drugs induce changes in feces , urine and laboratory values
TRANSCRIPT
مصطفى محمد حسنى عثمان/ مقدم من الصيدلى
2016-2015دبلومة صيدلة المستشفيات
changes in feces may be in color , size , consistency , odour
Green stools
If stool passes through the intestine too quickly, there might not be enough time for bile to be digested and broken down to provide the normal brownish stool color..
Examples of drugs that induce green color of stool : indomethacin , iron supplements
There are a variety of reasons why stool will be yellow, greasy, and foul smelling. It can be due to the intestine's inability to digest and absorb fat because of diseases of the intestinal lining (such as in celiac disease and cystic fibrosis) because the pancreas is unable to manufacture adequate digestive enzymes.
Examples of drugs that induce yellow color of stool : rhubarb , senna and orlistat
Black stools are a worrisome symptom because it may be due to a large amount of bleeding into the GI tract. These stools tend to be tarry (sticky), and foul smelling. This can be a medical emergency; black tarry stools should not be ignored.
Examples of drugs that induce black color of stool : aspirin , salicylates , chloramphenicol , clindamycin ,
iron supplements , ibubrofen , levodopa
The most common cause of bright red stool is
bleeding from hemorrhoids.
Examples of drugs that induce red color of stool : heparin , phenyl butazone , senna , salicylates , tetracycline , anti coagulants
Which is due to drugs that cause constipation like: Ibuprofen, naproxen Zyrtec ,
Claritin , a multivitamin with iron,
diltiazem and verapamil
Which is due to drugs that cause diarrhea like: Chemotherapy medicines used to treat cancer , drugs used to treat heartburn and stomach ulcers, such asomeprazole (Prilosec), esomeprazole (Nexium), lansoprazole (Prevacid), rabeprazole (AcipHex), pantoprazole (Protonix), cimetidine (Tagamet), ranitidine (Zantac), and nizatidine (Axid) , medicinesthat suppress the immune system (such as mycophenolate)
may be due to side effects of medicines (especially nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen, and naproxen)which
make food to be undigested
Normal urine color ranges from pale yellow to deep amber yellow
An unusual urine color can be a sign of disease. For instance, deep red to brown urine is an identifying characteristic of porphyria, a rare, inherited disorder of red blood cells
DARK BROWN
Chloroquin
Methyldopa
Nitrates
Nitrofurantoin
Metronidazole
Senna
Sulphonamides
Nitrofurantoin
Chloroquin
Primaquin
Triamterene
Amitriptyline
Methocarbamol
Methyline blue
Phenazopyridine
Sulfasalazine
Rifampin
Warfarin
Heparin
Heparin
Phenytoin
Senna
Ibubrufen
Phenylbutazone
Doxirubicin
Some people may experience instances of Dark urine while taking Metronidazole.The pigment responsible is most likely to be a metabolite of Metronidazole.. But definitely pay a visit to your physician if the dark color of urine persists even after stopping medication and if you experience any instances of decreased vision, burning or numbness or tingling or painful sensations in the hands or feet, changes in speech patterns and yellow eyes or skin. Alcoholic beverages should be avoided while taking Metronidazole and for at least one day afterwards the completion of medication.
it is petredinederivative
Pteridine isan aromatic chemical compound composed of fused pyrimidine and pyrazine rings. A pteridine is also a group of heterocyclic compounds containing a wide variety of substitutions on this structure. Pterins and flavins are classes of substituted pteridines that have important biological activity. Pteridine, is a precursor in the synthesis of dihydrofolic acid in many microorganisms. Pteridineand 4-Aminobenzoic acid convert by the enzyme dihydropteroate synthetase into dihydrofolic acid in the presence of glutamate. The enzyme dihydropteroatesynthetase is inhibited by Sulfonamide antibiotics
Discolor urine to dark-brown due to liver problems(hepatotoxicity)
DeprivanSedative cause dark colour of urine by prolonged use
Myfortic and Cellcept(immunosupressant) contain phenol group The mechanism of action appears to be caused by phenol's conjugation by the liver and subsequent excretion by the kidneys
drugs may affect the results of clinical laboratory tests
by:
a) In vivo effects, and/or
b) In vitro effects
Bilirubin
Daylight, 30% per hour!! ((non-drug
Decrease
Barbiturates induce glucuronyl transferase in
newborns
Any drug with liver toxicity or causing cholestasis
Increase
Methyldopa reacts with diazo reagent
Diuretics enhance excretion Decrease
Phenytoin (Dilantin) may cause osteomalacia
Antacids (large amounts), e.g., TUMS
Increase
Ascorbic acid interferes with glucose oxidase procedures
Decrease
Ascorbic acid interferes with procedures which utilize reduction
(e.g., reduction of cupric ion, ferricyanide, etc.)
Increase
Diuretics, cathartics, aspirin, steroids
Decrease
Blood transfusions Increase
Hemolysis (non-drug)
Refrigeration of whole blood (inhibition of Na/K-ATPase pump)
Marijuana (?)
Spironolactone inhibits Na/K-exchange in renal tubules
Marijuana (?) Decrease
After meals
Acetoacetic acid, acetone and ascorbic acid are chromogenic in picratereaction; glucose same as above
increase