/5 mL x 500 mL (P323.25)

Multivitamins

K-A Plus Multivitamins® [cap]

Diamond Lab [ Tobie Pharma ] MIMS Class : Vitamins &/or Minerals

Contents Vit A 4,000 iu, vit B2 2 mg, vit B1 2 mg, vit B6 1 mg, vit B12 1 mcg, vit C 60 mg, vit D 400 iu, vit E 10 mg, nicotinamide 15 mg, Ca pantothenate 10 mg, rutin 20 mg, Ca phosphate dibasic 307.5 mg, standardized Korean ginseng 40 mg, Ca fluoride 0.5 mg, cupric sulfate 2.8 mg, K sulfate 18 mg, manganese sulfate 2.8 mg, Zn sulfate 2.8 mg, Fe sulfate 30 mg, deanol 26 mg, inositol 25 mg, choline Cl 25 mg, linoleic acid 25 mg, Mg sulfate 50 mg, lysine HCl 25 mg

Indications Prevents & treats nutritional vit & mineral deficiencies, increases body resistance against diseases & overcomes undue fatigue & stress. Provides nutritional supplement for metabolic build up & conditions as in athletic exertions. Restores energy & vigor for physical activities & improves mental capacity for work.

Dosage 1-2 cap daily.

Administration May be taken with or without food (May be taken w/ meals for better absorption or if GI discomfort occurs.).

Storage Store at a temperature not exceeding 30°C.

Description Each capsule contains the following: Retinol acetate (vitamin A) 4000 IU, riboflavin (vitamin B2) 2 mg, thiamine mononitrate (vitamin B1) 2 mg, pyridoxine hydrochloride (vitamin B6) 1 mg, cyanocobalamin (vitamin B12) 1 mcg, ascorbic acid (vitamin C) 60 mg, ergocalciferol (vitamin D) 400 IU, L-tocopherol (vitamin E) 10 mg, nicotinamide 15 mg, calcium pantothenate 10 mg, rutin 20 mg, dibasic calcium phosphate 307.5 mg, Standardized Korean ginseng (made from roots of the best quality genuine Panax ginseng) 40 mg, calcium fluoride 0.5 mg, cupric sulfate 2.8 mg, potassium sulfate 18 mg, manganese sulfate 2.8 mg, zinc sulfate 2.8 mg, ferrous sulfate (equivalent to 7.2 mg elemental iron) 30 mg, deanol 26 mg, inositol 25 mg, choline chloride 25 mg, linoleic acid 25 mg, magnesium sulfate 50 mg and lysine hydrochloride 25 mg.

K-A Plus contains an effective combination of the necessary vitamins and minerals plus the revitalizing properties of Korean ginseng.

K-A Plus is designed to ensure optimum energy build up during everyday activities and stresses.

K-A Plus incorporates the most essential vitamin and mineral supplement necessary to stimulate appetite, correct vitamin deficiencies, restore physical stamina, maintain and improve physical and mental development. It also helps increase body resistance against infections and other stress-oriented conditions.

MIMS Class Vitamins &/or Minerals

ATC Classification

A11AA03 - Multivitamins and other minerals, incl. combinations ; Belongs to the class of multivitamins with minerals. Used as dietary supplements.

Poison Schedule Non-Rx

Presentation/PackingForm Packing/Price PhotoK-A Plus Multivitamins capsule

K-A Plus Multivitamins 30's (P240)

K-A Plus Multivitamins 100's (P800)

AmpicillinAmpico® [vial]

Sel-J Pharma [ Sel-J Pharma / Plethico ] MIMS Class : Penicillins

Contents Ampicillin

Indications Vial: Adults: 250 mg every 6 hrs IM or IV. Children: 50 mg/kg/day, IM or IV in divided doses every 6 or 8 hrs.

Infections of the Genitourinary Tract: Adults: 500 mg every 6 hrs IM or IV.

Larger doses may be required for severe infections.

Children: 100 mg/kg/day in divided doses every 6 hrs.

Infections of the GIT: Adults: 500 mg every 6 hrs IM or IV.

Children: 100 mg/kg/day IM or IV in divided doses every 6 hrs.

Dosage Infections of the ear, nose, throat & lower resp tract due to staphylococci & upper & lower resp tract infections due to H influenzae Adult 250 mg 6 hrly. Childn 50 mg/kg/day in divided doses 6-8 hrly. GUT infections Adult 500 mg 6 hrly. Childn 100 mg/kg/day in divided doses 6 hrly. Uncomplicated urethritis due to N gonorrhea Adult 3.5 g single dose administered simultaneously + 1 g probenecid. GIT infections Adult 500 mg 6 hrly. Childn 100 mg/kg/day in divided doses 6 hrly. Childn >20 kg Adult dose.

Overdosage In case of overdosage, discontinue, treat symptomatically and institute supportive measures as required. In patients with function impairment, ampicillin-class antibiotics can be removed by hemodialysis but not by dialysis.

Contraindications Allergy to penicillins.

Warnings Serious and occasionally fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on penicillin therapy. Although anaphylaxis is more frequent following parenteral therapy, it has occurred in patients on oral penicillins. These reactions are more apt to occur in individuals with a history of sensitivity to multiple allergens. There have been reports of individuals with a history of penicillin hypersensitivity who experienced severe

reactions when treated with cephalosporins. Before therapy with a penicillin, careful inquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins and other allergens. If an allergic reaction occurs, the drug should be discontinued and the appropriate therapy should be instituted. Serious anaphylactoid reactions require immediate emergency treatment with epinephrine. Oxygen, IV steroids and airway management, including intubation, should also be administered as indicated.

Special Precautions

Discontinue in case of superinfection. Prolonged therapy.

Adverse Drug Reactions

Glossitis, stomatitis, black, hairy tongue, nausea, vomiting, enterocolitis, pseudomembranous colitis & diarrhea. Erythematous maculopapular rash, urticaria, erythema multiforme & anaphylaxis. Moderate rise in SGOT. Anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia & agranulocytosis. Urticaria, other skin rashes.

Drug Interactions Allopurinol. Bacteriostatic antibiotics eg chloramphenicol, erythromycin, sulfonamide & tetracycline. OCs. Probenecid.

Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not

demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Storage Store at a temperature not exceeding 30°C. Protect from direct sunlight.

Shelf-Life: Vial: 24 months.

Description Each capsule contains ampicillin trihydrate equivalent to ampicillin anhydrous 500 mg. Each 250- 500- and 1-g vial contains ampicillin sodium 250- 500- and 1-g respectively.

Ampicillin is a semisynthetic penicillin derived from the basic penicillin nucleus, 6-amino-penicillanic acid.

Mechanism of Action

Antibacterial.

Pharmacology: Ampicillin is similar to benzyl penicillin in its bacterial action against sensitive organisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of

cell wall mucopeptide. Ampicillin differs in vitro spectrum. It exerts high in vitro activity against many strains of Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria catarrhalis, Escherichia coli, Proteus mirabilis, Bacteroides funduliformis, Salmonella and Shigella organisms. In vitro studies have also demonstrated the sensitivity of many strains of the following gram-positive bacteria; α-hemolytic streptococci, Diplococcus pneumoniae, nonpenicillinase-producing staphylococci, Bacillus anthracis, and most strains of enterococci and clostridia. Ampicillin generally provides less in vitro activity than penicillin G does against gram-positive bacteria. Because it does not resist destruction by penicillinase, it is not effective against penicillin-producing bacteria, particularly resistant staphylococci. All strains of Pseudomonas and most strains of Klebsiella and Aerobacter organisms are resistant.

Pharmacokinetics: Ampicillin is acid stable and therefore well absorbed. Food, however, retards absorption.

Blood serum levels of approximately 2 mcg/mL are attained within 1-2 hrs following a 250 mg oral dose given to fasting adults. Detectable amounts persist for about 6 hrs.

Ampicillin diffuses readily into all body tissues and fluids with the exception of brain and spinal fluid except when meninges are inflamed. Higher serum levels are obtained following IM injection. Most of the ampicillin is excreted unchanged in the urine and this excretion can be delayed by concurrent administration of probenecid. The active form appears in the bile in higher concentrations than those found in the serum. Ampicillin is 1 of the least serum bound of all the penicillins; averaging about 20% compared to approximately 60-90% for other penicillins.

MIMS Class Penicillins

ATC Classification

J01CA01 - Ampicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.

Poison Schedule Rx

Presentation/PackingForm Packing/Price

Ampico vial Ampico 1 g x 10'sAmpico 250 mg x 10'sAmpico 500 mg x 10's

Ferrous Sulfate

Brisofer® [cap]

Brymar Pharma [ Brymar Pharma ] MIMS Class : Vitamins & Minerals (Pre & Post Natal) / Antianemics

Contents Fe sulfate

Indications Iron deficiency.

Dosage 1 cap daily.

Administration Should be taken with food (Take after meals.).

Special Precautions

Administration w/ food. Gastric irritation.

Adverse Drug Reactions

Black stools.

Drug Interactions

Tetracycline, antacids.

MIMS Class Vitamins & Minerals (Pre & Post Natal) / Antianemics

ATC Classification

B03AA07 - Ferrous sulfate; Belongs to the class of oral iron bivalent preparations. Used in the treatment of anemia.

Poison Schedule Non-Rx

Presentation/Packing Form Packing/PriceBrisofer capsule Brisofer 250 mg x 100's